{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:57:40Z","timestamp":1790517460564,"version":"4.1.0"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"University of Malaya Research","award":["UMRG-RP021C-13HTM"],"award-info":[{"award-number":["UMRG-RP021C-13HTM"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virus Research"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.virusres.2017.02.012","type":"journal-article","created":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T21:04:49Z","timestamp":1488834289000},"page":"17-28","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Japanese encephalitis virus disrupts blood-brain barrier and modulates apoptosis proteins in THBMEC cells"],"prefix":"10.1016","volume":"233","author":[{"given":"Mazen M. Jamil","family":"Al-Obaidi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azadeh","family":"Bahadoran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee Sau","family":"Har","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang Seok","family":"Mui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayakumar","family":"Rajarajeswaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keivan","family":"Zandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishya","family":"Manikam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamala Devi","family":"Sekaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virusres.2017.02.012_bib0005","series-title":"Cellular and Molecular Immunology","author":"Abbas","year":"2014"},{"issue":"11","key":"10.1016\/j.virusres.2017.02.012_bib0010","doi-asserted-by":"publisher","first-page":"e1000205","DOI":"10.1371\/journal.ppat.1000205","article-title":"Alteration of blood?brain barrier integrity by retroviral infection","volume":"4","author":"Afonso","year":"2008","journal-title":"PLoS Pathog."},{"issue":"7","key":"10.1016\/j.virusres.2017.02.012_bib0015","doi-asserted-by":"publisher","first-page":"e69465","DOI":"10.1371\/journal.pone.0069465","article-title":"Japanese encephalitis virus disrupts cell\u2013cell junctions and affects the epithelial permeability barrier functions","volume":"8","author":"Agrawal","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.virusres.2017.02.012_bib0020","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.neuint.2007.08.012","article-title":"Expression of nuclear receptor mRNA and liver X receptor-mediated regulation of ABC transporter A1 at rat blood\u2013brain barrier","volume":"52","author":"Akanuma","year":"2008","journal-title":"Neurochem. Int."},{"issue":"2","key":"10.1016\/j.virusres.2017.02.012_bib0025","doi-asserted-by":"publisher","first-page":"a002584","DOI":"10.1101\/cshperspect.a002584","article-title":"Physiology and function of the tight junction","volume":"1","author":"Anderson","year":"2009","journal-title":"Cold Spring Harbor Perspect. Biol."},{"issue":"6","key":"10.1016\/j.virusres.2017.02.012_bib0030","doi-asserted-by":"publisher","first-page":"L1232","DOI":"10.1152\/ajplung.00109.2006","article-title":"TNF-\u03b1 increases tyrosine phosphorylation of vascular endothelial cadherin and opens the paracellular pathway through fyn activation in human lung endothelia","volume":"291","author":"Angelini","year":"2006","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"1","key":"10.1016\/j.virusres.2017.02.012_bib0035","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1742-2094-4-11","article-title":"Toll-like receptor 2 signaling is a mediator of apoptosis in herpes simplex virus-infected microglia","volume":"4","author":"Aravalli","year":"2007","journal-title":"J. Neuroinflammation"},{"issue":"3","key":"10.1016\/j.virusres.2017.02.012_bib0040","first-page":"593","article-title":"Apoptosis: the role of the endonuclease","volume":"136","author":"Arends","year":"1990","journal-title":"Am. J. Pathol."},{"issue":"2","key":"10.1016\/j.virusres.2017.02.012_bib0045","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1034\/j.1600-0420.2000.078002130.x","article-title":"Immortalization of human corneal endothelial cells using electroporation protocol optimized for human corneal endothelial and human retinal pigment epithelial cells","volume":"78","author":"Bednarz","year":"2000","journal-title":"Acta Ophthalmol. Scand."