{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:20:55Z","timestamp":1790623255929,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T00:00:00Z","timestamp":1683849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072270"],"award-info":[{"award-number":["82072270"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272306"],"award-info":[{"award-number":["82272306"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021QC095"],"award-info":[{"award-number":["ZR2021QC095"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010029","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010029","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virologica Sinica"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.virs.2023.05.007","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T11:54:35Z","timestamp":1683892475000},"page":"497-507","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Elucidating cellular interactome of chikungunya virus identifies host dependency factors"],"prefix":"10.1016","volume":"38","author":[{"given":"Peiqi","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Jian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7015-9661","authenticated-orcid":false,"given":"Leiliang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virs.2023.05.007_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0124792","article-title":"The ubiquitin proteasome system plays a role in venezuelan equine encephalitis virus infection","volume":"10","author":"Amaya","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.virs.2023.05.007_bib2","doi-asserted-by":"crossref","first-page":"4535","DOI":"10.1128\/MCB.19.6.4535","article-title":"Identification of chip, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions","volume":"19","author":"Ballinger","year":"1999","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.virs.2023.05.007_bib3","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/00325481.1986.11699488","article-title":"Permanent cardiac pacing in the era of peer review. The acceptable indications and the necessary documentation","volume":"80","author":"Benditt","year":"1986","journal-title":"Postgrad. Med."},{"key":"10.1016\/j.virs.2023.05.007_bib4","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1128\/JVI.06390-11","article-title":"Mapping of chikungunya virus interactions with host proteins identified nsp2 as a highly connected viral component","volume":"86","author":"Bourai","year":"2012","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.virs.2023.05.007_bib5","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3390\/v10020089","article-title":"The alphavirus exit pathway: what we know and what we wish we knew","volume":"10","author":"Brown","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.virs.2023.05.007_bib6","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/S0140-6736(11)60281-X","article-title":"Chikungunya: a re-emerging virus","volume":"379","author":"Burt","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.virs.2023.05.007_bib7","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.3389\/fmicb.2019.02236","article-title":"Vcp\/p97 is a proviral host factor for replication of chikungunya virus and other alphaviruses","volume":"10","author":"Carissimo","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.virs.2023.05.007_bib8","doi-asserted-by":"crossref","first-page":"a004374","DOI":"10.1101\/cshperspect.a004374","article-title":"Cellular strategies of protein quality control","volume":"3","author":"Chen","year":"2011","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.virs.2023.05.007_bib9","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3389\/fnins.2017.00185","article-title":"Protein quality control by molecular chaperones in neurodegeneration","volume":"11","author":"Ciechanover","year":"2017","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.virs.2023.05.007_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009603","article-title":"Characterisation of the semliki forest virus-host cell interactome reveals the viral capsid protein as an inhibitor of nonsense-mediated mrna decay","volume":"17","author":"Contu","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virs.2023.05.007_bib11","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.3390\/v13091881","article-title":"How viruses use the vcp\/p97 atpase molecular machine","volume":"13","author":"Das","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.virs.2023.05.007_bib12","doi-asserted-by":"crossref","first-page":"8967","DOI":"10.1073\/pnas.88.20.8967","article-title":"Sindbis virus rna polymerase is degraded by the n-end rule pathway","volume":"88","author":"de Groot","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.virs.2023.05.007_bib13","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00836-21","article-title":"Nap1l1 and nap1l4 binding to hypervariable domain of chikungunya virus nsp3 protein is bivalent and requires phosphorylation","volume":"95","author":"Dominguez","year":"2021","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.virs.2023.05.007_bib14","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1126\/science.318.5858.1860","article-title":"Infectious diseases. Chikungunya: No longer