{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T10:32:39Z","timestamp":1789295559541,"version":"build-2803163510"},"reference-count":49,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2304100"],"award-info":[{"award-number":["2022YFC2304100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD1800405"],"award-info":[{"award-number":["2023YFD1800405"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["7254390"],"award-info":[{"award-number":["7254390"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004476","name":"Chinese Center for Disease Control and Prevention","doi-asserted-by":"publisher","award":["2024A103"],"award-info":[{"award-number":["2024A103"]}],"id":[{"id":"10.13039\/501100004476","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virologica Sinica"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.virs.2025.07.001","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T11:17:57Z","timestamp":1751887077000},"page":"601-612","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Identification of a novel ectromelia virus from rodent: Implications for use as an in vivo infection model for vaccine and antiviral research"],"prefix":"10.1016","volume":"40","author":[{"given":"Shuting","family":"Huo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changcheng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyong","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiewei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingdong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongxian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liye","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifeng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibang","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6977-7841","authenticated-orcid":false,"given":"Li","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3083-2401","authenticated-orcid":false,"given":"Jiandong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5963-1136","authenticated-orcid":false,"given":"Wenjie","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virs.2025.07.001_bib1","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.3390\/vaccines10091419","article-title":"Preventing the next pandemic: is live vaccine efficacious against monkeypox, or is there a need for killed virus and mRNA vaccines?","volume":"10","author":"Abdelaal","year":"2022","journal-title":"Vaccines"},{"key":"10.1016\/j.virs.2025.07.001_bib2","doi-asserted-by":"crossref","first-page":"4999","DOI":"10.1128\/AAC.00678-09","article-title":"ST-246 inhibits in vivo poxvirus dissemination, virus shedding, and systemic disease manifestation","volume":"53","author":"Aklile","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.virs.2025.07.001_bib3","first-page":"278","article-title":"Infections ectromelia; experiments on interference and immunization","volume":"28","author":"Andrewes","year":"1947","journal-title":"Br. J. Exp. Pathol."},{"key":"10.1016\/j.virs.2025.07.001_bib4","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1016\/j.vaccine.2005.01.079","article-title":"A novel, cell culture-derived smallpox vaccine in vaccinia-naive adults","volume":"23","author":"Artenstein","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.virs.2025.07.001_bib5","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.3390\/microorganisms12122622","article-title":"Development of effective medical countermeasures against the main biowarfare agents: the importance of antibodies","volume":"12","author":"Avril","year":"2024","journal-title":"Microorganisms"},{"key":"10.1016\/j.virs.2025.07.001_bib6","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/nar\/27.2.573","article-title":"Tandem repeats finder: a program to analyze DNA sequences","volume":"27","author":"Benson","year":"1999","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.virs.2025.07.001_bib7","first-page":"209","article-title":"Bioinformatics: programmed for success","volume":"425","author":"Buckingham","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.virs.2025.07.001_bib9","article-title":"Old stories, new cases. Viral infectious diseases and children's health","volume":"9","author":"Camcioglu","year":"2024","journal-title":"Glob. Pediatr."},{"key":"10.1016\/j.virs.2025.07.001_bib10","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0042-6822(03)00520-8","article-title":"The genomic sequence of ectromelia virus, the causative agent of mousepox","volume":"317","author":"Chen","year":"2003","journal-title":"Virology"},{"key":"10.1016\/j.virs.2025.07.001_bib11","series-title":"Mousepox, A small animal model of smallpox. Methods in molecular biology (Clifton N.J.)","first-page":"177","author":"Esteban","year":"2012"},{"key":"10.1016\/j.virs.2025.07.001_bib12","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.virol.2005.02.014","article-title":"Host range, growth property, and virulence of the smallpox vaccine: vaccinia virus Tian Tan strain","volume":"335","author":"Fang","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.virs.2025.07.001_bib13","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/icb.1949.4","article-title":"Studies in mousepox, infectious ectromelia of mice; the effect of the age of the host upon the response to infection","volume":"27","author":"Fenner","year":"1949","journal-title":"Aust. J. Exp. Biol. Med. Sci."},{"key":"10.1016\/j.virs.2025.07.001_bib14","doi-asserted-by":"crossref","first-page":"3630","DOI":"10.1128\/JVI.03634-14","article-title":"Viral semaphorin inhibits dendritic cell phagocytosis and migration but is not essential for gammaherpesvirus-induced lymphoproliferation in malignant catarrhal fever","volume":"89","author":"Fran\u00e7oise","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.virs.2025.07.001_bib15","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1099\/0022-1317-82-9-2083","article-title":"Vaccinia virus semaphorin A39R is a 50\u201355 kDa secreted glycoprotein that affects the outcome of infection in a murine intradermal model","volume":"82","author":"Gardner","year":"2001","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virs.2025.07.001_bib16","doi-asserted-by":"crossref","first-page":"653","DOI":"10.2217\/fvl.11.27","article-title":"Development of the small-molecule antiviral ST-246 as a smallpox therapeutic","volume":"6","author":"Grosenbach","year":"2011","journal-title":"Future Virol."