{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T03:08:12Z","timestamp":1778728092255,"version":"3.51.4"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31270198"],"award-info":[{"award-number":["31270198"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271825"],"award-info":[{"award-number":["81271825"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Laboratory of Heilongjiang Provicial Higher Education for Pathogenic Biology"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virus Research"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.virusres.2014.10.012","type":"journal-article","created":{"date-parts":[[2014,10,23]],"date-time":"2014-10-23T05:49:25Z","timestamp":1414043365000},"page":"207-216","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Pyrrolidine dithiocarbamate inhibits enterovirus 71 replication by down-regulating ubiquitin\u2013proteasome system"],"prefix":"10.1016","volume":"195","author":[{"given":"Lexun","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoning","family":"Si","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengmin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaohua","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenran","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.virusres.2014.10.012_bib0005","doi-asserted-by":"crossref","first-page":"11994","DOI":"10.1128\/JVI.00653-10","article-title":"Apoptosis of hepatitis B virus-infected hepatocytes prevents release of infectious virus","volume":"84","author":"Arzberger","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2014.10.012_bib0010","doi-asserted-by":"crossref","first-page":"642","DOI":"10.3109\/00365548.2011.577094","article-title":"Clinical and virological features of enterovirus 71 infections in Denmark, 2005 to 2008","volume":"43","author":"Badran","year":"2011","journal-title":"Scand. J. Infect. Dis."},{"key":"10.1016\/j.virusres.2014.10.012_bib0015","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1056\/NEJMoa065954","article-title":"Neurodevelopment and cognition in children after enterovirus 71 infection","volume":"356","author":"Chang","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.virusres.2014.10.012_bib0020","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1080\/13550280490521032","article-title":"Diverse apoptotic pathways in enterovirus 71-infected cells","volume":"10","author":"Chang","year":"2004","journal-title":"J. Neurovirol."},{"key":"10.1016\/j.virusres.2014.10.012_bib0025","doi-asserted-by":"crossref","first-page":"459","DOI":"10.2174\/138920310791824057","article-title":"The ubiquitin\u2013proteasome system as a prospective molecular target for cancer treatment and prevention","volume":"11","author":"Chen","year":"2010","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1016\/j.virusres.2014.10.012_bib0030","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/jmv.20623","article-title":"Enterovirus 71 infection induces Fas ligand expression and apoptosis of Jurkat cells","volume":"78","author":"Chen","year":"2006","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.virusres.2014.10.012_bib0035","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S1684-1182(10)60016-3","article-title":"Comparison of clinical features between coxsackievirus A2 and enterovirus 71 during the enterovirus outbreak in Taiwan, 2008: a children's hospital experience","volume":"43","author":"Chen","year":"2010","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"10.1016\/j.virusres.2014.10.012_bib0040","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1128\/AAC.00101-09","article-title":"Novel antiviral agent DTriP-22 targets RNA-dependent RNA polymerase of enterovirus 71","volume":"53","author":"Chen","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.virusres.2014.10.012_bib0045","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1111\/j.1462-5822.2007.00988.x","article-title":"Enterovirus 71 triggering of neuronal apoptosis through activation of Abl-Cdk5 signalling","volume":"9","author":"Chen","year":"2007","journal-title":"Cell. Microbial."},{"key":"10.1016\/j.virusres.2014.10.012_bib0050","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s11373-007-9228-5","article-title":"Antiviral activity of pyridyl imidazolidinones against enterovirus 71 variants","volume":"15","author":"Chen","year":"2008","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.virusres.2014.10.012_bib0055","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1038\/emboj.2009.294","article-title":"ATM activates p53 by regulating MDM2 oligomerization and E3 processivity","volume":"28","author":"Cheng","year":"2009","journal-title":"EMBO J."