{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T07:43:53Z","timestamp":1778571833854,"version":"3.51.4"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5 T32 AI 78876-4"],"award-info":[{"award-number":["5 T32 AI 78876-4"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["SUB UC 39778-5-30658"],"award-info":[{"award-number":["SUB UC 39778-5-30658"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005302","name":"University of Illinois at Urbana-Champaign","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005302","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virus Research"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.virusres.2018.01.004","type":"journal-article","created":{"date-parts":[[2018,1,16]],"date-time":"2018-01-16T20:34:56Z","timestamp":1516134896000},"page":"55-64","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Characterizing the effects of insertion of a 5.2\u202fkb region of a VACV genome, which contains known immune evasion genes, on MVA immunogenicity"],"prefix":"10.1016","volume":"246","author":[{"given":"Melissa R.","family":"Ryerson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna L.","family":"Shisler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.virusres.2018.01.004_bib0005","first-page":"178","article-title":"Transcription factors as activators of gene transcription: AP-1 and NF-kappa B","volume":"52","author":"Adcock","year":"1997","journal-title":"Monaldi Arch. Chest Dis."},{"key":"10.1016\/j.virusres.2018.01.004_bib0010","doi-asserted-by":"crossref","first-page":"8580","DOI":"10.1038\/s41598-017-08719-y","article-title":"Modified vaccinia virus Ankara preferentially targets antigen presenting cells in vitro, ex vivo and in vivo","volume":"7","author":"Altenburg","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.virusres.2018.01.004_bib0015","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/BF01311113","article-title":"Partial deletion of the human host range gene in the attenuated vaccinia virus MVA","volume":"105","author":"Altenburger","year":"1989","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0020","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.0105-2896.2006.00392.x","article-title":"Immunity and immunological memory following smallpox vaccination","volume":"211","author":"Amanna","year":"2006","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.virusres.2018.01.004_bib0025","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1006\/viro.1998.9123","article-title":"The complete genomic sequence of the modified vaccinia Ankara strain: comparison with other orthopoxviruses","volume":"244","author":"Antoine","year":"1998","journal-title":"Virology"},{"key":"10.1016\/j.virusres.2018.01.004_bib0030","doi-asserted-by":"crossref","first-page":"9458","DOI":"10.1073\/pnas.1233578100","article-title":"Shared modes of protection against poxvirus infection by attenuated and conventional smallpox vaccine viruses","volume":"100","author":"Belyakov","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.virusres.2018.01.004_bib0035","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1099\/jgv.0.000576","article-title":"Vaccinia virus K1 ankyrin repeat protein inhibits NF-kappaB activation by preventing RelA acetylation","volume":"97","author":"Bravo Cruz","year":"2016","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0040","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00542-17","article-title":"Deletion of the K1L gene results in a vaccinia virus that is less pathogenic due to muted innate immune responses, yet still elicits protective immunity","volume":"91","author":"Bravo Cruz","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0045","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1006\/viro.1997.8845","article-title":"Host range and cytopathogenicity of the highly attenuated MVA strain of vaccinia virus: propagation and generation of recombinant viruses in a nonhuman mammalian cell line","volume":"238","author":"Carroll","year":"1997","journal-title":"Virology"},{"key":"10.1016\/j.virusres.2018.01.004_bib0050","doi-asserted-by":"crossref","first-page":"10397","DOI":"10.1128\/JVI.79.16.10397-10407.2005","article-title":"Vaccinia virus tropism for primary hematolymphoid cells is determined by restricted expression of a unique virus receptor","volume":"79","author":"Chahroudi","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0055","doi-asserted-by":"crossref","first-page":"8469","DOI":"10.1128\/JVI.02749-05","article-title":"Differences and similarities in viral life cycle progression and host cell physiology after infection of human dendritic cells with modified vaccinia virus Ankara and vaccinia