{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T01:54:06Z","timestamp":1793843646291,"version":"4.6.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["202201011115"],"award-info":[{"award-number":["202201011115"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M731321"],"award-info":[{"award-number":["2023M731321"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92269103"],"award-info":[{"award-number":["92269103"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170139"],"award-info":[{"award-number":["32170139"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015956","name":"Special Project for Research and Development in Key areas of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1111030003"],"award-info":[{"award-number":["2023A1111030003"]}],"id":[{"id":"10.13039\/501100015956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["2023VPPC-R07"],"award-info":[{"award-number":["2023VPPC-R07"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515011190"],"award-info":[{"award-number":["2022A1515011190"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virologica Sinica"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.virs.2024.11.001","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T19:09:11Z","timestamp":1730920151000},"page":"963-973","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Construction and validation of a mouse model for studying severe human adenovirus infections"],"prefix":"10.1016","volume":"39","author":[{"given":"Dingbin","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqian","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peipei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tie","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biyan","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuemei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Seto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxian","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2770-111X","authenticated-orcid":false,"given":"Qiwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virs.2024.11.001_bib1","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1002\/1873-3468.13696","article-title":"Innate immunity to adenovirus: lessons from mice","volume":"593","author":"Atasheva","year":"2019","journal-title":"FEBS Lett."},{"key":"10.1016\/j.virs.2024.11.001_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.meegid.2024.105619","article-title":"Clinical characteristics and phylogenetic analysis of human enteric adenovirus type 41 (HAdV-F41) from children with gastroenteritis during SARS-CoV-2 pandemic","volume":"123","author":"Bai","year":"2024","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.virs.2024.11.001_bib3","first-page":"1253","article-title":"Animal models in human adenovirus research","volume":"10","author":"Bertzbach","year":"2021","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.virs.2024.11.001_bib4","doi-asserted-by":"crossref","DOI":"10.1128\/Spectrum.00473-21","article-title":"Targeting aryl hydrocarbon receptor signaling enhances type I interferon-independent resistance to herpes simplex virus","volume":"9","author":"Chen","year":"2021","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.virs.2024.11.001_bib5","article-title":"Molecular identification and epidemiological features of human adenoviruses associated with acute respiratory infections in hospitalized children in southern China, 2012-2013","volume":"11","author":"Chen","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.virs.2024.11.001_bib6","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1099\/vir.0.19497-0","article-title":"Genetic content and evolution of adenoviruses","volume":"84","author":"Davison","year":"2003","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.virs.2024.11.001_bib7","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0303-7207(90)90088-P","article-title":"The binding of transformed aromatic hydrocarbon (Ah) receptor to its DNA recognition site is not affected by metal depletion","volume":"69","author":"Denison","year":"1990","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.virs.2024.11.001_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2021.105034","article-title":"Emerging antiviral therapeutics for human adenovirus infection: recent developments and novel strategies","volume":"188","author":"Dodge","year":"2021","journal-title":"Antivir. Res."},{"key":"10.1016\/j.virs.2024.11.001_bib9","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12879-018-3651-2","article-title":"Human adenovirus type 7 infection causes a more severe disease than type 3","volume":"19","author":"Fu","year":"2019","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.virs.2024.11.001_bib10","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1073\/pnas.88.5.1651","article-title":"A\u00a0mouse model for investigating the molecular pathogenesis of adenovirus pneumonia","volume":"88","author":"Ginsberg","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.virs.2024.11.001_bib11","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/s41593-020-0664-0","article-title":"AHR is a Zika\u00a0virus host factor and a candidate target for antiviral therapy","volume":"23","author":"Giovannoni","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.virs.2024.11.001_bib12","first-page":"574","article-title":"An ocular model of adenovirus type 5 infection in the NZ rabbit","volume":"33","author":"Gordon","year":"1992","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.virs.2024.11.001_bib13","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/BF01487691","article-title":"A\u00a0new hamster model for adenoviral vaccination","volume":"100","author":"Hjorth","year":"1988","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virs.2024.11.001_bib14","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.3201\/eid2509.181937","article-title":"Household transmission of human adenovirus type 55 in case of fatal acute respiratory disease","volume":"25","author":"Jing","year":"2019","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.virs.2024.11.001_bib15","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1128\/JVI.80.7.3549-3558.2006","article-title":"Replication properties of human adenovirus in vivo and in cultures of primary cells from different animal species","volume":"80","author":"Jogler","year":"2006","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.virs.2024.11.001_bib16","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01014-23","article-title":"Isolation of novel simian adenoviruses from macaques for development of a vector for human gene therapy and vaccines","volume":"97","author":"Lan","year":"2023","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.virs.2024.11.001_bib17","doi-asserted-by":"crossref","first-page":"5819","DOI":"10.4049\/jimmunol.177.9.5819","article-title":"Aryl hydrocarbon receptor activation impairs the priming but not the recall of influenza virus-specific CD8+ T cells in the lung","volume":"177","author":"Lawrence","year":"2006","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.virs.2024.11.001_bib18","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1080\/22221751.2021.1895679","article-title":"Chinese tree shrew: a permissive model for in vitro and in vivo replication of human adenovirus species B","volume":"10","author":"Li","year":"2021","journal-title":"Emerg. Microb. Infect."},{"key":"10.1016\/j.virs.2024.11.001_bib19","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/cgt.2009.5","article-title":"An acute toxicology study with INGN 007, an oncolytic adenovirus vector, in mice and permissive Syrian hamsters; comparisons with wild-type Ad5 and a replication-defective adenovirus vector","volume":"16","author":"Lichtenstein","year":"2009","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.virs.2024.11.001_bib20","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.virs.2022.01.010","article-title":"Analysis of severe human adenovirus infection outbreak in Guangdong Province, southern China in 2019","volume":"37","author":"Liu","year":"2022","journal-title":"Virol. Sin."},{"key":"10.1016\/j.virs.2024.11.001_bib21","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1055\/s-0036-1584923","article-title":"Adenovirus: epidemiology, global spread of novel serotypes, and advances in treatment and prevention","volume":"37","author":"Lynch","year":"2016","journal-title":"Semin. Respir. Crit. Care Med."},{"key":"10.1016\/j.virs.2024.11.001_bib22","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s12519-022-00568-8","article-title":"Current status of human adenovirus infection in China","volume":"18","author":"Mao","year":"2022","journal-title":"World J Pediatr"},{"key":"10.1016\/j.virs.2024.11.001_bib23","series-title":"Proceedings of the National Academy of Sciences of the United States of America","article-title":"The aryl hydrocarbon receptor facilitates the human cytomegalovirus-mediated G1\/S block to cell cycle progression","volume":"vol. 118","author":"Naseri-Nosar","year":"2021"},{"key":"10.1016\/j.virs.2024.11.001_bib24","doi-asserted-by":"crossref","first-page":"3851","DOI":"10.3390\/ijms19123851","article-title":"The role of the aryl hydrocarbon receptor (AHR) in immune and inflammatory diseases","volume":"19","author":"Neavin","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.virs.2024.11.001_bib25","article-title":"Liver damage induced in mice by human adenovirus type 5","volume":"18","author":"Postlethwaite","year":"1973","journal-title":"Scot. Med. J."},{"key":"10.1016\/j.virs.2024.11.001_bib26","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1128\/jvi.67.1.101-111.1993","article-title":"Pathogenesis of adenovirus type 5 pneumonia in cotton rats (Sigmodon hispidus)","volume":"67","author":"Prince","year":"1993","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.virs.2024.11.001_bib27","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/infdis\/jiw499","article-title":"Humanized mice reproduce acute and persistent human adenovirus infection","volume":"215","author":"Rodriguez","year":"2017","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.virs.2024.11.001_bib28","first-page":"1812","article-title":"The antiviral resistance and replication of cidofovir-resistant adenovirus variants in the New Zealand White rabbit ocular model","volume":"42","author":"Romanowski","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.virs.2024.11.001_bib29","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/j.1749-6632.1962.tb18887.x","article-title":"A\u00a0general review of the adenoviruses","volume":"101","author":"Rowe","year":"1962","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.virs.2024.11.001_bib30","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.virusres.2010.07.021","article-title":"Evaluation of innate immunity and vector toxicity following inoculation of bovine, porcine or human adenoviral vectors in a mouse model","volume":"153","author":"Sharma","year":"2010","journal-title":"Virus Res."