},{"key":"10.1016\/j.virusres.2014.10.012_bib0060","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/j.1440-1681.2005.04270.x","article-title":"Antiviral activities of extracts and selected pure constituents of Ocimum basilicum","volume":"32","author":"Chiang","year":"2005","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.virusres.2014.10.012_bib0065","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.4161\/cc.24128","article-title":"Dissecting the pathways that destabilize mutant p53: the proteasome or autophagy?","volume":"12","author":"Choudhury","year":"2013","journal-title":"Cell Cycle"},{"key":"10.1016\/j.virusres.2014.10.012_bib0070","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1093\/jac\/dks304","article-title":"Blocking human enterovirus 71 replication by targeting viral 2A protease","volume":"67","author":"Falah","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.virusres.2014.10.012_bib0075","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.antiviral.2007.11.004","article-title":"Inhibition of murine AIDS by pro-glutathione (GSH) molecules","volume":"77","author":"Fraternale","year":"2008","journal-title":"Antiviral Res."},{"key":"10.1016\/j.virusres.2014.10.012_bib0080","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1093\/emboj\/cdg332","article-title":"Evidence that reactive oxygen species do not mediate NF-kappaB activation","volume":"22","author":"Hayakawa","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.virusres.2014.10.012_bib0085","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1189\/jlb.1011530","article-title":"Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury","volume":"92","author":"Herold","year":"2012","journal-title":"J. Leukocyte Biol."},{"key":"10.1016\/j.virusres.2014.10.012_bib0090","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1093\/jac\/dkp502","article-title":"Inhibition of enterovirus 71 replication and the viral 3D polymerase by aurintricarboxylic acid","volume":"65","author":"Hung","year":"2010","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.virusres.2014.10.012_bib0095","doi-asserted-by":"crossref","first-page":"3630","DOI":"10.3390\/molecules18033630","article-title":"Synthesis and antiviral activity of N-phenylbenzamide derivatives, a novel class of enterovirus 71 inhibitors","volume":"18","author":"Ji","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.virusres.2014.10.012_bib0100","doi-asserted-by":"crossref","first-page":"4960","DOI":"10.1021\/pr100219y","article-title":"The ubiquitin\u2013proteasome pathway is important for dengue virus infection in primary human endothelial cells","volume":"9","author":"Kanlaya","year":"2010","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.virusres.2014.10.012_bib0105","doi-asserted-by":"crossref","first-page":"5948","DOI":"10.1128\/JVI.07039-11","article-title":"Hepatitis E virus replication requires an active ubiquitin\u2013proteasome system","volume":"86","author":"Karpe","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2014.10.012_bib0110","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.freeradbiomed.2013.10.014","article-title":"Treatment with the reactive oxygen species scavenger EUK-207 reduces lung damage and increases survival during 1918 influenza virus infection in mice","volume":"67","author":"Kash","year":"2014","journal-title":"Free Radical Biol. Med."},{"key":"10.1016\/j.virusres.2014.10.012_bib0115","doi-asserted-by":"crossref","first-page":"13892","DOI":"10.1128\/JVI.79.22.13892-13899.2005","article-title":"Inhibition of polyprotein processing and RNA replication of human rhinovirus by pyrrolidine dithiocarbamate involves metal ions","volume":"79","author":"Krenn","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2014.10.012_bib0120","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1743-422X-10-28","article-title":"Strategies to develop antivirals against enterovirus 71","volume":"10","author":"Kuo","year":"2013","journal-title":"Virol. J."},{"key":"10.1016\/j.virusres.2014.10.012_bib0125","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1099\/vir.0.82634-0","article-title":"PDTC inhibits picornavirus polyprotein processing and RNA replication by transporting zinc ions into cells","volume":"88","author":"Lanke","year":"2007","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virusres.2014.10.012_bib0130","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ab.2007.12.019","article-title":"A mammalian cell-based reverse two-hybrid system for functional analysis of 3C viral protease of human enterovirus 71","volume":"375","author":"Lee","year":"2008","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.virusres.2014.10.012_bib0135","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/jmv.20216","article-title":"Human endothelial cell activation and apoptosis induced by enterovirus 71 infection","volume":"74","author":"Liang","year":"2004","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.virusres.2014.10.012_bib0140","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1142\/S0192415X09006734","article-title":"Anti-enterovirus 71 activity screening of chinese herbs with anti-infection and inflammation activities","volume":"37","author":"Lin","year":"2009","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.virusres.2014.10.012_bib0145","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1038\/aps.2012.80","article-title":"Amelioration of influenza virus-induced reactive oxygen species