{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:22:08Z","timestamp":1791372128080,"version":"4.3.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,30]],"date-time":"2023-04-30T00:00:00Z","timestamp":1682812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences & Peking Union Medical College","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFC1200501"],"award-info":[{"award-number":["2019YFC1200501"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virologica Sinica"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.virs.2023.04.009","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T01:46:33Z","timestamp":1682991993000},"page":"344-350","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["A novel bat coronavirus with a polybasic furin-like cleavage site"],"prefix":"10.1016","volume":"38","author":[{"given":"Wentao","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingzhi","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5865-3165","authenticated-orcid":false,"given":"Jing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2763-1545","authenticated-orcid":false,"given":"Shan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virs.2023.04.009_bib1","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/s41587-019-0036-z","article-title":"SignalP 5.0 improves signal peptide predictions using deep neural networks","volume":"37","author":"Almagro Armenteros","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.virs.2023.04.009_bib2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nmeth.3176","article-title":"Fast and sensitive protein alignment using DIAMOND","volume":"12","author":"Buchfink","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.virs.2023.04.009_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jmammal\/gyx147","article-title":"How many species of mammals are there?","volume":"99","author":"Burgin","year":"2018","journal-title":"J.\u00a0Mammal."},{"key":"10.1016\/j.virs.2023.04.009_bib4","doi-asserted-by":"crossref","DOI":"10.1093\/database\/bau021","article-title":"DBatVir: the database of bat-associated viruses","volume":"2014","author":"Chen","year":"2014","journal-title":"Database."},{"key":"10.1016\/j.virs.2023.04.009_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2020.104742","article-title":"The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade","volume":"176","author":"Coutard","year":"2020","journal-title":"Antivir. Res."},{"key":"10.1016\/j.virs.2023.04.009_bib6","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/protein\/gzh013","article-title":"Prediction of proprotein convertase cleavage sites","volume":"17","author":"Duckert","year":"2004","journal-title":"Protein Eng. Des. Sel."},{"key":"10.1016\/j.virs.2023.04.009_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.591535","article-title":"Emergence of bat-related betacoronaviruses: hazard and risks","volume":"12","author":"Frutos","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.virs.2023.04.009_bib8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s12250-016-3713-9","article-title":"Coexistence of multiple coronaviruses in several bat colonies in an abandoned mineshaft","volume":"31","author":"Ge","year":"2016","journal-title":"Virol. Sin."},{"key":"10.1016\/j.virs.2023.04.009_bib9","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nbt.1883","article-title":"Full-length transcriptome assembly from RNA-Seq data without a reference genome","volume":"29","author":"Grabherr","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.virs.2023.04.009_bib10","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/sysbio\/syq010","article-title":"New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0","volume":"59","author":"Guindon","year":"2010","journal-title":"Syst. Biol."},{"key":"10.1016\/j.virs.2023.04.009_bib11","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41579-020-00459-7","article-title":"Characteristics of SARS-CoV-2 and COVID-19","volume":"19","author":"Hu","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.virs.2023.04.009_bib12","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41426-018-0155-5","article-title":"Genomic characterization and infectivity of a novel SARS-like coronavirus in Chinese bats","volume":"7","author":"Hu","year":"2018","journal-title":"Emerg. Microb. Infect."},{"key":"10.1016\/j.virs.2023.04.009_bib13","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s12250-020-00206-5","article-title":"The first disease X is caused by a highly transmissible acute respiratory syndrome coronavirus","volume":"35","author":"Jiang","year":"2020","journal-title":"Virol. Sin."},{"key":"10.1016\/j.virs.2023.04.009_bib14","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nmeth.4285","article-title":"ModelFinder: fast model selection for accurate phylogenetic estimates","volume":"14","author":"Kalyaanamoorthy","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.virs.2023.04.009_bib15","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/molbev\/mst010","article-title":"MAFFT multiple sequence alignment software version 7: improvements in performance and usability","volume":"30","author":"Katoh","year":"2013","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.virs.2023.04.009_bib16","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bbapap.2011.07.001","article-title":"Role of host cellular proteases in the pathogenesis of influenza and influenza-induced multiple organ failure","volume":"1824","author":"Kido","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.virs.2023.04.009_bib17","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/s41586-020-2169-0","article-title":"Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins","volume":"583","author":"Lam","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.virs.2023.04.009_bib18","doi-asserted-by":"crossref","first-page":"11906","DOI":"10.1128\/JVI.01305-12","article-title":"Recent transmission of a novel alphacoronavirus, bat coronavirus HKU10, from Leschenault's rousettes to pomona leaf-nosed bats: first evidence of interspecies transmission of coronavirus between bats of different suborders","volume":"86","author":"Lau","year":"2012","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.virs.2023.04.009_bib19","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/s41564-020-0688-y","article-title":"Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses","volume":"5","author":"Letko","year":"2020","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.virs.2023.04.009_bib20","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41579-020-0394-z","article-title":"Bat-borne