{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T16:08:23Z","timestamp":1789056503017,"version":"build-2803163510"},"reference-count":43,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974305"],"award-info":[{"award-number":["81974305"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31970155"],"award-info":[{"award-number":["31970155"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2023-PT310-02"],"award-info":[{"award-number":["2023-PT310-02"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["ZD2021CY001"],"award-info":[{"award-number":["ZD2021CY001"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2026ZD01908801"],"award-info":[{"award-number":["2026ZD01908801"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virologica Sinica"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.virs.2026.08.005","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T15:12:46Z","timestamp":1786374766000},"page":"779-790","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification and characterization of anti-chikungunya virus compounds using a biosafe toolkit"],"prefix":"10.1016","volume":"41","author":[{"given":"Yang","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guojie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sicheng","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jincun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3655-5000","authenticated-orcid":false,"given":"Xing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6296-509X","authenticated-orcid":false,"given":"Rong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2941-4808","authenticated-orcid":false,"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virs.2026.08.005_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/jof12020156","article-title":"Caspofungin reshapes the extracellular vesicles metabolome of candidozyma (Candida) auris, altering amino acid and nucleotide metabolism","volume":"12","author":"Alves","year":"2026","journal-title":"J. Fungi"},{"key":"10.1016\/j.virs.2026.08.005_bib2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.antiviral.2003.09.005","article-title":"In vitro inhibition of Chikungunya and Semliki Forest viruses replication by antiviral compounds: synergistic effect of interferon-alpha and ribavirin combination","volume":"61","author":"Briolant","year":"2004","journal-title":"Antivir. Res."},{"key":"10.1016\/j.virs.2026.08.005_bib3","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s11745-009-3305-7","article-title":"Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes","volume":"44","author":"Cenedella","year":"2009","journal-title":"Lipids"},{"key":"10.1016\/j.virs.2026.08.005_bib4","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/s41564-022-01164-2","article-title":"Chikungunya virus assembly and budding visualized in situ using cryogenic electron tomography","volume":"7","author":"Chmielewski","year":"2022","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.virs.2026.08.005_bib5","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00011-009-0057-z","article-title":"H89, an inhibitor of PKA and MSK, inhibits cyclic-AMP response element binding protein-mediated MAPK phosphatase-1 induction by lipopolysaccharide","volume":"58","author":"Cho","year":"2009","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.virs.2026.08.005_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.01297","article-title":"Chikungunya virus: an emergent arbovirus to the South American continent and a continuous threat to the world","volume":"11","author":"Cunha","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.virs.2026.08.005_bib7","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1093\/jac\/dku209","article-title":"Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral","volume":"69","author":"Delang","year":"2014","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.virs.2026.08.005_bib8","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1476-5381.1980.tb08721.x","article-title":"Effects of RMI 12330A, a new inhibitor of adenylate cyclase on myocardial function and subcellular activity","volume":"70","author":"Grupp","year":"1980","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.virs.2026.08.005_bib9","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00787-17","article-title":"Partially uncleaved alphavirus replicase forms spherule structures in the presence and absence of RNA template","volume":"91","author":"Hellstr\u00f6m","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.virs.2026.08.005_bib10","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.antiviral.2018.10.005","article-title":"Micafungin is a novel anti-viral agent of chikungunya virus through multiple mechanisms","volume":"159","author":"Ho","year":"2018","journal-title":"Antivir. Res."