},{"issue":"10","key":"10.1016\/j.virusres.2017.02.012_bib0050","doi-asserted-by":"publisher","first-page":"766","DOI":"10.2471\/BLT.10.085233","article-title":"Estimated global incidence of Japanese encephalitis: a systematic review","volume":"89","author":"Campbell","year":"2011","journal-title":"Bull. World Health Organ."},{"issue":"9","key":"10.1016\/j.virusres.2017.02.012_bib0055","doi-asserted-by":"publisher","first-page":"4698","DOI":"10.1128\/JVI.03149-13","article-title":"Enhancement of blood-brain barrier permeability and reduction of tight junction protein expression are modulated by chemokines\/cytokines induced by rabies virus infection","volume":"88","author":"Chai","year":"2014","journal-title":"J. Virol."},{"issue":"5573","key":"10.1016\/j.virusres.2017.02.012_bib0060","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1126\/science.1071924","article-title":"TNF-R1 signaling: a beautiful pathway","volume":"296","author":"Chen","year":"2002","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.virusres.2017.02.012_bib0065","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1099\/0022-1317-83-8-1897","article-title":"Suppression of Japanese encephalitis virus infection by non-steroidal anti-inflammatory drugs","volume":"83","author":"Chen","year":"2002","journal-title":"J. Gen. Virol."},{"issue":"4","key":"10.1016\/j.virusres.2017.02.012_bib0070","doi-asserted-by":"publisher","first-page":"e1002655","DOI":"10.1371\/journal.ppat.1002655","article-title":"CLEC5A regulates Japanese encephalitis virus-induced neuroinflammation and lethality","volume":"8","author":"Chen","year":"2012","journal-title":"PLoS Pathog."},{"issue":"2","key":"10.1016\/j.virusres.2017.02.012_bib0075","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1128\/JVI.02738-13","article-title":"Infection of pericytes in vitro by Japanese encephalitis virus disrupts the integrity of the endothelial barrier","volume":"88","author":"Chen","year":"2014","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.virusres.2017.02.012_bib0080","doi-asserted-by":"publisher","first-page":"e30315","DOI":"10.1371\/journal.pone.0030315","article-title":"Whole genomes of chandipura virus isolates and comparative analysis with other rhabdoviruses","volume":"7","author":"Cherian","year":"2012","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.virusres.2017.02.012_bib0085","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1007\/s10875-006-9024-4","article-title":"Bluetongue virus and double-stranded RNA increase human vascular permeability: role of p38 MAPK","volume":"26","author":"Chiang","year":"2006","journal-title":"J. Clin. Immunol."},{"issue":"4","key":"10.1016\/j.virusres.2017.02.012_bib0090","doi-asserted-by":"publisher","first-page":"S20","DOI":"10.1164\/ajrccm\/152.4_Pt_2.S20","article-title":"Potential roles of apoptosis in viral pathogenesis","volume":"152","author":"Collins","year":"1995","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"1","key":"10.1016\/j.virusres.2017.02.012_bib0095","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1006\/mvre.1997.2045","article-title":"Endothelial cells from diverse tissues exhibit differences in growth and morphology","volume":"55","author":"Craig","year":"1998","journal-title":"Microvasc. Res."},{"issue":"1","key":"10.1016\/j.virusres.2017.02.012_bib0100","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.virol.2008.10.025","article-title":"Heat shock protein 70 on Neuro2a cells is a putative receptor for Japanese encephalitis virus","volume":"385","author":"Das","year":"2009","journal-title":"Virology"},{"issue":"3","key":"10.1016\/j.virusres.2017.02.012_bib0105","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0165-2427(02)00012-0","article-title":"Bluetongue virus-induced activation of primary bovine lung microvascular endothelial cells","volume":"86","author":"DeMaula","year":"2002","journal-title":"Vet. Immunol. Immunopathol."},{"issue":"3","key":"10.1016\/j.virusres.2017.02.012_bib0110","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1101\/gad.13.3.239","article-title":"IAP family proteins\u2014suppressors of apoptosis","volume":"13","author":"Deveraux","year":"1999","journal-title":"Genes. Dev."