{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T04:41:15Z","timestamp":1792298475558,"version":"4.4.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Virus Research"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1016\/j.virusres.2009.03.007","type":"journal-article","created":{"date-parts":[[2009,3,26]],"date-time":"2009-03-26T05:26:46Z","timestamp":1238045206000},"page":"77-85","source":"Crossref","is-referenced-by-count":67,"title":["Japanese encephalitis virus NS2B-NS3 protease induces caspase 3 activation and mitochondria-mediated apoptosis in human medulloblastoma cells"],"prefix":"10.1016","volume":"143","author":[{"given":"Tsuey-Ching","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Lian","family":"Shiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Hsin","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Ju","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ching","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Wen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virusres.2009.03.007_bib1","series-title":"Fields Virology","first-page":"1043","article-title":"Flaviviruses","author":"Burk","year":"2001"},{"key":"10.1016\/j.virusres.2009.03.007_bib2","doi-asserted-by":"crossref","first-page":"12107","DOI":"10.1128\/JVI.78.22.12107-12119.2004","article-title":"Upregulation of RANTES gene expression in neuroglia by Japanese encephalitis virus infection","volume":"78","author":"Chen","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2009.03.007_bib3","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1159\/000095154","article-title":"Programmed cell death induced by Japanese encephalitis virus YL vaccine strain or its recombinant envelope protein in varied cultured cells","volume":"49","author":"Chen","year":"2006","journal-title":"Intervirology"},{"key":"10.1016\/j.virusres.2009.03.007_bib4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1006\/viro.2001.1033","article-title":"Mutations in the NS3 gene and 3\u2032-NCR of Japanese encephalitis virus isolated from an unconventional ecosystem and implications for natural attenuation of the virus","volume":"289","author":"Chiou","year":"2001","journal-title":"Virology"},{"key":"10.1016\/j.virusres.2009.03.007_bib5","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/glia.20474","article-title":"Proinflammatory mediators released by activated microglia induces neuronal death in Japanese encephalitis","volume":"55","author":"Ghoshal","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.virusres.2009.03.007_bib6","doi-asserted-by":"crossref","first-page":"26576","DOI":"10.1074\/jbc.M003412200","article-title":"Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation","volume":"275","author":"Hatai","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virusres.2009.03.007_bib7","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1096\/fj.05-4376com","article-title":"Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice","volume":"20","author":"Hsieh","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.virusres.2009.03.007_bib8","first-page":"105","article-title":"Neuroimages of Japanese encephalitis: report of three patients","volume":"60","author":"Huang","year":"1997","journal-title":"Chin. Med. J. (Taipei)"},{"key":"10.1016\/j.virusres.2009.03.007_bib9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0022-510X(99)00318-4","article-title":"Comparison of CT and MRI findings in the diagnosis of Japanese encephalitis","volume":"174","author":"Kalita","year":"2000","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.virusres.2009.03.007_bib10","doi-asserted-by":"crossref","first-page":"7406","DOI":"10.1158\/0008-5472.CAN-07-1089","article-title":"Isoobtusilactone A induces cell cycle arrest and apoptosis through reactive oxygen species\/apoptosis signal-regulating kinase 1 signaling pathway in human breast cancer cells","volume":"67","author":"Kuo","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.virusres.2009.03.007_bib11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.virusres.2008.05.015","article-title":"Interferon antagonist function of Japanese encephalitis virus NS4A and its interaction with DEAD-box RNA helicase DDX42","volume":"137","author":"Lin","year":"2008","journal-title":"Virus Res."},{"key":"10.1016\/j.virusres.2009.03.007_bib12","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10529-007-9529-9","article-title":"Protective immunity of E. coli-synthesized NS1 protein of Japanese encephalitis virus","volume":"30","author":"Lin","year":"2008","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.virusres.2009.03.007_bib13","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.virusres.2007.03.022","article-title":"Functional determinants of NS2B for activation of Japanese encephalitis virus NS3 protease","volume":"127","author":"Lin","year":"2007","journal-title":"Virus Res."},{"key":"10.1016\/j.virusres.2009.03.007_bib14","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.virusres.2005.09.002","article-title":"Japanese encephalitis virus NS2B-NS3 protease binding to phage-displayed human brain proteins with the domain of trypsin inhibitor and basic region leucine zipper","volume":"116","author":"Lin","year":"2006","journal-title":"Virus Res."},{"key":"10.1016\/j.virusres.2009.03.007_bib15","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1574-695X.2006.00045.x","article-title":"Severe acute respiratory syndrome coronavirus 3C-like protease-induced apoptosis","volume":"46","author":"Lin","year":"2006","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.virusres.2009.03.007_bib16","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1099\/vir.0.19496-0","article-title":"Replication-incompetent virions of Japanese encephalitis virus trigger neuronal cell death by oxidative stress in a culture system","volume":"85","author":"Lin","year":"2004","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virusres.2009.03.007_bib17","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.canlet.2008.06.031","article-title":"DNA damage and endoplasmic reticulum stress mediated curcumin-induced cell cycle arrest and apoptosis in human lung carcinoma A-549 cells through the activation caspases cascade- and mitochondrial-dependent pathway","volume":"272","author":"Lin","year":"2008","journal-title":"Cancer Lett."