{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T12:34:19Z","timestamp":1793450059176,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007925","name":"Huazhong Agricultural University","doi-asserted-by":"publisher","award":["IRIFH202209"],"award-info":[{"award-number":["IRIFH202209"]}],"id":[{"id":"10.13039\/501100007925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2662025DKPY009"],"award-info":[{"award-number":["2662025DKPY009"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virologica Sinica"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.virs.2026.09.013","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:54:50Z","timestamp":1790783690000},"page":"1200-1212","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["SwiVirScan, a high-throughput platform for profiling antibodies to swine-associated viruses, reveals extensive viral exposure histories in pigs"],"prefix":"10.1016","volume":"41","author":[{"given":"Qian","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhua","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengju","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyang","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxu","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0082-2229","authenticated-orcid":false,"given":"Pan","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virs.2026.09.013_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/v15040980","article-title":"Zoonotic animal influenza virus and potential mixing vessel hosts","volume":"15","author":"Abdelwhab","year":"2023","journal-title":"Viruses"},{"key":"10.1016\/j.virs.2026.09.013_bib2","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1146\/annurev-animal-021122-102606","article-title":"Advances in organ and tissue xenotransplantation","volume":"12","author":"Ali","year":"2024","journal-title":"Annu Rev Anim Biosci"},{"key":"10.1016\/j.virs.2026.09.013_bib3","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nbt.3519","article-title":"Near-optimal probabilistic RNA-seq quantification","volume":"34","author":"Bray","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.virs.2026.09.013_bib4","doi-asserted-by":"crossref","first-page":"e812","DOI":"10.1016\/S2542-5196(22)00147-4","article-title":"Disease control tools to secure animal and public health in a densely populated world","volume":"6","author":"Charlier","year":"2022","journal-title":"Lancet Planet. Health"},{"key":"10.1016\/j.virs.2026.09.013_bib5","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"Fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.virs.2026.09.013_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009928","article-title":"Induction of trained immunity by influenza vaccination - impact on COVID-19","volume":"17","author":"Debisarun","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virs.2026.09.013_bib7","doi-asserted-by":"crossref","DOI":"10.1186\/s12985-017-0836-z","article-title":"The porcine virome and xenotransplantation","volume":"14","author":"Denner","year":"2017","journal-title":"Virol. J."},{"key":"10.1016\/j.virs.2026.09.013_bib8","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1056\/NEJMoa2201422","article-title":"Genetically modified porcine-to-human cardiac xenotransplantation","volume":"387","author":"Griffith","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.virs.2026.09.013_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-82213-4","article-title":"Virome-wide serological profiling reveals association of herpesviruses with obesity","volume":"11","author":"Hasan","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.virs.2026.09.013_bib10","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1099\/jgv.0.000554","article-title":"Feral swine virome is dominated by single-stranded DNA viruses and contains a novel Orthopneumovirus which circulates both in feral and domestic swine","volume":"97","author":"Hause","year":"2016","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virs.2026.09.013_bib11","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.chom.2020.07.006","article-title":"Surveillance of European domestic pig populations identifies an emerging reservoir of potentially zoonotic swine influenza A viruses","volume":"28","author":"Henritzi","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.virs.2026.09.013_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2019.00120","article-title":"Porcine Torovirus (PToV)-A brief review of etiology, diagnostic assays and Current epidemiology","volume":"6","author":"Hu","year":"2019","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.virs.2026.09.013_bib13","doi-asserted-by":"crossref","first-page":"10899","DOI":"10.1073\/pnas.1821166116","article-title":"Temporal virus serological profiling of kidney graft recipients using VirScan","volume":"116","author":"Isnard","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.virs.2026.09.013_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.720952","article-title":"Sex differences in immunity to viral infections","volume":"12","author":"Jacobsen","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.virs.2026.09.013_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.86","article-title":"Hepatitis E virus infection","volume":"3","author":"Kamar","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.virs.2026.09.013_bib16","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1089\/cmb.2017.0096","article-title":"cutPrimers: a new tool for accurate cutting of primers from reads of targeted next generation sequencing","volume":"24","author":"Kechin","year":"2017","journal-title":"J. Comput. Biol."