},{"issue":"3","key":"10.1016\/j.virusres.2017.02.012_bib0115","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1046\/j.1440-1711.2003.01157.x","article-title":"Evasion of innate and adaptive immunity by flaviviruses","volume":"81","author":"Diamond","year":"2003","journal-title":"Immunol. Cell Biol."},{"issue":"1","key":"10.1016\/j.virusres.2017.02.012_bib0120","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/S0165-5728(02)00114-5","article-title":"The adhesion molecule ICAM-1 and its regulation in relation with the blood\u2013brain barrier","volume":"128","author":"Dietrich","year":"2002","journal-title":"J. Neuroimmunol."},{"issue":"1","key":"10.1016\/j.virusres.2017.02.012_bib0125","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2045-8118-10-33","article-title":"Comparative study of four immortalized human brain capillary endothelial cell lines, hCMEC\/D3, hBMEC, TY10, and BB19, and optimization of culture conditions, for an in vitro blood\u2013brain barrier model for drug permeability studies","volume":"10","author":"Eigenmann","year":"2013","journal-title":"Fluids Barriers CNS"},{"issue":"4","key":"10.1016\/j.virusres.2017.02.012_bib0130","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"issue":"23","key":"10.1016\/j.virusres.2017.02.012_bib0135","first-page":"5534","article-title":"In vitro antiviral activity of fisetin, rutin and naringenin against dengue virus type-2","volume":"5","author":"Fong","year":"2011","journal-title":"J. Med. Plants Res."},{"issue":"6","key":"10.1016\/j.virusres.2017.02.012_bib0140","doi-asserted-by":"crossref","first-page":"L1218","DOI":"10.1152\/ajplung.2000.279.6.L1218","article-title":"Reversibility of increased microvessel permeability in response to VE-cadherin disassembly","volume":"279","author":"Gao","year":"2000","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"11","key":"10.1016\/j.virusres.2017.02.012_bib0145","doi-asserted-by":"publisher","first-page":"2490","DOI":"10.1161\/01.ATV.0000242903.41158.a1","article-title":"The unfolded protein response is an important regulator of inflammatory genes in endothelial cells","volume":"26","author":"Gargalovic","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"22","key":"10.1016\/j.virusres.2017.02.012_bib0150","doi-asserted-by":"publisher","first-page":"12398","DOI":"10.1128\/JVI.01864-13","article-title":"Chandipura virus induces neuronal death through Fas-mediated extrinsic apoptotic pathway","volume":"87","author":"Ghosh","year":"2013","journal-title":"J. Virol."},{"issue":"5","key":"10.1016\/j.virusres.2017.02.012_bib0155","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1002\/glia.20474","article-title":"Proinflammatory mediators released by activated microglia induces neuronal death in Japanese encephalitis","volume":"55","author":"Ghoshal","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.virusres.2017.02.012_bib0160","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1109\/TBME.1986.325896","article-title":"Use of electric fields to monitor the dynamical aspect of cell behavior in tissue culture","volume":"2","author":"Giaever","year":"1986","journal-title":"Biomed. Eng. IEEE Trans."},{"issue":"17","key":"10.1016\/j.virusres.2017.02.012_bib0165","doi-asserted-by":"publisher","first-page":"7896","DOI":"10.1073\/pnas.88.17.7896","article-title":"Micromotion of mammalian cells measured electrically","volume":"88","author":"Giaever","year":"1991","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"6455","key":"10.1016\/j.virusres.2017.02.012_bib0170","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/366591a0","article-title":"A morphological biosensor for mammalian cells","volume":"366","author":"Giaever","year":"1993","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.virusres.2017.02.012_bib0175","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1128\/IAI.73.2.1014-1022.2005","article-title":"Borrelia burgdorferi, host-derived proteases, and the blood-brain barrier","volume":"73","author":"Grab","year":"2005","journal-title":"Infect. Immun."},{"issue":"18","key":"10.1016\/j.virusres.2017.02.012_bib0180","doi-asserted-by":"publisher","first-page":"9398","DOI":"10.1128\/JVI.00954-09","article-title":"Mouse adenovirus type 1-induced breakdown of the blood-brain barrier","volume":"83","author":"Gralinski","year":"2009","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.virusres.2017.02.012_bib0185","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1146\/annurev.micro.51.1.565","article-title":"Regulators of apoptosis on the road to persistent alphavirus infection","volume":"51","author":"Griffin","year":"1997","journal-title":"Annu. Rev. Microbiol."