},{"key":"10.1016\/j.virs.2026.08.005_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11320","article-title":"A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs","volume":"7","author":"Karlas","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.virs.2026.08.005_bib12","article-title":"The adenylyl cyclase inhibitor MDL-12,330A potentiates insulin secretion via blockade of voltage-dependent K(+) channels in pancreatic beta cells","volume":"8","author":"Li","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.virs.2026.08.005_bib13","doi-asserted-by":"crossref","first-page":"nwaf529","DOI":"10.1093\/nsr\/nwaf529","article-title":"Emerging local chikungunya virus transmission in a major urban area in Southern China: characteristics of clinical manifestations, viral evolution and climatic influences","volume":"13","author":"Liang","year":"2026","journal-title":"Natl. Sci. Rev."},{"key":"10.1016\/j.virs.2026.08.005_bib14","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.04854-22","article-title":"Development of a novel chikungunya virus-like replicon particle for rapid quantification and screening of neutralizing antibodies and antivirals","volume":"11","author":"Lin","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.virs.2026.08.005_bib15","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/0092-8674(91)90534-6","article-title":"Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic","volume":"67","author":"Lippincott-Schwartz","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.virs.2026.08.005_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.virs.2026.07.001","article-title":"Recent progress in anti-Chikungunya virus drug discovery: focus on the viral life cycle and direct-acting antivirals","author":"Liu","year":"2026","journal-title":"Virol. Sin."},{"key":"10.1016\/j.virs.2026.08.005_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.70457","article-title":"The single amino acid change of R516K enables efficient generation of vesicular Stomatitis virus-based Crimean-Congo hemorrhagic fever reporter virus","volume":"97","author":"Ma","year":"2025","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.virs.2026.08.005_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens14101047","article-title":"A review of the biology of Chikungunya virus highlighting the development of Current novel therapeutic and prevention approaches","volume":"14","author":"Martelossi-Cebinelli","year":"2025","journal-title":"Pathogens"},{"key":"10.1016\/j.virs.2026.08.005_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011972","article-title":"Distinct chikungunya virus polymerase palm subdomains contribute to viral protein accumulation and virion production","volume":"20","author":"Martin","year":"2024","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virs.2026.08.005_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.vaccine.2024.126483","article-title":"Chikungunya vaccine development, challenges, and pathway toward public health impact","volume":"42","author":"Maure","year":"2024","journal-title":"Vaccine"},{"key":"10.1016\/j.virs.2026.08.005_bib21","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/S1473-3099(24)00357-8","article-title":"Antibody persistence and safety of a live-attenuated chikungunya virus vaccine up to 2 years after single-dose administration in adults in the USA: a single-arm, multicentre, phase 3b study","volume":"24","author":"McMahon","year":"2024","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.virs.2026.08.005_bib22","doi-asserted-by":"crossref","first-page":"4809","DOI":"10.1002\/jmv.27951","article-title":"Antiviral efficacy of selective estrogen receptor modulators against SARS-CoV-2 infection in vitro and in vivo reveals bazedoxifene acetate as an entry inhibitor","volume":"94","author":"Miao","year":"2022","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.virs.2026.08.005_bib23","doi-asserted-by":"crossref","DOI":"10.1186\/s12985-014-0215-y","article-title":"pH-Dependent entry of chikungunya virus fusion into mosquito cells","volume":"11","author":"Nuckols","year":"2014","journal-title":"Virol. J."},{"key":"10.1016\/j.virs.2026.08.005_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0028923","article-title":"Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays","volume":"6","author":"Pohjala","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.virs.2026.08.005_bib25","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1099\/vir.0.82858-0","article-title":"Changing patterns of chikungunya virus: re-emergence of a zoonotic arbovirus","volume":"88","author":"Powers","year":"2007","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virs.2026.08.005_bib26","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/S0140-6736(25)00345-9","article-title":"Chikungunya virus virus-like particle vaccine safety and immunogenicity in adolescents and adults in the USA: a phase 3, randomised, double-blind, placebo-controlled trial","volume":"405","author":"Richardson","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.virs.2026.08.005_bib27","doi-asserted-by":"crossref","first-page":"882","DOI":"10.4269\/ajtmh.13-0403","article-title":"Incubation periods of mosquito-borne viral infections: a systematic review","volume":"90","author":"Rudolph","year":"2014","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.virs.2026.08.005_bib28","doi-asserted-by":"crossref","DOI":"10.1186\/s12916-022-02558-z","article-title":"Antiviral activity and mechanism of the antifungal drug, anidulafungin, suggesting its potential to promote treatment of viral diseases","volume":"20","author":"Shen","year":"2022","journal-title":"BMC Med."