formation by epigallocatechin gallate derived from green tea","volume":"33","author":"Ling","year":"2012","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.virusres.2014.10.012_bib0150","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.virusres.2014.10.012_bib0155","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1099\/vir.0.047753-0","article-title":"Calcium flux and calpain-mediated activation of the apoptosis-inducing factor contribute to enterovirus 71-induced apoptosis","volume":"94","author":"Lu","year":"2013","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virusres.2014.10.012_bib0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/JVI.77.1.1-9.2003","article-title":"Ubiquitin-dependent proteolysis of cyclin D1 is associated with coxsackievirus-induced cell growth arrest","volume":"77","author":"Luo","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2014.10.012_bib0165","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s10495-009-0414-y","article-title":"Inhibition of nuclear factor kappa B transcription activity drives a synergistic effect of pyrrolidine dithiocarbamate and cisplatin for treatment of renal cell carcinoma","volume":"15","author":"Morais","year":"2010","journal-title":"Apoptosis"},{"key":"10.1016\/j.virusres.2014.10.012_bib0170","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.virol.2013.11.023","article-title":"Reactive oxygen species activate NFkappaB (p65) and p53 and induce apoptosis in RVFV infected liver cells","volume":"449","author":"Narayanan","year":"2014","journal-title":"Virology"},{"key":"10.1016\/j.virusres.2014.10.012_bib0175","doi-asserted-by":"crossref","first-page":"33713","DOI":"10.1074\/jbc.R109.018481","article-title":"The 26 S proteasome: from basic mechanisms to drug targeting","volume":"284","author":"Navon","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virusres.2014.10.012_bib0180","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/S1474-4422(10)70209-X","article-title":"Clinical features, diagnosis, and management of enterovirus 71","volume":"9","author":"Ooi","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.virusres.2014.10.012_bib0185","doi-asserted-by":"crossref","first-page":"8675","DOI":"10.1128\/JVI.00869-13","article-title":"Pyrrolidine dithiocarbamate inhibits herpes simplex virus 1 and 2 replication, and its activity may be mediated through dysregulation of the ubiquitin\u2013proteasome system","volume":"87","author":"Qiu","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2014.10.012_bib0190","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1747-1028-7-26","article-title":"Therapeutic targeting of cancer cell cycle using proteasome inhibitors","volume":"7","author":"Rastogi","year":"2012","journal-title":"Cell Div."},{"key":"10.1016\/j.virusres.2014.10.012_bib0195","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1742-4690-6-52","article-title":"Shock and kill effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence","volume":"6","author":"Savarino","year":"2009","journal-title":"Retrovirology"},{"key":"10.1016\/j.virusres.2014.10.012_bib0200","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.antiviral.2012.12.005","article-title":"Antiviral drug discovery for the treatment of enterovirus 71 infections","volume":"97","author":"Shang","year":"2013","journal-title":"Antiviral Res."},{"key":"10.1016\/j.virusres.2014.10.012_bib0205","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1517\/14728222.2013.815728","article-title":"Targeting the ubiquitin\u2013proteasome system for cancer therapy","volume":"17","author":"Shen","year":"2013","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.virusres.2014.10.012_bib0210","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.bjid.2012.11.009","article-title":"Differential gene expressions of the MAPK signaling pathway in enterovirus 71-infected rhabdomyosarcoma cells","volume":"17","author":"Shi","year":"2013","journal-title":"Braz. J. Infect. Dis."},{"key":"10.1016\/j.virusres.2014.10.012_bib0215","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1186\/1471-2334-12-327","article-title":"Differential apoptosis gene expressions of rhabdomyosarcoma cells in response to enterovirus 71 infection","volume":"12","author":"Shi","year":"2012","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.virusres.2014.10.012_bib0220","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1021\/jm010536a","article-title":"Design, synthesis, and structure-activity relationship of pyridyl imidazolidinones: a novel class of potent and selective human enterovirus 71 inhibitors","volume":"45","author":"Shia","year":"2002","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.virusres.2014.10.012_bib0225","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1128\/AAC.48.9.3523-3529.2004","article-title":"Mutation in enterovirus 71 capsid protein VP1 confers resistance to the inhibitory effects of pyridyl imidazolidinone","volume":"48","author":"Shih","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.virusres.2014.10.012_bib0230","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1080\/13550280701798980","article-title":"Viral protein synthesis is required for Enterovirus 71 to induce apoptosis in human glioblastoma cells","volume":"14","author":"Shih","year":"2008","journal-title":"J. Neurovirol."