{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:36:46Z","timestamp":1792798606153,"version":"4.5.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virus Research"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.virusres.2015.09.003","type":"journal-article","created":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T16:00:37Z","timestamp":1441728037000},"page":"327-336","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Unravelling the genetic components involved in the immune response of pigs vaccinated against influenza virus"],"prefix":"10.1016","volume":"210","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1449-6708","authenticated-orcid":false,"given":"Ricardo","family":"Zanella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Gava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane de Oliveira","family":"Peixoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rejane","family":"Schaefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice Reis","family":"Ciacci-Zanella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalha","family":"Biondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Vinicius Gualberto Barbosa","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maur\u00edcio Eg\u00eddio","family":"Cant\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f4nica Corr\u00eaa","family":"Ledur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virusres.2015.09.003_bib0005","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/mp.2010.119","article-title":"Gene expression patterns in the hippocampus and amygdala of endogenous depression and chronic stress models","volume":"17","author":"Andrus","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.virusres.2015.09.003_bib0010","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-2156-14-8","article-title":"Methods of tagSNP selection and other variables affecting imputation accuracy in swine","volume":"14","author":"Badke","year":"2013","journal-title":"BMC Genet."},{"key":"10.1016\/j.virusres.2015.09.003_bib0015","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/cen3.12125","article-title":"The role of antiproliferative gene Tob1 in the immune system","volume":"5","author":"Baranzini","year":"2014","journal-title":"Clin. Exp. Neuroimmunol."},{"key":"10.1016\/j.virusres.2015.09.003_bib0020","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1477-9552.2003.tb00048.x","article-title":"The direct costs of livestock disease: the development of a system of models for the analysis of 30 endemic livestock diseases in Great Britain","volume":"54","author":"Bennett","year":"2003","journal-title":"J. Agric. Econ."},{"key":"10.1016\/j.virusres.2015.09.003_bib0025","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1477-9552.2005.tb00126.x","article-title":"Updated estimates of the costs associated with thirty four endemic livestock diseases in Great Britain: a note","volume":"56","author":"Bennett","year":"2005","journal-title":"J. Agric. Econ."},{"key":"10.1016\/j.virusres.2015.09.003_bib0030","doi-asserted-by":"crossref","first-page":"16834","DOI":"10.1073\/pnas.0605296103","article-title":"A genetic variant that disrupts MET transcription is associated with autism","volume":"103","author":"Campbell","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.virusres.2015.09.003_bib0035","doi-asserted-by":"crossref","first-page":"4168","DOI":"10.4049\/jimmunol.181.6.4168","article-title":"A novel role for non-neutralizing antibodies against nucleoprotein in facilitating resistance to influenza virus","volume":"181","author":"Carragher","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.virusres.2015.09.003_bib0040","unstructured":"CDC, 2015. http:\/\/www.cdc.gov\/media\/releases\/2015\/s0226-acip.html (access: 08.28.15.)."},{"key":"10.1016\/j.virusres.2015.09.003_bib0045","doi-asserted-by":"crossref","first-page":"e60640","DOI":"10.1371\/journal.pone.0060640","article-title":"Fyn kinase is required for optimal humoral responses","volume":"8","author":"Chaimowitz","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.virusres.2015.09.003_bib0050","first-page":"821","article-title":"Induction of met proto-oncogene (hepatocyte growth factor receptor) expression during human monocyte-macrophage differentiation","volume":"7","author":"Chen","year":"1996","journal-title":"Cell Growth Differ."},{"key":"10.1016\/j.virusres.2015.09.003_bib0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.0300-9475.2004.01382.x","article-title":"Influenza virus: immunity and vaccination strategies. Comparison of the immune response to inactivated and live, attenuated influenza vaccines","volume":"59","author":"Cox","year":"2004","journal-title":"Scand J. Immunol."},{"key":"10.1016\/j.virusres.2015.09.003_bib0060","first-page":"151","article-title":"Inactivated and adjuvanted influenza vaccines","volume":"386","author":"Del Giudice","year":"2015","journal-title":"Curr Top Microbiol. Immunol."