{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:58:51Z","timestamp":1791082731111,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["17fk0310111h0001"],"award-info":[{"award-number":["17fk0310111h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["18fk0310111h0002"],"award-info":[{"award-number":["18fk0310111h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["fk0310111h0001"],"award-info":[{"award-number":["fk0310111h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virus Research"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.virusres.2020.198191","type":"journal-article","created":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T19:24:07Z","timestamp":1602357847000},"page":"198191","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Development of an in vivo delivery system for CRISPR\/Cas9-mediated targeting of hepatitis B virus cccDNA"],"prefix":"10.1016","volume":"290","author":[{"given":"Mohammad Enamul Hoque","family":"Kayesh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Amako","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Abul","family":"Hashem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuko","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuro","family":"Hifumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Miyoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhito","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Mizokami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michinori","family":"Kohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Tsukiyama-Kohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virusres.2020.198191_bib0005","doi-asserted-by":"crossref","first-page":"S139","DOI":"10.1016\/S0168-8278(03)00316-7","article-title":"Entecavir, FTC, L-FMAU, LdT and others","volume":"3","author":"Buti","year":"2003","journal-title":"J. Hepatol."},{"key":"10.1016\/j.virusres.2020.198191_bib0010","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1440-1746.2010.06514.x","article-title":"JGH Foundation emerging leadership lecture. Significance of hepatitis B virus genotypes and mutations in the development of hepatocellular carcinoma in Asia","volume":"26","author":"Chan","year":"2011","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.virusres.2020.198191_bib0015","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1128\/JVI.79.5.3016-3027.2005","article-title":"Immune tolerance split between hepatitis B virus precore and core proteins","volume":"79","author":"Chen","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2020.198191_bib0020","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1231143","article-title":"Multiplex genome engineering using CRISPR\/Cas systems","volume":"339","author":"Cong","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.virusres.2020.198191_bib0025","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1038\/sj.gt.3301893","article-title":"Lentiviruses in gene therapy clinical research","volume":"9","author":"Connolly","year":"2002","journal-title":"Gene Ther."},{"key":"10.1016\/j.virusres.2020.198191_bib0030","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1038\/s41467-018-05843-9","article-title":"Cas9 immunity creates challenges for CRISPR gene editing therapies","volume":"9","author":"Crudele","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.virusres.2020.198191_bib0035","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.antiviral.2015.03.015","article-title":"Targeting hepatitis B virus cccDNA by CRISPR\/Cas9 nuclease efficiently inhibits viral replication","volume":"118","author":"Dong","year":"2015","journal-title":"Antiviral Res."},{"key":"10.1016\/j.virusres.2020.198191_bib0040","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.tibtech.2013.04.004","article-title":"ZFN, TALEN, and CRISPR\/Cas-based methods for genome engineering","volume":"31","author":"Gaj","year":"2013","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.virusres.2020.198191_bib0045","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1056\/NEJMra031087","article-title":"Hepatitis B virus infection--natural history and clinical consequences","volume":"350","author":"Ganem","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.virusres.2020.198191_bib0050","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1615\/CritRevEukaryotGeneExpr.2020028233","article-title":"CRISPR-CAS replacing antiviral drugs against HIV: an update","volume":"30","author":"Hashmat","year":"2020","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"10.1016\/j.virusres.2020.198191_bib0055","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1126\/science.1225829","article-title":"A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity","volume":"337","author":"Jinek","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.virusres.2020.198191_bib0060","doi-asserted-by":"crossref","first-page":"13734","DOI":"10.1038\/srep13734","article-title":"CRISPR\/Cas9 nickase-mediated disruption of hepatitis B virus open reading frame S and X","volume":"5","author":"Karimova","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.virusres.2020.198191_bib0065","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.antiviral.2015.10.004","article-title":"Targeting hepatitis B virus cccDNA using CRISPR \/Cas9","volume":"123","author":"Kennedy","year":"2015","journal-title":"Antiviral Res."