},{"key":"10.1016\/j.virusres.2014.10.012_bib0235","doi-asserted-by":"crossref","first-page":"8014","DOI":"10.1128\/JVI.79.13.8014-8023.2005","article-title":"Pyrrolidine dithiocarbamate reduces coxsackievirus B3 replication through inhibition of the ubiquitin\u2013proteasome pathway","volume":"79","author":"Si","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2014.10.012_bib0240","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1128\/JVI.02028-06","article-title":"Dysregulation of the ubiquitin\u2013proteasome system by curcumin suppresses coxsackievirus B3 replication","volume":"81","author":"Si","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2014.10.012_bib0245","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4062\/biomolther.2013.108","article-title":"Antiviral Activity of Hederasaponin B from Hedera helix against Enterovirus 71 Subgenotypes C3 and C4a","volume":"22","author":"Song","year":"2014","journal-title":"Biomolecules Ther."},{"key":"10.1016\/j.virusres.2014.10.012_bib0250","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1515\/CCLM.2002.078","article-title":"An evaluation of antiretroviral therapy associated with alpha-tocopherol supplementation in HIV-infected patients","volume":"40","author":"Spada","year":"2002","journal-title":"Clin. Chem. Lab. Med.: CCLM\/FESCC"},{"key":"10.1016\/j.virusres.2014.10.012_bib0255","doi-asserted-by":"crossref","first-page":"e69895","DOI":"10.1371\/journal.pone.0069895","article-title":"Genetic and antigenic characterization of enterovirus 71 in Ho Chi Minh city, Vietnam, 2011","volume":"8","author":"Thoa le","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.virusres.2014.10.012_bib0260","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s10495-010-0487-7","article-title":"Pyrrolidine dithiocarbamate (PDTC) blocks apoptosis and promotes ionizing radiation-induced necrosis of freshly-isolated normal mouse spleen cells","volume":"15","author":"Thompson","year":"2010","journal-title":"Apoptosis"},{"key":"10.1016\/j.virusres.2014.10.012_bib0265","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1128\/AAC.00841-08","article-title":"Real-time monitoring of human enterovirus (HEV)-infected cells and anti-HEV 3C protease potency by fluorescence resonance energy transfer","volume":"53","author":"Tsai","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.virusres.2014.10.012_bib0270","first-page":"726","article-title":"The ubiquitin proteasome pathway (UPP) in the regulation of cell cycle control and DNA damage repair and its implication in tumorigenesis","volume":"5","author":"Tu","year":"2012","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.virusres.2014.10.012_bib0275","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1093\/jac\/dkg282","article-title":"Antiviral function of pyrrolidine dithiocarbamate against influenza virus: the inhibition of viral gene replication and transcription","volume":"52","author":"Uchide","year":"2003","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.virusres.2014.10.012_bib0280","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0166-3542(02)00109-2","article-title":"Effect of antioxidants on apoptosis induced by influenza virus infection: inhibition of viral gene replication and transcription with pyrrolidine dithiocarbamate","volume":"56","author":"Uchide","year":"2002","journal-title":"Antiviral Res."},{"key":"10.1016\/j.virusres.2014.10.012_bib0285","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.tips.2011.09.001","article-title":"Suppressing production of reactive oxygen species (ROS) for influenza A virus therapy","volume":"33","author":"Vlahos","year":"2012","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.virusres.2014.10.012_bib0290","doi-asserted-by":"crossref","first-page":"e38035","DOI":"10.1371\/journal.pone.0038035","article-title":"COPI is required for enterovirus 71 replication","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.virusres.2014.10.012_bib0295","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s40139-013-0024-9","article-title":"Interactions Between Hepatitis C Virus and Mitochondria: Impact on Pathogenesis and Innate Immunity","volume":"1","author":"Wang","year":"2013","journal-title":"Curr. Pathobiol. Rep."},{"key":"10.1016\/j.virusres.2014.10.012_bib0300","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1038\/sj.cdd.4401941","article-title":"Mechanisms of apoptosis regulation by viral oncogenes in infection and tumorigenesis","volume":"13","author":"White","year":"2006","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.virusres.2014.10.012_bib0305","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00430-010-0182-x","article-title":"Therapy of experimental influenza virus infection with pyrrolidine dithiocarbamate","volume":"200","author":"Wiesener","year":"2011","journal-title":"Med. Microbial. Immunol."