},{"issue":"Suppl. 4","key":"10.1016\/j.virusres.2015.09.003_bib0065","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/irv.12199","article-title":"Comparison of influenza A virus infection in high- and low-birth-weight pigs using morphometric analysis","volume":"7","author":"Detmer","year":"2013","journal-title":"Influenza Other Respir Viruses"},{"key":"10.1016\/j.virusres.2015.09.003_bib0070","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1016\/j.vaccine.2011.01.082","article-title":"Enhanced pneumonia and disease in pigs vaccinated with an inactivated human-like (delta-cluster) H1N2 vaccine and challenged with pandemic 2009H1N1 influenza virus","volume":"29","author":"Gauger","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.virusres.2015.09.003_bib0075","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1079\/AHR200469","article-title":"Genetic variation and responses to vaccines","volume":"5","author":"Glass","year":"2004","journal-title":"Anim. Health Res. Rev."},{"key":"10.1016\/j.virusres.2015.09.003_bib0080","article-title":"Evaluation of screening assays for the detection of influenza A Virus serum antibodies in swine","author":"Goodell","year":"2014","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.virusres.2015.09.003_bib0085","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1128\/IAI.00126-13","article-title":"Rho kinase regulates induction of T-cell immune dysfunction in abdominal sepsis","volume":"81","author":"Hasan","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1016\/j.virusres.2015.09.003_bib0090","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.1038\/tp.2011.48","article-title":"Association of a MET genetic variant with autism-associated maternal autoantibodies to fetal brain proteins and cytokine expression","volume":"1","author":"Heuer","year":"2011","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.virusres.2015.09.003_bib0095","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/infdis\/jir436","article-title":"Live and inactivated influenza vaccines induce similar humoral responses, but only live vaccines induce diverse T-cell responses in young children","volume":"204","author":"Hoft","year":"2011","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.virusres.2015.09.003_bib0100","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0749-0720(15)30002-5","article-title":"Genetic control of disease resistance and immunoresponsiveness","volume":"17","author":"Kelm","year":"2001","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"10.1016\/j.virusres.2015.09.003_bib0105","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s13353-014-0199-8","article-title":"TLR4 single nucleotide polymorphisms (SNPs) associated with Salmonella shedding in pigs","volume":"55","author":"Kich","year":"2014","journal-title":"J. Appl. Genet."},{"key":"10.1016\/j.virusres.2015.09.003_bib0110","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1159\/000106559","article-title":"Genetic variation in the response to vaccination","volume":"10","author":"Kimman","year":"2007","journal-title":"Community Genet."},{"key":"10.1016\/j.virusres.2015.09.003_bib0115","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/978-1-4939-0758-8_24","article-title":"Hemagglutinin inhibition assay with swine sera","volume":"1161","author":"Kitikoon","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.virusres.2015.09.003_bib0120","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0378-1135(00)00172-3","article-title":"Systemic and mucosal immune responses to H1N1 influenza virus infection in pigs","volume":"74","author":"Larsen","year":"2000","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virusres.2015.09.003_bib0125","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/ncb919","article-title":"Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation","volume":"5","author":"Latour","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.virusres.2015.09.003_bib0130","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nrm909","article-title":"Stats: transcriptional control and biological impact","volume":"3","author":"Levy","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.virusres.2015.09.003_bib0135","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1074\/jbc.M110.196659","article-title":"Altered immune response in mice deficient for the G protein-coupled receptor GPR34","volume":"286","author":"Liebscher","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virusres.2015.09.003_bib0140","doi-asserted-by":"crossref","first-page":"e1003875","DOI":"10.1371\/journal.ppat.1003875","article-title":"Intranasal vaccination promotes detrimental Th17-mediated immunity against influenza