{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:58:54Z","timestamp":1791388734202,"version":"4.3.3"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC. 31570156"],"award-info":[{"award-number":["NSFC. 31570156"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Science and Technology Major Project on Infectious Diseases","award":["2012ZX10004503-003"],"award-info":[{"award-number":["2012ZX10004503-003"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virus Research"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.virusres.2019.03.017","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T12:15:12Z","timestamp":1553256912000},"page":"104-114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Characteristics of enterovirus 71-induced cell death and genome scanning to identify viral genes involved in virus-induced cell apoptosis"],"prefix":"10.1016","volume":"265","author":[{"given":"Jinjin","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xixi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5631-8884","authenticated-orcid":false,"given":"Jian-Er","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virusres.2019.03.017_bib0005","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01447-18","article-title":"Involvement of a non-structural protein in poliovirus capsid assembly","author":"Adeyemi","year":"2018","journal-title":"J. Virol."},{"issue":"4","key":"10.1016\/j.virusres.2019.03.017_bib0010","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s11908-012-0267-3","article-title":"The pathogenesis and prevention of encephalitis due to human enterovirus 71","volume":"14","author":"Bek","year":"2012","journal-title":"Curr. Infect. Dis. Rep."},{"issue":"1","key":"10.1016\/j.virusres.2019.03.017_bib0015","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00705-014-2249-2","article-title":"Prediction of signaling pathways involved in enterovirus 71 infection by algorithm analysis based on miRNA profiles and their target genes","volume":"160","author":"Bian","year":"2015","journal-title":"Arch. Virol."},{"issue":"1","key":"10.1016\/j.virusres.2019.03.017_bib0020","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/ncb2883","article-title":"Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis","volume":"16","author":"Cai","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.virusres.2019.03.017_bib0025","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1146\/annurev-immunol-032414-112248","article-title":"Programmed necrosis in the cross talk of cell death and inflammation","volume":"33","author":"Chan","year":"2015","journal-title":"Annu. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.virusres.2019.03.017_bib0030","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1080\/13550280490521032","article-title":"Diverse apoptotic pathways in enterovirus 71-infected cells","volume":"10","author":"Chang","year":"2004","journal-title":"J. Neurovirol."},{"issue":"6","key":"10.1016\/j.virusres.2019.03.017_bib0035","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/jmv.20623","article-title":"Enterovirus 71 infection induces Fas ligand expression and apoptosis of Jurkat cells","volume":"78","author":"Chen","year":"2006","journal-title":"J. Med. Virol."},{"issue":"11","key":"10.1016\/j.virusres.2019.03.017_bib0040","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1111\/j.1462-5822.2007.00988.x","article-title":"Enterovirus 71 triggering of neuronal apoptosis through activation of Abl-Cdk5 signalling","volume":"9","author":"Chen","year":"2007","journal-title":"Cell. Microbiol."},{"issue":"5","key":"10.1016\/j.virusres.2019.03.017_bib0045","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/jmv.23254","article-title":"Increased frequency of Th17 cells in the peripheral blood of children infected with enterovirus 71","volume":"84","author":"Chen","year":"2012","journal-title":"J. Med. Virol."},{"issue":"21","key":"10.1016\/j.virusres.2019.03.017_bib0050","doi-asserted-by":"crossref","first-page":"9862","DOI":"10.1128\/JVI.01499-16","article-title":"Enterovirus 71 2B induces cell apoptosis by directly inducing the conformational activation of the proapoptotic protein bax","volume":"90","author":"Cong","year":"2016","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.virusres.2019.03.017_bib0055","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jmb.2011.03.007","article-title":"Crystal structure of human enterovirus 71 3C protease","volume":"408","author":"Cui","year":"2011","journal-title":"J. Mol. Biol."},{"issue":"7610","key":"10.1016\/j.virusres.2019.03.017_bib0060","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature18590","article-title":"Pore-forming activity and structural autoinhibition of the gasdermin family","volume":"535","author":"Ding","year":"2016","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.virusres.2019.03.017_bib0065","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/1097-0320(20010201)43:2<134::AID-CYTO1028>3.0.CO;2-L","article-title":"Flow cytometric analysis of apoptotic subpopulations with a combination of annexin V-FITC, propidium iodide, and SYTO 17","volume":"43","author":"Eray","year":"2001","journal-title":"Cytometry"},{"issue":"12","key":"10.1016\/j.virusres.2019.03.017_bib0070","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1038\/cdd.2015.58","article-title":"Cytoplasmic translocation, aggregation, and cleavage of TDP-43 by enteroviral proteases modulate viral pathogenesis","volume":"22","author":"Fung","year":"2015","journal-title":"Cell Death Differ."