{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:31:24Z","timestamp":1791855084061,"version":"4.3.4"},"reference-count":34,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T00:00:00Z","timestamp":1657584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virologica Sinica"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.virs.2022.07.007","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T02:35:51Z","timestamp":1657593351000},"page":"637-645","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Epidemiological characteristics and disease burden of infectious mononucleosis in hospitalized children in China: A nationwide retrospective study"],"prefix":"10.1016","volume":"37","author":[{"given":"Mengjia","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoshuang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueping","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0243-8538","authenticated-orcid":false,"given":"Ran","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7634-9338","authenticated-orcid":false,"given":"Zhengde","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virs.2022.07.007_bib1","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1002\/ijc.27858","article-title":"EBV primary infection in childhood and its relation to B-cell lymphoma development: a mini-review from a developing region","volume":"133","author":"Chabay","year":"2013","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.virs.2022.07.007_bib2","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1097\/01.inf.0000095199.56025.96","article-title":"Epstein-Barr virus-associated infectious mononucleosis in Chinese children","volume":"22","author":"Chan","year":"2003","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.virs.2022.07.007_bib3","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1182\/blood-2017-11-814244","article-title":"Genetic and mechanistic diversity in pediatric hemophagocytic lymphohistiocytosis","volume":"132","author":"Chinn","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.virs.2022.07.007_bib4","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.12688\/f1000research.15544.1","article-title":"Increasing Epstein-Barr virus infection in Chinese children: a single institutional based retrospective study","volume":"7","author":"Devkota","year":"2018","journal-title":"F1000Res"},{"key":"10.1016\/j.virs.2022.07.007_bib5","first-page":"211","article-title":"Infectious mononucleosis","volume":"390","author":"Dunmire","year":"2015","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.virs.2022.07.007_bib6","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jcv.2018.03.001","article-title":"Primary Epstein-Barr virus infection","volume":"102","author":"Dunmire","year":"2018","journal-title":"J.\u00a0Clin. Virol."},{"key":"10.1016\/j.virs.2022.07.007_bib7","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/ped4.12144","article-title":"Disease spectrum analysis of hospitalized children in China: a study of 18 tertiary children's hospitals","volume":"3","author":"Feng","year":"2019","journal-title":"Pediatr Investig"},{"key":"10.1016\/j.virs.2022.07.007_bib8","first-page":"957","article-title":"Infectious mononucleosis","volume":"19","author":"Fernbach","year":"1972","journal-title":"Pediatr. Clin."},{"key":"10.1016\/j.virs.2022.07.007_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0175574","article-title":"Evolution of EBV seroprevalence and primary infection age in a French hospital and a city laboratory network, 2000-2016","volume":"12","author":"Fourcade","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.virs.2022.07.007_bib10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s12519-011-0244-1","article-title":"Epidemiologic and clinical characteristics of infectious mononucleosis associated with Epstein-Barr virus infection in children in Beijing, China","volume":"7","author":"Gao","year":"2011","journal-title":"World J Pediatr"},{"key":"10.1016\/j.virs.2022.07.007_bib11","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1017\/S0950268803008550","article-title":"Clinical and laboratory presentation of EBV positive infectious mononucleosis in young adults","volume":"131","author":"Grotto","year":"2003","journal-title":"Epidemiol. Infect."},{"key":"10.1016\/j.virs.2022.07.007_bib12","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.21037\/tp-20-464","article-title":"The epidemiology of blood transfusion in hospitalized children: a national cross-sectional study in China","volume":"10","author":"Guo","year":"2021","journal-title":"Transl. Pediatr."},{"key":"10.1016\/j.virs.2022.07.007_bib13","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1093\/oxfordjournals.aje.a121369","article-title":"Infectious mononucleosis in a general population","volume":"95","author":"Heath","year":"1972","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.virs.2022.07.007_bib14","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/ped4.12294","article-title":"Clinical characteristics and effectiveness of antiviral agents in hospitalized children with infectious mononucleosis in China: a multicenter retrospective study","volume":"5","author":"Hu","year":"2021","journal-title":"Pediatr Investig"},{"key":"10.1016\/j.virs.2022.07.007_bib15","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1111\/apa.15973","article-title":"Virus-triggered secondary hemophagocytic lymphohistiocytosis","volume":"110","author":"Imashuku","year":"2021","journal-title":"Acta Paediatr."},{"key":"10.1016\/j.virs.2022.07.007_bib16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3389\/fped.2016.00047","article-title":"Hemophagocytic lymphohistiocytosis in children: pathogenesis and treatment","volume":"4","author":"Ishii","year":"2016","journal-title":"Front Pediatr"},{"key":"10.1016\/j.virs.2022.07.007_bib17","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/00008480-200006000-00016","article-title":"Acute complications of Epstein-Barr virus infectious mononucleosis","volume":"12","author":"Jenson","year":"2000","journal-title":"Curr. Opin. Pediatr."