},{"key":"10.1016\/j.virs.2026.08.005_bib29","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nrrheum.2012.64","article-title":"Arthritogenic alphaviruses--an overview","volume":"8","author":"Suhrbier","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.virs.2026.08.005_bib30","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1128\/JVI.02990-13","article-title":"Stable, high-level expression of reporter proteins from improved alphavirus expression vectors to track replication and dissemination during encephalitic and arthritogenic disease","volume":"88","author":"Sun","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.virs.2026.08.005_bib31","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2025.2595790","article-title":"Isolation and genomic characterization of Chikungunya virus during the 2025 outbreak in Foshan, China","volume":"14","author":"Sun","year":"2025","journal-title":"Emerg. Microb. Infect."},{"key":"10.1016\/j.virs.2026.08.005_bib32","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1080\/14756366.2022.2050224","article-title":"Echinocandins - structure, mechanism of action and use in antifungal therapy","volume":"37","author":"Szyma\u0144ski","year":"2022","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.virs.2026.08.005_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011179","article-title":"The alphavirus nonstructural protein 2 NTPase induces a host translational shut-off through phosphorylation of eEF2 via cAMP-PKA-eEF2K signaling","volume":"19","author":"Treffers","year":"2023","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virs.2026.08.005_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.0030201","article-title":"A single mutation in chikungunya virus affects vector specificity and epidemic potential","volume":"3","author":"Tsetsarkin","year":"2007","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virs.2026.08.005_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002412","article-title":"Sequential adaptive mutations enhance efficient vector switching by Chikungunya virus and its epidemic emergence","volume":"7","author":"Tsetsarkin","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virs.2026.08.005_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001168","article-title":"Two Chikungunya isolates from the outbreak of La Reunion (Indian Ocean) exhibit different patterns of infection in the mosquito, Aedes albopictus","volume":"2","author":"Vazeille","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.virs.2026.08.005_bib37","doi-asserted-by":"crossref","first-page":"taaf105","DOI":"10.1093\/jtm\/taaf105","article-title":"Chikungunya virus in Guangdong, China in 2025","volume":"32","author":"Wang","year":"2025","journal-title":"J. Trav. Med."},{"key":"10.1016\/j.virs.2026.08.005_bib38","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1056\/NEJMra1406035","article-title":"Chikungunya virus and the global spread of a mosquito-borne disease","volume":"372","author":"Weaver","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.virs.2026.08.005_bib39","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/978-981-99-0113-5_16","article-title":"Pseudotyped viruses for the Alphavirus Chikungunya Virus","volume":"1407","author":"Wu","year":"2023","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.virs.2026.08.005_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/v16081332","article-title":"Antiviral activity of selective estrogen receptor modulators against severe fever with thrombocytopenia syndrome virus in vitro and in vivo","volume":"16","author":"Yan","year":"2024","journal-title":"Viruses"},{"key":"10.1016\/j.virs.2026.08.005_bib41","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1124\/pharmrev.120.000086","article-title":"Subcellular Organization of the cAMP signaling pathway","volume":"73","author":"Zaccolo","year":"2021","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.virs.2026.08.005_bib42","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/s41586-018-0121-3","article-title":"Mxra8 is a receptor for multiple arthritogenic alphaviruses","volume":"557","author":"Zhang","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.virs.2026.08.005_bib43","article-title":"A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry","volume":"12","author":"Zhu","year":"2021","journal-title":"Nat. Commun."}],"container-title":["Virologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1995820X26001343?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1995820X26001343?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:37:03Z","timestamp":1789054623000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1995820X26001343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S1995820X26001343"],"URL":"https:\/\/doi.org\/10.1016\/j.virs.2026.08.005","relation":{},"ISSN":["1995-820X"],"issn-type":[{"value":"1995-820X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification and characterization of anti-chikungunya virus compounds using a biosafe toolkit","name":"articletitle","label":"Article Title"},{"value":"Virologica Sinica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virs.2026.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}