{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:51:18Z","timestamp":1789671078862,"version":"4.0.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Elanco Biological R&D, Eli Lilly and Company"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virus Research"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.virusres.2016.10.007","type":"journal-article","created":{"date-parts":[[2016,10,23]],"date-time":"2016-10-23T14:01:34Z","timestamp":1477231294000},"page":"212-219","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Efficient priming of CD4\u2009T cells by Langerin-expressing dendritic cells targeted with porcine epidemic diarrhea virus spike protein domains in pigs"],"prefix":"10.1016","volume":"227","author":[{"given":"Sakthivel","family":"Subramaniam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianjun","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debin","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian M.","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Overend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle M.","family":"Yugo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon R.","family":"Matzinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J.","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Lynn","family":"Heffron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Catanzaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott P.","family":"Kenney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Opriessnig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-Wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Labarque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen Q.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Jin","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virusres.2016.10.007_bib0005","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.vetimm.2015.09.006","article-title":"Age-dependent variation in innate immune responses to porcine epidemic diarrhea virus infection in suckling versus weaned pigs","volume":"168","author":"Annamalai","year":"2015","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.virusres.2016.10.007_bib0010","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1038\/cti.2014.14","article-title":"Dendritic cell immunotherapy: clinical outcomes","volume":"3","author":"Apostolopoulos","year":"2014","journal-title":"Clin. Transl. Immunol."},{"key":"10.1016\/j.virusres.2016.10.007_bib0015","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1189\/jlb.1HI0714-351R","article-title":"Langerin-expressing dendritic cells in human tissues are related to CD1c+ dendritic cells and distinct from Langerhans cells and CD141 high XCR1+ dendritic cells","volume":"97","author":"Bigley","year":"2015","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.virusres.2016.10.007_bib0020","first-page":"1","article-title":"Coronavirus genome structure and replication","volume":"287","author":"Brian","year":"2005","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.virusres.2016.10.007_bib0025","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S1016-8478(23)15106-5","article-title":"Identification of the epitope region capable of inducing neutralizing antibodies against the porcine epidemic diarrhea virus","volume":"14","author":"Chang","year":"2002","journal-title":"Mol. Cells"},{"key":"10.1016\/j.virusres.2016.10.007_bib0030","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.4049\/jimmunol.180.7.4361","article-title":"Cutting edge: Langerin+ dendritic cells in the mesenteric lymph node set the stage for skin and gut immune system cross-talk","volume":"180","author":"Chang","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.virusres.2016.10.007_bib0035","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0034-5288(18)32994-1","article-title":"Virus-like particles associated with porcine epidemic diarrhoea","volume":"25","author":"Chasey","year":"1978","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.virusres.2016.10.007_bib0040","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1182\/blood-2010-06-288068","article-title":"Improved cellular and humoral immune responses in vivo following targeting of HIV Gag to dendritic cells within human anti-human DEC205 monoclonal antibody","volume":"116","author":"Cheong","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.virusres.2016.10.007_bib0045","series-title":"96th Annual Meeting of Conference of Research Workers in Animal Diseases","article-title":"Both CD4+ and CD8+ T-cells recognize porcine reproductive and respiratory syndrome virus epitopes and lyse infected macrophages in a biphasic mode","author":"Chung","year":"2015"},{"key":"10.1016\/j.virusres.2016.10.007_bib0050","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1297-9716-43-9","article-title":"Cell-mediated and humoral immune responses in pigs following primary and challenge-exposure to Lawsonia intracellularis","volume":"43","author":"Cordes","year":"2012","journal-title":"Vet. Res."