{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:12:00Z","timestamp":1790770320646,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Animal Care Staff and the EM Unit at OLF for their technical assistance"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virus Research"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.virusres.2016.04.019","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T01:46:47Z","timestamp":1461980807000},"page":"161-171","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Characterization of epitopes on the rabies virus glycoprotein by selection and analysis of escape mutants"],"prefix":"10.1016","volume":"220","author":[{"given":"Firouzeh","family":"Fallahi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander I.","family":"Wandeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan A.","family":"Nadin-Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"14","key":"10.1016\/j.virusres.2016.04.019_bib0005","doi-asserted-by":"crossref","first-page":"9062","DOI":"10.1128\/JVI.79.14.9062-9068.2005","article-title":"Novel human monoclonal antibody combination effectively neutralizing natural rabies virus variants and individual in vitro escape mutants","volume":"79","author":"Bakker","year":"2005","journal-title":"J. Virol."},{"issue":"8","key":"10.1016\/j.virusres.2016.04.019_bib0010","doi-asserted-by":"crossref","first-page":"4198","DOI":"10.1128\/JVI.65.8.4198-4203.1991","article-title":"Antigenicity of rabies virus glycoprotein","volume":"65","author":"Benmansour","year":"1991","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.virusres.2016.04.019_bib0015","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1099\/0022-1317-70-2-291","article-title":"Characterization of a new virus-neutralizing epitope that denotes a sequential determinant on the rabies virus glycoprotein","volume":"70","author":"Bunschoten","year":"1989","journal-title":"J. Gen.Virol."},{"issue":"12-13","key":"10.1016\/j.virusres.2016.04.019_bib0020","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.micinf.2010.06.005","article-title":"Fine mapping and interaction analysis of a linear rabies virus neutralizing epitope","volume":"12","author":"Cai","year":"2010","journal-title":"Microbes. Infect."},{"issue":"3","key":"10.1016\/j.virusres.2016.04.019_bib0025","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1099\/0022-1317-64-3-693","article-title":"Molecular basis of rabies virus virulence: II. Identification of a site on the CVS glycoprotein associated with virulence","volume":"64","author":"Coulon","year":"1983","journal-title":"J. Gen.Virol."},{"key":"10.1016\/j.virusres.2016.04.019_bib0030","series-title":"Laboratory Techniques in Rabies","first-page":"88","article-title":"The fluorescent antibody test","author":"Dean","year":"1996"},{"issue":"1","key":"10.1016\/j.virusres.2016.04.019_bib0035","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1073\/pnas.80.1.70","article-title":"Characterization of an antigenic determinant of the glycoprotein that correlates with pathogenicity of rabies virus","volume":"80","author":"Dietzschold","year":"1983","journal-title":"Proc.Natl.Acad.Sci.U.S.A"},{"issue":"8","key":"10.1016\/j.virusres.2016.04.019_bib0040","doi-asserted-by":"crossref","first-page":"3804","DOI":"10.1128\/JVI.64.8.3804-3809.1990","article-title":"Structural and immunological characterization of a linear virus-neutralizing epitope of the rabies virus glycoprotein and its possible use in a synthetic vaccine","volume":"64","author":"Dietzschold","year":"1990","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2016.04.019_bib0045","series-title":"Laboratory Techniques in Rabies","first-page":"200","article-title":"Competitive ELISA for the detection of rabies virus-neutralizing antibodies","author":"Elmgren","year":"1996"},{"key":"10.1016\/j.virusres.2016.04.019_bib0050","unstructured":"Elmgren L.D., 1999 Epitope mapping of Lyssavirus structural proteins ; PhD thesis, University of Ottawa."