{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T16:00:08Z","timestamp":1782316808335,"version":"3.54.5"},"reference-count":41,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Virus Research"],"published-print":{"date-parts":[[2005,9]]},"DOI":"10.1016\/j.virusres.2005.03.026","type":"journal-article","created":{"date-parts":[[2005,4,28]],"date-time":"2005-04-28T13:13:57Z","timestamp":1114694037000},"page":"95-99","source":"Crossref","is-referenced-by-count":20,"title":["A synthetic peptide based on the NS1 non-structural protein of tick-borne encephalitis virus induces a protective immune response against fatal encephalitis in an experimental animal model"],"prefix":"10.1016","volume":"112","author":[{"given":"O.M.","family":"Volpina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.D.","family":"Volkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.O.","family":"Koroev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.T.","family":"Ivanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.V.","family":"Ozherelkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.V.","family":"Khoretonenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.F.","family":"Vorovitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.R.","family":"Stephenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.V.","family":"Timofeev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virusres.2005.03.026_bib1","series-title":"Vaccines","first-page":"715","article-title":"Tick-borne encephalitis vaccine","author":"Barrett","year":"1994"},{"key":"10.1016\/j.virusres.2005.03.026_bib2","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S0958-1669(97)80066-3","article-title":"Design of peptide and polypeptide vaccines","volume":"8","author":"Ben-Yedidia","year":"1997","journal-title":"Curr. Opin. Biotechnol."},{"issue":"Suppl. A","key":"10.1016\/j.virusres.2005.03.026_bib3","first-page":"143","article-title":"Novel approaches to peptide and engineered protein vaccines for HIV using defined epitopes: advances in 1994\u20131995","volume":"9","author":"Berzofsky","year":"1995","journal-title":"AIDS"},{"key":"10.1016\/j.virusres.2005.03.026_bib4","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0198-8859(00)00147-6","article-title":"Modulation of TCR recognition of MHC class II\/peptide by processed remote N- and C-terminal epitope extensions","volume":"61","author":"Bonomi","year":"2000","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.virusres.2005.03.026_bib5","doi-asserted-by":"crossref","first-page":"4048","DOI":"10.4049\/jimmunol.161.8.4048","article-title":"Large protein fragments as substrates for endocytic antigen capture by MHC class II molecules","volume":"161","author":"Castellino","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.virusres.2005.03.026_bib6","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1007\/s007050170103","article-title":"Monoclonal antibody raised against envelope glycoprotein peptide neutralizes Japanese encephalitis virus","volume":"146","author":"Dewasthaly","year":"2001","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virusres.2005.03.026_bib7","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/BF01309478","article-title":"Precise localization of sequential virus subcomplex and complex B epitopes on the nonstructural-1 protein","volume":"137","author":"Falconar","year":"1994","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virusres.2005.03.026_bib8","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1007\/s007050050646","article-title":"Identification of an epitope on the dengue virus membrane (M) protein defined by cross-protective monoclonal antibodies: design of an improved epitope sequence based on common determinants present in both envelope (E and M) proteins","volume":"144","author":"Falconar","year":"1999","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virusres.2005.03.026_bib9","doi-asserted-by":"crossref","first-page":"466","DOI":"10.4269\/ajtmh.1997.56.466","article-title":"Recognition of synthetic oligopeptides from nonstructural proteins NS1 and NS3 of dengue-4 virus by sera from dengue virus-infected children","volume":"56","author":"Garcia","year":"1997","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.virusres.2005.03.026_bib10","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1099\/0022-1317-67-3-591","article-title":"Neutralizing (54K) and non-neutralizing (54K and 48K) monoclonal antibodies against structural and non-structural yellow fever virus proteins confer immunity in mice","volume":"67","author":"Gould","year":"1986","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virusres.2005.03.026_bib11","first-page":"301","article-title":"Immune enhancement of viral infection","volume":"31","author":"Halstead","year":"1982","journal-title":"Prog. Allergy"},{"key":"10.1016\/j.virusres.2005.03.026_bib12","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1126\/science.3277268","article-title":"Pathogenesis of dengue: challenges