},{"issue":"3","key":"10.1016\/j.virusres.2019.03.017_bib0075","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1099\/jgv.0.000705","article-title":"Enterovirus 71 induces apoptosis by directly modulating the conformational activation of pro-apoptotic protein Bax","volume":"98","author":"Han","year":"2017","journal-title":"J. Gen. Virol."},{"issue":"1","key":"10.1016\/j.virusres.2019.03.017_bib0080","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.chom.2010.12.001","article-title":"Enterovirus-induced miR-141 contributes to shutoff of host protein translation by targeting the translation initiation factor eIF4E","volume":"9","author":"Ho","year":"2011","journal-title":"Cell Host Microbe"},{"issue":"6","key":"10.1016\/j.virusres.2019.03.017_bib0085","doi-asserted-by":"crossref","DOI":"10.1096\/fasebj.21.6.A1351-c","article-title":"Quantitative analysis of mitochondrial membrane potential measurements with JC-1","volume":"21","author":"Huang","year":"2007","journal-title":"Faseb J."},{"issue":"2","key":"10.1016\/j.virusres.2019.03.017_bib0090","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.immuni.2013.02.003","article-title":"Necroptosis: the release of damage-associated molecular patterns and its physiological relevance","volume":"38","author":"Kaczmarek","year":"2013","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.virusres.2019.03.017_bib0095","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.coviro.2013.05.019","article-title":"Viral modulation of programmed necrosis","volume":"3","author":"Kaiser","year":"2013","journal-title":"Curr. Opin. Virol."},{"issue":"9","key":"10.1016\/j.virusres.2019.03.017_bib0100","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.tcb.2017.05.005","article-title":"Gasdermins: effectors of pyroptosis","volume":"27","author":"Kovacs","year":"2017","journal-title":"Trends Cell Biol."},{"issue":"Pt 6","key":"10.1016\/j.virusres.2019.03.017_bib0105","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1099\/0022-1317-83-6-1367","article-title":"Infection with enterovirus 71 or expression of its 2A protease induces apoptotic cell death","volume":"83","author":"Kuo","year":"2002","journal-title":"J. Gen. Virol."},{"issue":"10","key":"10.1016\/j.virusres.2019.03.017_bib0110","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3345\/kjp.2016.59.10.395","article-title":"Enterovirus 71 infection and neurological complications","volume":"59","author":"Lee","year":"2016","journal-title":"Korean J. Pediatr."},{"key":"10.1016\/j.virusres.2019.03.017_bib0115","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01069-17","article-title":"Enterovirus 71 inhibits pyroptosis through cleavage of GSDMD","author":"Lei","year":"2017","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.virusres.2019.03.017_bib0120","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1006\/viro.2001.1310","article-title":"The 3C protease activity of enterovirus 71 induces human neural cell apoptosis","volume":"293","author":"Li","year":"2002","journal-title":"Virology"},{"issue":"2","key":"10.1016\/j.virusres.2019.03.017_bib0125","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02016-16","article-title":"Enterovirus 71 3C promotes apoptosis through cleavage of PinX1, a telomere binding protein","volume":"91","author":"Li","year":"2017","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.virusres.2019.03.017_bib0130","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1086\/345905","article-title":"Proinflammatory cytokine reactions in enterovirus 71 infections of the central nervous system","volume":"36","author":"Lin","year":"2003","journal-title":"Clin. Infect. Dis."},{"issue":"10","key":"10.1016\/j.virusres.2019.03.017_bib0135","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.3181\/0903-RM-116","article-title":"Enterovirus 71 infection of human dendritic cells","volume":"234","author":"Lin","year":"2009","journal-title":"Exp. Biol. Med. (Maywood)"},{"issue":"36","key":"10.1016\/j.virusres.2019.03.017_bib0140","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.3748\/wjg.v17.i36.4135","article-title":"Viral kinetics of enterovirus 71 in human abdomyosarcoma cells","volume":"17","author":"Lu","year":"2011","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.virusres.2019.03.017_bib0145","doi-asserted-by":"crossref","DOI":"10.1186\/2193-1801-2-267","article-title":"Characterisation of enterovirus 71 replication kinetics in human colorectal cell line, HT29","volume":"2","author":"Lui","year":"2013","journal-title":"Springerplus"},{"issue":"8","key":"10.1016\/j.virusres.2019.03.017_bib0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006585","article-title":"HRS plays an important role for TLR7 signaling to orchestrate inflammation and innate immunity upon EV71 infection","volume":"13","author":"Luo","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virusres.2019.03.017_bib0155","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.coviro.2015.02.007","article-title":"Inflammasome control of viral infection","volume":"12","author":"Lupfer","year":"2015","journal-title":"Curr. Opin. Virol."