},{"issue":"52","key":"10.1016\/j.virusres.2016.04.019_bib0055","doi-asserted-by":"crossref","first-page":"7447","DOI":"10.1016\/j.vaccine.2012.10.015","article-title":"Rabies virus vaccines: is there a need for a pan-lyssavirus vaccine?","volume":"30","author":"Evans","year":"2012","journal-title":"Vaccine"},{"issue":"22","key":"10.1016\/j.virusres.2016.04.019_bib0060","doi-asserted-by":"crossref","first-page":"14141","DOI":"10.1128\/JVI.79.22.14141-14148.2005","article-title":"A single amino acid change in rabies virus glycoprotein increases virus spread and enhances virus pathogenicity","volume":"79","author":"Faber","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2016.04.019_bib0065","unstructured":"Finney D.J London Griffin and Company, 1978. Statistical method in biological assay."},{"issue":"7","key":"10.1016\/j.virusres.2016.04.019_bib0070","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1099\/0022-1317-76-7-1541","article-title":"Low-pH induced conformational changes in viral fusion proteins: implications for the fusion mechanism","volume":"76","author":"Gaudin","year":"1995","journal-title":"J. Gen.Virol."},{"issue":"34","key":"10.1016\/j.virusres.2016.04.019_bib0075","doi-asserted-by":"crossref","first-page":"4648","DOI":"10.1016\/j.vaccine.2009.05.055","article-title":"Peptide mimotopes of rabies virus glycoprotein with immunogenic activity","volume":"27","author":"Houimel","year":"2009","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.virusres.2016.04.019_bib0080","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1348-0421.2009.00192.x","article-title":"Amino acid substitutions at positions 242, 255 and 268 in rabies virus glycoprotein affect spread of viral infection","volume":"54","author":"Ito","year":"2010","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.virusres.2016.04.019_bib0085","series-title":"Rabies","first-page":"299","article-title":"Pathogenesis","author":"Jackson","year":"2013"},{"key":"10.1016\/j.virusres.2016.04.019_bib0090","series-title":"Rabies","first-page":"269","article-title":"Human disease","author":"Jackson","year":"2013"},{"issue":"7","key":"10.1016\/j.virusres.2016.04.019_bib0095","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1348-0421.2003.tb03412.x","article-title":"Mapping of the low pH-sensitive conformational epitope of rabies virus glycoprotein recognized by a monoclonal antibody #1-30-44","volume":"47","author":"Kankanamge","year":"2003","journal-title":"Microbiol. Immunol"},{"issue":"4","key":"10.1016\/j.virusres.2016.04.019_bib0100","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0264-410X(94)90095-7","article-title":"Vaccination against rabies: construction and characterization of SAG2, a double avirulent derivative of SADBern","volume":"12","author":"Lafay","year":"1994","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.virusres.2016.04.019_bib0105","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1099\/0022-1317-77-2-339","article-title":"Immunodominant epitopes defined by a yeast-expressed library of random fragments of the rabies virus glycoprotein map outside major antigenic sites","volume":"77","author":"Lafay","year":"1996","journal-title":"J. Gen.Virol."},{"issue":"4","key":"10.1016\/j.virusres.2016.04.019_bib0110","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1099\/0022-1317-64-4-843","article-title":"Antigenic sites on the CVS rabies virus glycoprotein: analysis with monoclonal antibodies","volume":"64","author":"Lafon","year":"1983","journal-title":"J. Gen.Virol."},{"key":"10.1016\/j.virusres.2016.04.019_bib0115","first-page":"219","article-title":"Investigation of the antigenic structure of rabies virus glycoprotein by monoclonal antibodies","volume":"57","author":"Lafon","year":"1984","journal-title":"Dev. Biol. Stand"},{"issue":"1","key":"10.1016\/j.virusres.2016.04.019_bib0120","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0168-1702(97)00080-4","article-title":"A virus-neutralizing epitope on the glycoprotein of rabies virus that contains Trp251 is a linear epitope","volume":"51","author":"Luo","year":"1997","journal-title":"Virus Res."},{"issue":"3","key":"10.1016\/j.virusres.2016.04.019_bib0125","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1348-0421.1998.tb02270.x","article-title":"Antigenic and functional analyses of glycoprotein of rabies virus using monoclonal antibodies","volume":"42","author":"Luo","year":"1998","journal-title":"Microbiol. Immunol."