{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T17:28:12Z","timestamp":1785605292183,"version":"3.56.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:00:00Z","timestamp":1770422400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100024068","name":"Witten\/Herdecke University","doi-asserted-by":"publisher","award":["IFF2017-17"],"award-info":[{"award-number":["IFF2017-17"]}],"id":[{"id":"10.13039\/501100024068","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"DFG","doi-asserted-by":"publisher","award":["EH 192\/5-1"],"award-info":[{"award-number":["EH 192\/5-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007812","name":"University of Washington","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007812","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virologica Sinica"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.virs.2026.02.007","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T08:03:15Z","timestamp":1770710595000},"page":"172-181","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Desmoglein 2 (DSG2)-knockout human respiratory epithelial cell model to study species B adenovirus receptor usage"],"prefix":"10.1016","volume":"41","author":[{"given":"Nora","family":"Bahlmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montaha","family":"Alshawabkeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Tsoukas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Schr\u00f6er","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Schellhorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mareike","family":"Sieler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Dittmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Ehrke-Schulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6639-4888","authenticated-orcid":false,"given":"Anja","family":"Ehrhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6243-6286","authenticated-orcid":false,"given":"Wenli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virs.2026.02.007_bib1","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.3390\/v14081835","article-title":"Properties of adenovirus vectors with increased affinity to DSG2 and the potential benefits of oncolytic approaches and gene therapy","volume":"14","author":"Bahlmann","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.virs.2026.02.007_bib2","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1126\/science.275.5304.1320","article-title":"Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5","volume":"275","author":"Bergelson","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.virs.2026.02.007_bib3","doi-asserted-by":"crossref","first-page":"7080","DOI":"10.1158\/0008-5472.CAN-11-2009","article-title":"Epithelial junction opener JO-1 improves monoclonal antibody therapy of cancer","volume":"71","author":"Beyer","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.virs.2026.02.007_bib4","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1089\/hum.2013.215","article-title":"CD46-mediated transduction of a species D adenovirus vaccine improves mucosal vaccine efficacy","volume":"25","author":"Camacho","year":"2014","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.virs.2026.02.007_bib5","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2014408118","article-title":"Interplay between desmoglein2 and hypoxia controls metastasis in breast cancer","volume":"118","author":"Chang","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.virs.2026.02.007_bib6","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1002\/1878-0261.13055","article-title":"Desmoglein-2 expression is an independent predictor of poor prognosis patients with multiple myeloma","volume":"16","author":"Ebert","year":"2022","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.virs.2026.02.007_bib7","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00910-23","article-title":"Toward the understanding of DSG2 and CD46 interaction with HAdV-11 fiber, a super-complex analysis","volume":"97","author":"Effantin","year":"2023","journal-title":"J. Virol."},{"key":"10.1016\/j.virs.2026.02.007_bib8","unstructured":"EMA. 2025. Gene Therapy Medicinal Products in EU [Online]. Available: https:\/\/www.pei.de\/EN\/medicinal-products\/atmp\/gene-therapy-medicinal-products\/gene-therapy-node.html [Accessed 25 September 2025]."},{"key":"10.1016\/j.virs.2026.02.007_bib9","unstructured":"FDA. 2025. Approved Cellular and Gene Therapy Products [Online]. Available: https:\/\/www.fda.gov\/vaccines-blood-biologics\/cellular-gene-therapy-products\/approved-cellular-and-gene-therapy-products [Accessed 25 September 2025]."},{"key":"10.1016\/j.virs.2026.02.007_bib10","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00747-20","article-title":"Human Desmoglein-2 and human CD46 mediate human adenovirus type 55 infection, but human Desmoglein-2 plays the major roles","volume":"94","author":"Feng","year":"2020","journal-title":"J. Virol."