},{"issue":"9","key":"10.1016\/j.virusres.2017.02.012_bib0190","doi-asserted-by":"publisher","first-page":"e1004319","DOI":"10.1371\/journal.ppat.1004319","article-title":"Distinct dictation of Japanese encephalitis virus-induced neuroinflammation and lethality via triggering TLR3 and TLR4 signal pathways","volume":"10","author":"Han","year":"2014","journal-title":"PLoS Pathog."},{"issue":"2","key":"10.1016\/j.virusres.2017.02.012_bib0195","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1124\/pr.57.2.4","article-title":"The blood-brain barrier\/neurovascular unit in health and disease","volume":"57","author":"Hawkins","year":"2005","journal-title":"Pharmacol. Rev."},{"issue":"4","key":"10.1016\/j.virusres.2017.02.012_bib0200","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1159\/000314686","article-title":"Pathogen-mediated inflammatory atherosclerosis is mediated in part via Toll-like receptor 2-induced inflammatory responses","volume":"2","author":"Hayashi","year":"2010","journal-title":"J. Innate Immun."},{"issue":"6","key":"10.1016\/j.virusres.2017.02.012_bib0205","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1128\/JVI.68.6.3667-3673.1994","article-title":"Apoptosis: a mechanism of cell killing by influenza A and B viruses","volume":"68","author":"Hinshaw","year":"1994","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.virusres.2017.02.012_bib0210","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1006\/bbrc.1997.8051","article-title":"Hydrocortisone reinforces the blood\u2013brain barrier properties in a serum free cell culture system","volume":"244","author":"Hoheisel","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.virusres.2017.02.012_bib0215","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1002\/ana.20065","article-title":"Vascular endothelial growth factor mediates vasogenic edema in acute lead encephalopathy","volume":"55","author":"Hossain","year":"2004","journal-title":"Ann. Neurol."},{"issue":"6","key":"10.1016\/j.virusres.2017.02.012_bib0220","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1073\/pnas.0307588100","article-title":"Electrical wound-healing assay for cells in vitro","volume":"101","author":"Keese","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.virusres.2017.02.012_bib0225","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/S0962-8924(98)01321-X","article-title":"Bcl-2-family proteins: the role of the BH3 domain in apoptosis","volume":"8","author":"Kelekar","year":"1998","journal-title":"Trends Cell Biol."},{"issue":"2","key":"10.1016\/j.virusres.2017.02.012_bib0230","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1111\/j.1471-4159.2012.07889.x","article-title":"Endothelial Japanese encephalitis virus infection enhances migration and adhesion of leukocytes to brain microvascular endothelia via MEK-dependent expression of ICAM1 and the CINC and RANTES chemokines","volume":"123","author":"Lai","year":"2012","journal-title":"J. Neurochem."},{"issue":"6","key":"10.1016\/j.virusres.2017.02.012_bib0235","doi-asserted-by":"publisher","first-page":"993","DOI":"10.4269\/ajtmh.13-0382","article-title":"Endothelial cell permeability and adherens junction disruption induced by jun\u00edn virus infection","volume":"90","author":"Lander","year":"2014","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"6414","key":"10.1016\/j.virusres.2017.02.012_bib0240","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1038\/361739a0","article-title":"Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene","volume":"361","author":"Levine","year":"1993","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.virusres.2017.02.012_bib0245","doi-asserted-by":"crossref","first-page":"5963","DOI":"10.1128\/JVI.71.8.5963-5971.1997","article-title":"Effect of enforced expression of human bcl-2 on Japanese encephalitis virus-induced apoptosis in cultured cells","volume":"71","author":"Liao","year":"1997","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.virusres.2017.02.012_bib0250","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1099\/vir.0.19496-0","article-title":"Replication-incompetent virions of Japanese encephalitis virus trigger neuronal cell death by oxidative stress in a culture system","volume":"85","author":"Lin","year":"2004","journal-title":"J. Gen. Virol."