{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:44:32Z","timestamp":1791308672888,"version":"4.3.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virus Research"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.virusres.2014.06.008","type":"journal-article","created":{"date-parts":[[2014,6,21]],"date-time":"2014-06-21T16:33:48Z","timestamp":1403368428000},"page":"280-285","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Gallic acid-based small-molecule inhibitors of JC and BK polyomaviral infection"],"prefix":"10.1016","volume":"189","author":[{"given":"Bethany A.","family":"O\u2019Hara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chamila","family":"Rupasinghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achani","family":"Yatawara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Gaidos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale F.","family":"Mierke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter J.","family":"Atwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virusres.2014.06.008_bib0005","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/s11940-008-0019-8","article-title":"Progressive multifocal leukoencephalopathy","volume":"10","author":"Aksamit","year":"2008","journal-title":"Curr. Treat. Options Neurol."},{"key":"10.1016\/j.virusres.2014.06.008_bib0010","doi-asserted-by":"crossref","first-page":"13,490","DOI":"10.1128\/JVI.02252-13","article-title":"5-Ht2 receptors facilitate Jc polyomavirus entry","volume":"87","author":"Assetta","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2014.06.008_bib0015","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1200\/JCO.1995.13.5.1103","article-title":"Association of BK virus with failure of prophylaxis against hemorrhagic cystitis following bone marrow transplantation","volume":"13","author":"Bedi","year":"1995","journal-title":"J. Clin. Oncol."},{"issue":"Suppl. 2","key":"10.1016\/j.virusres.2014.06.008_bib0020","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.3949\/ccjm.78.s2.03","article-title":"The clinical features of PML","volume":"78","author":"Berger","year":"2011","journal-title":"Cleve Clin. J. Med."},{"key":"10.1016\/j.virusres.2014.06.008_bib0025","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1212\/WNL.0b013e31823b9c8f","article-title":"The manifold faces of PML and the challenge of diagnosis","volume":"77","author":"Berger","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.virusres.2014.06.008_bib0030","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1056\/NEJMoa1107829","article-title":"Risk of natalizumab-associated progressive multifocal leukoencephalopathy","volume":"366","author":"Bloomgren","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.virusres.2014.06.008_bib0035","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/01.tp.0000269706.59977.a5","article-title":"Polyomavirus BK versus JC replication and nephropathy in renal transplant recipients: a prospective evaluation","volume":"84","author":"Drachenberg","year":"2007","journal-title":"Transplantation"},{"key":"10.1016\/j.virusres.2014.06.008_bib0040","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1128\/CMR.05031-11","article-title":"Molecular biology, epidemiology, and pathogenesis of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain","volume":"25","author":"Ferenczy","year":"2012","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.virusres.2014.06.008_bib0045","first-page":"1241","article-title":"The human polyomavirus JCV, uses serotonin receptors to infect cells","volume":"306","author":"Fonseca-Elphick","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.virusres.2014.06.008_bib0050","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.virusres.2013.09.030","article-title":"Pseudovirus mimics cell entry and trafficking of the human polyomavirus JCPyV","volume":"178","author":"Gee","year":"2013","journal-title":"Virus Res."},{"key":"10.1016\/j.virusres.2014.06.008_bib0055","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1007\/s00415-011-6116-8","article-title":"Progressive multifocal leukoencephalopathy and natalizumab","volume":"258","author":"Hellwig","year":"2011","journal-title":"J. Neurol."},{"key":"10.1016\/j.virusres.2014.06.008_bib0060","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1086\/431488","article-title":"BK virus: opportunity makes a pathogen","volume":"41","author":"Hirsch","year":"2005","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.virusres.2014.06.008_bib0065","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1056\/NEJMoa020439","article-title":"Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients","volume":"347","author":"Hirsch","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.virusres.2014.06.008_bib0070","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S1473-3099(03)00770-9","article-title":"Polyomavirus BK","volume":"3","author":"Hirsch","year":"2003","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.virusres.2014.06.008_bib0075","doi-asserted-by":"crossref","first-page":"e1000363","DOI":"10.1371\/journal.ppat.1000363","article-title":"Seroepidemiology of human polyomaviruses","volume":"5","author":"Kean","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virusres.2014.06.008_bib0080","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/0-387-32957-9_2","article-title":"Discovery and epidemiology of the human polyomaviruses BK virus (BKV) and JC virus (JCV)","volume":"577","author":"Knowles","year":"2006","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.virusres.2014.06.008_bib0085","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/jmv.10450","article-title":"Population-based study of antibody to the human polyomaviruses BKV and JCV and the simian polyomavirus SV40","volume":"71","author":"Knowles","year":"2003","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.virusres.2014.06.008_bib0090","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1128\/JVI.80.3.1361-1366.2006","article-title":"Identification