},{"issue":"2","key":"10.1016\/j.virusres.2019.03.017_bib0160","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.coviro.2012.02.009","article-title":"Recent advances in the molecular epidemiology and control of human enterovirus 71 infection","volume":"2","author":"McMinn","year":"2012","journal-title":"Curr. Opin. Virol."},{"issue":"22","key":"10.1016\/j.virusres.2019.03.017_bib0165","doi-asserted-by":"crossref","first-page":"4530","DOI":"10.1016\/j.jmb.2013.08.016","article-title":"Crystal structure of 2A proteinase from hand, foot and mouth disease virus","volume":"425","author":"Mu","year":"2013","journal-title":"J. Mol. Biol."},{"issue":"3","key":"10.1016\/j.virusres.2019.03.017_bib0170","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.immuni.2013.06.018","article-title":"The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism","volume":"39","author":"Murphy","year":"2013","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.virusres.2019.03.017_bib0175","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nri.2016.153","article-title":"Programmed cell death and the immune system","volume":"17","author":"Nagata","year":"2017","journal-title":"Nat. Rev. Immunol."},{"issue":"50","key":"10.1016\/j.virusres.2019.03.017_bib0180","doi-asserted-by":"crossref","first-page":"33533","DOI":"10.1074\/jbc.273.50.33533","article-title":"Importance of poly(ADP-ribose) polymerase and its cleavage in apoptosis - Lesson from an uncleavable mutant","volume":"273","author":"Oliver","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.virusres.2019.03.017_bib0185","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/bpa.12279","article-title":"Understanding enterovirus 71 neuropathogenesis and its impact on other neurotropic enteroviruses","volume":"25","author":"Ong","year":"2015","journal-title":"Brain Pathol."},{"issue":"11","key":"10.1016\/j.virusres.2019.03.017_bib0190","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/S1474-4422(10)70209-X","article-title":"Clinical features, diagnosis, and management of enterovirus 71","volume":"9","author":"Ooi","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.virusres.2019.03.017_bib0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.tcb.2017.05.007","article-title":"Apoptosis and Necroptosis as host defense strategies to prevent viral infection","author":"Orzalli","year":"2017","journal-title":"Trends Cell Biol."},{"issue":"7534","key":"10.1016\/j.virusres.2019.03.017_bib0200","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nature14191","article-title":"Necroptosis and its role in inflammation","volume":"517","author":"Pasparakis","year":"2015","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.virusres.2019.03.017_bib0205","doi-asserted-by":"crossref","first-page":"6613","DOI":"10.3390\/v7122961","article-title":"Innate immunity and immune evasion by enterovirus 71","volume":"7","author":"Pathinayake","year":"2015","journal-title":"Viruses"},{"key":"10.1016\/j.virusres.2019.03.017_bib0210","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/1471-2180-14-147","article-title":"Activation of JNK1\/2 and p38 MAPK signaling pathways promotes enterovirus 71 infection in immature dendritic cells","volume":"14","author":"Peng","year":"2014","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.virusres.2019.03.017_bib0215","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.coi.2017.10.011","article-title":"Recent advances in inflammasome biology","volume":"50","author":"Place","year":"2017","journal-title":"Curr. Opin. Immunol."},{"issue":"7575","key":"10.1016\/j.virusres.2019.03.017_bib0220","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.virusres.2019.03.017_bib0225","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.tibs.2016.10.004","article-title":"Pyroptosis: gasdermin-mediated programmed necrotic cell death","volume":"42","author":"Shi","year":"2017","journal-title":"Trends Biochem. Sci."},{"issue":"1","key":"10.1016\/j.virusres.2019.03.017_bib0230","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1080\/13550280701798980","article-title":"Viral protein synthesis is required for Enterovirus 71 to induce apoptosis in human glioblastoma cells","volume":"14","author":"Shih","year":"2008","journal-title":"J. Neurovirol."},{"issue":"19","key":"10.1016\/j.virusres.2019.03.017_bib0235","doi-asserted-by":"crossref","first-page":"9658","DOI":"10.1128\/JVI.05063-11","article-title":"Host factors in enterovirus 71 replication","volume":"85","author":"Shih","year":"2011","journal-title":"J. Virol."},{"issue":"11","key":"10.1016\/j.virusres.2019.03.017_bib0240","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S1473-3099(10)70194-8","article-title":"Virology, epidemiology, pathogenesis, and control of enterovirus 71","volume":"10","author":"Solomon","year":"2010","journal-title":"Lancet Infect. Dis."