},{"key":"10.1016\/j.virs.2026.02.007_bib11","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0140-6736(20)31604-4","article-title":"Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1\/2, single-blind, randomised controlled trial","volume":"396","author":"Folegatti","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.virs.2026.02.007_bib12","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1038\/nm952","article-title":"CD46 is a cellular receptor for group B adenoviruses","volume":"9","author":"Gaggar","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.virs.2026.02.007_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.70464","article-title":"An epidemic of respiratory and ocular infections caused by the reemergence of a recombinant human adenovirus, the novel type HAdV-B114 (P7H3F3)","volume":"97","author":"Ganzenmueller","year":"2025","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.virs.2026.02.007_bib14","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.bbamem.2007.07.014","article-title":"Desmosome structure, composition and function","volume":"1778","author":"Garrod","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.virs.2026.02.007_bib15","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1093\/jnci\/51.5.1417","article-title":"In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors","volume":"51","author":"Giard","year":"1973","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.virs.2026.02.007_bib16","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/S1473-3099(22)00506-0","article-title":"Efficacy, safety, and immunogenicity of a booster regimen of Ad26.COV2.S vaccine against COVID-19 (ENSEMBLE2): results of a randomised, double-blind, placebo-controlled, phase 3 trial","volume":"22","author":"Hardt","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.virs.2026.02.007_bib45","unstructured":"Human Adenovirus Working Group. 2024. Assigned Human Adenovirus Genotype [Online]. Available: http:\/\/hadvwg.gmu.edu\/ [Accessed 25 September 2025]."},{"key":"10.1016\/j.virs.2026.02.007_bib17","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nprot.2009.4","article-title":"A rapid protocol for construction and production of high-capacity adenoviral vectors","volume":"4","author":"Jager","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.virs.2026.02.007_bib18","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.canlet.2020.04.001","article-title":"Desmoglein-2 modulates tumor progression and osimertinib drug resistance through the EGFR\/Src\/PAK1 pathway in lung adenocarcinoma","volume":"483","author":"Jin","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.virs.2026.02.007_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0209038","article-title":"A multigene typing system for human adenoviruses reveals a new genotype in a collection of Swedish clinical isolates","volume":"13","author":"Kajan","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.virs.2026.02.007_bib20","doi-asserted-by":"crossref","DOI":"10.1128\/jcm.00836-22","article-title":"Adenovirus infections: new insights for the clinical laboratory","volume":"62","author":"Kajon","year":"2024","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.virs.2026.02.007_bib21","doi-asserted-by":"crossref","first-page":"4531","DOI":"10.1038\/onc.2013.442","article-title":"Loss of the desmosomal cadherin desmoglein-2 suppresses colon cancer cell proliferation through EGFR signaling","volume":"33","author":"Kamekura","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.virs.2026.02.007_bib22","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s40265-023-01846-z","article-title":"Nadofaragene firadenovec: first approval","volume":"83","author":"Lee","year":"2023","journal-title":"Drugs"},{"key":"10.1016\/j.virs.2026.02.007_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004657","article-title":"Human adenovirus 52 uses sialic acid-containing glycoproteins and the coxsackie and adenovirus receptor for binding to target cells","volume":"11","author":"Lenman","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virs.2026.02.007_bib24","doi-asserted-by":"crossref","first-page":"10862","DOI":"10.1128\/JVI.00928-12","article-title":"Adenovirus serotype 26 utilizes CD46 as a primary cellular receptor and only transiently activates T lymphocytes following vaccination of rhesus monkeys","volume":"86","author":"Li","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.virs.2026.02.007_bib25","doi-asserted-by":"crossref","DOI":"10.1172\/JCI188355","article-title":"The multiverse of CD46 and oncologic interactions","volume":"135","author":"Liszewski","year":"2025","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.virs.2026.02.007_bib26","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00281-005-0002-3","article-title":"Emerging roles and new functions of CD46","volume":"27","author":"Liszewski","year":"2005","journal-title":"Springer Semin. Immunopathol."},{"key":"10.1016\/j.virs.2026.02.007_bib27","article-title":"Human adenovirus type 17 from species D transduces endothelial cells and human CD46 is involved in cell entry","volume":"8","author":"Liu","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.virs.2026.02.007_bib28","doi-asserted-by":"crossref","first-page":"14429","DOI":"10.1128\/JVI.79.22.14429-14436.2005","article-title":"CD46 is a cellular receptor for all species B adenoviruses except types 3 and 7","volume":"79","author":"Marttila","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.virs.2026.02.007_bib29","article-title":"Desmoglein-2 as a cancer modulator: friend or foe?","volume":"13","author":"Myo","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.virs.2026.02.007_bib30","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/JU.0000000000004020","article-title":"Efficacy of intravesical nadofaragene firadenovec for patients with bacillus calmette-guerin-unresponsive nonmuscle-invasive bladder cancer: 5-year Follow-Up from a phase 3 trial","volume":"212","author":"Narayan","year":"2024","journal-title":"J. Urol."