{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:46:43Z","timestamp":1790164003968,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Virus Research"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1016\/j.virusres.2010.11.010","type":"journal-article","created":{"date-parts":[[2010,12,18]],"date-time":"2010-12-18T09:14:58Z","timestamp":1292663698000},"page":"415-422","source":"Crossref","is-referenced-by-count":30,"title":["A virulent strain of porcine reproductive and respiratory syndrome virus does not up-regulate interleukin-10 levels in vitro or in vivo"],"prefix":"10.1016","volume":"155","author":[{"given":"Sakthivel","family":"Subramaniam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Hyang","family":"Sur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byungjoon","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asit K.","family":"Pattnaik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando A.","family":"Osorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.virusres.2010.11.010_bib0005","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1089\/jir.1998.18.485","article-title":"Interferon-alpha response to swine arterivirus (PoAV), the porcine reproductive and respiratory syndrome virus","volume":"18","author":"Albina","year":"1998","journal-title":"J. Interferon Cytokine Res."},{"issue":"22","key":"10.1016\/j.virusres.2010.11.010_bib0010","doi-asserted-by":"crossref","first-page":"10834","DOI":"10.1128\/JVI.74.22.10834-10837.2000","article-title":"Porcine reproductive and respiratory syndrome virus: description of persistence in individual pigs upon experimental infection","volume":"74","author":"Allende","year":"2000","journal-title":"J. Virol."},{"issue":"8","key":"10.1016\/j.virusres.2010.11.010_bib0015","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.1128\/JVI.80.8.3994-4004.2006","article-title":"Influence of N-linked glycosylation of porcine reproductive and respiratory syndrome virus GP5 on virus infectivity, antigenicity, and ability to induce neutralizing antibodies","volume":"80","author":"Ansari","year":"2006","journal-title":"J. Virol."},{"issue":"8","key":"10.1016\/j.virusres.2010.11.010_bib0020","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1177\/42.8.8027531","article-title":"A simple technique for preservation of fixation-sensitive antigens in paraffin-embedded tissues","volume":"42","author":"Beckstead","year":"1994","journal-title":"J. Histochem. Cytochem."},{"issue":"3","key":"10.1016\/j.virusres.2010.11.010_bib0025","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1128\/JVI.01326-09","article-title":"Porcine reproductive and respiratory syndrome virus nonstructural protein 1beta modulates host innate immune response by antagonizing IRF3 activation","volume":"84","author":"Beura","year":"2009","journal-title":"J. Virol."},{"issue":"11","key":"10.1016\/j.virusres.2010.11.010_bib0030","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1038\/nm1492","article-title":"Interleukin-10 determines viral clearance or persistence in vivo","volume":"12","author":"Brooks","year":"2006","journal-title":"Nat. Med."},{"issue":"3\u20134","key":"10.1016\/j.virusres.2010.11.010_bib0035","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.vetmic.2007.12.002","article-title":"Phenotypic and functional modulation of bone marrow-derived dendritic cells by porcine reproductive and respiratory syndrome virus","volume":"129","author":"Chang","year":"2008","journal-title":"Vet. Microbiol."},{"issue":"2\u20133","key":"10.1016\/j.virusres.2010.11.010_bib0040","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0021-9975(03)00036-7","article-title":"Expression of interleukin-10 and interleukin-12 in piglets experimentally infected with porcine reproductive and respiratory syndrome virus (PRRSV)","volume":"129","author":"Chung","year":"2003","journal-title":"J. Comp. Pathol."},{"issue":"1","key":"10.1016\/j.virusres.2010.11.010_bib0045","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4049\/jimmunol.157.1.12","article-title":"IL-10 production is enhanced in human T cells by IL-12 and IL-6 and in monocytes by tumor necrosis factor-alpha","volume":"157","author":"Daftarian","year":"1996","journal-title":"J. Immunol."},{"issue":"Pt 7","key":"10.1016\/j.virusres.2010.11.010_bib0050","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1099\/vir.0.80959-0","article-title":"Immune responses of pigs after experimental infection with a European strain of porcine reproductive and respiratory syndrome virus","volume":"86","author":"Diaz","year":"2005","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virusres.2010.11.010_bib0055","unstructured":"Diaz, I., Gimeno, M., Lopez-Soria, S., Galindo-Cardiel, I., Darwich, L., Montoya, M., Martin, M., Domingo, M., Pujols, J., Mateu, E., 2008. Homologous immunity against PRRSV: should the paradigm be questioned? in page 52: Proceedings 2008 PRRSV International Symposium, December 5\u20136, 2008, Chicago. Available from: http:\/\/www.prrssymposium.org\/Documents\/Proceedings\/PrrsSymposiumProceedings2008.PDF."