{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T20:40:34Z","timestamp":1687466434965},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Virus Research"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.virusres.2012.05.002","type":"journal-article","created":{"date-parts":[[2012,5,16]],"date-time":"2012-05-16T16:26:42Z","timestamp":1337185602000},"page":"219-225","source":"Crossref","is-referenced-by-count":19,"title":["In vivo electroporation enhances immunogenicity and protection against influenza A virus challenge of an M2e-HSP70c DNA vaccine"],"prefix":"10.1016","volume":"167","author":[{"given":"Mohammad Hossein Zabeh","family":"Jazi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehran","family":"Dabaghian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majid","family":"Tebianian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Javad","family":"Gharagozlou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyyed Mahmoud","family":"Ebrahimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.virusres.2012.05.002_bib0005","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.exppara.2010.12.007","article-title":"Evaluation of DNA\/DNA and prime-boost vaccination using LPG3 against Leishmania major infection in susceptible BALB\/c mice and its antigenic properties in human leishmaniasis","volume":"127","author":"Abdian","year":"2011","journal-title":"Experimental Parasitology"},{"key":"10.1016\/j.virusres.2012.05.002_bib0010","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.2174\/138161207782341295","article-title":"M2 protein \u2013 a proton channel of influenza A virus","volume":"13","author":"Betakova","year":"2007","journal-title":"Current Pharmaceutical Design"},{"key":"10.1016\/j.virusres.2012.05.002_bib0015","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/mt.2009.5","article-title":"Electroporation for the delivery of DNA-based vaccines and immunotherapeutics: current clinical developments","volume":"17","author":"Bodles-Brakhop","year":"2009","journal-title":"Molecular Therapy"},{"key":"10.1016\/j.virusres.2012.05.002_bib0020","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1586\/14760584.7.8.1185","article-title":"Heat-shock proteins as powerful weapons in vaccine development","volume":"7","author":"Bolhassani","year":"2008","journal-title":"Expert Review of Vaccines"},{"key":"10.1016\/j.virusres.2012.05.002_bib0025","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/ni1343","article-title":"Influenza and the challenge for immunology","volume":"7","author":"Doherty","year":"2006","journal-title":"Nature Immunology"},{"key":"10.1016\/j.virusres.2012.05.002_bib0030","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.micinf.2010.01.001","article-title":"Research and development of universal influenza vaccines","volume":"12","author":"Du","year":"2010","journal-title":"Microbes and Infection"},{"key":"10.1016\/j.virusres.2012.05.002_bib0035","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1007\/s11033-009-9846-2","article-title":"Heterologous expression, purification and characterization of the influenza A virus M2e gene fused to Mycobacterium tuberculosis HSP 70359-610 in prokaryotic system as a fusion protein","volume":"37","author":"Ebrahimi","year":"2010","journal-title":"Molecular Biology Reports"},{"key":"10.1016\/j.virusres.2012.05.002_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11262-010-0547-7","article-title":"Influenza A viruses: why focusing on M2e-based universal vaccines","volume":"42","author":"Ebrahimi","year":"2011","journal-title":"Virus Genes"},{"key":"10.1016\/j.virusres.2012.05.002_bib0045","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.pep.2009.11.001","article-title":"Cloning, expression and purification of the influenza A (H9N2) virus M2e antigen and truncated Mycobacterium tuberculosis HSP70 as a fusion protein in Pichia pastoris","volume":"70","author":"Ebrahimi","year":"2010","journal-title":"Protein Expression and Purification"},{"key":"10.1016\/j.virusres.2012.05.002_bib0050","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1637\/9538-092110-Reg.1","article-title":"Study of infection with an Iranian field-isolated H9N2 avian influenza virus in vaccinated and unvaccinated Japanese quail","volume":"55","author":"Ebrahimi","year":"2011","journal-title":"Avian Diseases"},{"key":"10.1016\/j.virusres.2012.05.002_bib0055","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1016\/j.vaccine.2004.02.021","article-title":"Preclinical study of influenza virus A M2 peptide conjugates vaccines in mice, ferrets, and rhesus monkeys","volume":"22","author":"Fan","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.virusres.2012.05.002_bib0060","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.virusres.2004.02.030","article-title":"A universal human influenza A vaccine","volume":"103","author":"Fiers","year":"2004","journal-title":"Virus Research"},{"key":"10.1016\/j.virusres.2012.05.002_bib0065","doi-asserted-by":"crossref","first-page":"6280","DOI":"10.1016\/j.vaccine.2009.07.007","article-title":"M2e-based