virus","volume":"80","author":"Chahroudi","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0060","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1099\/vir.0.81417-0","article-title":"Deletion of gene A41L enhances vaccinia virus immunogenicity and vaccine efficacy","volume":"87","author":"Clark","year":"2006","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0065","first-page":"1498","article-title":"Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B","volume":"10","author":"Collart","year":"1990","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0070","doi-asserted-by":"crossref","first-page":"e1638","DOI":"10.1371\/journal.pone.0001638","article-title":"Recombination-mediated genetic engineering of a bacterial artificial chromosome clone of modified vaccinia virus Ankara (MVA)","volume":"3","author":"Cottingham","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.virusres.2018.01.004_bib0075","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1002\/embj.201488027","article-title":"Dendritic cell maturation: functional specialization through signaling specificity and transcriptional programming","volume":"33","author":"Dalod","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.virusres.2018.01.004_bib0080","doi-asserted-by":"crossref","first-page":"e1000480","DOI":"10.1371\/journal.ppat.1000480","article-title":"Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome","volume":"5","author":"Delaloye","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virusres.2018.01.004_bib0085","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1006\/viro.2000.0203","article-title":"Vaccinia virus-related events and phenotypic changes after infection of dendritic cells derived from human monocytes","volume":"268","author":"Drillien","year":"2000","journal-title":"Virology"},{"key":"10.1016\/j.virusres.2018.01.004_bib0090","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1099\/vir.0.79998-0","article-title":"Modified vaccinia virus Ankara induces moderate activation of human dendritic cells","volume":"85","author":"Drillien","year":"2004","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0095","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1139\/o97-043","article-title":"Cleavage of poly(ADP-ribose) polymerase: a sensitive parameter to study cell death","volume":"75","author":"Duriez","year":"1997","journal-title":"Biochem. Cell Biol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0100","doi-asserted-by":"crossref","first-page":"6762","DOI":"10.4049\/jimmunol.163.12.6762","article-title":"Vaccinia virus inhibits the maturation of human dendritic cells: a novel mechanism of immune evasion","volume":"163","author":"Engelmayer","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0105","doi-asserted-by":"crossref","first-page":"e32220","DOI":"10.1371\/journal.pone.0032220","article-title":"Improving the MVA vaccine potential by deleting the viral gene coding for the IL-18 binding protein","volume":"7","author":"Falivene","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.virusres.2018.01.004_bib0110","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1016\/j.vaccine.2007.12.059","article-title":"Short- and long-term immunogenicity and protection induced by non-replicating smallpox vaccine candidates in mice and comparison with the traditional 1st generation vaccine","volume":"26","author":"Ferrier-Rembert","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.virusres.2018.01.004_bib0115","doi-asserted-by":"crossref","first-page":"739","DOI":"10.3109\/14653249.2010.549123","article-title":"Uptake of antigens from modified vaccinia Ankara virus-infected leukocytes enhances the immunostimulatory capacity of dendritic cells","volume":"13","author":"Flechsig","year":"2011","journal-title":"Cytotherapy"},{"key":"10.1016\/j.virusres.2018.01.004_bib0120","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4049\/jimmunol.0900999","article-title":"Altered CD8(+) T cell immunodominance after vaccinia virus infection and the na\u00efve repertoire in inbred and F(1) mice","volume":"184","author":"Flesch","year":"2010","journal-title":"J. Immunol. (Baltim. Md: 1950)"},{"key":"10.1016\/j.virusres.2018.01.004_bib0125","series-title":"Vaccinia Virus and Poxvirology: Methods and Protocols","first-page":"199","article-title":"Analyzing CD8\u2009T cells in mouse models of poxvirus infection","author":"Flesch","year":"2012"},{"key":"10.1016\/j.virusres.2018.01.004_bib0130","doi-asserted-by":"crossref","first-page":"8562","DOI":"10.1016\/j.vaccine.2007.10.017","article-title":"Clinical and immunologic responses to multiple doses of IMVAMUNE\u00ae (Modified Vaccinia Ankara) followed by Dryvax\u00ae challenge","volume":"25","author":"Frey","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.virusres.2018.01.004_bib0135","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.4161\/hv.28974","article-title":"Enhancing poxvirus vectors vaccine immunogenicity","volume":"10","author":"Garc\u00eda-Arriaza","year":"2014","journal-title":"Hum. Vaccines Immunother."