{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:57:52Z","timestamp":1791039472119,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Virus Research"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1016\/j.virusres.2008.05.015","type":"journal-article","created":{"date-parts":[[2008,7,11]],"date-time":"2008-07-11T06:42:19Z","timestamp":1215758539000},"page":"49-55","source":"Crossref","is-referenced-by-count":60,"title":["Interferon antagonist function of Japanese encephalitis virus NS4A and its interaction with DEAD-box RNA helicase DDX42"],"prefix":"10.1016","volume":"137","author":[{"given":"Cheng-Wen","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieh-Wen","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuey-Ching","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Wein","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Hsiu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Ju","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Ho","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Yong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Ching","family":"Kao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virusres.2008.05.015_bib1","doi-asserted-by":"crossref","first-page":"4508","DOI":"10.1128\/AAC.49.11.4508-4514.2005","article-title":"Randomized, placebo-controlled trial of nonpegylated and pegylated forms of recombinant human alpha IFN 2a for suppression of dengue virus viremia in rhesus monkeys","volume":"49","author":"Ajariyakhajorn","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.virusres.2008.05.015_bib2","doi-asserted-by":"crossref","first-page":"12828","DOI":"10.1128\/JVI.79.20.12828-12839.2005","article-title":"Inhibition of IFN-stimulated JAK-STAT signaling by a tick-borne flavivirus and identification of NS5 as an IFN antagonist","volume":"79","author":"Best","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2008.05.015_bib3","series-title":"Fields Virology","first-page":"1043","article-title":"Flaviviridae","author":"Burke","year":"2001"},{"key":"10.1016\/j.virusres.2008.05.015_bib4","doi-asserted-by":"crossref","first-page":"11809","DOI":"10.1128\/JVI.00791-07","article-title":"Differential effects of mutations in NS4B on West Nile Virus replication and inhibition of IFN signaling","volume":"81","author":"Evans","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2008.05.015_bib5","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1128\/JVI.79.3.1343-1350.2005","article-title":"West Nile virus inhibits the signal transduction pathway of alpha IFN","volume":"79","author":"Guo","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2008.05.015_bib6","doi-asserted-by":"crossref","first-page":"8163","DOI":"10.4049\/jimmunol.174.12.8163","article-title":"Dengue virus type 2 antagonizes IFN-alpha but not IFN-gamma antiviral effect via down-regulating Tyk2-STAT signaling in the human dendritic cell","volume":"174","author":"Ho","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.virusres.2008.05.015_bib7","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1126\/science.1132505","article-title":"5\u2032-Triphosphate RNA is the ligand for RIG-I","volume":"314","author":"Hornung","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.virusres.2008.05.015_bib8","doi-asserted-by":"crossref","first-page":"4621","DOI":"10.1111\/j.1432-1033.2004.04425.x","article-title":"Weapons of STAT destruction","volume":"271","author":"Horvath","year":"2004","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.virusres.2008.05.015_bib9","doi-asserted-by":"crossref","first-page":"5727","DOI":"10.1038\/sj.onc.1202960","article-title":"The human papilloma virus (HPV)-18 E6 oncoprotein physically associates with Tyk2 and impairs Jak-STAT activation by IFN-alpha","volume":"18","author":"Li","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.virusres.2008.05.015_bib10","doi-asserted-by":"crossref","first-page":"5908","DOI":"10.1128\/JVI.02714-05","article-title":"Blocking of IFN-induced Jak-Stat signaling by Japanese encephalitis virus NS5 through a protein tyrosine phosphatase-mediated mechanism","volume":"80","author":"Lin","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2008.05.015_bib11","doi-asserted-by":"crossref","first-page":"9285","DOI":"10.1128\/JVI.78.17.9285-9294.2004","article-title":"Blocking of the alpha IFN-induced Jak-Stat signaling pathway by Japanese encephalitis virus infection","volume":"78","author":"Lin","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2008.05.015_bib12","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.virusres.2007.03.022","article-title":"Functional determinants of NS2B for activation of Japanese encephalitis virus NS3 protease","volume":"127","author":"Lin","year":"2007","journal-title":"Virus Res."},{"key":"10.1016\/j.virusres.2008.05.015_bib13","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.virusres.2005.09.002","article-title":"Japanese encephalitis virus NS2B-NS3 protease binding to phage-displayed human brain proteins with the domain of trypsin inhibitor and basic region leucine zipper","volume":"116","author":"Lin","year":"2006","journal-title":"Virus Res."