universal influenza A vaccine","volume":"27","author":"Fiers","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.virusres.2012.05.002_bib0070","doi-asserted-by":"crossref","first-page":"12658","DOI":"10.1073\/pnas.0911806107","article-title":"Human antibodies reveal a protective epitope that is highly conserved among human and nonhuman influenza A viruses","volume":"107","author":"Grandea III Andres","year":"2010","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.virusres.2012.05.002_bib0075","doi-asserted-by":"crossref","first-page":"6017","DOI":"10.1016\/j.biomaterials.2009.07.029","article-title":"Transdermal immunization with low-pressure-gene-gun mediated chitosan-based DNA vaccines against Japanese encephalitis virus","volume":"30","author":"Huang","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.virusres.2012.05.002_bib0080","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.vaccine.2007.10.062","article-title":"Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellin","volume":"26","author":"Huleatt","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.virusres.2012.05.002_bib0085","doi-asserted-by":"crossref","first-page":"8682","DOI":"10.1128\/JVI.72.11.8682-8689.1998","article-title":"Human cytotoxic T-lymphocyte repertoire to influenza A viruses","volume":"72","author":"Jameson","year":"1998","journal-title":"Journal of Virology"},{"key":"10.1016\/j.virusres.2012.05.002_bib0090","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1016\/S0264-410X(02)00266-9","article-title":"A molecular assembly system that renders antigens of choice highly repetitive for induction of protective B cell responses","volume":"20","author":"Jegerlehner","year":"2002","journal-title":"Vaccine"},{"key":"10.1016\/j.virusres.2012.05.002_bib0095","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/nrg2432","article-title":"DNA vaccines: ready for prime time?","volume":"9","author":"Kutzler","year":"2008","journal-title":"Nature Reviews Genetics"},{"key":"10.1016\/j.virusres.2012.05.002_bib0100","doi-asserted-by":"crossref","first-page":"e2517","DOI":"10.1371\/journal.pone.0002517","article-title":"Heterosubtypic protection against pathogenic human and avian influenza viruses via in vivo electroporation of synthetic consensus DNA antigens","volume":"3","author":"Laddy","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.virusres.2012.05.002_bib0105","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during assembly of the head of bacteriophage T4","volume":"277","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.virusres.2012.05.002_bib0110","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0092-8674(85)90211-9","article-title":"Influenza virus M2 protein is an integral membrane protein expressed on the infected-cell surface","volume":"40","author":"Lamb","year":"1985","journal-title":"Cell"},{"key":"10.1016\/j.virusres.2012.05.002_bib0115","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1016\/j.vaccine.2006.01.012","article-title":"A truncated C-terminal fragment of Mycobacterium tuberculosis HSP70 gene enhanced potency of HPV DNA vaccine","volume":"24","author":"Li","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.virusres.2012.05.002_bib0120","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0928-8244(03)00009-9","article-title":"N-terminus of M2 protein could induce antibodies with inhibitory activity against influenza virus replication","volume":"35","author":"Liu","year":"2003","journal-title":"FEMS Immunology and Medical Microbiology"},{"key":"10.1016\/j.virusres.2012.05.002_bib0125","doi-asserted-by":"crossref","first-page":"5257","DOI":"10.1128\/JVI.00055-07","article-title":"Effect of plasmid DNA vaccine design and in vivo electroporation on the resulting vaccine-specific immune responses in rhesus macaques","volume":"81","author":"Luckay","year":"2007","journal-title":"Journal of Virology"},{"key":"10.1016\/j.virusres.2012.05.002_bib0130","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jviromet.2008.08.011","article-title":"Immunization with DNA encoding influenza A virus nucleoprotein fused to a tissue plasminogen activator signal sequence elicits strong immune responses and protection against H5N1 challenge in mice","volume":"154","author":"Luo","year":"2008","journal-title":"Journal of Virological Methods"},{"key":"10.1016\/j.virusres.2012.05.002_bib0135","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/13484","article-title":"A universal influenza A vaccine based on the extracellular domain of the M2e protein","volume":"5","author":"Neirynck","year":"1999","journal-title":"Nature Medicine"},{"key":"10.1016\/j.virusres.2012.05.002_bib0140","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3201\/eid1201.051043","article-title":"Making better influenza virus vaccines?","volume":"12","author":"Palese","year":"2006","journal-title":"Emerging Infectious