},{"key":"10.1016\/j.virusres.2020.198191_bib0070","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1440-1746.2010.06546.x","article-title":"Hepatitis B virus x protein in the pathogenesis of hepatitis B virus-induced hepatocellular carcinoma","volume":"26","author":"Kew","year":"2011","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.virusres.2020.198191_bib0075","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1128\/JCM.40.2.439-445.2002","article-title":"Sensitive enzyme immunoassay for hepatitis B virus core-related antigens and their correlation to virus load","volume":"40","author":"Kimura","year":"2002","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.virusres.2020.198191_bib0080","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/nbt.4192","article-title":"Repair of double-strand breaks induced by CRISPR\u2013Cas9 leads to large deletions and complex rearrangements","volume":"36","author":"Kosicki","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.virusres.2020.198191_bib0085","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.4254\/wjh.v7.i8.1030","article-title":"Current and future antiviral drug therapies of hepatitis B chronic infection","volume":"7","author":"Koumbi","year":"2015","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.virusres.2020.198191_bib0090","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1056\/NEJM199712113372406","article-title":"Hepatitis B virus infection","volume":"337","author":"Lee","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.virusres.2020.198191_bib0095","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3389\/fcimb.2017.00091","article-title":"Removal of integrated hepatitis B virus DNA using CRISPR-Cas9","volume":"7","author":"Li","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.virusres.2020.198191_bib0100","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.3389\/fimmu.2018.02080","article-title":"Inhibition of HBV expression in HBV transgenic mice using AAV-delivered CRISPR-SaCas9","volume":"9","author":"Li","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.virusres.2020.198191_bib0105","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ymthe.2020.04.017","article-title":"AAV-CRISPR gene editing is negated by pre-existing immunity to Cas9","volume":"28","author":"Li","year":"2020","journal-title":"Mol. Ther."},{"key":"10.1016\/j.virusres.2020.198191_bib0110","doi-asserted-by":"crossref","first-page":"e186","DOI":"10.1038\/mtna.2014.38","article-title":"The CRISPR\/Cas9 system facilitates clearance of the intrahepatic HBV templates in vivo","volume":"3","author":"Lin","year":"2014","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.virusres.2020.198191_bib0115","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1080\/10717544.2018.1474964","article-title":"Delivering CRISPR: a review of the challenges and approaches","volume":"25","author":"Lino","year":"2018","journal-title":"Drug Deliv."},{"key":"10.1016\/j.virusres.2020.198191_bib0120","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1099\/vir.0.000159","article-title":"Inhibition of hepatitis B virus by the CRISPR\/Cas9 system via targeting the conserved regions of the viral genome","volume":"96","author":"Liu","year":"2015","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virusres.2020.198191_bib0125","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.antiviral.2018.02.011","article-title":"Inhibition of hepatitis B virus replication via HBV DNA cleavage by Cas9 from Staphylococcus aureus","volume":"152","author":"Liu","year":"2018","journal-title":"Antivir. Res."},{"key":"10.1016\/j.virusres.2020.198191_bib0130","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.jhep.2011.02.015","article-title":"Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection","volume":"55","author":"Lucifora","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.virusres.2020.198191_bib0135","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1021\/acssynbio.7b00404","article-title":"Rational design of mini-Cas9 for transcriptional activation","volume":"7","author":"Ma","year":"2018","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.virusres.2020.198191_bib0140","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.virusres.2017.01.003","article-title":"Advances with using CRISPR\/Cas-mediated gene editing to treat infections with hepatitis B virus and hepatitis C virus","volume":"244","author":"Moyo","year":"2018","journal-title":"Virus Res."},{"key":"10.1016\/j.virusres.2020.198191_bib0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0059611","article-title":"Targeted induction of interferon-\u03bb in humanized chimeric mouse liver abrogates hepatotropic virus infection","volume":"8","author":"Nakagawa","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.virusres.2020.198191_bib0150","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1111\/cas.12799","article-title":"Novel reporter system to monitor early stages of the hepatitis B virus life cycle","volume":"106","author":"Nishitsuji","year":"2015","journal-title":"Cancer Sci."},{"key":"10.1016\/j.virusres.2020.198191_bib0155","doi-asserted-by":"crossref","first-page":"3843","DOI":"10.1128\/JCM.00415-10","article-title":"Detection of hepatitis B and C viruses in almost all hepatocytes by modified PCR-based in situ hybridization","volume":"48","author":"Nuriya","year":"2010","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.virusres.2020.198191_bib0160","doi-asserted-by":"crossref","first-page":"10833","DOI":"10.1038\/srep10833","article-title":"CRISPR\/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus","volume":"5","author":"Ramanan","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.virusres.2020.198191_bib0165","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/978-1-61779-370-7_6","article-title":"AAV-mediated liver-directed gene therapy","volume":"807","author":"Sands","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.virusres.2020.198191_bib0170","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1016\/S0140-6736(15)61412-X","article-title":"Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013","volume":"386","author":"Schweitzer","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.virusres.2020.198191_bib0175","doi-asserted-by":"crossref","first-page":"e216","DOI":"10.1038\/mtna.2014.68","article-title":"Targeting hepatitis B virus with CRISPR\/Cas9","volume":"3","author":"Seeger","year":"2014","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.virusres.2020.198191_bib0180","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/mt.2016.94","article-title":"Complete spectrum of CRISPR\/Cas9-induced mutations on HBV cccDNA","volume":"24","author":"Seeger","year":"2016","journal-title":"Mol. Ther."