{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T06:33:45Z","timestamp":1792305225197,"version":"4.4.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T00:00:00Z","timestamp":1625356800000},"content-version":"vor","delay-in-days":306,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100009730","name":"Universidade Federal de Ouro Preto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009730","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virus Research"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.virusres.2020.198084","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T11:19:00Z","timestamp":1593688740000},"page":"198084","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"special_numbering":"C","title":["Zika virus induces oxidative stress and decreases antioxidant enzyme activities in vitro and in vivo"],"prefix":"10.1016","volume":"286","author":[{"given":"Let\u00edcia Trindade","family":"Almeida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane Coelho","family":"Ferraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Carla","family":"da Silva Caetano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00edlia Bueno","family":"da Silva Menegatto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Cl\u00e1udia","family":"dos Santos Pereira Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaela Lameira Souza","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Caetano","family":"Camini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samille Henriques","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla Yanca","family":"da Silva Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breno","family":"de Mello Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza Oliveira","family":"Perucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Talvani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Carlos","family":"de Magalh\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cintia Lopes","family":"de Brito Magalh\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virusres.2020.198084_bib0005","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"13","author":"Aebi","year":"1984","journal-title":"Oxyg. Radic. Biol. Syst."},{"key":"10.1016\/j.virusres.2020.198084_bib0010","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.apjtm.2017.03.020","article-title":"Advances in research on Zika virus","volume":"10","author":"Ali","year":"2017","journal-title":"Asian Pac. J. Trop. Med."},{"key":"10.1016\/j.virusres.2020.198084_bib0015","article-title":"Oxidative stress response in the pathogenesis of dengue virus virulence, disease prognosis and therapeutics: an update","author":"Balakrishna","year":"2019","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virusres.2020.198084_bib0020","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","article-title":"Microsomal lipid peroxidation","volume":"52","author":"Buege","year":"1978","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.virusres.2020.198084_bib0025","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s00705-016-3187-y","article-title":"Implications of oxidative stress on viral pathogenesis","volume":"162","author":"Camini","year":"2017","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virusres.2020.198084_bib0030","doi-asserted-by":"crossref","first-page":"8941","DOI":"10.1074\/jbc.M110.186684","article-title":"Hepatitis C virus impairs the induction of cytoprotective Nrf2 target genes by delocalization of small maf proteins","volume":"286","author":"Carvajal-Yepes","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virusres.2020.198084_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.ppat.1005053","article-title":"Activation of TLR2 and TLR6 by dengue NS1 protein and its implications in the immunopathogenesis of dengue virus infection","volume":"11","author":"Chen","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virusres.2020.198084_bib0040","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.medmal.2013.02.004","article-title":"Regulation of oxidative stress by Nrf2 in the pathophysiology of infectious diseases","volume":"43","author":"Deramaudt","year":"2013","journal-title":"Med. Mal. Infect."},{"key":"10.1016\/j.virusres.2020.198084_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0004658","article-title":"A susceptible mouse model for zika virus infection","volume":"10","author":"Dowall","year":"2016","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.virusres.2020.198084_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.micinf.2019.04.005","article-title":"Zika virus infection: an update","author":"Ferraris","year":"2019","journal-title":"Microbes Infect."},{"key":"10.1016\/j.virusres.2020.198084_bib0055","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-11866-7","article-title":"Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice","author":"Figueiredo","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.virusres.2020.198084_bib0060","first-page":"1","article-title":"Clinical relevance of biomarkers of oxidative stress","author":"Frijhoff","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.virusres.2020.198084_bib0065","doi-asserted-by":"crossref","first-page":"51715","DOI":"10.1074\/jbc.R400024200","article-title":"The Nox family of NAD(P)H oxidases: host defense and beyond","volume":"279","author":"Geiszt","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virusres.2020.198084_bib0070","first-page":"1058","article-title":"Biochemistry of oxidative stress","volume":"25","author":"Halliwell","year":"2007","journal-title":"Angew. Chemie Int. Ed. English"},{"issue":"102 Suppl","key":"10.1016\/j.virusres.2020.198084_bib0075","first-page":"5","article-title":"Oxygen-derived species: their relation to human disease and environmental stress","author":"Halliwell","year":"1994","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.virusres.2020.198084_bib0080","series-title":"Free Radicals in Biology & Medice","author":"Halliwell","year":"2015"},{"key":"10.1016\/j.virusres.2020.198084_bib0085","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.micinf.2016.03.009","article-title":"Zika virus: epidemiology, clinical features and host-virus interactions","volume":"18","author":"Hamel","year":"2016","journal-title":"Microbes Infect."