},{"key":"10.1016\/j.virs.2026.09.013_bib17","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.vetmic.2009.06.003","article-title":"Vaccine efficacy and immune response to swine influenza virus challenge in pigs infected with porcine reproductive and respiratory syndrome virus at the time of SIV vaccination","volume":"139","author":"Kitikoon","year":"2009","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virs.2026.09.013_bib18","doi-asserted-by":"crossref","first-page":"e00111","DOI":"10.1128\/CMR.00111-17","article-title":"Virological and immunological outcomes of coinfections","volume":"31","author":"Kumar","year":"2018","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.virs.2026.09.013_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/v12010107","article-title":"Virus metagenomics in farm animals: a systematic review","volume":"12","author":"Kwok","year":"2020","journal-title":"Viruses"},{"key":"10.1016\/j.virs.2026.09.013_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.onehlt.2021.100362","article-title":"Estimating the global prevalence of hepatitis E virus in swine and pork products","volume":"14","author":"Li","year":"2022","journal-title":"One Health"},{"key":"10.1016\/j.virs.2026.09.013_bib21","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2020.05.038","article-title":"A viral exposure signature defines early onset of hepatocellular carcinoma","volume":"182","author":"Liu","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.virs.2026.09.013_bib22","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.meegid.2012.01.017","article-title":"Phylogenetic analysis of 626 hepatitis E virus (HEV) isolates from humans and animals in China (1986-2011) showing genotype diversity and zoonotic transmission","volume":"12","author":"Liu","year":"2012","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.virs.2026.09.013_bib23","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41579-018-0115-z","article-title":"Host and viral determinants of influenza A virus species specificity","volume":"17","author":"Long","year":"2019","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.virs.2026.09.013_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.onehlt.2022.100384","article-title":"The pig as an amplifying host for new and emerging zoonotic viruses","volume":"14","author":"McLean","year":"2022","journal-title":"One Health"},{"key":"10.1016\/j.virs.2026.09.013_bib25","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1055\/s-0033-1338113","article-title":"Zoonotic and foodborne transmission of hepatitis E virus","volume":"33","author":"Meng","year":"2013","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.virs.2026.09.013_bib26","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1126\/science.aay6485","article-title":"Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens","volume":"366","author":"Mina","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.virs.2026.09.013_bib27","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1038\/s41591-023-02471-9","article-title":"Pig-to-human heart xenotransplantation in two recently deceased human recipients","volume":"29","author":"Moazami","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.virs.2026.09.013_bib28","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1038\/s41596-018-0025-6","article-title":"PhIP-Seq characterization of serum antibodies using oligonucleotide-encoded peptidomes","volume":"13","author":"Mohan","year":"2018","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.virs.2026.09.013_bib29","doi-asserted-by":"crossref","DOI":"10.1111\/xen.12775","article-title":"Porcine cytomegalovirus\/porcine roseolovirus (PCMV\/PRV): a threat for xenotransplantation?","volume":"29","author":"Mueller","year":"2022","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.virs.2026.09.013_bib30","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms7696","article-title":"Global migration of influenza A viruses in swine","volume":"6","author":"Nelson","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.virs.2026.09.013_bib31","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41590-026-02432-7","article-title":"Demographic and genetic factors shape the epitope specificity of the human antibody repertoire against viruses","volume":"27","author":"Olin","year":"2026","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.virs.2026.09.013_bib32","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.virusres.2011.09.014","article-title":"Concurrent infections are important for expression of porcine circovirus associated disease","volume":"164","author":"Opriessnig","year":"2012","journal-title":"Virus Res."