},{"key":"10.1016\/j.virs.2022.07.007_bib18","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.3389\/fimmu.2017.01867","article-title":"Chronic active epstein-barr virus disease","volume":"8","author":"Kimura","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.virs.2022.07.007_bib19","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1128\/JCM.00164-09","article-title":"Evidence-based approach for interpretation of Epstein-Barr virus serological patterns","volume":"47","author":"Klutts","year":"2009","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.virs.2022.07.007_bib20","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1186\/s12889-020-09049-x","article-title":"Epidemiology of Epstein-Barr virus infection and infectious mononucleosis in the United Kingdom","volume":"20","author":"Kuri","year":"2020","journal-title":"BMC Publ. Health"},{"key":"10.1016\/j.virs.2022.07.007_bib21","doi-asserted-by":"crossref","first-page":"h1825","DOI":"10.1136\/bmj.h1825","article-title":"Infectious mononucleosis","volume":"350","author":"Lennon","year":"2015","journal-title":"BMJ"},{"key":"10.1016\/j.virs.2022.07.007_bib22","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s10096-011-1371-2","article-title":"Secular and seasonal trends of infectious mononucleosis among young adults in Israel: 1978-2009","volume":"31","author":"Levine","year":"2012","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.virs.2022.07.007_bib23","first-page":"450","article-title":"Serological epidemiology investigation of Epstein-barr virus infection based on 733 children to be operated (in Chinese)","volume":"7","author":"Liu","year":"2012","journal-title":"Chin. J. Evid. Based Pediatr."},{"key":"10.1016\/j.virs.2022.07.007_bib24","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1080\/09674845.2021.1903683","article-title":"Infectious Mononucleosis: diagnosis and clinical interpretation","volume":"78","author":"Naughton","year":"2021","journal-title":"Br. J. Biomed. Sci."},{"key":"10.1016\/j.virs.2022.07.007_bib25","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1136\/jcp.10.1.20","article-title":"The reported incidence of glandular fever; an analysis of a report of the public health laboratory service","volume":"10","author":"Newell","year":"1957","journal-title":"J.\u00a0Clin. Pathol."},{"key":"10.1016\/j.virs.2022.07.007_bib26","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1128\/CMR.00044-10","article-title":"Progress and problems in understanding and managing primary Epstein-Barr virus infections","volume":"24","author":"Odumade","year":"2011","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.virs.2022.07.007_bib27","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/jmv.24963","article-title":"Etiology of community-acquired pneumonia in 1500 hospitalized children","volume":"90","author":"Oumei","year":"2018","journal-title":"J.\u00a0Med. Virol."},{"key":"10.1016\/j.virs.2022.07.007_bib28","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1097\/MPH.0b013e31822d4ea7","article-title":"Prevalence of coinfection in children with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis","volume":"34","author":"Qiang","year":"2012","journal-title":"J.\u00a0Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.virs.2022.07.007_bib29","first-page":"142","article-title":"Prevalence of Epstein-Barr Viral DNA among children at a single hospital in Suzhou, China","volume":"98","author":"Shi","year":"2022","journal-title":"J.\u00a0Pediatr."},{"key":"10.1016\/j.virs.2022.07.007_bib30","first-page":"315","article-title":"Infectious mononucleosis","volume":"26","author":"Shurin","year":"1979","journal-title":"Pediatr. Clin."},{"key":"10.1016\/j.virs.2022.07.007_bib31","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3345\/kjp.2011.54.10.409","article-title":"Clinical features of Epstein-Barr virus-associated infectious mononucleosis in hospitalized Korean children","volume":"54","author":"Son","year":"2011","journal-title":"Korean J Pediatr"},{"key":"10.1016\/j.virs.2022.07.007_bib32","first-page":"563","article-title":"Principle suggestions for diagnosis and treatment of main nontumorous Epstein-Barr virus-associated diseases in children (in Chinese)","volume":"54","year":"2016","journal-title":"Chinese Journal of Pediatrics"},{"key":"10.1016\/j.virs.2022.07.007_bib33","first-page":"2","article-title":"Expert consensus on laboratory diagnosis and clinical application of Epstein-Barr virus infection (in Chinese)","volume":"32","author":"Xie","year":"2018","journal-title":"Chin. J. Exp. Clin. Virol."},{"key":"10.1016\/j.virs.2022.07.007_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0099857","article-title":"Epstein-Barr virus (EBV) infection in Chinese children: a retrospective study of age-specific prevalence","volume":"9","author":"Xiong","year":"2014","journal-title":"PLoS One"}],"container-title":["Virologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1995820X22001213?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1995820X22001213?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T19:18:22Z","timestamp":1761851902000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1995820X22001213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S1995820X22001213"],"URL":"https:\/\/doi.org\/10.1016\/j.virs.2022.07.007","relation":{},"ISSN":["1995-820X"],"issn-type":[{"value":"1995-820X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epidemiological characteristics and disease burden of infectious mononucleosis in hospitalized children in China: A nationwide retrospective study","name":"articletitle","label":"Article Title"},{"value":"Virologica Sinica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virs.2022.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}