},{"issue":"3","key":"10.1016\/j.virusres.2017.02.012_bib0255","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s004410051130","article-title":"Japanese encephalitis virus is transported across the cerebral blood vessels by endocytosis in mouse brain","volume":"293","author":"Liou","year":"1998","journal-title":"Cell Tissue Res."},{"issue":"6","key":"10.1016\/j.virusres.2017.02.012_bib0260","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1080\/13550280802339643","article-title":"The blood-brain barrier in the cerebrum is the initial site for the Japanese encephalitis virus entering the central nervous system","volume":"14","author":"Liu","year":"2008","journal-title":"J. Neurovirol."},{"issue":"1","key":"10.1016\/j.virusres.2017.02.012_bib0265","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1006\/excr.1993.1014","article-title":"Monitoring motion of confluent cells in tissue culture","volume":"204","author":"Lo","year":"1993","journal-title":"Exp. Cell Res."},{"issue":"4","key":"10.1016\/j.virusres.2017.02.012_bib0270","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1002\/(SICI)1096-9071(199912)59:4<552::AID-JMV21>3.0.CO;2-A","article-title":"Lassa and Mopeia virus replication in human monocytes\/macrophages and in endothelial cells: different effects on IL-8 and TNF-\u03b1 gene expression","volume":"59","author":"Lukashevich","year":"1999","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.virusres.2017.02.012_bib0275","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/S0378-4320(00)00105-6","article-title":"Bluetongue and equine viral arteritis viruses as models of virus-induced fetal injury and abortion","volume":"60","author":"MacLachlan","year":"2000","journal-title":"Anim. Reprod. Sci."},{"issue":"2","key":"10.1016\/j.virusres.2017.02.012_bib0280","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/S0165-5728(01)00348-4","article-title":"Rhesus macaque brain microvessel endothelial cells behave in a manner phenotypically distinct from umbilical vein endothelial cells","volume":"118","author":"MacLean","year":"2001","journal-title":"J. Neuroimmunol."},{"issue":"6-7","key":"10.1016\/j.virusres.2017.02.012_bib0285","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1111\/j.1863-2378.2008.01208.x","article-title":"The zoonotic flaviviruses of Southern, South-Eastern and Eastern Asia, and australasia: the potential for emergent viruses","volume":"56","author":"Mackenzie","year":"2009","journal-title":"Zoonoses Public Health"},{"issue":"2","key":"10.1016\/j.virusres.2017.02.012_bib0290","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1111\/j.1750-3639.2007.00067.x","article-title":"Inflammatory cell migration into the central nervous system: a few new twists on an old tale","volume":"17","author":"Man","year":"2007","journal-title":"Brain Pathol."},{"issue":"4","key":"10.1016\/j.virusres.2017.02.012_bib0295","first-page":"504","article-title":"Electric measurements can be used to monitor the attachment and spreading of cells in tissue culture","volume":"11","author":"Mitra","year":"1991","journal-title":"Biotechniques"},{"issue":"3","key":"10.1016\/j.virusres.2017.02.012_bib0300","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1007\/s11481-011-9271-x","article-title":"Japanese encephalitis virus-infected macrophages induce neuronal death","volume":"6","author":"Nazmi","year":"2011","journal-title":"J. Neuroimmune Pharmacol."},{"issue":"2","key":"10.1016\/j.virusres.2017.02.012_bib0305","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/84675","article-title":"Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke","volume":"7","author":"Paul","year":"2001","journal-title":"Nat. Med."},{"issue":"8","key":"10.1016\/j.virusres.2017.02.012_bib0310","doi-asserted-by":"crossref","first-page":"5329","DOI":"10.1128\/JVI.70.8.5329-5335.1996","article-title":"Induction of apoptosis by La Crosse virus infection and role of neuronal differentiation and human bcl-2 expression in its prevention","volume":"70","author":"Pekosz","year":"1996","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.virusres.2017.02.012_bib0315","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s11481-006-9025-3","article-title":"Blood\u2013brain barrier: structural components and function under physiologic and pathologic conditions","volume":"1","author":"Persidsky","year":"2006","journal-title":"J. Neuroimmune Pharmacol."