{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T09:49:35Z","timestamp":1793180975351,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32188101"],"award-info":[{"award-number":["32188101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971976"],"award-info":[{"award-number":["81971976"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virologica Sinica"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.virs.2024.06.009","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T19:20:49Z","timestamp":1719602449000},"page":"632-644","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["AIMP2 restricts EV71 replication by recruiting SMURF2 to promote the degradation of 3D polymerase"],"prefix":"10.1016","volume":"39","author":[{"given":"Junrui","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuhan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyu","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0384-8598","authenticated-orcid":false,"given":"Ke","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5728-6327","authenticated-orcid":false,"given":"Shuwen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virs.2024.06.009_bib1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1080\/22221751.2021.1906754","article-title":"Viral determinants that drive Enterovirus-A71 fitness and virulence","volume":"10","author":"Ang","year":"2021","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.virs.2024.06.009_bib2","doi-asserted-by":"crossref","DOI":"10.3791\/52065-v","article-title":"Viral concentration determination through plaque assays: using traditional and novel overlay systems","author":"Baer","year":"2014","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.virs.2024.06.009_bib3","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/s41579-018-0005-4","article-title":"The life cycle of non-polio enteroviruses and how to target it","volume":"16","author":"Baggen","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.virs.2024.06.009_bib4","doi-asserted-by":"crossref","first-page":"31373","DOI":"10.1074\/jbc.M111.254896","article-title":"Sumoylation-promoted enterovirus 71 3C degradation correlates with a reduction in viral replication and cell apoptosis","volume":"286","author":"Chen","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.virs.2024.06.009_bib5","doi-asserted-by":"crossref","first-page":"2710","DOI":"10.1242\/jcs.049767","article-title":"AIMP2 promotes TNFalpha-dependent apoptosis via ubiquitin-mediated degradation of TRAF2","volume":"122","author":"Choi","year":"2009","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.virs.2024.06.009_bib6","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1093\/carcin\/bgp170","article-title":"Multidirectional tumor-suppressive activity of AIMP2\/p38 and the enhanced susceptibility of AIMP2 heterozygous mice to carcinogenesis","volume":"30","author":"Choi","year":"2009","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.virs.2024.06.009_bib7","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1001\/jama.2018.17288","article-title":"Hand, foot, and mouth disease","volume":"320","author":"Cox","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.virs.2024.06.009_bib8","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1128\/JVI.02170-14","article-title":"Interaction of NS2 with AIMP2 facilitates the switch from ubiquitination to SUMOylation of M1 in influenza A virus-infected cells","volume":"89","author":"Gao","year":"2015","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.virs.2024.06.009_bib9","doi-asserted-by":"crossref","first-page":"4066","DOI":"10.1038\/s41467-019-12040-9","article-title":"A\u00a0second open reading frame in human enterovirus determines viral replication in intestinal epithelial cells","volume":"10","author":"Guo","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.virs.2024.06.009_bib10","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/BF01310816","article-title":"Genetic and phenotypic characteristics of enterovirus 71 isolates from patients with encephalitis and with hand, foot and mouth disease","volume":"79","author":"Hagiwara","year":"1984","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virs.2024.06.009_bib11","doi-asserted-by":"crossref","first-page":"11206","DOI":"10.1073\/pnas.0800297105","article-title":"AIMP2\/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53","volume":"105","author":"Han","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.virs.2024.06.009_bib12","doi-asserted-by":"crossref","first-page":"9339","DOI":"10.1093\/nar\/gkac675","article-title":"N4-acetylcytidine regulates the replication and pathogenicity of enterovirus 71","volume":"50","author":"Hao","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.virs.2024.06.009_bib13","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1097\/INF.0000000000000711","article-title":"Clinical analysis of 134 children with nervous system damage caused by enterovirus 71 infection","volume":"34","author":"Hu","year":"2015","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.virs.2024.06.009_bib14","doi-asserted-by":"crossref","first-page":"e00305","DOI":"10.1128\/mBio.00305-20","article-title":"Nonproteolytic K29-linked ubiquitination of the PB2 replication protein of influenza A viruses by proviral cullin 4-based E3 