},{"key":"10.1016\/j.virusres.2010.11.010_bib0060","unstructured":"Diaz, I., Gimeno., M., Navarrol, N., Cano, E., Montoya, M., Pujols, J., Mateu., E., 2008. Clustering of European-type PRRSV strains based on IL-10\/TNF-A induction and their correlation with IFN-secreting cell levels induced in pigs. in page 53: Proceedings 2008 PRRSV International Symposium, December 5\u20136, 2008, Chicago. Available from: http:\/\/www.prrssymposium.org\/Documents\/Proceedings\/PrrsSymposiumProceedings2008.PDF."},{"issue":"3","key":"10.1016\/j.virusres.2010.11.010_bib0065","doi-asserted-by":"crossref","DOI":"10.4142\/jvs.2010.11.3.177","article-title":"Distribution and characterization of IL-10-secreting cells in lymphoid tissues of PCV2-infected pigs","volume":"11","author":"Doster","year":"2010","journal-title":"J. Vet. Sci."},{"issue":"11","key":"10.1016\/j.virusres.2010.11.010_bib0070","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.4049\/jimmunol.147.11.3815","article-title":"IL-10 inhibits cytokine production by activated macrophages","volume":"147","author":"Fiorentino","year":"1991","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.virusres.2010.11.010_bib0075","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1128\/CVI.00224-07","article-title":"Porcine reproductive and respiratory syndrome virus infects mature porcine dendritic cells and up-regulates interleukin-10 production","volume":"15","author":"Flores-Mendoza","year":"2008","journal-title":"Clin. Vaccine Immunol."},{"issue":"2","key":"10.1016\/j.virusres.2010.11.010_bib0080","doi-asserted-by":"crossref","first-page":"920","DOI":"10.4049\/jimmunol.160.2.920","article-title":"Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-alpha: role of the p38 and p42\/44 mitogen-activated protein kinases","volume":"160","author":"Foey","year":"1998","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.virusres.2010.11.010_bib0085","doi-asserted-by":"crossref","first-page":"2798","DOI":"10.4049\/jimmunol.165.5.2798","article-title":"IL-10 is induced in the reperfused myocardium and may modulate the reaction to injury","volume":"165","author":"Frangogiannis","year":"2000","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.virusres.2010.11.010_bib0200","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jcpa.2009.07.004","article-title":"Cytokine expression by macrophages in the lung of pigs infected with the porcine reproductive and respiratory syndrome virus","volume":"142","author":"Gomez-Laguna","year":"2010","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.virusres.2010.11.010_bib0095","series-title":"Porcine monocyte- and skin-derived dendritic cells are susceptible to PRRS virus infection, but cytokine production is differently modulated","author":"Hernandez","year":"2006"},{"issue":"4","key":"10.1016\/j.virusres.2010.11.010_bib0100","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1089\/088282402320914494","article-title":"Cytokine mRNA profiles in bronchoalveolar cells of piglets experimentally infected in utero with porcine reproductive and respiratory syndrome virus: association of sustained expression of IFN-gamma and IL-10 after viral clearance","volume":"15","author":"Johnsen","year":"2002","journal-title":"Viral Immunol."},{"issue":"7","key":"10.1016\/j.virusres.2010.11.010_bib0105","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1007\/s00705-007-0955-8","article-title":"Direct inoculation of RNA transcripts from an infectious cDNA clone of porcine reproductive and respiratory syndrome virus (PRRSV) into the lymph nodes and tonsils of pigs initiates PRRSV infection in vivo","volume":"152","author":"Key","year":"2007","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virusres.2010.11.010_bib0110","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/1743-422X-6-177","article-title":"Age-dependent resistance to Porcine reproductive and respiratory syndrome virus replication in swine","volume":"6","author":"Klinge","year":"2009","journal-title":"Virol. J."},{"issue":"49\u201350","key":"10.1016\/j.virusres.2010.11.010_bib0115","doi-asserted-by":"crossref","first-page":"7071","DOI":"10.1016\/j.vaccine.2006.07.010","article-title":"Infectious clone-derived viruses from virulent and vaccine strains of porcine reproductive and respiratory syndrome virus mimic biological properties of their parental viruses in a pregnant sow model","volume":"24","author":"Kwon","year":"2006","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.virusres.2010.11.010_bib0120","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.virol.2008.07.030","article-title":"Identification of virulence determinants of porcine reproductive and respiratory syndrome virus through construction of chimeric clones","volume":"380","author":"Kwon","year":"2008","journal-title":"Virology"},{"issue":"3","key":"10.1016\/j.virusres.2010.11.010_bib0125","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1051\/vetres:2003001","article-title":"Apoptosis in the lungs of pigs infected with porcine reproductive and respiratory syndrome virus and associations with the production of apoptogenic cytokines","volume":"34","author":"Labarque","year":"2003","journal-title":"Vet. Res."},{"issue":"1","key":"10.1016\/j.virusres.2010.11.010_bib0130","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0168-1702(00)00172-6","article-title":"Porcine reproductive and respiratory syndrome (PRRS) virus down-modulates TNF-alpha production in infected macrophages","volume":"69","author":"Lopez-Fuertes","year":"2000","journal-title":"Virus Res."