},{"key":"10.1016\/j.virusres.2018.01.004_bib0140","doi-asserted-by":"crossref","first-page":"e66894","DOI":"10.1371\/journal.pone.0066894","article-title":"Improving adaptive and memory immune responses of an HIV\/AIDS vaccine candidate MVA-B by deletion of vaccinia virus genes (C6L and K7R) blocking interferon signaling pathways","volume":"8","author":"Garc\u00eda-Arriaza","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.virusres.2018.01.004_bib0145","doi-asserted-by":"crossref","first-page":"3392","DOI":"10.1128\/JVI.02723-13","article-title":"Deletion of the vaccinia virus N2L gene encoding an inhibitor of IRF3 improves the immunogenicity of modified vaccinia virus Ankara expressing HIV-1 antigens","volume":"88","author":"Garc\u00eda-Arriaza","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0150","doi-asserted-by":"crossref","first-page":"e24244","DOI":"10.1371\/journal.pone.0024244","article-title":"A candidate HIV\/AIDS vaccine (MVA-B) lacking vaccinia virus gene C6L enhances memory HIV-1-specific T-cell responses","volume":"6","author":"Garcia-Arriaza","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.virusres.2018.01.004_bib0155","doi-asserted-by":"crossref","first-page":"11925","DOI":"10.1128\/JVI.00903-07","article-title":"Cross-priming of cytotoxic T cells dictates antigen requisites for modified vaccinia virus Ankara vector vaccines","volume":"81","author":"Gasteiger","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0160","doi-asserted-by":"crossref","first-page":"8676","DOI":"10.1128\/JVI.00935-06","article-title":"Poxviral regulation of the host NF-\u03baB response: the vaccinia virus M2L protein inhibits induction of NF-\u03baB activation via an ERK2 pathway in virus-infected human embryonic kidney cells","volume":"80","author":"Gedey","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0165","doi-asserted-by":"crossref","first-page":"5452","DOI":"10.1128\/JVI.00264-12","article-title":"Modified vaccinia virus Ankara-based vaccine vectors induce apoptosis in dendritic cells draining from the skin via both the extrinsic and intrinsic caspase pathways, preventing efficient antigen presentation","volume":"86","author":"Guzman","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0170","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1101\/gad.183434.111","article-title":"NF-\u03baB, the first quarter-century: remarkable progress and outstanding questions","volume":"26","author":"Hayden","year":"2012","journal-title":"Genes Dev."},{"key":"10.1016\/j.virusres.2018.01.004_bib0175","doi-asserted-by":"crossref","first-page":"6758","DOI":"10.1038\/sj.onc.1209943","article-title":"NF-[kappa]B and the immune response","volume":"25","author":"Hayden","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.virusres.2018.01.004_bib0180","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1189\/jlb.3A1116-492R","article-title":"TLR10 suppresses the activation and differentiation of monocytes with effects on DC-mediated adaptive immune responses","volume":"101","author":"Hess","year":"2017","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0185","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.virol.2007.11.034","article-title":"Characterization of wild-type and mutant vaccinia virus M2L proteins\u2019 abilities to localize to the endoplasmic reticulum and to inhibit NF-kappaB activation during infection","volume":"373","author":"Hinthong","year":"2008","journal-title":"Virology"},{"key":"10.1016\/j.virusres.2018.01.004_bib0190","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/embr.201337983","article-title":"The I\u03baB kinase complex in NF-\u03baB regulation and beyond","volume":"15","author":"Hinz","year":"2014","journal-title":"EMBO Rep."},{"key":"10.1016\/j.virusres.2018.01.004_bib0195","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3390\/v8050139","article-title":"Deletion of A44L, A46R and C12L vaccinia virus genes from the MVA genome improved the vector immunogenicity by modifying the innate immune response generating enhanced and optimized specific T-cell responses","volume":"8","author":"Holgado","year":"2016","journal-title":"Viruses"},{"key":"10.1016\/j.virusres.2018.01.004_bib0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.antiviral.2009.06.006","article-title":"Vaccinia virus vaccines: past, present and future","volume":"84","author":"Jacobs","year":"2009","journal-title":"Antivir. Res."