},{"key":"10.1016\/j.virusres.2014.10.012_bib0310","doi-asserted-by":"crossref","first-page":"6751","DOI":"10.1128\/JVI.03355-13","article-title":"HPV16 E6* induces oxidative stress and DNA damage","volume":"88","author":"Williams","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2014.10.012_bib0315","doi-asserted-by":"crossref","first-page":"18407","DOI":"10.1074\/jbc.M109.059568","article-title":"MDM2 promotes proteasomal degradation of p21Waf1 via a conformation change","volume":"285","author":"Xu","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virusres.2014.10.012_bib0320","first-page":"176","article-title":"[Analysis on molecular epidemiological features of enterovirus type 71 in Guizhou Province, 2008\u20132011]","volume":"29","author":"Yan","year":"2013","journal-title":"Bing du xue bao"},{"key":"10.1016\/j.virusres.2014.10.012_bib0325","doi-asserted-by":"crossref","first-page":"5733","DOI":"10.1007\/s11033-013-2676-2","article-title":"Protective effects of the nuclear factor kappa B inhibitor pyrrolidine dithiocarbamate in bladder ischemia-reperfusion injury in rats","volume":"40","author":"Yucel","year":"2013","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.virusres.2014.10.012_bib0330","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s00705-011-1222-6","article-title":"In vitro and in vivo evaluation of ribavirin and pleconaril antiviral activity against enterovirus 71 infection","volume":"157","author":"Zhang","year":"2012","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virusres.2014.10.012_bib0335","article-title":"Prenylated benzoylphloroglucinols and xanthones from the leaves of Garcinia oblongifolia with antienteroviral activity","author":"Zhang","year":"2014","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.virusres.2014.10.012_bib0340","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1440-1827.2012.02837.x","article-title":"Clinicopathologic features and molecular analysis of enterovirus 71 infection: report of an autopsy case from the epidemic of hand, foot and mouth disease in China","volume":"62","author":"Zhang","year":"2012","journal-title":"Pathol. Int."},{"key":"10.1016\/j.virusres.2014.10.012_bib0345","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1177\/1933719114525272","article-title":"Synergistic Effect of Pyrrolidine Dithiocarbamate and Cisplatin in Human Cervical Carcinoma","volume":"21","author":"Zheng","year":"2014","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.virusres.2014.10.012_bib0350","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.virusres.2008.04.012","article-title":"Mutations at nucleotides 573 and 579 within 5\u2032-untranslated region augment the virulence of coxsackievirus B1","volume":"135","author":"Zhong","year":"2008","journal-title":"Virus Res."},{"key":"10.1016\/j.virusres.2014.10.012_bib0355","doi-asserted-by":"crossref","first-page":"149","DOI":"10.7883\/yoken.66.149","article-title":"Molecular epidemiology of human enterovirus 71 strains in the Nanchang region of China in 2011","volume":"66","author":"Zhou","year":"2013","journal-title":"Jpn. J. Infect. Dis."},{"key":"10.1016\/j.virusres.2014.10.012_bib0360","doi-asserted-by":"crossref","first-page":"e18291","DOI":"10.1371\/journal.pone.0018291","article-title":"HIV infection enhances TRAIL-induced cell death in macrophage by down-regulating decoy receptor expression and generation of reactive oxygen species","volume":"6","author":"Zhu","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.virusres.2014.10.012_bib0365","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1053\/j.gastro.2007.09.017","article-title":"Hepatitis C virus triggers apoptosis of a newly developed hepatoma cell line through antiviral defense system","volume":"133","author":"Zhu","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.virusres.2014.10.012_bib0370","doi-asserted-by":"crossref","first-page":"e56318","DOI":"10.1371\/journal.pone.0056318","article-title":"Phylogenetic analysis of Enterovirus 71 circulating in Beijing, China from 2007 to 2009","volume":"8","author":"Zhu","year":"2013","journal-title":"PLoS One"}],"container-title":["Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170214004171?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170214004171?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T08:54:33Z","timestamp":1538124873000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168170214004171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":74,"alternative-id":["S0168170214004171"],"URL":"https:\/\/doi.org\/10.1016\/j.virusres.2014.10.012","relation":{},"ISSN":["0168-1702"],"issn-type":[{"value":"0168-1702","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pyrrolidine dithiocarbamate inhibits enterovirus 71 replication by down-regulating ubiquitin\u2013proteasome system","name":"articletitle","label":"Article Title"},{"value":"Virus Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virusres.2014.10.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}