},{"key":"10.1016\/j.virusres.2008.05.015_bib14","doi-asserted-by":"crossref","first-page":"6089","DOI":"10.1016\/j.febslet.2005.09.075","article-title":"Binding interaction of SARS coronavirus 3CL(pro) protease with vacuolar-H+ATPase G1 subunit","volume":"579","author":"Lin","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.virusres.2008.05.015_bib15","series-title":"Fields Virology","first-page":"991","article-title":"Flaviviridae: the viruses and their replication","author":"Lindenbach","year":"2001"},{"key":"10.1016\/j.virusres.2008.05.015_bib16","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1128\/JVI.79.3.1934-1942.2005","article-title":"Inhibition of IFN signaling by the New York 99 strain and Kunjin subtype of West Nile virus involves blockage of STAT1 and STAT2 activation by nonstructural proteins","volume":"79","author":"Liu","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2008.05.015_bib17","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1128\/JVI.80.5.2396-2404.2006","article-title":"A single amino acid substitution in the West Nile virus nonstructural protein NS2A disables its ability to inhibit alpha\/beta IFN induction and attenuates virus virulence in mice","volume":"80","author":"Liu","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2008.05.015_bib18","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1128\/JVI.01265-06","article-title":"Inhibition of retinoic acid-inducible gene I-mediated induction of beta IFN by the NS1 protein of influenza A virus","volume":"81","author":"Mibayashi","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2008.05.015_bib19","doi-asserted-by":"crossref","first-page":"8873","DOI":"10.1074\/jbc.M609919200","article-title":"The non-structural protein 4A of dengue virus is an integral membrane protein inducing membrane alterations in a 2K-regulated manner","volume":"282","author":"Miller","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virusres.2008.05.015_bib20","doi-asserted-by":"crossref","first-page":"14333","DOI":"10.1073\/pnas.2335168100","article-title":"Inhibition of IFN signaling by dengue virus","volume":"100","author":"Munoz-Jordan","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.virusres.2008.05.015_bib21","doi-asserted-by":"crossref","first-page":"8004","DOI":"10.1128\/JVI.79.13.8004-8013.2005","article-title":"Inhibition of alpha\/beta IFN signaling by the NS4B protein of flaviviruses","volume":"79","author":"Munoz-Jordan","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2008.05.015_bib22","doi-asserted-by":"crossref","first-page":"6936","DOI":"10.1128\/JVI.02830-06","article-title":"Identification of residues critical for the IFN antagonist function of Langat Virus NS5 reveals a role for the RNA-dependent RNA polymerase domain","volume":"81","author":"Park","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2008.05.015_bib23","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1126\/science.1132998","article-title":"RIG-I-mediated antiviral responses to single-stranded RNA bearing 5\u2032-phosphates","volume":"314","author":"Pichlmair","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.virusres.2008.05.015_bib24","doi-asserted-by":"crossref","first-page":"4623","DOI":"10.1128\/JVI.80.9.4623-4632.2006","article-title":"Regulated cleavages at the West Nile virus NS4A-2K\u2013NS4B junctions play a major role in rearranging cytoplasmic membranes and Golgi trafficking of the NS4A protein","volume":"8","author":"Roosendaal","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2008.05.015_bib25","doi-asserted-by":"crossref","first-page":"13350","DOI":"10.1128\/JVI.79.21.13350-13361.2005","article-title":"Alpha\/beta IFN protects against lethal West Nile virus infection by restricting cellular tropism and enhancing neuronal survival","volume":"79","author":"Samuel","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2008.05.015_bib26","doi-asserted-by":"crossref","first-page":"12005","DOI":"10.1128\/JVI.01359-07","article-title":"Differential expression of IFN (IFN) regulatory factors and IFN-stimulated genes at early times after West Nile virus infection of mouse embryo fibroblasts","volume":"81","author":"Scherbik","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2008.05.015_bib27","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/jnnp.68.4.405","article-title":"Japanese encephalitis","volume":"68","author":"Solomon","year":"2000","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.virusres.2008.05.015_bib28","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S0140-6736(03)12709-2","article-title":"IFN alfa-2a in Japanese encephalitis: a randomised double-blind placebo-controlled trial","volume":"361","author":"Solomon","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.virusres.2008.05.015_bib29","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1093\/nar\/gkj403","article-title":"Ddx42p\u2014a human DEAD box protein with RNA chaperone activities","volume":"34","author":"Uhlmann-Schiffler","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.virusres.2008.05.015_bib30","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1073\/pnas.95.3.1085","article-title":"The polyoma virus T antigen interferes with IFN-inducible gene expression","volume":"95","author":"Weihua","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.virusres.2008.05.015_bib31","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.4049\/jimmunol.175.5.2851","article-title":"Shared and unique functions of the DExD\/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity","volume":"175","author":"Yoneyama","year":"2005","journal-title":"J. Immunol."}],"container-title":["Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170208002116?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170208002116?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T03:57:15Z","timestamp":1545883035000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168170208002116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["S0168170208002116"],"URL":"https:\/\/doi.org\/10.1016\/j.virusres.2008.05.015","relation":{},"ISSN":["0168-1702"],"issn-type":[{"value":"0168-1702","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]}}}