to molecular biology","volume":"239","author":"Halstead","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.virusres.2005.03.026_bib13","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0166-0934(96)02066-6","article-title":"Identification of peptides mimicking the antigenicity and immunogenicity of conformational epitopes on Japanese encephalitis virus protein using synthetic peptide libraries","volume":"61","author":"Hirabayashi","year":"1996","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.virusres.2005.03.026_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1096-9071(199901)57:1<1::AID-JMV1>3.0.CO;2-T","article-title":"Antibody responses to an immunodominant nonstructural 1 synthetic peptide in patients with dengue fever and dengue hemorrhagic fever","volume":"57","author":"Huang","year":"1999","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.virusres.2005.03.026_bib15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1089\/vim.1997.10.11","article-title":"Production of virus-specific antisera using synthetic peptides corresponding to sequences in the yellow fever E protein: brief report","volume":"10","author":"Jackson","year":"1997","journal-title":"Viral Immunol."},{"key":"10.1016\/j.virusres.2005.03.026_bib16","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1128\/JVI.66.4.2086-2095.1992","article-title":"High level expression of TBEV NS1 protein by using an adenovirus-based vector: protection elicited in a murine model","volume":"66","author":"Jacobs","year":"1992","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2005.03.026_bib17","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1099\/0022-1317-75-9-2399","article-title":"Protection elicited by a replication-defective adenovirus vector expressing the tick-borne encephalitis virus non-structural glycoprotein NS1","volume":"75","author":"Jacobs","year":"1994","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virusres.2005.03.026_bib18","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1128\/JVI.72.4.3076-3081.1998","article-title":"Neutralizing antibodies protect against lethal flavivirus challenge but allow for the development of active humoral immunity to a non-structural protein","volume":"72","author":"Kreil","year":"1998","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2005.03.026_bib19","series-title":"Fields\u2019 Virology","first-page":"961","article-title":"Flaviviruses","author":"Monath","year":"1996"},{"key":"10.1016\/j.virusres.2005.03.026_bib20","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1111\/j.1348-0421.1995.tb03294.x","article-title":"Recognition of nonstructural protein peptides by cytotoxic T lymphocytes raised against Japanese encephalitis virus","volume":"39","author":"Murali-Krishna","year":"1995","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.virusres.2005.03.026_bib21","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0065-2776(08)60585-4","article-title":"The use of multiple antigen peptides in the analysis and induction of protective immune responses against infectious diseases","volume":"60","author":"Nardin","year":"1995","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.virusres.2005.03.026_bib22","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1111\/j.1348-0421.1999.tb03352.x","article-title":"Synthetic peptide vaccines effective in preventing virus infection","volume":"43","author":"Ogasawara","year":"1999","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.virusres.2005.03.026_bib23","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2174\/1386207023330589","article-title":"Mimotopes of viral antigens and biologically important molecules as candidate vaccines and potential immunotherapeutics","volume":"5","author":"Partidos","year":"2002","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"10.1016\/j.virusres.2005.03.026_bib24","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1099\/0022-1317-66-8-1831","article-title":"Antibody dependent enhancement of TBEV infectivity","volume":"88","author":"Phillpotts","year":"1985","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virusres.2005.03.026_bib25","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0042-6822(89)90509-6","article-title":"Synthetic peptides derived from the deduced amino acid sequence of the E-glycoprotein of Murray Valley encephalitis virus elicit antiviral antibody","volume":"171","author":"Roehrig","year":"1989","journal-title":"Virology"},{"key":"10.1016\/j.virusres.2005.03.026_bib26","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/0042-6822(90)90532-V","article-title":"Antibodies to dengue 2 virus E-glycoprotein synthetic peptides identify antigenic conformation","volume":"177","author":"Roehrig","year":"1990","journal-title":"Virology"},{"key":"10.1016\/j.virusres.2005.03.026_bib27","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.4049\/jimmunol.135.4.2805","article-title":"Protection against 17D yellow fever encephalitis in mice by passive transfer of monoclonal antibodies to the nonstructural glycoprotein gp48 and by active immunization with gp48","volume":"135","author":"Schlesinger","year":"1985","journal-title":"J. Immunol."