{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:27:31Z","timestamp":1789590451367,"version":"build-2803163510"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Science and Technology Major Project of Infectious Diseases","award":["2012ZX10004503-005"],"award-info":[{"award-number":["2012ZX10004503-005"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401669"],"award-info":[{"award-number":["81401669"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371817"],"award-info":[{"award-number":["81371817"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virus Research"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.virusres.2015.08.002","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T16:37:51Z","timestamp":1439224671000},"page":"165-168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Construction and characterization of an infectious clone of coxsackievirus A6 that showed high virulence in neonatal mice"],"prefix":"10.1016","volume":"210","author":[{"given":"Lisheng","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangheng","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaona","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longfa","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangzhong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningshao","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.virusres.2015.08.002_bib0005","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1099\/vir.0.80784-0","article-title":"Temperature-sensitive mutants of enterovirus 71 show attenuation in cynomolgus monkeys","volume":"86","author":"Arita","year":"2005","journal-title":"J. Gen. Virol."},{"issue":"1","key":"10.1016\/j.virusres.2015.08.002_bib0010","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jcv.2010.02.002","article-title":"Co-circulation of coxsackieviruses A6 and A10 in hand, foot and mouth disease outbreak in Finland","volume":"48","author":"Blomqvist","year":"2010","journal-title":"J. Clin. Virol."},{"issue":"2","key":"10.1016\/j.virusres.2015.08.002_bib0015","doi-asserted-by":"crossref","first-page":"e244","DOI":"10.1542\/peds.2006-3331","article-title":"Epidemiologic features of hand-foot-mouth disease and herpangina caused by enterovirus 71 in Taiwan, 1998\u20132005","volume":"120","author":"Chen","year":"2007","journal-title":"Pediatrics"},{"issue":"9","key":"10.1016\/j.virusres.2015.08.002_bib0020","doi-asserted-by":"crossref","first-page":"6406","DOI":"10.1074\/jbc.M111.301622","article-title":"Molecular determinants of enterovirus 71 viral entry: cleft around GLN-172 on VP1 protein interacts with variable region on scavenge receptor B 2","volume":"287","author":"Chen","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.virusres.2015.08.002_bib0025","doi-asserted-by":"crossref","first-page":"e49973","DOI":"10.1371\/journal.pone.0049973","article-title":"Immunological and biochemical characterization of coxsackie virus A16 viral particles","volume":"7","author":"Chong","year":"2012","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.virusres.2015.08.002_bib0030","doi-asserted-by":"crossref","first-page":"e1002826","DOI":"10.1371\/journal.ppat.1002826","article-title":"Identification of site-specific adaptations conferring increased neural cell tropism during human enterovirus 71 infection","volume":"8","author":"Cordey","year":"2012","journal-title":"PLoS Pathog."},{"issue":"1","key":"10.1016\/j.virusres.2015.08.002_bib0035","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1473-3099(13)70264-0","article-title":"Atypical hand, foot, and mouth disease: a vesiculobullous eruption caused by Coxsackie virus A6","volume":"14","author":"Feder","year":"2014","journal-title":"Lancet Infect. Dis."},{"issue":"5","key":"10.1016\/j.virusres.2015.08.002_bib0040","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nmeth.1318","article-title":"Enzymatic assembly of DNA molecules up to several hundred kilobases","volume":"6","author":"Gibson","year":"2009","journal-title":"Nat. Methods"},{"issue":"37","key":"10.1016\/j.virusres.2015.08.002_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2807\/ese.15.37.19663-en","article-title":"2010. Onychomadesis outbreak linked to hand, foot, and mouth disease, Spain, July 2008","volume":"15","author":"Guimbao","year":"2010","journal-title":"Euro Surveill."},{"issue":"0","key":"10.1016\/j.virusres.2015.08.002_bib0050","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.virusres.2015.05.011","article-title":"Construction and characterization of an infectious cDNA clone of Echovirus 25","volume":"205","author":"Hou","year":"2015","journal-title":"Virus Res."