},{"issue":"3","key":"10.1016\/j.virusres.2010.11.010_bib0135","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.vetimm.2004.09.005","article-title":"Role of neutralizing antibodies in PRRSV protective immunity","volume":"102","author":"Lopez","year":"2004","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"1","key":"10.1016\/j.virusres.2010.11.010_bib0140","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0042-6822(03)00009-6","article-title":"Gradual development of the interferon-gamma response of swine to porcine reproductive and respiratory syndrome virus infection or vaccination","volume":"309","author":"Meier","year":"2003","journal-title":"Virology"},{"key":"10.1016\/j.virusres.2010.11.010_bib0145","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-2172-9-10","article-title":"Activation of tonsil dendritic cells with immuno-adjuvants","volume":"9","author":"Polak","year":"2008","journal-title":"BMC Immunol."},{"issue":"2","key":"10.1016\/j.virusres.2010.11.010_bib0150","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0966-842X(00)01919-3","article-title":"Hijacking and exploitation of IL-10 by intracellular pathogens","volume":"9","author":"Redpath","year":"2001","journal-title":"Trends Microbiol."},{"issue":"9","key":"10.1016\/j.virusres.2010.11.010_bib0155","doi-asserted-by":"crossref","first-page":"5230","DOI":"10.4049\/jimmunol.162.9.5230","article-title":"The porcine 2A10 antigen is homologous to human CD163 and related to macrophage differentiation","volume":"162","author":"Sanchez","year":"1999","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.virusres.2010.11.010_bib0160","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.virol.2009.10.024","article-title":"European genotype of porcine reproductive and respiratory syndrome (PRRSV) infects monocyte-derived dendritic cells but does not induce Treg cells","volume":"396","author":"Silva-Campa","year":"2010","journal-title":"Virology"},{"issue":"1\u20132","key":"10.1016\/j.virusres.2010.11.010_bib0165","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0022-1759(01)00489-6","article-title":"Cytokine mRNA quantification by real-time PCR","volume":"259","author":"Stordeur","year":"2002","journal-title":"J. Immunol. Methods"},{"issue":"2","key":"10.1016\/j.virusres.2010.11.010_bib0205","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.virol.2010.07.016","article-title":"Porcine reproductive and respiratory syndrome virus non-structural protein 1 suppresses tumor necrosis factor-alpha promoter activation by inhibiting NF-\u03baB and Sp1","volume":"402","author":"Subramaniam","year":"2010","journal-title":"Virology."},{"issue":"Pt 2","key":"10.1016\/j.virusres.2010.11.010_bib0175","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1099\/vir.0.18698-0","article-title":"Upregulation of IL-10 gene expression in porcine peripheral blood mononuclear cells by porcine reproductive and respiratory syndrome virus","volume":"84","author":"Suradhat","year":"2003","journal-title":"J. Gen. Virol."},{"issue":"5","key":"10.1016\/j.virusres.2010.11.010_bib0180","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1128\/CDLI.11.5.901-908.2004","article-title":"Increased production of proinflammatory cytokines following infection with porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae","volume":"11","author":"Thanawongnuwech","year":"2004","journal-title":"Clin. Diagn. Lab Immunol."},{"issue":"2","key":"10.1016\/j.virusres.2010.11.010_bib0185","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.virol.2004.04.046","article-title":"A highly pathogenic porcine reproductive and respiratory syndrome virus generated from an infectious cDNA clone retains the in vivo virulence and transmissibility properties of the parental virus","volume":"325","author":"Truong","year":"2004","journal-title":"Virology"},{"issue":"2","key":"10.1016\/j.virusres.2010.11.010_bib0190","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00705-006-0857-1","article-title":"Porcine reproductive and respiratory syndrome virus productively infects monocyte-derived dendritic cells and compromises their antigen-presenting ability","volume":"152","author":"Wang","year":"2007","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virusres.2010.11.010_bib0195","unstructured":"Yoo, D., Pattnaik, A., Kim, O., 2007. Mutational analysis of PRRSV non-structural protein 11 endoribonuclease Nendou and the virus replication, In page 30: Proceedings 2007 International Symposium, December 7\u20138, 2007, Chicago. Available from: http:\/\/www.prrssymposium.org\/Documents\/Proceedings\/PrrsSymposiumProceedings2007.PDF."}],"container-title":["Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170210004181?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170210004181?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T15:06:08Z","timestamp":1685891168000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168170210004181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["S0168170210004181"],"URL":"https:\/\/doi.org\/10.1016\/j.virusres.2010.11.010","relation":{},"ISSN":["0168-1702"],"issn-type":[{"value":"0168-1702","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}