},{"issue":"11","key":"10.1016\/j.virusres.2016.04.019_bib0130","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1099\/vir.0.80362-0","article-title":"Identification of a conserved linear epitope at the N terminus of the rabies virus glycoprotein","volume":"85","author":"Mansfield","year":"2004","journal-title":"J. Gen.Virol."},{"issue":"8","key":"10.1016\/j.virusres.2016.04.019_bib0135","doi-asserted-by":"crossref","first-page":"4672","DOI":"10.1128\/JVI.79.8.4672-4678.2005","article-title":"Novel rabies virus-neutralizing epitope recognized by human monoclonal antibody: fine mapping and escape mutant analysis","volume":"79","author":"Marissen","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2016.04.019_bib0140","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1002\/jmv.21547","article-title":"Development of real-time reverse transcriptase polymerase chain reaction methods for human rabies diagnosis","volume":"81","author":"Nadin-Davis","year":"2009","journal-title":"J. Med. Virol."},{"issue":"1","key":"10.1016\/j.virusres.2016.04.019_bib0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-0934(98)00106-2","article-title":"Polymerase chain reaction protocols for rabies virus discrimination","volume":"75","author":"Nadin-Davis","year":"1998","journal-title":"J. Virol. Methods"},{"issue":"9","key":"10.1016\/j.virusres.2016.04.019_bib0150","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/j.1348-0421.1995.tb03258.x","article-title":"Mapping and characterization of a sequential epitope on the rabies virus glycoprotein which is recognized by a neutralizing monoclonal antibody, RG719","volume":"39","author":"Ni","year":"1995","journal-title":"Microbiol. Immunol"},{"issue":"1","key":"10.1016\/j.virusres.2016.04.019_bib0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/JVI.62.1.1-7.1988","article-title":"Antigenic site II of the rabies virus glycoprotein: structure and role in viral virulence","volume":"62","author":"Prehaud","year":"1988","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.virusres.2016.04.019_bib0160","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1006\/viro.1995.1356","article-title":"Monoclonal antibodies which recognize the acidic configuration of the rabies glycoprotein at the surface of the virion can be neutralizing","volume":"210","author":"Raux","year":"1995","journal-title":"Virology"},{"issue":"6","key":"10.1016\/j.virusres.2016.04.019_bib0165","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1080\/13550280500385310","article-title":"Glycoprotein-mediated induction of apoptosis limits the spread of attenuated rabies viruses in the central nervous system of mice","volume":"11","author":"Sarmento","year":"2005","journal-title":"J. Neurovirol."},{"issue":"3","key":"10.1016\/j.virusres.2016.04.019_bib0170","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1128\/JVI.53.3.926-934.1985","article-title":"Rabies virulence: effect on pathogenicity and sequence characterization of rabies virus mutations affecting antigenic site III of the glycoprotein","volume":"53","author":"Seif","year":"1985","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.virusres.2016.04.019_bib0175","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.virusres.2006.08.011","article-title":"Involvement of nucleoprotein, phosphoprotein, and matrix protein genes of rabies virus in virulence for adult mice","volume":"123","author":"Shimizu","year":"2007","journal-title":"Virus Res."},{"issue":"2","key":"10.1016\/j.virusres.2016.04.019_bib0180","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.virusres.2006.01.014","article-title":"A highly attenuated rabies virus HEP-Flury strain reverts to virulent by single amino acid substitution to arginine at position 333 in glycoprotein","volume":"119","author":"Takayama-Ito","year":"2006","journal-title":"Virus Res."