},{"issue":"2","key":"10.1016\/j.virusres.2019.03.017_bib0245","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.cellsig.2009.09.018","article-title":"Enterovirus 71 induces COX-2 expression via MAPKs, NF-kappaB, and AP-1 in SK-N-SH cells: role of PGE(2) in viral replication","volume":"22","author":"Tung","year":"2010","journal-title":"Cell. Signal."},{"issue":"4","key":"10.1016\/j.virusres.2019.03.017_bib0250","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1086\/376998","article-title":"Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: roles of cytokines and cellular immune activation in patients with pulmonary edema","volume":"188","author":"Wang","year":"2003","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.virusres.2019.03.017_bib0255","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/876241","article-title":"Cytokine immunopathogenesis of enterovirus 71 brain stem encephalitis","volume":"2012","author":"Wang","year":"2012","journal-title":"Clin. Dev. Immunol."},{"issue":"1","key":"10.1016\/j.virusres.2019.03.017_bib0260","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.celrep.2015.05.047","article-title":"Reciprocal regulation between enterovirus 71 and the NLRP3 inflammasome","volume":"12","author":"Wang","year":"2015","journal-title":"Cell Rep."},{"issue":"10","key":"10.1016\/j.virusres.2019.03.017_bib0265","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006674","article-title":"Enterovirus 71 protease 2A(pro) and 3C(pro) differentially inhibit the cellular endoplasmic reticulum-associated degradation (ERAD) pathway via distinct mechanisms, and enterovirus 71 hijacks ERAD component p97 to promote its replication","volume":"13","author":"Wang","year":"2017","journal-title":"PLoS Pathog."},{"issue":"1","key":"10.1016\/j.virusres.2019.03.017_bib0270","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006123","article-title":"EV71 3D protein binds with NLRP3 and enhances the assembly of inflammasome complex","volume":"13","author":"Wang","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virusres.2019.03.017_bib0275","article-title":"Pyroptosis induced by enterovirus 71 and coxsackievirus B3 infection affects viral replication and host response","volume":"8","author":"Wang","year":"2018","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.virusres.2019.03.017_bib0280","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.micinf.2010.03.006","article-title":"Neural pathogenesis of enterovirus 71 infection","volume":"12","author":"Weng","year":"2010","journal-title":"Microbes Infect."},{"issue":"4","key":"10.1016\/j.virusres.2019.03.017_bib0285","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S1473-3099(13)70342-6","article-title":"Hand, foot, and mouth disease in China, 2008\u201312: an epidemiological study","volume":"14","author":"Xing","year":"2014","journal-title":"Lancet Infect. Dis."},{"issue":"4","key":"10.1016\/j.virusres.2019.03.017_bib0290","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3109\/00365548.2011.634433","article-title":"Epidemic characteristics of hand, foot, and mouth disease in Shanghai from 2009 to 2010: enterovirus 71 subgenotype C4 as the primary causative agent and a high incidence of mixed infections with coxsackievirus A16","volume":"44","author":"Yan","year":"2012","journal-title":"Scand. J. Infect. Dis."},{"issue":"2","key":"10.1016\/j.virusres.2019.03.017_bib0295","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006901","article-title":"Picornavirus 2A protease regulates stress granule formation to facilitate viral translation","volume":"14","author":"Yang","year":"2018","journal-title":"PLoS Pathog."},{"issue":"1","key":"10.1016\/j.virusres.2019.03.017_bib0300","doi-asserted-by":"crossref","first-page":"5845","DOI":"10.1038\/s41598-017-05589-2","article-title":"AIM2 inflammasome-mediated pyroptosis in enterovirus A71-Infected neuronal cells restricts viral replication","volume":"7","author":"Yogarajah","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.virusres.2019.03.017_bib0305","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3389\/fmicb.2018.00286","article-title":"Enterovirus A71 proteins: structure and function","volume":"9","author":"Yuan","year":"2018","journal-title":"Front. Microbiol."}],"container-title":["Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170218307834?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170218307834?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T02:18:44Z","timestamp":1663121924000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168170218307834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":61,"alternative-id":["S0168170218307834"],"URL":"https:\/\/doi.org\/10.1016\/j.virusres.2019.03.017","relation":{},"ISSN":["0168-1702"],"issn-type":[{"value":"0168-1702","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characteristics of enterovirus 71-induced cell death and genome scanning to identify viral genes involved in virus-induced cell apoptosis","name":"articletitle","label":"Article Title"},{"value":"Virus Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virusres.2019.03.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}