a third world disease","volume":"318","author":"Enserink","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.virs.2023.05.007_bib15","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1186\/s13071-015-1070-4","article-title":"Mosquito rasputin interacts with chikungunya virus nsp3 and determines the infection rate in aedes albopictus","volume":"8","author":"Fros","year":"2015","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.virs.2023.05.007_bib16","doi-asserted-by":"crossref","first-page":"446","DOI":"10.3109\/10409238.2013.831024","article-title":"Gpi transamidase and gpi anchored proteins: oncogenes and biomarkers for cancer","volume":"48","author":"Gamage","year":"2013","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.virs.2023.05.007_bib17","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1152\/physrev.00027.2001","article-title":"The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction","volume":"82","author":"Glickman","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.virs.2023.05.007_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007842","article-title":"Separate domains of g3bp promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery","volume":"15","author":"G\u00f6tte","year":"2019","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virs.2023.05.007_bib19","doi-asserted-by":"crossref","first-page":"3900","DOI":"10.1016\/j.celrep.2017.11.094","article-title":"A\u00a0global interactome map of the dengue virus ns1 identifies virus restriction and dependency host factors","volume":"21","author":"Hafirassou","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.virs.2023.05.007_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008876","article-title":"A\u00a0molecular understanding of alphavirus entry","volume":"16","author":"Holmes","year":"2020","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virs.2023.05.007_bib21","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.virol.2010.10.026","article-title":"Chaperonin tric\/cct participates in replication of hepatitis c virus genome via interaction with the viral ns5b protein","volume":"410","author":"Inoue","year":"2011","journal-title":"Virology"},{"key":"10.1016\/j.virs.2023.05.007_bib22","doi-asserted-by":"crossref","first-page":"42938","DOI":"10.1074\/jbc.M101968200","article-title":"Chip is a u-box-dependent e3 ubiquitin ligase: identification of hsc70 as a target for ubiquitylation","volume":"276","author":"Jiang","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.virs.2023.05.007_bib23","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.pt.2014.12.008","article-title":"Chikungunya on the move","volume":"31","author":"Johansson","year":"2015","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.virs.2023.05.007_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0008336","article-title":"Bortezomib inhibits chikungunya virus replication by interfering with viral protein synthesis","volume":"14","author":"Kaur","year":"2020","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.virs.2023.05.007_bib25","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev-virology-031413-085521","article-title":"Mechanisms of virus membrane fusion proteins","volume":"1","author":"Kielian","year":"2014","journal-title":"Annu Rev Virol"},{"key":"10.1016\/j.virs.2023.05.007_bib26","doi-asserted-by":"crossref","first-page":"796","DOI":"10.3390\/v2040796","article-title":"Alphavirus entry and membrane fusion","volume":"2","author":"Kielian","year":"2010","journal-title":"Viruses"},{"key":"10.1016\/j.virs.2023.05.007_bib27","doi-asserted-by":"crossref","first-page":"4614","DOI":"10.1128\/jvi.64.10.4614-4624.1990","article-title":"Biosynthesis, maturation, and acid activation of the semliki forest virus fusion protein","volume":"64","author":"Kielian","year":"1990","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.virs.2023.05.007_bib28","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/s41564-018-0122-x","article-title":"The tric chaperonin controls reovirus replication through outer-capsid folding","volume":"3","author":"Knowlton","year":"2018","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.virs.2023.05.007_bib29","doi-asserted-by":"crossref","first-page":"e01764","DOI":"10.1128\/JVI.01764-18","article-title":"The host dhx9 dexh-box helicase is recruited to chikungunya virus replication complexes for optimal genomic rna translation","volume":"93","author":"Matkovic","year":"2019","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.virs.2023.05.007_bib30","doi-asserted-by":"crossref","first-page":"e00838","DOI":"10.1128\/JVI.00838-18","article-title":"Multiple host factors interact with the hypervariable domain of chikungunya virus nsp3 and determine viral replication in cell-specific mode","volume":"92","author":"Meshram","year":"2018","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.virs.2023.05.007_bib31","doi-asserted-by":"crossref","first-page":"11644","DOI":"10.1128\/JVI.01432-14","article-title":"Reemergence of chikungunya virus","volume":"88","author":"Morrison","year":"2014","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.virs.2023.05.007_bib32","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1093\/embo-reports\/kve246","article-title":"Chip is a chaperone-dependent e3 ligase that ubiquitylates unfolded protein","volume":"2","author":"Murata","year":"2001","journal-title":"EMBO Rep."