},{"key":"10.1016\/j.virs.2025.07.001_bib17","doi-asserted-by":"crossref","first-page":"546","DOI":"10.3390\/v10100546","article-title":"Whole genome characterization of Orthopoxvirus (OPV) Abatino, a zoonotic virus representing a putative novel clade of Old World orthopoxviruses","volume":"10","author":"Gruber","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.virs.2025.07.001_bib18","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2024.2373309","article-title":"Identification of the VP37 pocket of monkeypox virus as a promising target for pan-orthopoxvirus inhibitors through virtual screening and antiviral assays","volume":"13","author":"Huo","year":"2024","journal-title":"Emerg. Microb. Infect."},{"key":"10.1016\/j.virs.2025.07.001_bib19","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1128\/JVI.02012-09","article-title":"A mouse model of lethal infection for evaluating prophylactics and therapeutics against monkeypox virus","volume":"84","author":"Jennifer","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.virs.2025.07.001_bib20","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/molbev\/mst010","article-title":"MAFFT multiple sequence alignment software version 7: improvements in performance and usability","volume":"30","author":"Katoh","year":"2013","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.virs.2025.07.001_bib21","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1101\/gr.215087.116","article-title":"Canu: scalable and accurate long-read assembly via adaptive k-mer weighting and repeat separation","volume":"27","author":"Koren","year":"2017","journal-title":"Genome Res."},{"key":"10.1016\/j.virs.2025.07.001_bib22","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1038\/cdd.2008.83","article-title":"Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands","volume":"15","author":"Kvansakul","year":"2008","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.virs.2025.07.001_bib23","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.cell.2010.07.040","article-title":"Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1","volume":"142","author":"Liu","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.virs.2025.07.001_bib24","first-page":"1","article-title":"ViennaRNA package 2.0. Algorithms","volume":"6","author":"Lorenz","year":"2011","journal-title":"Mol. Biol."},{"key":"10.1016\/j.virs.2025.07.001_bib25","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.virol.2014.06.010","article-title":"The genome sequence of ectromelia virus Naval and Cornell isolates from outbreaks in North America","volume":"462\u2013463","author":"Mavian","year":"2014","journal-title":"Virology"},{"key":"10.1016\/j.virs.2025.07.001_bib26","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.3390\/v13061146","article-title":"Comparative pathogenesis, genomics and phylogeography of mousepox","volume":"13","author":"Mavian","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.virs.2025.07.001_bib27","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.virol.2014.10.023","article-title":"Ectromelia virus encodes an anti-apoptotic protein that regulates cell death","volume":"475","author":"Mehta","year":"2015","journal-title":"Virology"},{"key":"10.1016\/j.virs.2025.07.001_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0034604","article-title":"Genome sequence of erythromelalgia-related poxvirus identifies it as an ectromelia virus strain","volume":"7","author":"Mendez-Rios","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.virs.2025.07.001_bib29","doi-asserted-by":"crossref","first-page":"4354","DOI":"10.1128\/jvi.63.10.4354-4361.1989","article-title":"Nucleotide sequence required for resolution of the concatemer junction of vaccinia virus DNA","volume":"63","author":"Merchlinsky","year":"1989","journal-title":"J. Virol."},{"key":"10.1016\/j.virs.2025.07.001_bib30","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1093\/molbev\/msaa015","article-title":"IQ-TREE 2: new models and efficient methods for phylogenetic inference in the genomic era","volume":"37","author":"Minh","year":"2020","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.virs.2025.07.001_bib31","doi-asserted-by":"crossref","first-page":"4000","DOI":"10.1111\/1462-2920.15186","article-title":"Inclusion of Oxford Nanopore long reads improves all microbial and viral metagenome-assembled genomes from a complex aquifer system","volume":"22","author":"Overholt","year":"2020","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.virs.2025.07.001_bib32","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.antiviral.2012.02.005","article-title":"Evaluation of disease and viral biomarkers as triggers for therapeutic intervention in respiratory mousepox \u2013 an animal model of smallpox","volume":"94","author":"Parker","year":"2012","journal-title":"Antivir. Res."},{"key":"10.1016\/j.virs.2025.07.001_bib33","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.3390\/v2091918","article-title":"Ectromelia virus infections of mice as a model to support the licensure of anti-orthopoxvirus therapeutics","volume":"2","author":"Parker","year":"2010","journal-title":"Viruses"},{"key":"10.1016\/j.virs.2025.07.001_bib34","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.antiviral.2007.08.003","article-title":"Efficacy of therapeutic intervention with an oral ether\u2013lipid analogue of cidofovir (CMX001) in a lethal mousepox model","volume":"77","author":"Parker","year":"2008","journal-title":"Antivir. Res."