},{"key":"10.1016\/j.virusres.2018.01.004_bib0205","first-page":"3976","article-title":"Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis","volume":"53","author":"Kaufmann","year":"1993","journal-title":"Cancer Res."},{"key":"10.1016\/j.virusres.2018.01.004_bib0210","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1471-2172-11-26","article-title":"Differential cytokine regulation by NF-\u03baB and AP-1 in Jurkat T-cells","volume":"11","author":"Khalaf","year":"2010","journal-title":"BMC Immunol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0215","doi-asserted-by":"crossref","first-page":"e25674","DOI":"10.1371\/journal.pone.0025674","article-title":"Improved NYVAC-based vaccine vectors","volume":"6","author":"Kibler","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.virusres.2018.01.004_bib0220","doi-asserted-by":"crossref","first-page":"8471","DOI":"10.1007\/s13277-016-5035-9","article-title":"Major apoptotic mechanisms and genes involved in apoptosis","volume":"37","author":"Kiraz","year":"2016","journal-title":"Tumour Biol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0225","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.4049\/jimmunol.164.8.4277","article-title":"TNF-\u03b1 gene expression in macrophages: regulation by NF-\u03baB is independent of c-Jun or C\/EBP\u03b2","volume":"164","author":"Liu","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0230","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1471-2172-9-15","article-title":"Dendritic cells are preferentially targeted among hematolymphocytes by Modified Vaccinia Virus Ankara and play a key role in the induction of virus-specific T cell responses in vivo","volume":"9","author":"Liu","year":"2008","journal-title":"BMC Immunol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0235","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/BF01641272","article-title":"Abstammung, Eigenschaften und Verwendung des attenuierten Vaccinia-Stammes MVA","volume":"3","author":"Mayr","year":"1975","journal-title":"Infection"},{"key":"10.1016\/j.virusres.2018.01.004_bib0240","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1099\/vir.0.83156-0","article-title":"Genomic sequence of chorioallantois vaccinia virus Ankara, the ancestor of modified vaccinia virus Ankara","volume":"88","author":"Meisinger-Henschel","year":"2007","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0245","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.1016\/j.vaccine.2013.07.057","article-title":"Attenuation and immunogenicity of host-range extended modified vaccinia virus Ankara recombinants","volume":"31","author":"Melamed","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.virusres.2018.01.004_bib0250","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.virol.2005.06.002","article-title":"Enhanced immunogenicity and protective effect conferred by vaccination with combinations of modified vaccinia virus Ankara and licensed smallpox vaccine Dryvax in a mouse model","volume":"339","author":"Meseda","year":"2005","journal-title":"Virology"},{"issue":"Pt. 5","key":"10.1016\/j.virusres.2018.01.004_bib0255","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1099\/0022-1317-72-5-1031","article-title":"Mapping of deletions in the genome of the highly attenuated vaccinia virus MVA and their influence on virulence","volume":"72","author":"Meyer","year":"1991","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0260","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.immuni.2008.02.020","article-title":"Human effector and memory CD8+ T cell responses to smallpox and yellow fever vaccines","volume":"28","author":"Miller","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.virusres.2018.01.004_bib0265","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1006\/smim.2000.0296","article-title":"Immunology 101 at poxvirus U: immune evasion genes","volume":"13","author":"Moss","year":"2001","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0270","doi-asserted-by":"crossref","first-page":"a010199","DOI":"10.1101\/cshperspect.a010199","article-title":"Poxvirus DNA replication","volume":"5","author":"Moss","year":"2013","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0275","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1006\/viro.2001.1090","article-title":"Cowpox virus and other members of the Orthopoxvirus genus interfere with the regulation of NF-\u03baB activation","volume":"288","author":"Oie","year":"2001","journal-title":"Virology"},{"key":"10.1016\/j.virusres.2018.01.004_bib0280","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/sj.icb.7100118","article-title":"Correlates