},{"key":"10.1016\/j.virusres.2020.198191_bib0185","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1038\/sj.mt.6300293","article-title":"Characterization of the relationship of AAV capsid domain swapping to liver transduction efficiency","volume":"15","author":"Shen","year":"2007","journal-title":"Mol. Ther."},{"key":"10.1016\/j.virusres.2020.198191_bib0190","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1128\/JCM.00726-13","article-title":"Application of a newly developed high sensitivity HBsAg chemiluminescent enzyme immunoassay for hepatitis B patients with HBsAg seroclearance","volume":"51","author":"Shinkai","year":"2013","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.virusres.2020.198191_bib0195","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/jmv.10566","article-title":"Virological significance of low-level hepatitis B virus infection in patients with hepatitis C virus associated liver disease","volume":"72","author":"Tanaka","year":"2004","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.virusres.2020.198191_bib0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142145","article-title":"Generation of novel chimeric mice with humanized livers by using hemizygous cDNA-uPA\/SCID mice","volume":"10","author":"Tateno","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.virusres.2020.198191_bib0205","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/s41578-019-0145-9","article-title":"Engineered materials for in vivo delivery of genome-editing machinery","volume":"4","author":"Tong","year":"2019","journal-title":"Nat. Rev. Mater."},{"key":"10.1016\/j.virusres.2020.198191_bib0210","doi-asserted-by":"crossref","first-page":"9554","DOI":"10.3748\/wjg.v21.i32.9554","article-title":"Dual gRNAs guided CRISPR\/Cas9 system inhibits hepatitis B virus replication","volume":"21","author":"Wang","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.virusres.2020.198191_bib0215","first-page":"255","article-title":"The CRISPR\/Cas9 genome editing methodology as a weapon against human viruses","volume":"19","author":"White","year":"2015","journal-title":"Discov. Med."},{"key":"10.1016\/j.virusres.2020.198191_bib0220","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s40472-019-00237-2","article-title":"Evasion of pre-existing immunity to Cas9: a prerequisite for successful genome editing in vivo? Curr","volume":"6","author":"Wignakumar","year":"2019","journal-title":"Transpl. Rep."},{"key":"10.1016\/j.virusres.2020.198191_bib0225","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1021\/acs.accounts.9b00106","article-title":"Delivery aspects of CRISPR\/Cas for in vivo genome editing","volume":"52","author":"Wilbie","year":"2019","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.virusres.2020.198191_bib0230","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1177\/135965350601100704","article-title":"One-year entecavir or lamivudine therapy results in reduction of hepatitis B virus intrahepatic covalently closed circular DNA levels","volume":"11","author":"Wong","year":"2006","journal-title":"Antivir Ther."},{"key":"10.1016\/j.virusres.2020.198191_bib0235","doi-asserted-by":"crossref","first-page":"10405","DOI":"10.1073\/pnas.162250899","article-title":"The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy","volume":"99","author":"Xie","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.virusres.2020.198191_bib0240","article-title":"Rational designs of in vivo CRISPR-Cas delivery systems","author":"Xu","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.virusres.2020.198191_bib0245","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.jhep.2015.10.014","article-title":"Novel pH-sensitive multifunctional envelope-type nanodevice for siRNA-based treatments for chronic HBV infection","volume":"64","author":"Yamamoto","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.virusres.2020.198191_bib0250","doi-asserted-by":"crossref","first-page":"e264","DOI":"10.1038\/mtna.2015.37","article-title":"Off-target effects in CRISPR\/Cas9-mediated genome engineering","volume":"4","author":"Zhang","year":"2015","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.virusres.2020.198191_bib0255","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/gt.2015.2","article-title":"Harnessing the clustered regularly interspaced short palindromic repeat (CRISPR)\/CRISPR-associated Cas9 system to disrupt the hepatitis B virus","volume":"22","author":"Zhen","year":"2015","journal-title":"Gene Ther."},{"key":"10.1016\/j.virusres.2020.198191_bib0260","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1186\/s12879-014-0608-y","article-title":"A novel method for detection of HBVcccDNA in hepatocytes using rolling circle amplification combined with in situ PCR","volume":"14","author":"Zhong","year":"2014","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.virusres.2020.198191_bib0265","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.virusres.2016.04.003","article-title":"CRISPR\/Cas9 produces anti-hepatitis B virus effect in hepatoma cells and transgenic mouse","volume":"217","author":"Zhu","year":"2016","journal-title":"Virus Res."}],"container-title":["Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170220310984?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170220310984?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:27:58Z","timestamp":1777508878000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168170220310984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":53,"alternative-id":["S0168170220310984"],"URL":"https:\/\/doi.org\/10.1016\/j.virusres.2020.198191","relation":{},"ISSN":["0168-1702"],"issn-type":[{"value":"0168-1702","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of an in vivo delivery system for CRISPR\/Cas9-mediated targeting of hepatitis B virus cccDNA","name":"articletitle","label":"Article Title"},{"value":"Virus Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virusres.2020.198191","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"198191"}}