},{"key":"10.1016\/j.virusres.2005.03.026_bib28","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1128\/JVI.60.3.1153-1155.1986","article-title":"Protection against yellow fever in monkeys by immunization with yellow fever virus nonstructural protein NS1","volume":"60","author":"Schlesinger","year":"1986","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2005.03.026_bib29","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/0264-410X(88)90095-3","article-title":"Flavivirus vaccines","volume":"6","author":"Stephenson","year":"1988","journal-title":"Vaccine"},{"key":"10.1016\/j.virusres.2005.03.026_bib30","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1099\/0022-1317-65-1-81","article-title":"Antigenic variation among members of the tick-borne encephalitis complex","volume":"65","author":"Stephenson","year":"1984","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virusres.2005.03.026_bib31","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1099\/0022-1317-68-5-1307","article-title":"The synthesis of immunogenic polypeptides encoded by TBEV","volume":"68","author":"Stephenson","year":"1987","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virusres.2005.03.026_bib32","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1099\/0022-1317-79-4-689","article-title":"Immunological basis for protection in a murine model of tick-borne encephalitis for protection elicited by a recombinant adenovirus carrying the gene encoding the NS1 non-structural protein","volume":"79","author":"Timofeev","year":"1998","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virusres.2005.03.026_bib33","first-page":"22","article-title":"Protective activity of the bacterial plasmid carrying NS1 non-structural protein of tick-borne encephalitis virus","volume":"1","author":"Timofeev","year":"2001","journal-title":"Vopr. Virusol."},{"key":"10.1016\/j.virusres.2005.03.026_bib34","volume":"vol. 9","author":"Udenfriend","year":"1987"},{"key":"10.1016\/j.virusres.2005.03.026_bib35","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/0264-410X(94)90329-8","article-title":"Towards a new generation of flavivirus vaccines","volume":"12","author":"Venugopal","year":"1994","journal-title":"Vaccine"},{"key":"10.1016\/j.virusres.2005.03.026_bib36","first-page":"100","article-title":"Study of the antigenic structure of tick-borne encephalitis virus using synthetic peptides","volume":"24","author":"Volkova","year":"1998","journal-title":"Bioorg. Khim."},{"key":"10.1016\/j.virusres.2005.03.026_bib37","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s007050050566","article-title":"A monoclonal antibody that recognizes the predicted tick-borne encephalitis virus E protein fusion sequence blocks fusion","volume":"144","author":"Volkova","year":"1999","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virusres.2005.03.026_bib38","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/S0264-410X(96)00038-2","article-title":"Synthetic vaccine against foot-and-mouse disease based on a palmitoyl derivate of the VP1 protein 135\u2013159 fragment of the A22 virus strain","volume":"14","author":"Volpina","year":"1996","journal-title":"Vaccine"},{"key":"10.1016\/j.virusres.2005.03.026_bib39","first-page":"387","article-title":"Structure prediction for peptides capable of induction antibody formation in mice","volume":"28","author":"Volpina","year":"2002","journal-title":"Russ. J. Bioorg. Chem."},{"key":"10.1016\/j.virusres.2005.03.026_bib40","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0168-1702(01)00246-5","article-title":"Neutralizing peptide ligands selected from phage-displayed libraries mimic the conformational epitope on domain III of the Japanese encephalitis virus envelope protein","volume":"76","author":"Wu","year":"2001","journal-title":"Virus Res."},{"key":"10.1016\/j.virusres.2005.03.026_bib41","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1099\/vir.0.19228-0","article-title":"Identification of a dengue virus type 2 (DEN-2) serotype-specific B-cell epitope and detection of DEN-2-immunized animal serum samples using an epitope-based peptide antigen","volume":"84","author":"Wu","year":"2003","journal-title":"J. Gen. Virol."}],"container-title":["Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170205000936?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170205000936?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T02:55:06Z","timestamp":1683082506000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168170205000936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":41,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["S0168170205000936"],"URL":"https:\/\/doi.org\/10.1016\/j.virusres.2005.03.026","relation":{},"ISSN":["0168-1702"],"issn-type":[{"value":"0168-1702","type":"print"}],"subject":[],"published":{"date-parts":[[2005,9]]}}}