},{"key":"10.1016\/j.virs.2025.07.001_bib35","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3390\/vaccines8010070","article-title":"Deletion of vaccinia virus A40R gene improves the immunogenicity of the HIV-1 vaccine candidate MVA-B","volume":"8","author":"P\u00e9rez","year":"2020","journal-title":"Vaccines"},{"key":"10.1016\/j.virs.2025.07.001_bib8","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1128\/AAC.00879-06","article-title":"Efficacy of delayed treatment with ST-246 given orally against systemic orthopoxvirus infections in mice","volume":"51","author":"Quenelle","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.virs.2025.07.001_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12864-021-07460-1","article-title":"Adaptation of Oxford Nanopore technology for hepatitis C whole genome sequencing and identification of within-host viral variants","volume":"22","author":"Riaz","year":"2021","journal-title":"BMC Genom."},{"key":"10.1016\/j.virs.2025.07.001_bib37","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1371\/journal.pbio.0030045","article-title":"Aging and death in an organism that reproduces by morphologically symmetric division","volume":"3","author":"Stewart","year":"2005","journal-title":"PLoS Biol."},{"key":"10.1016\/j.virs.2025.07.001_bib38","doi-asserted-by":"crossref","first-page":"39728","DOI":"10.1074\/jbc.M607465200","article-title":"The vaccinia virus protein F1L interacts with bim and inhibits activation of the pro-apoptotic protein bax","volume":"281","author":"Taylor","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virs.2025.07.001_bib39","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0168-1702(02)00119-3","article-title":"Poxvirus immune modulators: functional insights from animal models","volume":"88","author":"Turner","year":"2002","journal-title":"Virus Res."},{"key":"10.1016\/j.virs.2025.07.001_bib40","article-title":"Pseudogenes","volume":"2012","author":"Tutar","year":"2012","journal-title":"Int. J. Genomics"},{"key":"10.1016\/j.virs.2025.07.001_bib41","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/eji.200425669","article-title":"Poxvirus semaphorin A39R inhibits phagocytosis by dendritic cells and neutrophils","volume":"35","author":"Walzer","year":"2005","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.virs.2025.07.001_bib42","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/s41590-023-01715-7","article-title":"Rational design of a \u2018two-in-one\u2019immunogen DAM drives potent immune response against mpox virus","volume":"25","author":"Wang","year":"2024","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.virs.2025.07.001_bib43","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s12250-020-00263-w","article-title":"Identification, isolation, and characterization of an ectromelia virus new strain from an experimental mouse","volume":"36","author":"Wang","year":"2021","journal-title":"Virol. Sin."},{"key":"10.1016\/j.virs.2025.07.001_bib44","doi-asserted-by":"crossref","first-page":"14345 LP","DOI":"10.1073\/pnas.2235583100","article-title":"Vaccinia virus encodes a previously uncharacterized mitochondrial-associated inhibitor of apoptosis","volume":"100","author":"Wasilenko","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.virs.2025.07.001_bib45","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1099\/0022-1317-80-8-2137","article-title":"The vaccinia virus A40R gene product is a nonstructural, type II membrane glycoprotein that is expressed at the cell surface","volume":"80","author":"Wilcock","year":"1999","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virs.2025.07.001_bib46","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.3390\/cells10102577","article-title":"NanoHIV: a bioinformatics pipeline for producing accurate, near full-length HIV proviral genomes sequenced using the oxford nanopore technology","volume":"10","author":"Wright","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.virs.2025.07.001_bib47","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1099\/0022-1317-73-8-2011","article-title":"Further characterization of the biological and pathogenic properties of erythromelalgia-related poxviruses","volume":"73","author":"Zheng","year":"1992","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virs.2025.07.001_bib48","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/BF00371930","article-title":"Presence of specific IgG antibody to the A type inclusions of erythromelalgia-related poxvirus in the sera of patients with epidemic erythromelalgia","volume":"283","author":"Zheng","year":"1991","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.virs.2025.07.001_bib49","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0140-6736(88)90372-8","article-title":"Poxviruses isolated from epidemic erythromelalgia in China","volume":"England) 1","author":"Zheng","year":"1988","journal-title":"Lancet (London"}],"container-title":["Virologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1995820X2500094X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1995820X2500094X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T18:02:03Z","timestamp":1756404123000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1995820X2500094X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S1995820X2500094X"],"URL":"https:\/\/doi.org\/10.1016\/j.virs.2025.07.001","relation":{},"ISSN":["1995-820X"],"issn-type":[{"value":"1995-820X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of a novel ectromelia virus from rodent: Implications for use as an in vivo infection model for vaccine and antiviral research","name":"articletitle","label":"Article Title"},{"value":"Virologica Sinica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virs.2025.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd\u00e9","name":"copyright","label":"Copyright"}]}}