},{"key":"10.1016\/j.virusres.2009.03.007_bib18","series-title":"Fields Virology","first-page":"991","article-title":"Flaviridae: the viruses and their replication","author":"Lindenbach","year":"2001"},{"key":"10.1016\/j.virusres.2009.03.007_bib19","first-page":"1","article-title":"The blood\u2013brain barrier in the cerebrum is the initial site for the Japanese encephalitis virus entering the central nervous system","volume":"20","author":"Liu","year":"2008","journal-title":"J. Neurovirol."},{"key":"10.1016\/j.virusres.2009.03.007_bib20","first-page":"55","article-title":"Clinical, radiological and neurophysiological spectrum of JEV encephalitis and other non-specific encephalitis during post-monsoon period in India","volume":"51","author":"Misra","year":"2003","journal-title":"Neurol. India"},{"key":"10.1016\/j.virusres.2009.03.007_bib21","doi-asserted-by":"crossref","first-page":"5701","DOI":"10.1128\/JVI.76.11.5701-5710.2002","article-title":"Langat flavivirus protease NS3 binds caspase-8 and induces apoptosis","volume":"76","author":"Prikhod\u2019ko","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2009.03.007_bib22","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.virol.2005.08.043","article-title":"Host cell killing by the West Nile Virus NS2B-NS3 proteolytic complex: NS3 alone is sufficient to recruit caspase-8-based apoptotic pathway","volume":"345","author":"Ramanathan","year":"2006","journal-title":"Virology"},{"key":"10.1016\/j.virusres.2009.03.007_bib23","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1002\/ijc.23639","article-title":"Genistein selectively potentiates arsenic trioxide-induced apoptosis in human leukemia cells via reactive oxygen species generation and activation of reactive oxygen species-inducible protein kinases (p38-MAPK, AMPK)","volume":"123","author":"S\u00e1nchez","year":"2008","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.virusres.2009.03.007_bib24","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1099\/vir.0.19022-0","article-title":"Dengue virus type 2 NS3 protease and NS2B-NS3 protease precursor induce apoptosis","volume":"84","author":"Shafee","year":"2003","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virusres.2009.03.007_bib25","doi-asserted-by":"crossref","first-page":"L436","DOI":"10.1152\/ajplung.00097.2007","article-title":"MAPK and heat shock protein 27 activation are associated with respiratory syncytial virus induction of human bronchial epithelial monolayer disruption","volume":"293","author":"Singh","year":"2007","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.virusres.2009.03.007_bib26","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/jnnp.68.4.405","article-title":"Japanese encephalitis","volume":"68","author":"Solomon","year":"2000","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.virusres.2009.03.007_bib27","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1128\/JVI.76.9.4162-4171.2002","article-title":"Japanese encephalitis virus infection initiates endoplasmic reticulum stress and an unfolded protein response","volume":"76","author":"Su","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2009.03.007_bib28","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1365-3083.2006.001764.x","article-title":"Role of MAP kinase-dependent apoptotic pathway in innate immune responses and viral infection","volume":"63","author":"Sumbayev","year":"2006","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.virusres.2009.03.007_bib29","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.neuint.2008.01.014","article-title":"Tumor necrosis factor receptor-associated death domain mediated neuronal death contributes to the glial activation and subsequent neuroinflammation in Japanese encephalitis","volume":"52","author":"Swarup","year":"2008","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.virusres.2009.03.007_bib30","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1146\/annurev.pharmtox.48.113006.094606","article-title":"Apoptosis signal-regulating kinase 1 in stress and immune response","volume":"48","author":"Takeda","year":"2008","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.virusres.2009.03.007_bib31","series-title":"Factors in the Emergence of Arbovirus Diseases","first-page":"179","article-title":"Factors in the changing epidemiology of Japanese encephalitis and West Nile fever","author":"Tsai","year":"1997"},{"key":"10.1016\/j.virusres.2009.03.007_bib32","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1099\/vir.0.2008\/000182-0","article-title":"Japanese encephalitis virus infection activates caspase-8 and -9 in a FADD-independent and mitochondrion-dependent manner","volume":"89","author":"Tsao","year":"2008","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virusres.2009.03.007_bib33","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.mrfmmm.2006.06.015","article-title":"Capsaicin induced cell cycle arrest and apoptosis in human esophagus epidermoid carcinoma CE 81T\/VGH cells through the elevation of intracellular reactive oxygen species and Ca2+ productions and caspase-3 activation","volume":"601","author":"Wu","year":"2006","journal-title":"Mutat. Res."}],"container-title":["Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170209001051?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170209001051?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T16:30:12Z","timestamp":1545323412000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168170209001051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S0168170209001051"],"URL":"https:\/\/doi.org\/10.1016\/j.virusres.2009.03.007","relation":{},"ISSN":["0168-1702"],"issn-type":[{"value":"0168-1702","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}