},{"key":"10.1016\/j.virs.2026.09.013_bib33","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01879-16","article-title":"A novel Porcine circovirus distantly related to known circoviruses is associated with porcine dermatitis and nephropathy syndrome and reproductive failure","volume":"91","author":"Palinski","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.virs.2026.09.013_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2023.1212018","article-title":"Applications of VirScan to broad serological profiling of bat reservoirs for emerging zoonoses","volume":"11","author":"Ruhs","year":"2023","journal-title":"Front. Public Health"},{"key":"10.1016\/j.virs.2026.09.013_bib35","doi-asserted-by":"crossref","first-page":"e338","DOI":"10.1097\/INF.0000000000002003","article-title":"Detection of porcine bocavirus from a child with acute respiratory tract infection","volume":"37","author":"Safamanesh","year":"2018","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.virs.2026.09.013_bib36","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/s41577-020-0348-8","article-title":"Considering how biological sex impacts immune responses and COVID-19 outcomes","volume":"20","author":"Scully","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.virs.2026.09.013_bib37","doi-asserted-by":"crossref","first-page":"11697","DOI":"10.1128\/JVI.05217-11","article-title":"The fecal virome of pigs on a high-density farm","volume":"85","author":"Shan","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.virs.2026.09.013_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2021.100994","article-title":"Pathobiology of Japanese encephalitis virus infection","volume":"81","author":"Sharma","year":"2021","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.virs.2026.09.013_bib39","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.191","article-title":"SeqKit2: a Swiss army knife for sequence and alignment processing","volume":"3","author":"Shen","year":"2024","journal-title":"iMeta"},{"key":"10.1016\/j.virs.2026.09.013_bib40","doi-asserted-by":"crossref","DOI":"10.1126\/science.abd4250","article-title":"Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity","volume":"370","author":"Shrock","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.virs.2026.09.013_bib41","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1016\/j.vaccine.2005.12.010","article-title":"Negative impact of porcine reproductive and respiratory syndrome virus infection on the efficacy of classical swine fever vaccine","volume":"24","author":"Suradhat","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.virs.2026.09.013_bib42","series-title":"Swine Viral Disease Matrix","year":"2018"},{"key":"10.1016\/j.virs.2026.09.013_bib43","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41581-022-00624-6","article-title":"Progress in xenotransplantation: overcoming immune barriers","volume":"18","author":"Sykes","year":"2022","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.virs.2026.09.013_bib44","doi-asserted-by":"crossref","first-page":"11495","DOI":"10.1073\/pnas.1806068115","article-title":"Global trends in infectious diseases of swine","volume":"115","author":"VanderWaal","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.virs.2026.09.013_bib45","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.immuni.2021.12.004","article-title":"Analysis of antibody binding specificities in twin and SNP-genotyped cohorts reveals that antiviral antibody epitope selection is a heritable trait","volume":"55","author":"Venkataraman","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.virs.2026.09.013_bib46","doi-asserted-by":"crossref","first-page":"e254","DOI":"10.1016\/S2666-5247(20)30114-2","article-title":"Interference between rhinovirus and influenza A virus: a clinical data analysis and experimental infection study","volume":"1","author":"Wu","year":"2020","journal-title":"Lancet Microbe"},{"key":"10.1016\/j.virs.2026.09.013_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.meegid.2021.105198","article-title":"Prevalence and diversity of rotavirus A in pigs: evidence for a possible reservoir in human infection","volume":"98","author":"Wu","year":"2022","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.virs.2026.09.013_bib48","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaa0698","article-title":"Viral immunology. Comprehensive serological profiling of human populations using a synthetic human virome","volume":"348","author":"Xu","year":"2015","journal-title":"Science"}],"container-title":["Virologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1995820X26001756?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1995820X26001756?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T12:17:18Z","timestamp":1793449038000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1995820X26001756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S1995820X26001756"],"URL":"https:\/\/doi.org\/10.1016\/j.virs.2026.09.013","relation":{},"ISSN":["1995-820X"],"issn-type":[{"value":"1995-820X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SwiVirScan, a high-throughput platform for profiling antibodies to swine-associated viruses, reveals extensive viral exposure histories in pigs","name":"articletitle","label":"Article Title"},{"value":"Virologica Sinica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virs.2026.09.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd.","name":"copyright","label":"Copyright"}]}}