},{"key":"10.1016\/j.virs.2023.05.007_bib33","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1016\/j.celrep.2013.11.028","article-title":"Genome-wide rnai screen identifies sec61a and vcp as conserved regulators of sindbis virus entry","volume":"5","author":"Panda","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.virs.2023.05.007_bib34","doi-asserted-by":"crossref","first-page":"10118","DOI":"10.1128\/JVI.75.21.10118-10131.2001","article-title":"Evolutionary relationships and systematics of the alphaviruses","volume":"75","author":"Powers","year":"2001","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.virs.2023.05.007_bib35","doi-asserted-by":"crossref","first-page":"e00467","DOI":"10.1128\/mBio.00467-20","article-title":"A\u00a0sensitive yellow fever virus entry reporter identifies valosin-containing protein (vcp\/p97) as an essential host factor for flavivirus uncoating","volume":"11","author":"Ramanathan","year":"2020","journal-title":"mBio"},{"key":"10.1016\/j.virs.2023.05.007_bib36","doi-asserted-by":"crossref","first-page":"e00477","DOI":"10.1128\/JVI.00477-18","article-title":"Persistent replication of a chikungunya virus replicon in human cells is associated with presence of stable cytoplasmic granules containing nonstructural protein 3","volume":"92","author":"Remenyi","year":"2018","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.virs.2023.05.007_bib37","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1038\/s41467-019-10037-y","article-title":"Feedback inhibition of camp effector signaling by a chaperone-assisted ubiquitin system","volume":"10","author":"Rinaldi","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.virs.2023.05.007_bib38","doi-asserted-by":"crossref","first-page":"4457","DOI":"10.1128\/JVI.03612-14","article-title":"Stress granule components g3bp1 and g3bp2 play a proviral role early in chikungunya virus replication","volume":"89","author":"Scholte","year":"2015","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.virs.2023.05.007_bib39","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nrmicro2368","article-title":"Biology and pathogenesis of chikungunya virus","volume":"8","author":"Schwartz","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.virs.2023.05.007_bib40","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s12250-020-00245-y","article-title":"Perinatal vertical transmission of chikungunya virus in ruili, a town on the border between China and Myanmar","volume":"36","author":"Shen","year":"2021","journal-title":"Virol. Sin."},{"key":"10.1016\/j.virs.2023.05.007_bib41","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.molcel.2017.10.028","article-title":"Vcp\/p97-mediated unfolding as a principle in protein homeostasis and signaling","volume":"69","author":"van den Boom","year":"2018","journal-title":"Mol. Cell."},{"key":"10.1016\/j.virs.2023.05.007_bib42","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.bbrc.2019.04.098","article-title":"Intraviral interactome of chikungunya virus reveals the homo-oligomerization and palmitoylation of structural protein tf","volume":"513","author":"Yin","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.virs.2023.05.007_bib43","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.molcel.2005.09.023","article-title":"Chaperoned ubiquitylation--crystal structures of the chip u box e3 ubiquitin ligase and a chip-ubc13-uev1a complex","volume":"20","author":"Zhang","year":"2005","journal-title":"Mol. Cell."},{"key":"10.1016\/j.virs.2023.05.007_bib44","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/s41419-020-02953-5","article-title":"Chip as a therapeutic target for neurological diseases","volume":"11","author":"Zhang","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.virs.2023.05.007_bib45","article-title":"March8 targets cytoplasmic lysine residues of various viral envelope glycoproteins","volume":"10","author":"Zhang","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.virs.2023.05.007_bib46","doi-asserted-by":"crossref","first-page":"9579","DOI":"10.1128\/JVI.01299-13","article-title":"Imaging of the alphavirus capsid protein during virus replication","volume":"87","author":"Zheng","year":"2013","journal-title":"J.\u00a0Virol."}],"container-title":["Virologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1995820X2300055X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1995820X2300055X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T19:20:00Z","timestamp":1761852000000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1995820X2300055X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S1995820X2300055X"],"URL":"https:\/\/doi.org\/10.1016\/j.virs.2023.05.007","relation":{},"ISSN":["1995-820X"],"issn-type":[{"value":"1995-820X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elucidating cellular interactome of chikungunya virus identifies host dependency factors","name":"articletitle","label":"Article Title"},{"value":"Virologica Sinica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virs.2023.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}