of gangliosides GD1b and GT1b as receptors for BK virus","volume":"80","author":"Low","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2014.06.008_bib0095","doi-asserted-by":"crossref","first-page":"9677","DOI":"10.1128\/JVI.00978-10","article-title":"Role of N-linked glycosylation of the 5-HT2A receptor in JC virus infection","volume":"84","author":"Maginnis","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2014.06.008_bib0100","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1073\/pnas.82.4.1257","article-title":"Establishment of a line of human fetal glial cells that supports JC virus multiplication","volume":"82","author":"Major","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.virusres.2014.06.008_bib0105","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.virol.2012.03.014","article-title":"The VP1 subunit of JC polyomavirus recapitulates early events in viral trafficking and is a novel tool to study polyomavirus entry","volume":"428","author":"Nelson","year":"2012","journal-title":"Virology"},{"key":"10.1016\/j.virusres.2014.06.008_bib0110","doi-asserted-by":"crossref","first-page":"e1003688","DOI":"10.1371\/journal.ppat.1003688","article-title":"A structure-guided mutation in the major capsid protein retargets BK polyomavirus","volume":"9","author":"Neu","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virusres.2014.06.008_bib0115","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.chom.2010.09.004","article-title":"Structure\u2013function analysis of the human JC polyomavirus establishes the LSTc pentasaccharide as a functional receptor motif","volume":"8","author":"Neu","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.virusres.2014.06.008_bib0120","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.chom.2010.09.004","article-title":"Structure\u2013function analysis of the human JC polyomavirus establishes the LSTc pentasaccharide as a functional receptor motif","volume":"8","author":"Neu","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.virusres.2014.06.008_bib0125","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1097\/01.ASN.0000023435.07320.81","article-title":"Clinical course of polyoma virus nephropathy in 67 renal transplant patients","volume":"13","author":"Ramos","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.virusres.2014.06.008_bib0130","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/0092-8674(86)90071-1","article-title":"Self assembly of purified polyomavirus capsid protein VP1","volume":"46","author":"Salunke","year":"1986","journal-title":"Cell"},{"key":"10.1016\/j.virusres.2014.06.008_bib0135","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1111\/j.1600-6143.2010.03310.x","article-title":"Reducing immunosuppression preserves allograft function in presumptive and definitive polyomavirus-associated nephropathy","volume":"10","author":"Schaub","year":"2010","journal-title":"Am. J. Transplant."},{"issue":"Suppl. 2","key":"10.1016\/j.virusres.2014.06.008_bib0140","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.3949\/ccjm.78.s2.06","article-title":"HIV-associated PML: changing epidemiology and clinical approach","volume":"78","author":"Simpson","year":"2011","journal-title":"Cleve Clin. J. Med."},{"key":"10.1016\/j.virusres.2014.06.008_bib0145","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0969-2126(96)00020-2","article-title":"The structure of simian virus 40 refined at 3.1\u00c5 resolution","volume":"4","author":"Stehle","year":"1996","journal-title":"Structure"},{"key":"10.1016\/j.virusres.2014.06.008_bib0150","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0969-2126(96)00021-4","article-title":"Crystal structures of murine polyomavirus in complex with straight-chain and branched-chain sialyloligosaccharide receptor fragments","volume":"4","author":"Stehle","year":"1996","journal-title":"Structure"},{"key":"10.1016\/j.virusres.2014.06.008_bib0155","doi-asserted-by":"crossref","first-page":"5139","DOI":"10.1093\/emboj\/16.16.5139","article-title":"High-resolution structure of a polyomavirus VP1-oligosaccharide complex: implications for assembly and receptor binding","volume":"16","author":"Stehle","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.virusres.2014.06.008_bib0160","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/369160a0","article-title":"Structure of murine polyomavirus complexed with an oligosaccharide receptor fragment","volume":"369","author":"Stehle","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.virusres.2014.06.008_bib0165","doi-asserted-by":"crossref","first-page":"4346","DOI":"10.1093\/emboj\/cdg439","article-title":"Gangliosides are receptors for murine polyomavirus and SV40","volume":"22","author":"Tsai","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.virusres.2014.06.008_bib0170","first-page":"524","article-title":"The BK virus load in urine in association with the development of hemorrhagic cystitis after hematopoietic stem cell transplantation","volume":"30","author":"Xie","year":"2009","journal-title":"Zhonghua Xue Ye Xue Za Zhi"}],"container-title":["Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170214002512?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170214002512?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,11]],"date-time":"2019-08-11T20:15:58Z","timestamp":1565554558000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168170214002512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":34,"alternative-id":["S0168170214002512"],"URL":"https:\/\/doi.org\/10.1016\/j.virusres.2014.06.008","relation":{},"ISSN":["0168-1702"],"issn-type":[{"value":"0168-1702","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gallic acid-based small-molecule inhibitors of JC and BK polyomaviral infection","name":"articletitle","label":"Article Title"},{"value":"Virus Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virusres.2014.06.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}