ligases","volume":"11","author":"Karim","year":"2020","journal-title":"mBio"},{"key":"10.1016\/j.virs.2024.06.009_bib15","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.1158\/0008-5472.CAN-15-3255","article-title":"Oncogenic mutation of AIMP2\/p38 inhibits its tumor-suppressive interaction with Smurf2","volume":"76","author":"Kim","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.virs.2024.06.009_bib16","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1177\/030089161109700321","article-title":"Expression of AIMP1, 2 and 3, the scaffolds for the multi-tRNA synthetase complex, is downregulated in gastric and colorectal cancer","volume":"97","author":"Kim","year":"2011","journal-title":"Tumori"},{"key":"10.1016\/j.virs.2024.06.009_bib17","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3390\/ijms22010323","article-title":"Role of host-mediated post-translational modifications (PTMs) in RNA virus pathogenesis","volume":"22","author":"Kumar","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.virs.2024.06.009_bib18","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01069-17","article-title":"Enterovirus 71 inhibits pyroptosis through cleavage of gasdermin D","volume":"91","author":"Lei","year":"2017","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.virs.2024.06.009_bib19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ymeth.2020.02.008","article-title":"Functional analyses of mammalian virus 5'UTR-derived, small RNAs that regulate virus translation","volume":"183","author":"Li","year":"2020","journal-title":"Methods"},{"key":"10.1016\/j.virs.2024.06.009_bib20","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/nar\/gkn901","article-title":"Far upstream element binding protein 2 interacts with enterovirus 71 internal ribosomal entry site and negatively regulates viral translation","volume":"37","author":"Lin","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.virs.2024.06.009_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2023.105583","article-title":"Identification of a novel acylthiourea-based potent broad-spectrum inhibitor for enterovirus 3D polymerase in vitro and in vivo","volume":"213","author":"Liu","year":"2023","journal-title":"Antiviral Res."},{"key":"10.1016\/j.virs.2024.06.009_bib22","doi-asserted-by":"crossref","first-page":"10472","DOI":"10.1128\/JVI.01756-16","article-title":"SUMO modification stabilizes enterovirus 71 polymerase 3D to facilitate viral replication","volume":"90","author":"Liu","year":"2016","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.virs.2024.06.009_bib23","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41564-018-0297-1","article-title":"An upstream protein-coding region in enteroviruses modulates virus infection in gut epithelial cells","volume":"4","author":"Lulla","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.virs.2024.06.009_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2776(09)03001-6","article-title":"Chapter 1: The physiological role of lysyl tRNA synthetase in the immune system","volume":"103","author":"Nechushtan","year":"2009","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.virs.2024.06.009_bib25","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.molcel.2012.10.010","article-title":"Structural switch of lysyl-tRNA synthetase between translation and transcription","volume":"49","author":"Ofir-Birin","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.virs.2024.06.009_bib26","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/S1474-4422(10)70209-X","article-title":"Clinical features, diagnosis, and management of enterovirus 71","author":"Ooi","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.virs.2024.06.009_bib27","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/0955-0674(90)90168-E","article-title":"Eukaryotic protein degradation","volume":"2","author":"Rivett","year":"1990","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.virs.2024.06.009_bib28","first-page":"408","article-title":"Hand-Foot-and-Mouth disease: rapid evidence review","volume":"100","author":"Saguil","year":"2019","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.virs.2024.06.009_bib29","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1093\/infdis\/129.3.304","article-title":"An apparently new enterovirus isolated from patients with disease of the central nervous system","volume":"129","author":"Schmidt","year":"1974","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.virs.2024.06.009_bib30","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.antiviral.2012.12.010","article-title":"Development and characterization of a stable eGFP enterovirus 71 for antiviral screening","volume":"97","author":"Shang","year":"2013","journal-title":"Antiviral Res."},{"key":"10.1016\/j.virs.2024.06.009_bib31","doi-asserted-by":"crossref","first-page":"9658","DOI":"10.1128\/JVI.05063-11","article-title":"Host factors in enterovirus 71 replication","volume":"85","author":"Shih","year":"2011","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.virs.2024.06.009_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113908","article-title":"Pharmacological inhibition of AIMP2 aggregation attenuates \u03b1-synuclein aggregation and toxicity in Parkinson's disease","volume":"156","author":"Shin","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.virs.2024.06.009_bib33","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S1473-3099(10)70194-8","article-title":"Virology, epidemiology, pathogenesis, and control of enterovirus 71","volume":"10","author":"Solomon","year":"2010","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.virs.2024.06.009_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2019.104650","article-title":"Emetine protects mice from enterovirus infection by inhibiting viral translation","volume":"173","author":"Tang","year":"2020","journal-title":"Antiviral Res."