virus diversity, spillover and emergence","volume":"18","author":"Letko","year":"2020","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.virs.2023.04.009_bib21","doi-asserted-by":"crossref","first-page":"W242","DOI":"10.1093\/nar\/gkw290","article-title":"Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees","volume":"44","author":"Letunic","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.virs.2023.04.009_bib22","first-page":"e00807","article-title":"Discovery of bat coronaviruses through surveillance and probe capture-based next-generation sequencing","volume":"5","author":"Li","year":"2020","journal-title":"mSphere"},{"key":"10.1016\/j.virs.2023.04.009_bib23","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1080\/22221751.2021.1964925","article-title":"A\u00a0novel SARS-CoV-2 related coronavirus with complex recombination isolated from bats in Yunnan province, China","volume":"10","author":"Li","year":"2021","journal-title":"Emerg. Microb. Infect."},{"key":"10.1016\/j.virs.2023.04.009_bib24","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s40249-020-00662-x","article-title":"Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues","volume":"9","author":"Li","year":"2020","journal-title":"Infect Dis Poverty"},{"key":"10.1016\/j.virs.2023.04.009_bib25","doi-asserted-by":"crossref","first-page":"W116","DOI":"10.1093\/nar\/gki442","article-title":"InterProScan: protein domains identifier","volume":"33","author":"Quevillon","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.virs.2023.04.009_bib26","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s00408-020-00408-4","article-title":"ACE2: the major cell entry receptor for SARS-CoV-2","volume":"198","author":"Scialo","year":"2020","journal-title":"Lung"},{"key":"10.1016\/j.virs.2023.04.009_bib27","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/s12250-020-00252-z","article-title":"A\u00a0comprehensive review of animal models for coronaviruses: SARS-CoV-2, SARS-CoV, and MERS-CoV","volume":"35","author":"Singh","year":"2020","journal-title":"Virol. Sin."},{"key":"10.1016\/j.virs.2023.04.009_bib28","doi-asserted-by":"crossref","first-page":"8683","DOI":"10.1128\/JVI.00797-10","article-title":"Modifications to the hemagglutinin cleavage site control the virulence of a neurotropic H1N1 influenza virus","volume":"84","author":"Sun","year":"2010","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.virs.2023.04.009_bib29","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/s41586-022-04532-4","article-title":"Bat coronaviruses related to SARS-CoV-2 and infectious for human cells","volume":"604","author":"Temmam","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.virs.2023.04.009_bib30","doi-asserted-by":"crossref","first-page":"e00127-20","DOI":"10.1128\/JVI.00127-20","article-title":"Receptor recognition by the novel coronavirus from wuhan: an analysis based on decade-long structural studies of SARS coronavirus","volume":"94","author":"Wan","year":"2020","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.virs.2023.04.009_bib31","doi-asserted-by":"crossref","first-page":"W296","DOI":"10.1093\/nar\/gky427","article-title":"SWISS-MODEL: homology modelling of protein structures and complexes","volume":"46","author":"Waterhouse","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.virs.2023.04.009_bib32","doi-asserted-by":"crossref","DOI":"10.15212\/ZOONOSES-2021-0010","article-title":"Analysis of intermediate hosts and susceptible animals of SARS-CoV-2 by computational methods","author":"Yang","year":"2021","journal-title":"Zoonoses"},{"key":"10.1016\/j.virs.2023.04.009_bib33","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1016\/j.cub.2020.05.023","article-title":"A\u00a0novel bat coronavirus closely related to SARS-CoV-2 contains natural insertions at the S1\/S2 cleavage site of the spike protein","volume":"30","author":"Zhou","year":"2020","journal-title":"Curr. Biol."},{"key":"10.1016\/j.virs.2023.04.009_bib34","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","article-title":"A\u00a0pneumonia outbreak associated with a new coronavirus of probable bat origin","volume":"579","author":"Zhou","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.virs.2023.04.009_bib35","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3390\/v14020288","article-title":"Discovery and evolutionary analysis of a novel bat-borne paramyxovirus","volume":"14","author":"Zhu","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.virs.2023.04.009_bib36","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1007\/s12250-021-00402-x","article-title":"Genomic characterization of a new coronavirus from migratory birds in jiangxi province of China","volume":"36","author":"Zhu","year":"2021","journal-title":"Virol. Sin."},{"key":"10.1016\/j.virs.2023.04.009_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.755599","article-title":"Discovery and evolution of a divergent coronavirus in the plateau pika from China that extends the host range of alphacoronaviruses","volume":"12","author":"Zhu","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.virs.2023.04.009_bib38","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1007\/s12250-020-00325-z","article-title":"Beta- and novel delta-coronaviruses are identified from wild animals in the qinghai-Tibetan plateau, China","volume":"36","author":"Zhu","year":"2021","journal-title":"Virol. Sin."}],"container-title":["Virologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1995820X23000470?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1995820X23000470?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T19:19:25Z","timestamp":1761851965000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1995820X23000470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S1995820X23000470"],"URL":"https:\/\/doi.org\/10.1016\/j.virs.2023.04.009","relation":{},"ISSN":["1995-820X"],"issn-type":[{"value":"1995-820X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel bat coronavirus with a polybasic furin-like cleavage site","name":"articletitle","label":"Article Title"},{"value":"Virologica Sinica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virs.2023.04.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}