},{"key":"10.1016\/j.virs.2026.02.007_bib31","doi-asserted-by":"crossref","first-page":"6169","DOI":"10.1038\/s41598-019-42229-3","article-title":"Structure-based design of JOC-x, a conjugatable tumor tight junction opener to enhance cancer therapy","volume":"9","author":"Pitner","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.virs.2026.02.007_bib32","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12935-020-01292-x","article-title":"DSG2 expression is correlated with poor prognosis and promotes early-stage cervical cancer","volume":"20","author":"Qin","year":"2020","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.virs.2026.02.007_bib33","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.3390\/genes13112056","article-title":"Role of fiber shaft length in tumor targeting with Ad5\/3 vectors","volume":"13","author":"Richter","year":"2022","journal-title":"Genes"},{"key":"10.1016\/j.virs.2026.02.007_bib34","doi-asserted-by":"crossref","first-page":"7909","DOI":"10.1128\/JVI.72.10.7909-7915.1998","article-title":"The coxsackievirus-adenovirus receptor protein can function as a cellular attachment protein for adenovirus serotypes from subgroups A, C, D, E, and F","volume":"72","author":"Roelvink","year":"1998","journal-title":"J. Virol."},{"key":"10.1016\/j.virs.2026.02.007_bib35","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1158\/0008-5472.CAN-14-3534","article-title":"Cell-cell adhesion and cytoskeleton tension oppose each other in regulating tumor cell aggregation","volume":"75","author":"Saias","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.virs.2026.02.007_bib36","article-title":"ADEVO: proof-of-concept of adenovirus-directed EVOlution by random peptide display on the fiber knob","volume":"32","author":"Sallard","year":"2024","journal-title":"Mol. Ther. Oncol."},{"issue":"Pt 6","key":"10.1016\/j.virs.2026.02.007_bib37","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1099\/0022-1317-80-6-1519","article-title":"Molecular determinants of adenovirus serotype 5 fibre binding to its cellular receptor CAR","volume":"80","author":"Santis","year":"1999","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virs.2026.02.007_bib38","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1128\/JVI.06181-11","article-title":"Avidity binding of human adenovirus serotypes 3 and 7 to the membrane cofactor CD46 triggers infection","volume":"86","author":"Trinh","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.virs.2026.02.007_bib39","doi-asserted-by":"crossref","first-page":"841","DOI":"10.3390\/cells11050841","article-title":"A human in vitro model to study adenoviral receptors and virus cell interactions","volume":"11","author":"Tsoukas","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.virs.2026.02.007_bib40","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/s41467-019-09220-y","article-title":"CryoEM structure of adenovirus type 3 fibre with desmoglein 2 shows an unusual mode of receptor engagement","volume":"10","author":"Vassal-Stermann","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.virs.2026.02.007_bib41","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1107\/S2053230X19015784","article-title":"Intermediate-resolution crystal structure of the human adenovirus B serotype 3 fibre knob in complex with the EC2-EC3 fragment of desmoglein 2","volume":"75","author":"Vassal-Stermann","year":"2019","journal-title":"Acta Crystal. Struc. Biol. Commun."},{"key":"10.1016\/j.virs.2026.02.007_bib42","doi-asserted-by":"crossref","first-page":"4360","DOI":"10.1182\/bloodadvances.2022007975","article-title":"In vivo HSC transduction in rhesus macaques with an HDAd5\/3+ vector targeting desmoglein 2 and transiently overexpressing cxcr4","volume":"6","author":"Wang","year":"2022","journal-title":"Blood Adv."},{"key":"10.1016\/j.virs.2026.02.007_bib43","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nm.2270","article-title":"Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14","volume":"17","author":"Wang","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.virs.2026.02.007_bib44","doi-asserted-by":"crossref","first-page":"11346","DOI":"10.1128\/JVI.01825-13","article-title":"Structural and functional studies on the interaction of adenovirus fiber knobs and desmoglein 2","volume":"87","author":"Wang","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.virs.2026.02.007_bib46","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1016\/j.ymthe.2024.08.013","article-title":"Targeted, safe, and efficient gene delivery to human hematopoietic stem and progenitor cells in vivo using the engineered AVID adenovirus vector platform","volume":"32","author":"Yao","year":"2024","journal-title":"Mol. Ther."},{"key":"10.1016\/j.virs.2026.02.007_bib47","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1007\/s12250-021-00414-7","article-title":"Desmoglein 2 (DSG2) is A receptor of human adenovirus type 55 causing adult severe community-acquired pneumonia","volume":"36","author":"Zhang","year":"2021","journal-title":"Virol. Sin."},{"key":"10.1016\/j.virs.2026.02.007_bib48","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/j.celrep.2017.05.008","article-title":"An engineered virus library as a resource for the spectrum-wide exploration of virus and vector diversity","volume":"19","author":"Zhang","year":"2017","journal-title":"Cell Rep."}],"container-title":["Virologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1995820X26000192?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1995820X26000192?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T19:33:23Z","timestamp":1776195203000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1995820X26000192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S1995820X26000192"],"URL":"https:\/\/doi.org\/10.1016\/j.virs.2026.02.007","relation":{},"ISSN":["1995-820X"],"issn-type":[{"value":"1995-820X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Desmoglein 2 (DSG2)-knockout human respiratory epithelial cell model to study species B adenovirus receptor usage","name":"articletitle","label":"Article Title"},{"value":"Virologica Sinica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virs.2026.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}