infection","volume":"10","author":"Maroof","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virusres.2015.09.003_bib0145","doi-asserted-by":"crossref","first-page":"7098","DOI":"10.1016\/j.vaccine.2010.08.003","article-title":"Immunogenicity and protective efficacy of an elastase-dependent live attenuated swine influenza virus vaccine administered intranasally in pigs","volume":"28","author":"Masic","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.virusres.2015.09.003_bib0150","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1128\/CMR.00005-07","article-title":"Current status of veterinary vaccines","volume":"20","author":"Meeusen","year":"2007","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.virusres.2015.09.003_bib0155","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.prevetmed.2012.11.021","article-title":"Diseases at the livestock-wildlife interface: status, challenges, and opportunities in the United States","volume":"110","author":"Miller","year":"2013","journal-title":"Prev. Vet. Med."},{"key":"10.1016\/j.virusres.2015.09.003_bib0160","series-title":"Vaccines","first-page":"1369","article-title":"Immunization in developing countries","author":"Mitchell","year":"2013"},{"key":"10.1016\/j.virusres.2015.09.003_bib0165","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/1297-9686-35-2-199","article-title":"Genetic parameters for resistance to the Salmonella abortusovis vaccinal strain Rv6 in sheep","volume":"35","author":"Moreno","year":"2003","journal-title":"Genet. Sel. Evol."},{"key":"10.1016\/j.virusres.2015.09.003_bib0170","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/ni.2067","article-title":"Systems biology of vaccination for seasonal influenza in humans","volume":"12","author":"Nakaya","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.virusres.2015.09.003_bib0175","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.3201\/eid2108.141891","article-title":"Influenza A Viruses of human origin in swine, Brazil","volume":"21","author":"Nelson","year":"2015","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.virusres.2015.09.003_bib0180","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/sj.gene.6364051","article-title":"Genetic regulation of immune responses to vaccines in early life","volume":"5","author":"Newport","year":"2004","journal-title":"Genes Immun."},{"key":"10.1016\/j.virusres.2015.09.003_bib0185","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/nyas.12027","article-title":"Rules of engagement: distinct functions for the four class I PI3K catalytic isoforms in immunity","volume":"1280","author":"Okkenhaug","year":"2013","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.virusres.2015.09.003_bib0190","doi-asserted-by":"crossref","first-page":"814","DOI":"10.3201\/eid0808.010474","article-title":"Serologic evidence of H1 swine Influenza virus infection in swine farm residents and employees","volume":"8","author":"Olsen","year":"2002","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.virusres.2015.09.003_bib0195","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S1074-7613(00)00077-7","article-title":"Immune response in Stat2 knockout mice","volume":"13","author":"Park","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.virusres.2015.09.003_bib0200","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/1471-2105-12-202","article-title":"Qxpak. 5: old mixed model solutions for new genomics problems","volume":"12","author":"Perez-Enciso","year":"2011","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.virusres.2015.09.003_bib0205","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.iy.11.040193.002315","article-title":"Regulation of lymphocyte function by protein phosphorylation","volume":"11","author":"Perlmutter","year":"1993","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.virusres.2015.09.003_bib0210","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.coi.2014.04.005","article-title":"A systems biology approach to the effect of aging, immunosenescence and vaccine response","volume":"29","author":"Poland","year":"2014","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.virusres.2015.09.003_bib0215","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.virusres.2015.09.003_bib0220","first-page":"307","article-title":"Pathogenesis and vaccination of influenza A virus in swine","volume":"385","author":"Rajao","year":"2014","journal-title":"Curr. Top Microbiol. Immunol."},{"key":"10.1016\/j.virusres.2015.09.003_bib0225","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/irv.12072","article-title":"Genetic characterization of influenza virus circulating in Brazilian pigs during 2009 and 2010 reveals a high prevalence of the pandemic H1N1 subtype","volume":"7","author":"Rajao","year":"2013","journal-title":"Influenza Other Respir Viruses"},{"key":"10.1016\/j.virusres.2015.09.003_bib0230","first-page":"493","article-title":"A simple method of estimating fifty percent endpoints","volume":"27","author":"Reed","year":"1938","journal-title":"Am. J. Hyg."