},{"key":"10.1016\/j.virs.2024.11.001_bib31","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adf0211","article-title":"Aryl hydrocarbon receptor is a proviral host factor and a candidate pan-SARS-CoV-2 therapeutic target","volume":"9","author":"Shi","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.virs.2024.11.001_bib32","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.virs.2023.07.007","article-title":"Abnormal liver function in children hospitalized with acute respiratory infection of adenoviruses: a retrospective study","volume":"38","author":"Tian","year":"2023","journal-title":"Virol. Sin."},{"key":"10.1016\/j.virs.2024.11.001_bib33","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00284-17","article-title":"Pathology in permissive Syrian hamsters after infection with species C human adenovirus (HAdV-C) is the result of virus replication: HAdV-C6 replicates more and causes more pathology than HAdV-C5","volume":"91","author":"Tollefson","year":"2017","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.virs.2024.11.001_bib34","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nature06881","article-title":"The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins","volume":"453","author":"Veldhoen","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.virs.2024.11.001_bib35","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.29182","article-title":"Genome and proteomic analysis of risk factors for fatal outcome in children with severe community-acquired pneumonia caused by human adenovirus 7","volume":"95","author":"Wei","year":"2023","journal-title":"J.\u00a0Med. Virol."},{"key":"10.1016\/j.virs.2024.11.001_bib36","article-title":"Molecular typing and rapid identification of human adenoviruses associated with respiratory diseases using universal PCR and sequencing primers for the three major capsid genes: penton base, hexon, and fiber","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.virs.2024.11.001_bib37","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s12250-020-00234-1","article-title":"Construction and characterization of a novel recombinant attenuated and replication-deficient candidate human adenovirus type 3 vaccine: \u201cadenovirus vaccine within an adenovirus vector\u201d","volume":"36","author":"Yan","year":"2021","journal-title":"Virol. Sin."},{"key":"10.1016\/j.virs.2024.11.001_bib38","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.virol.2017.10.015","article-title":"Male Syrian hamsters are more susceptible to intravenous infection with species C human adenoviruses than are females","volume":"514","author":"Ying","year":"2018","journal-title":"Virology"},{"key":"10.1016\/j.virs.2024.11.001_bib39","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1038\/mt.2012.116","article-title":"Failure of translation of human adenovirus mRNA in murine cancer cells can be partially overcome by L4-100K expression in vitro and in vivo","volume":"20","author":"Young","year":"2012","journal-title":"Mol. Ther."},{"key":"10.1016\/j.virs.2024.11.001_bib40","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2023.2256416","article-title":"Betacoronaviruses SARS-CoV-2 and HCoV-OC43 infections in IGROV-1 cell line require aryl hydrocarbon receptor","volume":"12","author":"Yousefi","year":"2023","journal-title":"Emerg. Microb. Infect."},{"key":"10.1016\/j.virs.2024.11.001_bib41","doi-asserted-by":"crossref","DOI":"10.1038\/srep37216","article-title":"Fatal community-acquired pneumonia in children caused by Re-emergent human adenovirus 7d associated with higher severity of illness and fatality rate","volume":"6","author":"Yu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.virs.2024.11.001_bib43","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1007\/s12250-021-00414-7","article-title":"Desmoglein 2 (DSG2) is a receptor of human adenovirus type 55 causing adult severe community-acquired pneumonia","volume":"36","author":"Zhang","year":"2021","journal-title":"Virol. Sin."},{"key":"10.1016\/j.virs.2024.11.001_bib44","doi-asserted-by":"crossref","first-page":"e0020923","DOI":"10.1128\/jvi.00209-23","article-title":"Generation of human embryonic stem cell-derived lung organoids for modeling infection and replication differences between human adenovirus types 3 and 55 and evaluating potential antiviral drugs","volume":"97","author":"Zhao","year":"2023","journal-title":"J.\u00a0Virol."}],"container-title":["Virologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1995820X2400172X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1995820X2400172X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T20:07:25Z","timestamp":1770062845000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1995820X2400172X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S1995820X2400172X"],"URL":"https:\/\/doi.org\/10.1016\/j.virs.2024.11.001","relation":{},"ISSN":["1995-820X"],"issn-type":[{"value":"1995-820X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Construction and validation of a mouse model for studying severe human adenovirus infections","name":"articletitle","label":"Article Title"},{"value":"Virologica Sinica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virs.2024.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd\u00e9","name":"copyright","label":"Copyright"}]}}