{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:20:26Z","timestamp":1778545226076,"version":"3.51.4"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Sciences Foundation of China","doi-asserted-by":"crossref","award":["81373142"],"award-info":[{"award-number":["81373142"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Important National Science & Technology Specific Projects","award":["2014ZX09102042"],"award-info":[{"award-number":["2014ZX09102042"]}]},{"name":"Science and Technology Projects of Yunnan Province","award":["2012ZA009"],"award-info":[{"award-number":["2012ZA009"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virus Research"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.virusres.2016.01.002","type":"journal-article","created":{"date-parts":[[2016,1,8]],"date-time":"2016-01-08T17:45:46Z","timestamp":1452275146000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Global gene expression analysis of peripheral blood mononuclear cells in rhesus monkey infants with CA16 infection-induced HFMD"],"prefix":"10.1016","volume":"214","author":[{"given":"Jie","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajie","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunguang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lichun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yancui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruotong","family":"Ning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiwen","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haijing","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanlong","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qihan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longding","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.virusres.2016.01.002_bib0005","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/1471-2148-8-142","article-title":"RPS4Y gene family evolution in primates","volume":"8","author":"Andr\u00e9s","year":"2008","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/j.virusres.2016.01.002_bib0010","doi-asserted-by":"crossref","first-page":"106","DOI":"10.47102\/annals-acadmedsg.V38N2p106","article-title":"Epidemiology and control of hand, foot and mouth disease in Singapore, 2001\u20132007","volume":"38","author":"Ang","year":"2009","journal-title":"Ann. Acad. Med. (Singapore)"},{"key":"10.1016\/j.virusres.2016.01.002_bib0015","first-page":"629","article-title":"Deaths among children during an outbreak of hand, foot, and mouth disease\u2014Taiwan, Republic of China, April\u2013July 1998","volume":"47","author":"Centers for Disease Control and Prevention","year":"1998","journal-title":"Morb. Mortal Wkly. Rep."},{"key":"10.1016\/j.virusres.2016.01.002_bib0020","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1056\/NEJMoa065954","article-title":"Neurodevelopment and cognition in children after enterovirus 71 infection","volume":"356","author":"Chang","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.virusres.2016.01.002_bib0025","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.tim.2014.09.007","article-title":"Response of host inflammasomes to viral infection","volume":"23","author":"Chen","year":"2015","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.virusres.2016.01.002_bib0030","unstructured":"China. The guidance to experimental animal welfare and ethical treatment, 2006. Available http:\/\/www.most.gov.cn\/fggw\/zfwj\/zfwj2006\/200609\/t20060930_54389.htm (accessed 30.08.06.)."},{"key":"10.1016\/j.virusres.2016.01.002_bib0035","doi-asserted-by":"crossref","first-page":"467","DOI":"10.2217\/fmb.12.22","article-title":"Viral and host factors that contribute to pathogenicity of enterovirus 71","volume":"7","author":"Huang","year":"2012","journal-title":"Future Microbiol."},{"key":"10.1016\/j.virusres.2016.01.002_bib0040","doi-asserted-by":"crossref","first-page":"254","DOI":"10.7883\/yoken.JJID.2009.254","article-title":"Genetic changes of coxsackievirus A16 and enterovirus 71 isolated from hand, foot, and mouth disease patients in Toyama, Japan between 1981 and 2007","volume":"62","author":"Iwai","year":"2009","journal-title":"Jpn. J. Infect. Dis."},{"key":"10.1016\/j.virusres.2016.01.002_bib0045","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1056\/NEJMoa1303224","article-title":"An inactivated enterovirus 71 vaccine in healthy children","volume":"370","author":"Li","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.virusres.2016.01.002_bib0050","doi-asserted-by":"crossref","first-page":"603","DOI":"10.2174\/1566524014666140603101113","article-title":"The characteristics of Bax inhibitor-1 and its related diseases","volume":"14","author":"Li","year":"2014","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.virusres.2016.01.002_bib0055","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.intimp.2012.07.015","article-title":"G protein-coupled receptor FPR1 as a pharmacologic target in inflammation and human glioblastoma","volume":"14","author":"Liu","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.virusres.2016.01.002_bib0060","doi-asserted-by":"crossref","first-page":"e54451","DOI":"10.1371\/journal.pone.0054451","article-title":"Study of the integrated immune response induced by an inactivated EV71 vaccine","volume":"8","author":"Liu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.virusres.2016.01.002_bib0065","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/978-1-60761-175-2_7","article-title":"PANTHER pathway: an ontology-based pathway database coupled with data analysis tools","volume":"563","author":"Mi","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.virusres.2016.01.002_bib0070","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1038\/nprot.2013.092","article-title":"Large-scale