},{"key":"10.1016\/j.virusres.2020.198084_bib0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virol.2016.12.019","article-title":"Nrf2-dependent induction of innate host defense via heme oxygenase-1 inhibits Zika virus replication","volume":"503","author":"Huang","year":"2017","journal-title":"Virology"},{"key":"10.1016\/j.virusres.2020.198084_bib0095","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1155\/2017\/3496043","article-title":"Oxidative stress in infection and consequent disease","volume":"2017","author":"Ivanov","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.virusres.2020.198084_bib0100","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.neuint.2009.06.008","article-title":"Imbalance in oxidant\/antioxidant system in different brain regions of rat after the infection of Japanese encephalitis virus","volume":"55","author":"Kumar","year":"2009","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.virusres.2020.198084_bib0105","first-page":"1","article-title":"Apoptosis induction by pseudorabies virus via oxidative stress and subsequent DNA damage signaling","author":"Lai","year":"2019","journal-title":"Intervirology"},{"key":"10.1016\/j.virusres.2020.198084_bib0110","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.chom.2016.03.010","article-title":"A mouse model of Zika virus pathogenesis","volume":"19","author":"Lazear","year":"2016","journal-title":"Cell Host Microbe"},{"issue":"10","key":"10.1016\/j.virusres.2020.198084_bib0115","first-page":"1","article-title":"Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes","volume":"101","author":"Ledur","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.virusres.2020.198084_bib0120","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/6208067","article-title":"Therapeutic modulation of virus-induced oxidative stress via the Nrf2-dependent antioxidative pathway","volume":"2018","author":"Lee","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.virusres.2020.198084_bib0125","series-title":"Carbonyl Assays for Determination of Oxidatively Modified Proteins","first-page":"186","author":"Levine","year":"1994"},{"key":"10.1016\/j.virusres.2020.198084_bib0130","doi-asserted-by":"crossref","DOI":"10.3390\/v10010049","article-title":"Zika virus fatally infects wild type neonatal mice and replicates in central nervous system","volume":"10","author":"Li","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.virusres.2020.198084_bib0135","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0304-3940(02)00236-7","article-title":"Japanese encephalitis virus stimulates superoxide dismutase activity in rat glial cultures","volume":"324","author":"Liao","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.virusres.2020.198084_bib0140","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.4254\/wjh.v7.i29.2880","article-title":"Oxidative stress modulation in hepatitis C virus infected cells","volume":"7","author":"Lozano-Sepulveda","year":"2015","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.virusres.2020.198084_bib0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.ppat.1006004","article-title":"Zika (PRVABC59) infection is associated with t cell infiltration and neurodegeneration in CNS of immunocompetent neonatal C57Bl\/6 mice","volume":"12","author":"Manangeeswaran","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virusres.2020.198084_bib0150","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","article-title":"Involvement of the superoxide anion radical in the autoxidation of Pyrogallol and a convenient assay for superoxide dismutase","volume":"47","author":"Marklund","year":"1974","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.virusres.2020.198084_bib0155","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/j.1440-1746.2009.06128.x","article-title":"Hepatitis C virus induces oxidative stress, DNA damage and modulates the DNA repair enzyme NEIL1","volume":"25","author":"Pal","year":"2009","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.virusres.2020.198084_bib0160","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1099\/jgv.0.001153","article-title":"In vitro and in vivo models for studying Zika virus biology","volume":"99","author":"Pena","year":"2018","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virusres.2020.198084_bib0165","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0006-291X(79)90630-2","article-title":"Sendai virus stimulates chemiluminescence in mouse spleen cells","volume":"91","author":"Peterhans","year":"1979","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.virusres.2020.198084_bib0170","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/8416763","article-title":"Oxidative stress: harms and benefits for human health","volume":"2017","author":"Pizzino","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.virusres.2020.198084_bib0175","first-page":"1","article-title":"The role of Nrf2 transcription factor in viral infection","volume":"22","author":"Ramezani","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.virusres.2020.198084_bib0180","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0304-3940(01)02300-X","article-title":"Role of reactive oxygen intermediates in Japanese encephalitis virus infection in murine neuroblastoma cells","volume":"315","author":"Raung","year":"2001","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.virusres.2020.198084_bib0185","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/467452","article-title":"RNA viruses: ROS-mediated cell death","volume":"2014","author":"Reshi","year":"2014","journal-title":"Int. J. Cell Biol."