},{"key":"10.1016\/j.virs.2024.06.009_bib35","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s12250-018-0071-9","article-title":"Recent progress on functional genomics research of enterovirus 71","volume":"34","author":"Wang","year":"2019","journal-title":"Virol. Sin."},{"key":"10.1016\/j.virs.2024.06.009_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007287","article-title":"Interferon-stimulated TRIM69 interrupts dengue virus replication by ubiquitinating viral nonstructural protein 3","volume":"14","author":"Wang","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virs.2024.06.009_bib37","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202303108","article-title":"Inhibition of lysosome-tethered Ragulator-Rag-3D complex restricts the replication of Enterovirus 71 and Coxsackie A16","volume":"222","author":"Wang","year":"2023","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.virs.2024.06.009_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005067","article-title":"Human enterovirus nonstructural protein 2CATPase functions as both an RNA helicase and ATP-independent RNA chaperone","volume":"11","author":"Xia","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virs.2024.06.009_bib39","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1007\/s12250-021-00410-x","article-title":"Ectopic expression of TRIM25 restores RIG-I expression and IFN production reduced by multiple enteroviruses 3C(pro)","volume":"36","author":"Xiao","year":"2021","journal-title":"Virol. Sin."},{"key":"10.1016\/j.virs.2024.06.009_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2023.199240","article-title":"HMGB1 release induced by EV71 infection exacerbates blood-brain barrier disruption via VE-cadherin phosphorylation","volume":"338","author":"You","year":"2023","journal-title":"Virus Res."},{"key":"10.1016\/j.virs.2024.06.009_bib41","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3389\/fmicb.2018.00286","article-title":"Enterovirus A71 proteins: structure and function","volume":"9","author":"Yuan","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.virs.2024.06.009_bib42","doi-asserted-by":"crossref","first-page":"4559","DOI":"10.1158\/0008-5472.CAN-15-3357","article-title":"AIMP2 controls intestinal stem cell compartments and tumorigenesis by modulating Wnt\/\u03b2-catenin signaling","volume":"76","author":"Yum","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.virs.2024.06.009_bib43","doi-asserted-by":"crossref","first-page":"10031","DOI":"10.1128\/JVI.01677-15","article-title":"Nuclear protein Sam68 interacts with the enterovirus 71 internal ribosome entry site and positively regulates viral protein translation","volume":"89","author":"Zhang","year":"2015","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.virs.2024.06.009_bib44","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1007\/s12250-021-00417-4","article-title":"ANXA2 facilitates enterovirus 71 infection by interacting with 3D polymerase and PI4KB to assist the assembly of replication organelles","volume":"36","author":"Zhang","year":"2021","journal-title":"Virol. Sin."},{"key":"10.1016\/j.virs.2024.06.009_bib45","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.virs.2022.04.013","article-title":"EV71 3C protease cleaves host anti-viral factor OAS3 and enhances virus replication","volume":"37","author":"Zhou","year":"2022","journal-title":"Virol. Sin."},{"key":"10.1016\/j.virs.2024.06.009_bib46","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/s41419-020-02794-2","article-title":"Roles of aminoacyl-tRNA synthetase-interacting multi-functional proteins in physiology and cancer","volume":"11","author":"Zhou","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.virs.2024.06.009_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.599765","article-title":"Roles of aminoacyl-tRNA synthetases in cancer","volume":"8","author":"Zhou","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.virs.2024.06.009_bib48","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20192083","article-title":"TRIM24 facilitates antiviral immunity through mediating K63-linked TRAF3 ubiquitination","volume":"217","author":"Zhu","year":"2020","journal-title":"J.\u00a0Exp. Med."}],"container-title":["Virologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1995820X24001081?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1995820X24001081?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T14:18:02Z","timestamp":1733149082000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1995820X24001081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S1995820X24001081"],"URL":"https:\/\/doi.org\/10.1016\/j.virs.2024.06.009","relation":{},"ISSN":["1995-820X"],"issn-type":[{"value":"1995-820X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AIMP2 restricts EV71 replication by recruiting SMURF2 to promote the degradation of 3D polymerase","name":"articletitle","label":"Article Title"},{"value":"Virologica Sinica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virs.2024.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}