},{"issue":"2","key":"10.1016\/j.virusres.2016.04.019_bib0185","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.virusres.2005.08.004","article-title":"Multiple amino acids in the glycoprotein of rabies virus are responsible for pathogenicity in adult mice","volume":"115","author":"Takayama-Ito","year":"2006","journal-title":"Virus Res."},{"issue":"17","key":"10.1016\/j.virusres.2016.04.019_bib0190","doi-asserted-by":"crossref","first-page":"8926","DOI":"10.1128\/JVI.00787-10","article-title":"Molecular basis of neurovirulence of flury rabies virus vaccine strains: importance of the polymerase and the glycoprotein R333Q mutation","volume":"84","author":"Tao","year":"2010","journal-title":"J. Virol."},{"issue":"24","key":"10.1016\/j.virusres.2016.04.019_bib0195","doi-asserted-by":"crossref","first-page":"4876","DOI":"10.1093\/nar\/25.24.4876","article-title":"The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools","volume":"25","author":"Thompson","year":"1997","journal-title":"Nucleic Acids Res."},{"issue":"9","key":"10.1016\/j.virusres.2016.04.019_bib0200","doi-asserted-by":"crossref","first-page":"7181","DOI":"10.1128\/JVI.72.9.7181-7190.1998","article-title":"The neural cell adhesion molecule is a receptor for rabies virus","volume":"72","author":"Thoulouze","year":"1998","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.virusres.2016.04.019_bib0205","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/0042-6822(89)90122-0","article-title":"Arginine or lysine in position 333 of ERA and CVS glycoprotein is necessary for rabies virulence in adult mice","volume":"172","author":"Tuffereau","year":"1989","journal-title":"Virology"},{"issue":"24","key":"10.1016\/j.virusres.2016.04.019_bib0210","doi-asserted-by":"crossref","first-page":"7250","DOI":"10.1093\/emboj\/17.24.7250","article-title":"Low-affinity nerve-growth factor receptor (P75NTR) can serve as a receptor for rabies virus","volume":"17","author":"Tuffereau","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.virusres.2016.04.019_bib0215","article-title":"Progress towards eliminating canine rabies: policies and perspective from Latin America and the Caribbean","volume":"20120143","author":"Vigilato","year":"2013","journal-title":"Philos. Trans. R. Soc. B 368"},{"key":"10.1016\/j.virusres.2016.04.019_bib0220","unstructured":"World Health Organization, 2013. WHO expert consultation on Rabies, second report. WHO technical report series no.982. Geneva : WHO."},{"issue":"5","key":"10.1016\/j.virusres.2016.04.019_bib0225","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1099\/0022-1317-80-5-1211","article-title":"Deduced structural model for animal rhabdovirus glycoproteins","volume":"80","author":"Walker","year":"1999","journal-title":"J. Gen.Virol."},{"key":"10.1016\/j.virusres.2016.04.019_bib0230","series-title":"Laboratory Techniques in Rabies","first-page":"96","article-title":"Virus isolation in neuroblastoma cell culture","author":"Webster","year":"1996"},{"key":"10.1016\/j.virusres.2016.04.019_bib0235","series-title":"Rabies","first-page":"17","article-title":"Rabies virus","author":"Wunner","year":"2013"},{"issue":"1","key":"10.1016\/j.virusres.2016.04.019_bib0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0042-6822(85)90440-4","article-title":"Antigenic variants of CVS rabies virus with altered glycosylation sites","volume":"140","author":"Wunner","year":"1985","journal-title":"Virology"}],"container-title":["Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170216300120?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170216300120?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T04:16:37Z","timestamp":1600488997000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168170216300120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":48,"alternative-id":["S0168170216300120"],"URL":"https:\/\/doi.org\/10.1016\/j.virusres.2016.04.019","relation":{},"ISSN":["0168-1702"],"issn-type":[{"value":"0168-1702","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of epitopes on the rabies virus glycoprotein by selection and analysis of escape mutants","name":"articletitle","label":"Article Title"},{"value":"Virus Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virusres.2016.04.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}