Diseases"},{"key":"10.1016\/j.virusres.2012.05.002_bib0145","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.vaccine.2008.11.111","article-title":"Priming with a DNA vaccine delivered by attenuated Salmonella typhimurium and boosting with a killed vaccine confers protection of chickens against infection with the H9 subtype of avian influenza virus","volume":"27","author":"Pan","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.virusres.2012.05.002_bib0150","doi-asserted-by":"crossref","first-page":"8997","DOI":"10.1074\/jbc.R500020200","article-title":"The M2 proton channels of influenza A and B viruses","volume":"281","author":"Pinto","year":"2006","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.virusres.2012.05.002_bib0155","first-page":"493","article-title":"Simple method for estimating fifty per cent endpoints","volume":"27","author":"Reed","year":"1938","journal-title":"American Journal of Hygiene"},{"key":"10.1016\/j.virusres.2012.05.002_bib0160","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2217\/17460794.3.2.167","article-title":"The influenza matrix protein 2 as vaccine target","volume":"3","author":"Saelens","year":"2008","journal-title":"Future Virology"},{"key":"10.1016\/j.virusres.2012.05.002_bib0165","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1586\/erv.09.6","article-title":"Universal M2 ectodomain-based influenza A vaccines: preclinical and clinical developments","volume":"8","author":"Schotsaert.","year":"2009","journal-title":"Expert Review of Vaccines"},{"key":"10.1016\/j.virusres.2012.05.002_bib0170","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1189\/jlb.68.6.793","article-title":"DNA vaccination: antigen presentation and the induction of immunity","volume":"68","author":"Shedlock","year":"2000","journal-title":"Journal of Leukocyte Biology"},{"key":"10.1016\/j.virusres.2012.05.002_bib0175","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1128\/JVI.61.8.2515-2522.1987","article-title":"Herpes simplex virus type 1 pathogenicity in footpad and ear skin of mice depends on langerhans cell density, mouse genetics, and virus strain","volume":"61","author":"Sprecher","year":"1987","journal-title":"Journal of Virology"},{"key":"10.1016\/j.virusres.2012.05.002_bib0180","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev.immunol.20.100301.064801","article-title":"Interaction of heat shock proteins with peptides and antigen presenting cells: chaperoning of the innate and adaptive immune responses","volume":"20","author":"Srivastava","year":"2002","journal-title":"Annual Review of Immunology"},{"key":"10.1016\/j.virusres.2012.05.002_bib0185","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nri2054","article-title":"Scientific barriers to developing vaccines against avian influenza viruses","volume":"7","author":"Subbarao","year":"2007","journal-title":"Nature Reviews Immunology"},{"key":"10.1016\/j.virusres.2012.05.002_bib0190","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1016\/S0264-410X(02)00136-6","article-title":"Influenza DNA vaccines","volume":"20","author":"Ulmer","year":"2002","journal-title":"Vaccine"},{"key":"10.1016\/j.virusres.2012.05.002_bib0195","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1126\/science.8456302","article-title":"Heterologous protection against influenza by injection of DNA encoding a viral protein","volume":"259","author":"Ulmer","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.virusres.2012.05.002_bib0200","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1016\/j.vaccine.2008.02.033","article-title":"The relative immunogenicity of DNA vaccines delivered by the intramuscular needle injection, electroporation and gene gun methods","volume":"6","author":"Wang","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.virusres.2012.05.002_bib0205","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1099\/jmm.0.006825-0","article-title":"Immune effects against influenza A virus and a novel DNA vaccine with co-expression of haemagglutinin- and neuraminidase-encoding genes","volume":"58","author":"Zhang","year":"2006","journal-title":"Journal of Medical Microbiology"},{"key":"10.1016\/j.virusres.2012.05.002_bib0210","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1743-422X-7-9","article-title":"An M2e-based multiple antigenic peptide vaccine protects mice from lethal challenge with divergent H5N1 influenza viruses","volume":"7","author":"Zhao","year":"2010","journal-title":"Virology Journal"}],"container-title":["Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170212001578?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170212001578?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T19:58:09Z","timestamp":1687463889000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168170212001578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0168170212001578"],"URL":"https:\/\/doi.org\/10.1016\/j.virusres.2012.05.002","relation":{},"ISSN":["0168-1702"],"issn-type":[{"value":"0168-1702","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}