},{"key":"10.1016\/j.virusres.2020.198084_bib0190","doi-asserted-by":"crossref","first-page":"0","DOI":"10.1590\/0037-8682-0105-2019","article-title":"Descriptive study of suspected congenital Zika syndrome cases during the 2015-2016 epidemic in Brazil","volume":"52","author":"Roma","year":"2019","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.virusres.2020.198084_bib0195","doi-asserted-by":"crossref","DOI":"10.4269\/ajtmh.16-0111","article-title":"Characterization of a novel murine model to study zika virus","author":"Rossi","year":"2016","journal-title":"Am. J. Trop. Med. Hyg. AJTMH"},{"key":"10.1016\/j.virusres.2020.198084_bib0200","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.freeradbiomed.2009.04.035","article-title":"Oxidative damage in dengue fever","volume":"47","author":"Seet","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.virusres.2020.198084_bib0205","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1007\/s10495-011-0639-4","article-title":"Type i IFNs signaling and apoptosis resistance in glioblastoma cells","volume":"16","author":"Sgorbissa","year":"2011","journal-title":"Apoptosis"},{"key":"10.1016\/j.virusres.2020.198084_bib0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0214016","article-title":"Zika virus replication and cytopathic effects in liver cells","volume":"14","author":"Sherman","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.virusres.2020.198084_bib0215","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.redox.2015.01.002","article-title":"Oxidative stress: a concept in redox biology and medicine","volume":"4","author":"Sies","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.virusres.2020.198084_bib0220","series-title":"ICTV ICTV Virus Taxonomy Profile: Flaviviridae","first-page":"2","author":"Simmonds","year":"2018"},{"key":"10.1016\/j.virusres.2020.198084_bib0225","doi-asserted-by":"crossref","first-page":"e00173","DOI":"10.1128\/mSphere.00173-19","article-title":"Zika virus infectes trabecular meshwork and causes trabeculitis and glaucomatous pathology in mouse eyes","volume":"4","author":"Singh","year":"2019","journal-title":"mSpher"},{"key":"10.1016\/j.virusres.2020.198084_bib0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2014.00222","article-title":"A new paradigm: innate immune sensing of viruses via the unfolded protein response","volume":"5","author":"Smith","year":"2014","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.virusres.2020.198084_bib0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2016.01233","article-title":"Interplay between inflammation and cellular stress triggered by Flaviviridae viruses","volume":"7","author":"Valad\u00e3o","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.virusres.2020.198084_bib0240","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0220049","article-title":"Long-term outcomes of Guillain-Barr\u00e9 syndrome possibly associated with Zika virus infection","volume":"14","author":"Walteros","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.virusres.2020.198084_bib0245","article-title":"Inhibitory effect of glutathione on oxidative liver injury induced by dengue virus serotype 2 infections in mice","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.virusres.2020.198084_bib0250","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.bbrc.2018.02.118","article-title":"Zika virus infected primary microglia impairs NPCs proliferation and differentiation","volume":"497","author":"Wang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.virusres.2020.198084_bib0255","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1101\/gad.298216.117","article-title":"How does Zika virus cause microcephaly?","volume":"31","author":"Wen","year":"2017","journal-title":"Genes Dev."},{"key":"10.1016\/j.virusres.2020.198084_bib0260","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/s41564-019-0425-6","article-title":"Basal expression of interferon regulatory factor 1 drives intrinsic hepatocyte resistance to multiple RNA viruses","volume":"4","author":"Yamane","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.virusres.2020.198084_bib0265","doi-asserted-by":"crossref","first-page":"12349","DOI":"10.1128\/JVI.01365-15","article-title":"Flavivirus infection impairs peroxisome biogenesis and early antiviral signaling","volume":"89","author":"You","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2020.198084_bib0270","first-page":"1","article-title":"Review article flaviviridae viruses and oxidative stress: implications for viral pathogenesis","volume":"2019","author":"Zhang","year":"2019","journal-title":"Oxid. Med. Cell. Longev."}],"container-title":["Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170220300332?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170220300332?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T14:16:27Z","timestamp":1759155387000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168170220300332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":54,"alternative-id":["S0168170220300332"],"URL":"https:\/\/doi.org\/10.1016\/j.virusres.2020.198084","relation":{},"ISSN":["0168-1702"],"issn-type":[{"value":"0168-1702","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zika virus induces oxidative stress and decreases antioxidant enzyme activities in vitro and in vivo","name":"articletitle","label":"Article Title"},{"value":"Virus Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virusres.2020.198084","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"198084"}}