},{"issue":"1","key":"10.1016\/j.virusres.2015.08.002_bib0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virol.2009.10.017","article-title":"Introduction of a strong temperature-sensitive phenotype into enterovirus 71 by altering an amino acid of virus 3D polymerase","volume":"396","author":"Kung","year":"2010","journal-title":"Virology"},{"issue":"1","key":"10.1016\/j.virusres.2015.08.002_bib0060","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1186\/1743-422X-8-534","article-title":"Construction and characterization of an infectious clone of coxsackievirus A16","volume":"8","author":"Liu","year":"2011","journal-title":"Virol. J."},{"issue":"12","key":"10.1016\/j.virusres.2015.08.002_bib0065","doi-asserted-by":"crossref","first-page":"e52073","DOI":"10.1371\/journal.pone.0052073","article-title":"Circulation of Coxsackievirus A10 and A6 in hand-foot-mouth disease in China, 2009\u20132011","volume":"7","author":"Lu","year":"2012","journal-title":"PloS one"},{"issue":"2","key":"10.1016\/j.virusres.2015.08.002_bib0070","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1086\/318454","article-title":"Neurological manifestations of enterovirus 71 infection in children during an outbreak of hand, foot, and mouth disease in Western Australia","volume":"32","author":"McMinn","year":"2001","journal-title":"Clin. Infect. Dis."},{"issue":"7","key":"10.1016\/j.virusres.2015.08.002_bib0075","doi-asserted-by":"crossref","first-page":"e21757","DOI":"10.1371\/journal.pone.0021757","article-title":"Display of VP1 on the surface of baculovirus and its immunogenicity against heterologous human enterovirus 71 strains in mice","volume":"6","author":"Meng","year":"2011","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.virusres.2015.08.002_bib0080","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jcv.2014.04.023","article-title":"Coxsackievirus A6 associated hand, foot and mouth disease in adults: clinical presentation and review of the literature","volume":"60","author":"Ramirez-Fort","year":"2014","journal-title":"J. Clin. Virol."},{"issue":"3","key":"10.1016\/j.virusres.2015.08.002_bib0085","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1128\/JVI.02139-12","article-title":"Ribavirin-resistant mutants of human enterovirus 71 express a high replication fidelity phenotype during growth in cell culture","volume":"87","author":"Sadeghipour","year":"2013","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.virusres.2015.08.002_bib0090","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF02256567","article-title":"Mutations at KFRDI and VGK domains of enterovirus 71 3C protease affect its RNA binding and proteolytic activities","volume":"11","author":"Shih","year":"2004","journal-title":"J. Biomed. Sci."},{"issue":"8","key":"10.1016\/j.virusres.2015.08.002_bib0095","doi-asserted-by":"crossref","first-page":"5888","DOI":"10.1074\/jbc.M611145200","article-title":"Reticulon 3 binds the 2C protein of enterovirus 71 and is required for viral replication","volume":"282","author":"Tang","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virusres.2015.08.002_bib0100","doi-asserted-by":"crossref","first-page":"7619","DOI":"10.1073\/pnas.1300233110","article-title":"Rational design of thermostable vaccines by engineered peptide-induced virus self-biomineralization under physiological conditions","author":"Wang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.virusres.2015.08.002_bib0105","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/nsmb.2255","article-title":"A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71","volume":"19","author":"Wang","year":"2012","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"1","key":"10.1016\/j.virusres.2015.08.002_bib0110","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1186\/1471-2334-11-346","article-title":"An outbreak of coxsackievirus A6 hand, foot, and mouth disease associated with onychomadesis in Taiwan, 2010","volume":"11","author":"Wei","year":"2011","journal-title":"BMC Infect. Dis."},{"issue":"7","key":"10.1016\/j.virusres.2015.08.002_bib0115","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/nm.1992","article-title":"Scavenger receptor B2 is a cellular receptor for enterovirus 71","volume":"15","author":"Yamayoshi","year":"2009","journal-title":"Nat. Med."}],"container-title":["Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170215300344?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170215300344?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T04:38:07Z","timestamp":1653021487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168170215300344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":23,"alternative-id":["S0168170215300344"],"URL":"https:\/\/doi.org\/10.1016\/j.virusres.2015.08.002","relation":{},"ISSN":["0168-1702"],"issn-type":[{"value":"0168-1702","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Construction and characterization of an infectious clone of coxsackievirus A6 that showed high virulence in neonatal mice","name":"articletitle","label":"Article Title"},{"value":"Virus Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virusres.2015.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}