gene function analysis with the PANTHER classification system","volume":"8","author":"Mi","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.virusres.2016.01.002_bib0075","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1186\/1471-2334-12-299","article-title":"Pandemic influenza A\/H1N1 virus infection and TNF, LTA, IL1B, IL6, IL8, and CCL polymorphisms in Mexican population: a case-control study","volume":"12","author":"Morales-Garcia","year":"2012","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.virusres.2016.01.002_bib0080","series-title":"Guide for the Care and Use of Laboratory Animals","author":"National Academy of Science","year":"2011"},{"key":"10.1016\/j.virusres.2016.01.002_bib0085","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/gene.2011.21","article-title":"IRF7: activation, regulation, modification and function","volume":"12","author":"Ning","year":"2011","journal-title":"Genes Immun."},{"key":"10.1016\/j.virusres.2016.01.002_bib0090","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1172\/JCI72030","article-title":"CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis","volume":"124","author":"Nouailles","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.virusres.2016.01.002_bib0095","doi-asserted-by":"crossref","first-page":"e29780","DOI":"10.1371\/journal.pone.0029780","article-title":"Impact of the genome wide supported NRGN gene on anterior cingulate morphology in schizophrenia","volume":"7","author":"Ohi","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.virusres.2016.01.002_bib0100","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1089\/vim.2014.0054","article-title":"Inflammatory and cell-mediated immune responses in the respiratory tract of chickens to infection with avian infectious bronchitis virus","volume":"27","author":"Okino","year":"2014","journal-title":"Viral Immunol."},{"key":"10.1016\/j.virusres.2016.01.002_bib0105","first-page":"339","article-title":"Analysis on the epidemiological and genetic characteristics of enterovirus type 71 and coxsackie A16 virus infection in Jiangsu, China","volume":"30","author":"Pan","year":"2009","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi."},{"key":"10.1016\/j.virusres.2016.01.002_bib0110","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/ni.1716","article-title":"C-C chemokine receptor 6\u2014regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE","volume":"10","author":"Reboldi","year":"2009","journal-title":"Nat. Immunol."},{"issue":"7","key":"10.1016\/j.virusres.2016.01.002_bib0115","doi-asserted-by":"crossref","first-page":"5009","DOI":"10.1074\/jbc.M210436200","article-title":"Vps51 is part of the yeast Vps fifty-three tethering complex essential for retrograde traffic from the early endosome and Cvt vesicle completion","volume":"278","author":"Reggiori","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virusres.2016.01.002_bib0120","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.tibtech.2014.09.010","article-title":"Cellular targets for improved manufacturing of virus-based biopharmaceuticals in animal cells","volume":"32","author":"Rodrigues","year":"2014","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.virusres.2016.01.002_bib0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cyto.2009.11.021","article-title":"Gene modulation and immunoregulatory roles of interferon gamma","volume":"50","author":"Saha","year":"2010","journal-title":"Cytokine"},{"key":"10.1016\/j.virusres.2016.01.002_bib0130","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/1439-7633(20000703)1:1<16::AID-CBIC16>3.0.CO;2-Y","article-title":"Affinity, specificity, diversity: a challenge for the ABC transporter TAP in cellular immunity","volume":"1","author":"Schmitt","year":"2000","journal-title":"Chembiochem"},{"key":"10.1016\/j.virusres.2016.01.002_bib0135","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0065-2776(07)96002-2","article-title":"Regulation of interferon-gamma during innate and adaptive immune responses","volume":"96","author":"Schoenborn","year":"2007","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.virusres.2016.01.002_bib0140","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1053\/j.gastro.2014.03.046","article-title":"Monocytes activate natural killer cells via inflammasome-induced interleukin 18 in response to hepatitis C virus replication","volume":"147","author":"Serti","year":"2014","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.virusres.2016.01.002_bib0145","doi-asserted-by":"crossref","first-page":"e0122109","DOI":"10.1371\/journal.pone.0122109","article-title":"Coxsackievirus A16 elicits incomplete autophagy involving the mTOR and ERK pathways","volume":"10","author":"Shi","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.virusres.2016.01.002_bib0150","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S1473-3099(10)70194-8","article-title":"Virology, epidemiology, pathogenesis, and control of enterovirus 71","volume":"10","author":"Solomon","year":"2010","journal-title":"Lancet Infect. Dis."},{"issue":"2","key":"10.1016\/j.virusres.2016.01.002_bib0155","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.cellsig.2009.09.018","article-title":"Enterovirus 71 induces COX-2 expression via MAPKs, NF-kappaB, and AP-1 in SK-N-SH cells: Role of PGE(2) in viral replication","volume":"22","author":"Tung","year":"2010","journal-title":"Cell Signal."},{"key":"10.1016\/j.virusres.2016.01.002_bib0160","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1586\/14787210.2014.895666","article-title":"Update of enterovirus 71 infection: epidemiology, pathogenesis and vaccine","volume":"12","author":"Wang","year":"2014","journal-title":"Expert Rev. Anti Infect. Ther."