},{"issue":"3","key":"10.1016\/j.virusres.2017.02.012_bib0320","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/j.1574-695X.2009.00594.x","article-title":"Pathogen translocation across the blood-brain barrier","volume":"57","author":"Pulzova","year":"2009","journal-title":"FEMS Immunol. Med. Microbiol."},{"issue":"6","key":"10.1016\/j.virusres.2017.02.012_bib0325","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1099\/vir.0.040899-0","article-title":"West Nile virus-induced disruption of the blood\u2013brain barrier in mice is characterized by the degradation of the junctional complex proteins and increase in multiple matrix metalloproteinases","volume":"93","author":"Roe","year":"2012","journal-title":"J. Gen. Virol."},{"issue":"7","key":"10.1016\/j.virusres.2017.02.012_bib0330","doi-asserted-by":"publisher","first-page":"e102598","DOI":"10.1371\/journal.pone.0102598","article-title":"West Nile virus-induced cell adhesion molecules on human brain microvascular endothelial cells regulate leukocyte adhesion and modulate permeability of the in vitro blood-brain barrier model","volume":"9","author":"Roe","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.virusres.2017.02.012_bib0335","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1128\/JVI.71.2.1583-1590.1997","article-title":"bcl-2 acts early to restrict Semliki Forest virus replication and delays virus-induced programmed cell death","volume":"71","author":"Scallan","year":"1997","journal-title":"J. Virol."},{"issue":"20","key":"10.1016\/j.virusres.2017.02.012_bib0340","doi-asserted-by":"publisher","first-page":"10682","DOI":"10.1128\/JVI.05032-11","article-title":"The role of the blood-brain barrier during Venezuelan equine encephalitis virus infection","volume":"85","author":"Sch\u00e4fer","year":"2011","journal-title":"J. Virol."},{"issue":"6","key":"10.1016\/j.virusres.2017.02.012_bib0345","doi-asserted-by":"publisher","first-page":"C1213","DOI":"10.1152\/ajpcell.00558.2003","article-title":"The tight junction: a multifunctional complex","volume":"286","author":"Schneeberger","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"2","key":"10.1016\/j.virusres.2017.02.012_bib0350","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/S0165-5728(00)00290-3","article-title":"Inflammation is a component of neurodegeneration in response to Venezuelan equine encephalitis virus infection in mice","volume":"109","author":"Schoneboom","year":"2000","journal-title":"J. Neuroimmunol."},{"issue":"1","key":"10.1016\/j.virusres.2017.02.012_bib0355","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2164-9-289","article-title":"Venezuelan equine encephalitis virus infection causes modulation of inflammatory and immune response genes in mouse brain","volume":"9","author":"Sharma","year":"2008","journal-title":"BMC Genomics"},{"issue":"21","key":"10.1016\/j.virusres.2017.02.012_bib0360","doi-asserted-by":"publisher","first-page":"11749","DOI":"10.1128\/JVI.01136-07","article-title":"Fas ligand interactions contribute to CD8+ T-cell-mediated control of West Nile virus infection in the central nervous system","volume":"81","author":"Shrestha","year":"2007","journal-title":"J. Virol."},{"issue":"10","key":"10.1016\/j.virusres.2017.02.012_bib0365","doi-asserted-by":"crossref","first-page":"6291","DOI":"10.1128\/JVI.68.10.6291-6298.1994","article-title":"Semliki Forest virus infects mouse brain endothelial cells and causes blood-brain barrier damage","volume":"68","author":"Soilu-H\u00e4nninen","year":"1994","journal-title":"J. Virol."},{"issue":"4","key":"10.1016\/j.virusres.2017.02.012_bib0370","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1136\/jnnp.68.4.405","article-title":"Japanese encephalitis","volume":"68","author":"Solomon","year":"2000","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"9","key":"10.1016\/j.virusres.2017.02.012_bib0375","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1056\/NEJMp058263","article-title":"Control of Japanese encephalitis-within our grasp","volume":"355","author":"Solomon","year":"2006","journal-title":"New Engl. J. Med."