},{"key":"10.1016\/j.virusres.2015.09.003_bib0235","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/eji.201444465","article-title":"Better safe than sorry: TOB1 employs multiple parallel regulatory pathways to keep Th17 cells quiet","volume":"44","author":"Salerno","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.virusres.2015.09.003_bib0240","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.virol.2014.06.027","article-title":"Divergent immune responses and disease outcomes in piglets immunized with inactivated and attenuated H3N2 swine influenza vaccines in the presence of maternally-derived antibodies","volume":"464\u2013465","author":"Sandbulte","year":"2014","journal-title":"Virology"},{"key":"10.1016\/j.virusres.2015.09.003_bib0245","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1590\/S0100-736X2011000900007","article-title":"Isolation and characterization of a pandemic H1N1 influenza virus in pigs in Brazil","volume":"31","author":"Schaefer","year":"2011","journal-title":"Pesquisa Veterinaria Bras."},{"key":"10.1016\/j.virusres.2015.09.003_bib0250","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00705-014-2223-z","article-title":"A human-like H1N2 influenza virus detected during an outbreak of acute respiratory disease in swine in Brazil","volume":"160","author":"Schaefer","year":"2015","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virusres.2015.09.003_bib0255","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/j.1365-2052.2009.01896.x","article-title":"A whole genome association analysis identifies loci associated with Mycobacterium avium subsp. paratuberculosis infection status in US holstein cattle","volume":"40","author":"Settles","year":"2009","journal-title":"Anim. Genet."},{"key":"10.1016\/j.virusres.2015.09.003_bib0260","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0165-2427(01)00430-5","article-title":"A single amino acid deletion in the antigen binding site of BoLA\u2013DRB3 is predicted to affect peptide binding","volume":"85","author":"Sitte","year":"2002","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.virusres.2015.09.003_bib0265","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1016\/S0264-410X(00)00468-0","article-title":"Twin studies of immunogenicity\u2013determining the genetic contribution to vaccine failure","volume":"19","author":"Tan","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.virusres.2015.09.003_bib0270","series-title":"R: A Language and Environment for Statistical Computing","author":"Team","year":"2009"},{"key":"10.1016\/j.virusres.2015.09.003_bib0275","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1289\/ehp.01109757","article-title":"Vaccine-induced antibody responses as parameters of the influence of endogenous and environmental factors","volume":"109","author":"Van Loveren","year":"2001","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.virusres.2015.09.003_bib0280","series-title":"Diseases of Swine","first-page":"557","article-title":"Influenza Virus","author":"Van Reeth","year":"2012"},{"key":"10.1016\/j.virusres.2015.09.003_bib0285","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nature05911","article-title":"Genome-wide association study of 14,000 cases of seven common diseases and 3000 shared controls","volume":"447","author":"Wellcome Trust Case Control","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.virusres.2015.09.003_bib0290","doi-asserted-by":"crossref","first-page":"190","DOI":"10.4049\/jimmunol.0903505","article-title":"Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150)","volume":"185","author":"Yusuf","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.virusres.2015.09.003_bib0295","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1365-2052.2010.02076.x","article-title":"Identification of loci associated with tolerance to Johne\u2019s disease in Holstein cattle","volume":"42","author":"Zanella","year":"2011","journal-title":"Anim. Genet."}],"container-title":["Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170215300587?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170215300587?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T12:26:19Z","timestamp":1537359979000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168170215300587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":59,"alternative-id":["S0168170215300587"],"URL":"https:\/\/doi.org\/10.1016\/j.virusres.2015.09.003","relation":{},"ISSN":["0168-1702"],"issn-type":[{"value":"0168-1702","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unravelling the genetic components involved in the immune response of pigs vaccinated against influenza virus","name":"articletitle","label":"Article Title"},{"value":"Virus Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virusres.2015.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}