of protective immunity in poxvirus infection: where does antibody stand?","volume":"86","author":"Panchanathan","year":"2007","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0285","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.cell.2011.11.036","article-title":"Bridging innate and adaptive immunity","volume":"147","author":"Paul William","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.virusres.2018.01.004_bib0290","doi-asserted-by":"crossref","first-page":"e48524","DOI":"10.1371\/journal.pone.0048524","article-title":"Deletion of the viral anti-apoptotic gene F1L in the HIV\/AIDS vaccine candidate MVA-C enhances immune responses against HIV-1 antigens","volume":"7","author":"Perdiguero","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.virusres.2018.01.004_bib0295","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/0042-6822(90)90296-4","article-title":"Vaccinia virus host range genes","volume":"179","author":"Perkus","year":"1990","journal-title":"Virology"},{"key":"10.1016\/j.virusres.2018.01.004_bib0300","doi-asserted-by":"crossref","first-page":"e16819","DOI":"10.1371\/journal.pone.0016819","article-title":"Improved innate and adaptive immunostimulation by genetically modified HIV-1 protein expressing NYVAC vectors","volume":"6","author":"Quakkelaar","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.virusres.2018.01.004_bib0305","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1615\/CritRevImmunol.v31.i5.20","article-title":"LPS-induced cytokine production in human monocytes and macrophages","volume":"31","author":"Rossol","year":"2011","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0310","doi-asserted-by":"crossref","first-page":"5511","DOI":"10.1128\/JVI.00468-14","article-title":"Differential induction of apoptosis, interferon signaling, and phagocytosis in macrophages infected with a panel of attenuated and nonattenuated poxviruses","volume":"88","author":"Royo","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0315","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/icb.2014.10","article-title":"Strikingly poor CD8+ T-cell immunogenicity of vaccinia virus strain MVA in BALB\/c mice","volume":"92","author":"Russell","year":"2014","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0320","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01385-17","article-title":"Vaccinia virus encodes a novel inhibitor of apoptosis that associates with the apoptosome","volume":"91","author":"Ryerson","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0325","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.3390\/v7041726","article-title":"The evolution of poxvirus vaccines","volume":"7","author":"S\u00e1nchez-Sampedro","year":"2015","journal-title":"Viruses"},{"key":"10.1016\/j.virusres.2018.01.004_bib0330","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1084\/jem.171.1.35","article-title":"Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages","volume":"171","author":"Shakhov","year":"1990","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.virusres.2018.01.004_bib0335","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1128\/JVI.78.7.3553-3560.2004","article-title":"The vaccinia virus K1L gene product inhibits host NF- B activation by preventing I B degradation","volume":"78","author":"Shisler","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0340","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.2144\/00286st04","article-title":"Transient host range selection for genetic engineering of modified vaccinia virus Ankara","volume":"28","author":"Staib","year":"2000","journal-title":"Biotechniques"},{"key":"10.1016\/j.virusres.2018.01.004_bib0345","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1099\/vir.0.80646-0","article-title":"Inactivation of the viral interleukin 1\u03b2 receptor improves CD8+ T-cell memory responses elicited upon immunization with modified vaccinia virus Ankara","volume":"86","author":"Staib","year":"2005","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0350","doi-asserted-by":"crossref","first-page":"10847","DOI":"10.1073\/pnas.89.22.10847","article-title":"Nonreplicating vaccinia vector efficiently expresses recombinant genes","volume":"89","author":"Sutter","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.virusres.2018.01.004_bib0355","doi-asserted-by":"crossref","first-page":"6318","DOI":"10.1128\/JVI.00427-06","article-title":"Poxvirus CD8(+) T-cell determinants and cross-reactivity in BALB\/c