},{"issue":"1","key":"10.1016\/j.virusres.2017.02.012_bib0380","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/S0165-5728(97)00036-2","article-title":"Selective expression of adhesion molecules on human brain microvascular endothelial cells","volume":"76","author":"Stins","year":"1997","journal-title":"J. Neuroimmunol."},{"issue":"4","key":"10.1016\/j.virusres.2017.02.012_bib0385","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s11626-997-0042-1","article-title":"Bovine brain microvascular endothelial cells transfected with SV40-large T antigen: development of an immortalized cell line to study pathophysiology of CNS disease","volume":"33","author":"Stins","year":"1997","journal-title":"Vitro Cell. Dev. Biol. Anim."},{"issue":"12","key":"10.1016\/j.virusres.2017.02.012_bib0390","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1097\/01.LAB.0000107008.13321.C8","article-title":"Induction of intercellular adhesion molecule-1 on human brain endothelial cells by HIV-1 gp120: role of CD4 and chemokine coreceptors","volume":"83","author":"Stins","year":"2003","journal-title":"Lab. Invest."},{"issue":"9","key":"10.1016\/j.virusres.2017.02.012_bib0395","doi-asserted-by":"publisher","first-page":"4162","DOI":"10.1128\/JVI.76.9.4162-4171.2002","article-title":"Japanese encephalitis virus infection initiates endoplasmic reticulum stress and an unfolded protein response","volume":"76","author":"Su","year":"2002","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.virusres.2017.02.012_bib0400","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1111\/j.1471-4159.2007.04790.x","article-title":"Tumor necrosis factor receptor-1-induced neuronal death by TRADD contributes to the pathogenesis of Japanese encephalitis","volume":"103","author":"Swarup","year":"2007","journal-title":"J. Neurochem."},{"issue":"7","key":"10.1016\/j.virusres.2017.02.012_bib0405","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1016\/j.neuint.2008.01.014","article-title":"Tumor necrosis factor receptor-associated death domain mediated neuronal death contributes to the glial activation and subsequent neuroinflammation in Japanese encephalitis","volume":"52","author":"Swarup","year":"2008","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.virusres.2017.02.012_bib0410","first-page":"e51300","article-title":"Electric cell-substrate impedance sensing for the quantification of endothelial proliferation, barrier function, and motility","volume":"85","author":"Szulcek","year":"2014","journal-title":"JoVE (J. Visual. Exp.)"},{"issue":"3","key":"10.1016\/j.virusres.2017.02.012_bib0415","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1093\/infdis\/142.3.394","article-title":"Protection against Japanese encephalitis virus in mice and hamsters by treatment with carboxymethylacridanone, a potent interferon inducer","volume":"142","author":"Taylor","year":"1980","journal-title":"J. Infect. Dis."},{"issue":"3","key":"10.1016\/j.virusres.2017.02.012_bib0420","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1128\/JVI.71.3.1739-1746.1997","article-title":"Regulation of apoptosis by viral gene products","volume":"71","author":"Teodoro","year":"1997","journal-title":"J. Virol."},{"issue":"17","key":"10.1016\/j.virusres.2017.02.012_bib0425","doi-asserted-by":"publisher","first-page":"7919","DOI":"10.1073\/pnas.89.17.7919","article-title":"Electrical method for detection of endothelial cell shape change in real time: assessment of endothelial barrier function","volume":"89","author":"Tiruppathi","year":"1992","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"8","key":"10.1016\/j.virusres.2017.02.012_bib0430","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1099\/vir.0.2008\/000182-0","article-title":"Japanese encephalitis virus infection activates caspase-8 and-9 in a FADD-independent and mitochondrion-dependent manner","volume":"89","author":"Tsao","year":"2008","journal-title":"J. Gen. Virol."