},{"key":"10.1016\/j.virusres.2016.10.007_bib0055","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0165-2427(01)00417-2","article-title":"Mucosal and systemic isotype-specific antibody responses and protection in conventional pigs exposed to virulent or attenuated porcine epidemic diarrhoea virus","volume":"85","author":"de Arriba","year":"2002","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.virusres.2016.10.007_bib0060","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.vetmic.2015.05.016","article-title":"Effects of porcine epidemic diarrhea virus on porcine monocyte-derived dendritic cells and intestinal dendritic cells","volume":"179","author":"Gao","year":"2015","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virusres.2016.10.007_bib0065","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.rvsc.2016.03.023","article-title":"Effects of inactivated porcine epidemic diarrhea virus on porcine monocyte-derived dendritic cells and intestinal dendritic cells","volume":"106","author":"Gao","year":"2016","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.virusres.2016.10.007_bib0070","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.dci.2008.06.003","article-title":"Porcine T lymphocytes and NK cells\u2014an update","volume":"33","author":"Gerner","year":"2009","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.virusres.2016.10.007_bib0075","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.vetmic.2014.12.019","article-title":"Previous infection of sows with a mild strain of porcine epidemic diarrhea virus confers protection against infection with a severe strain","volume":"176","author":"Goede","year":"2015","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virusres.2016.10.007_bib0080","doi-asserted-by":"crossref","first-page":"e00737","DOI":"10.1128\/mBio.00737-13","article-title":"Origin, evolution, and genotyping of emergent porcine epidemic diarrhea virus strains in the United States","volume":"4","author":"Huang","year":"2013","journal-title":"mBio"},{"key":"10.1016\/j.virusres.2016.10.007_bib0085","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.4049\/jimmunol.180.6.3647","article-title":"Cutting edge: Langerin\/CD207 receptor on dendritic cells mediates efficient antigen presentation on MHC I and II products in vivo","volume":"180","author":"Idoyaga","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.virusres.2016.10.007_bib0090","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1073\/pnas.1019547108","article-title":"Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A","volume":"108","author":"Idoyaga","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.virusres.2016.10.007_bib0095","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0022-1759(88)90196-2","article-title":"The measurement of relative antibody affinity by ELISA using thiocyanate elution","volume":"106","author":"Macdonald","year":"1988","journal-title":"J. Immunol. Methods"},{"issue":"4","key":"10.1016\/j.virusres.2016.10.007_bib0100","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/mi.2015.105","article-title":"The respiratory DC\/macrophage network at steady-state and upon influenza infection in the swine biomedical model","volume":"9","author":"Maisonnasse","year":"2015","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.virusres.2016.10.007_bib0105","doi-asserted-by":"crossref","first-page":"5883","DOI":"10.4049\/jimmunol.1303150","article-title":"Pig skin includes dendritic cell subsets transcriptomically related to human CD1a and CD14 dendritic cells presenting different migrating behaviors and T cell activation capacities","volume":"193","author":"Marquet","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.virusres.2016.10.007_bib0110","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.00555-13","article-title":"Complete genome sequence of porcine epidemic diarrhea virus strain USA\/Colorado\/2013 from the United States","volume":"1","author":"Marthaler","year":"2013","journal-title":"Genome Announc."},{"key":"10.1016\/j.virusres.2016.10.007_bib0115","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/mi.2014.111","article-title":"Cholera toxin adjuvant promotes a balanced Th1\/Th2\/Th17 response independently of IL-12 and IL-17 by acting on Gsalpha in CD11b(+) DCs","volume":"8","author":"Mattsson","year":"2015","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.virusres.2016.10.007_bib0120","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.vetimm.2008.07.012","article-title":"Langerhans cells in porcine skin","volume":"126","author":"Nfon","year":"2008","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.virusres.2016.10.007_bib0125","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1007\/s00705-014-2163-7","article-title":"Immunogenicity and protective efficacy of recombinant S1 domain of the porcine epidemic diarrhea virus spike protein","volume":"159","author":"Oh","year":"2014","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virusres.2016.10.007_bib0130","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1080\/01652176.2014.979512","article-title":"Comparison of serum neutralization and enzyme-linked immunosorbent assay on sera from porcine epidemic diarrhea virus vaccinated pigs","volume":"34","author":"Paudel","year":"2014","journal-title":"Vet. Q."