},{"key":"10.1016\/j.virusres.2016.01.002_bib0165","first-page":"1","article-title":"Cytokine immunopathogenesis of enterovirus 71 brain stem encephalitis","volume":"2012","author":"Wang","year":"2012","journal-title":"Clin. Dev. Immunol."},{"issue":"3","key":"10.1016\/j.virusres.2016.01.002_bib0170","doi-asserted-by":"crossref","first-page":"e1003231","DOI":"10.1371\/journal.ppat.1003231","article-title":"Enterovirus 71 protease 2Apro targets MAVS to inhibit anti-viral type I interferon responses","volume":"9","author":"Wang","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virusres.2016.01.002_bib0175","doi-asserted-by":"crossref","first-page":"4436","DOI":"10.1016\/j.vaccine.2014.06.062","article-title":"Coxsackievirus A 16 infection does not interfere with the specific immune response induced by an enterovirus 71 inactivated vaccine in rhesus monkeys","volume":"32","author":"Wang","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.virusres.2016.01.002_bib0180","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.micinf.2010.03.006","article-title":"Neural pathogenesis of enterovirus 71 infection","volume":"12","author":"Weng","year":"2010","journal-title":"Microb. Infect."},{"key":"10.1016\/j.virusres.2016.01.002_bib0185","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1017\/S0950268809991555","article-title":"Human enterovirus 71 and hand, foot and mouth disease","volume":"138","author":"Wong","year":"2010","journal-title":"Epidemiol. Infect."},{"key":"10.1016\/j.virusres.2016.01.002_bib0190","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1056\/NEJM196305092681904","article-title":"Fatal infection in an infant associated with coxsackie virus group A, type 16","volume":"268","author":"Wright","year":"1963","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.virusres.2016.01.002_bib0195","doi-asserted-by":"crossref","first-page":"7027","DOI":"10.1523\/JNEUROSCI.0408-14.2014","article-title":"Activation of neurotensin receptor 1 facilitates neuronal excitability and spatial learning and memory in the entorhinal cortex: beneficial actions in an Alzheimer\u2019s disease model","volume":"34","author":"Xiao","year":"2014","journal-title":"J. Neurosci."},{"issue":"19","key":"10.1016\/j.virusres.2016.01.002_bib0200","doi-asserted-by":"crossref","first-page":"11356","DOI":"10.1128\/JVI.01400-14","article-title":"Downregulation of microRNA miR-526a by enterovirus inhibits RIG-I-dependent innate immune response","volume":"88","author":"Xu","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2016.01.002_bib0205","first-page":"38","article-title":"Coxsackieviruses infection in northern Taiwan\u2014epidemiology and clinical characteristics","volume":"42","author":"Yen","year":"2009","journal-title":"J. Microbiol. Immunol. Infect."},{"issue":"3","key":"10.1016\/j.virusres.2016.01.002_bib0210","doi-asserted-by":"crossref","first-page":"425","DOI":"10.4161\/15384101.2014.980631","article-title":"Enterovirus 71 mediates cell cycle arrest in S phase through non-structural protein 3D","volume":"14","author":"Yu","year":"2015","journal-title":"Cell Cycle"},{"key":"10.1016\/j.virusres.2016.01.002_bib0215","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1038\/labinvest.2011.82","article-title":"Pathogenesis study of enterovirus 71 infection in rhesus monkeys","volume":"91","author":"Zhang","year":"2011","journal-title":"Lab. Invest."},{"key":"10.1016\/j.virusres.2016.01.002_bib0220","first-page":"3341","article-title":"Severe hand-foot-and-mouth disease caused by mixed infection of enterovirus 71 and coxsackieA16: reports of 6 cases","volume":"2011","author":"Zhang","year":"2011","journal-title":"Chin. Gen. Pract."},{"key":"10.1016\/j.virusres.2016.01.002_bib0225","doi-asserted-by":"crossref","first-page":"e83766","DOI":"10.1371\/journal.pone.0083766","article-title":"The gene expression profile of peripheral blood mononuclear cells from EV71-infected rhesus infants and the significance in viral pathogenesis","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.virusres.2016.01.002_bib0230","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.bjid.2012.08.001","article-title":"Etiologic and epidemiologic analysis of hand, foot, and mouth disease in Guangzhou city: a review of 4,753 cases","volume":"16","author":"Zou","year":"2012","journal-title":"Braz. J. Infect. Dis."},{"key":"10.1016\/j.virusres.2016.01.002_bib0235","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1099\/jgv.0.000021","article-title":"Silencing the shutoff protein of Epstein\u2013Barr virus in productively infected B cells points to (innate) targets for immune evasion","volume":"96","author":"van Gent","year":"2015","journal-title":"J. Gen. Virol."}],"container-title":["Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170216300089?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170216300089?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T12:18:31Z","timestamp":1692188311000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168170216300089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":47,"alternative-id":["S0168170216300089"],"URL":"https:\/\/doi.org\/10.1016\/j.virusres.2016.01.002","relation":{},"ISSN":["0168-1702"],"issn-type":[{"value":"0168-1702","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Global gene expression analysis of peripheral blood mononuclear cells in rhesus monkey infants with CA16 infection-induced HFMD","name":"articletitle","label":"Article Title"},{"value":"Virus Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virusres.2016.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}