},{"issue":"1","key":"10.1016\/j.virusres.2017.02.012_bib0435","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1423-0127-18-20","article-title":"Autoimmunity-related demyelination in infection by Japanese encephalitis virus","volume":"18","author":"Tseng","year":"2011","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.virusres.2017.02.012_bib0440","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1146\/annurev.ento.54.110807.090510","article-title":"Ecology and geographical expansion of Japanese encephalitis virus","volume":"54","author":"Van den Hurk","year":"2009","journal-title":"Annu. Rev. Entomol."},{"issue":"11","key":"10.1016\/j.virusres.2017.02.012_bib0445","first-page":"1186","article-title":"Brain pericytes from stress-susceptible pigs increase blood-brain barrier permeability in vitro","volume":"9","author":"Vandenhaute","year":"2012","journal-title":"Fluids Barriers CNS"},{"issue":"1","key":"10.1016\/j.virusres.2017.02.012_bib0450","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1096\/fj.04-2073fje","article-title":"Soluble tumor necrosis factor (TNF) receptor-1 induces apoptosis via reverse TNF signaling and autocrine transforming growth factor-\u03b21","volume":"19","author":"Waetzig","year":"2005","journal-title":"FASEB J."},{"issue":"5383","key":"10.1016\/j.virusres.2017.02.012_bib0455","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1126\/science.281.5383.1680","article-title":"NF-\u03baB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation","volume":"281","author":"Wang","year":"1998","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.virusres.2017.02.012_bib0460","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1053\/tvjl.1998.0289","article-title":"Molecular epidemiological studies of veterinary arboviral encephalitides","volume":"157","author":"Weaver","year":"1999","journal-title":"Vet. J."},{"issue":"1","key":"10.1016\/j.virusres.2017.02.012_bib0465","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1006\/excr.2000.4919","article-title":"Electric cell?substrate impedance sensing (ECIS) as a noninvasive means to monitor the kinetics of cell spreading to artificial surfaces","volume":"259","author":"Wegener","year":"2000","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.virusres.2017.02.012_bib0470","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.brainres.2011.11.052","article-title":"HIV-1 Tat protein increases the permeability of brain endothelial cells by both inhibiting occludin expression and cleaving occludin via matrix metalloproteinase-9","volume":"1436","author":"Xu","year":"2012","journal-title":"Brain Res."},{"issue":"5","key":"10.1016\/j.virusres.2017.02.012_bib0475","doi-asserted-by":"publisher","first-page":"e37886","DOI":"10.1371\/journal.pone.0037886","article-title":"West Nile virus infection causes endocytosis of a specific subset of tight junction membrane proteins","volume":"7","author":"Xu","year":"2012","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.virusres.2017.02.012_bib0480","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.micinf.2010.04.007","article-title":"Japanese encephalitis virus down-regulates thioredoxin and induces ROS-mediated ASK1-ERK\/p38 MAPK activation in human promonocyte cells","volume":"12","author":"Yang","year":"2010","journal-title":"Microbes Infect."},{"issue":"1-2","key":"10.1016\/j.virusres.2017.02.012_bib0485","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S0014-5793(01)02573-X","article-title":"West Nile virus-induced bax-dependent apoptosis","volume":"500","author":"del Carmen Parquet","year":"2001","journal-title":"FEBS Lett."}],"container-title":["Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170216308358?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170216308358?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T08:27:25Z","timestamp":1601713645000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168170216308358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":97,"alternative-id":["S0168170216308358"],"URL":"https:\/\/doi.org\/10.1016\/j.virusres.2017.02.012","relation":{},"ISSN":["0168-1702"],"issn-type":[{"value":"0168-1702","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Japanese encephalitis virus disrupts blood-brain barrier and modulates apoptosis proteins in THBMEC cells","name":"articletitle","label":"Article Title"},{"value":"Virus Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virusres.2017.02.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}