},{"key":"10.1016\/j.virusres.2016.10.007_bib0135","series-title":"96th Annual Meeting of the Conference of Research Workers in Animal Diseases","article-title":"Does systemic antibody play a role in the protection in piglets against PEDV","author":"Poonsuk","year":"2015"},{"key":"10.1016\/j.virusres.2016.10.007_bib0140","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/jid.2011.437","article-title":"Changing views of the role of Langerhans cells","volume":"132","author":"Romani","year":"2012","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.virusres.2016.10.007_bib0145","doi-asserted-by":"crossref","first-page":"5111","DOI":"10.2527\/jas.2015-9136","article-title":"Assessment of the economic impacts of porcine epidemic diarrhea virus in the United States","volume":"93","author":"Schulz","year":"2015","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.virusres.2016.10.007_bib0150","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11262-012-0713-1","article-title":"Porcine epidemic diarrhoea virus: a comprehensive review of molecular epidemiology, diagnosis, and vaccines","volume":"44","author":"Song","year":"2012","journal-title":"Virus Genes"},{"key":"10.1016\/j.virusres.2016.10.007_bib0155","doi-asserted-by":"crossref","first-page":"166","DOI":"10.7774\/cevr.2015.4.2.166","article-title":"Porcine epidemic diarrhea: a review of current epidemiology and available vaccines","volume":"4","author":"Song","year":"2015","journal-title":"Clin. Exp. Vaccine Res."},{"key":"10.1016\/j.virusres.2016.10.007_bib0160","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1177\/1040638713501675","article-title":"Emergence of porcine epidemic diarrhea virus in the United States: clinical signs, lesions, and viral genomic sequences","volume":"25","author":"Stevenson","year":"2013","journal-title":"J. Vet. Diagn. Invest."},{"key":"10.1016\/j.virusres.2016.10.007_bib0165","doi-asserted-by":"crossref","first-page":"6768","DOI":"10.1016\/j.vaccine.2014.10.005","article-title":"In vivo targeting of porcine reproductive and respiratory syndrome virus antigen through porcine DC-SIGN to dendritic cells elicits antigen-specific CD4T cell immunity in pigs","volume":"32","author":"Subramaniam","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.virusres.2016.10.007_bib0170","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.vetmic.2008.02.022","article-title":"Identification of two novel B cell epitopes on porcine epidemic diarrhea virus spike protein","volume":"131","author":"Sun","year":"2008","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virusres.2016.10.007_bib0175","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/978-1-4615-2996-5_8","article-title":"Sequence analysis of the nucleocapsid protein gene of porcine epidemic diarrhoea virus","volume":"342","author":"Tobler","year":"1993","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.virusres.2016.10.007_bib0180","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2796.2011.02496.x","article-title":"Dendritic cell-targeted protein vaccines: a novel approach to induce T-cell immunity","volume":"271","author":"Trumpfheller","year":"2012","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.virusres.2016.10.007_bib0185","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S1074-7613(00)80160-0","article-title":"Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules","volume":"12","author":"Valladeau","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.virusres.2016.10.007_bib0190","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1002\/eji.201041305","article-title":"Human Langerhans cells capture measles virus through Langerin and present viral antigens to CD4(+) T cells but are incapable of cross-presentation","volume":"41","author":"van der Vlist","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.virusres.2016.10.007_bib0195","doi-asserted-by":"crossref","first-page":"4722","DOI":"10.4049\/jimmunol.180.7.4722","article-title":"Langerin expressing cells promote skin immune responses under defined conditions","volume":"180","author":"Wang","year":"2008","journal-title":"J. Immunol."}],"container-title":["Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170216304968?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170216304968?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T04:04:38Z","timestamp":1718856278000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168170216304968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":39,"alternative-id":["S0168170216304968"],"URL":"https:\/\/doi.org\/10.1016\/j.virusres.2016.10.007","relation":{},"ISSN":["0168-1702"],"issn-type":[{"value":"0168-1702","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficient priming of CD4\u2009T cells by Langerin-expressing dendritic cells targeted with porcine epidemic diarrhea virus spike protein domains in pigs","name":"articletitle","label":"Article Title"},{"value":"Virus Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virusres.2016.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}