mice","volume":"80","author":"Tscharke","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0360","doi-asserted-by":"crossref","first-page":"e1002247","DOI":"10.1371\/journal.ppat.1002247","article-title":"Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7","volume":"7","author":"Unterholzner","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virusres.2018.01.004_bib0365","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.imlet.2008.02.003","article-title":"Human and murine model cell lines for dendritic cell biology evaluated","volume":"117","author":"van Helden","year":"2008","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.virusres.2018.01.004_bib0370","doi-asserted-by":"crossref","first-page":"961","DOI":"10.4161\/hv.21080","article-title":"A vaccinia virus renaissance","volume":"8","author":"Verardi","year":"2012","journal-title":"Hum. Vaccines Immunother."},{"key":"10.1016\/j.virusres.2018.01.004_bib0375","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.4049\/jimmunol.158.6.2919","article-title":"Bacterial lipopolysaccharide stimulates the production of cytokines and the expression of costimulatory molecules by human peripheral blood dendritic cells: evidence for a soluble CD14-dependent pathway","volume":"158","author":"Verhasselt","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0380","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/bs.aivir.2016.07.001","article-title":"Modified vaccinia virus Ankara","volume":"97","author":"Volz","year":"2017","journal-title":"Adv. Virus Res."},{"key":"10.1016\/j.virusres.2018.01.004_bib0385","doi-asserted-by":"crossref","first-page":"4263","DOI":"10.1128\/IAI.00594-07","article-title":"Coxiella burnetii inhibits apoptosis in human THP-1 cells and monkey primary alveolar macrophages","volume":"75","author":"Voth","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.virusres.2018.01.004_bib0390","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.virol.2009.08.020","article-title":"The effect of the vaccinia K1 protein on the PKR-eIF2alpha pathway in RK13 and HeLa cells","volume":"394","author":"Willis","year":"2009","journal-title":"Virology"},{"key":"10.1016\/j.virusres.2018.01.004_bib0395","doi-asserted-by":"crossref","first-page":"7765","DOI":"10.1074\/jbc.M110.194704","article-title":"Viral double-stranded RNAs from vaccinia virus early or intermediate gene transcripts possess PKR activating function, resulting in NF-kappaB activation, when the K1 protein is absent or mutated","volume":"286","author":"Willis","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virusres.2018.01.004_bib0400","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1006\/viro.1998.9397","article-title":"Marker rescue of the host range restriction defects of modified vaccinia virus Ankara","volume":"251","author":"Wyatt","year":"1998","journal-title":"Virology"},{"key":"10.1016\/j.virusres.2018.01.004_bib0405","doi-asserted-by":"crossref","first-page":"4590","DOI":"10.1073\/pnas.0401165101","article-title":"Highly attenuated smallpox vaccine protects mice with and without immune deficiencies against pathogenic vaccinia virus challenge","volume":"101","author":"Wyatt","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.virusres.2018.01.004_bib0410","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.cellimm.2007.06.005","article-title":"Vaccinia virus infection induces dendritic cell maturation but inhibits antigen presentation by MHC class II","volume":"246","author":"Yao","year":"2007","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.virusres.2018.01.004_bib0415","doi-asserted-by":"crossref","DOI":"10.1186\/1743-422X-10-34","article-title":"Interleukin-1\u03b2 receptor expressed by modified vaccinia virus Ankara interferes with interleukin-1\u03b2 activity produced in various virus-infected antigen-presenting cells","volume":"10","author":"Zimmerling","year":"2013","journal-title":"Virol. J."}],"container-title":["Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170217308602?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170217308602?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T14:05:13Z","timestamp":1759154713000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168170217308602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":83,"alternative-id":["S0168170217308602"],"URL":"https:\/\/doi.org\/10.1016\/j.virusres.2018.01.004","relation":{},"ISSN":["0168-1702"],"issn-type":[{"value":"0168-1702","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterizing the effects of insertion of a 5.2\u202fkb region of a VACV genome, which contains known immune evasion genes, on MVA immunogenicity","name":"articletitle","label":"Article Title"},{"value":"Virus Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virusres.2018.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}