{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T16:18:36Z","timestamp":1787674716369,"version":"build-2784847793"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virus Research"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.virusres.2022.198905","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T22:34:39Z","timestamp":1662158079000},"page":"198905","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Berbamine hydrochloride inhibits bovine viral diarrhea virus replication via interfering in late-stage autophagy"],"prefix":"10.1016","volume":"321","author":[{"given":"Jun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjing","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0183-5611","authenticated-orcid":false,"given":"Jiufeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virusres.2022.198905_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetimm.2020.110055","article-title":"Immune response and onset of protection from bovine viral diarrhea virus 2 infection induced by modified-live virus vaccination concurrent with injectable trace minerals administration in newly received beef calves","volume":"225","author":"Bittar","year":"2020","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.virusres.2022.198905_bib0002","first-page":"1","article-title":"Berberis lyceum and Fumaria indica: in vitro cytotoxicity, antioxidant activity, and in silico screening of their selected phytochemicals as novel hepatitis C virus nonstructural protein 5A inhibitors","author":"Brice Landry","year":"2021","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.virusres.2022.198905_bib0003","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1177\/0300985813520250","article-title":"Bovine viral diarrhea virus infections: manifestations of infection and recent advances in understanding pathogenesis and control","volume":"51","author":"Brodersen","year":"2014","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.virusres.2022.198905_bib0004","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1016\/j.intimp.2011.06.002","article-title":"Inhibition of H1N1 influenza A virus growth and induction of inflammatory mediators by the isoquinoline alkaloid berberine and extracts of goldenseal (Hydrastis canadensis)","volume":"11","author":"Cecil","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.virusres.2022.198905_bib0005","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1017\/S1466252315000110","article-title":"Immune response to bovine viral diarrhea virus\u2013looking at newly defined targets","volume":"16","author":"Chase","year":"2015","journal-title":"Anim. Health Res. Rev."},{"key":"10.1016\/j.virusres.2022.198905_bib0006","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/978-981-15-0602-4_27","article-title":"Autophagy and the immune response","volume":"1206","author":"Cui","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.virusres.2022.198905_bib0008","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41580-018-0003-4","article-title":"Mechanism and medical implications of mammalian autophagy","volume":"19","author":"Dikic","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.virusres.2022.198905_bib0009","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1080\/22221751.2021.1941276","article-title":"Berbamine inhibits Japanese encephalitis virus (JEV) infection by compromising TPRMLs-mediated endolysosomal trafficking of low-density lipoprotein receptor (LDLR)","volume":"10","author":"Huang","year":"2021","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.virusres.2022.198905_bib0010","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41392-021-00584-6","article-title":"Berbamine inhibits SARS-CoV-2 infection by compromising TRPMLs-mediated endolysosomal trafficking of ACE2","volume":"6","author":"Huang","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.virusres.2022.198905_bib0011","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.cellsig.2012.01.020","article-title":"Autophagy in regulation of Toll-like receptor signaling","volume":"24","author":"Into","year":"2012","journal-title":"Cell Signal."},{"key":"10.1016\/j.virusres.2022.198905_bib0012","doi-asserted-by":"crossref","first-page":"533","DOI":"10.4161\/auto.7.5.14732","article-title":"Autophagy: a novel guardian of HCV against innate immune response","volume":"7","author":"Ke","year":"2011","journal-title":"Autophagy"},{"key":"10.1016\/j.virusres.2022.198905_bib0013","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1172\/JCI73939","article-title":"mTOR: a pharmacologic target for autophagy regulation","volume":"125","author":"Kim","year":"2015","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.virusres.2022.198905_bib0014","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.ejphar.2015.05.068","article-title":"Current knowledge and pharmacological profile of berberine: an update","volume":"761","author":"Kumar","year":"2015","journal-title":"Eur. J. Pharmacol."},{"issue":"20","key":"10.1016\/j.virusres.2022.198905_bib0015","doi-asserted-by":"crossref","first-page":"9200","DOI":"10.7150\/thno.47077","article-title":"Aichi virus 3C protease modulates LC3- and SQSTM1\/SQSTM1\/p62-involved antiviral response","volume":"10","author":"Kung","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.virusres.2022.198905_bib0016","first-page":"367","article-title":"Bovine viral diarrhea virus\u2013associated disease in feedlot cattle","volume":"31","author":"Larson","year":"2015","journal-title":"Vet. Clin. N. Am."},{"key":"10.1016\/j.virusres.2022.198905_bib0017","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1080\/15548627.2018.1474314","article-title":"Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion","volume":"14","author":"Mauthe","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.virusres.2022.198905_bib0018","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1080\/15548627.2015.1066957","article-title":"Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A\/SERCA-dependent autophagosome-lysosome fusion","volume":"11","author":"Mauvezin","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.virusres.2022.198905_bib0019","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: renovation of cells and tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"issue":"15","key":"10.1016\/j.virusres.2022.198905_bib0020","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4103\/0973-7847.125517","article-title":"Phytochemistry and pharmacology of berberis species","volume":"8","author":"Mokhber-Dezfuli","year":"2014","journal-title":"Pharmacogn. Rev."},{"key":"10.1016\/j.virusres.2022.198905_bib0021","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nature10992","article-title":"Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure","volume":"485","author":"Oka","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.virusres.2022.198905_bib0022","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1002\/cncr.31335","article-title":"Targeting autophagy in cancer","volume":"124","author":"Onorati","year":"2018","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.virusres.2022.198905_bib0023","doi-asserted-by":"crossref","first-page":"93","DOI":"10.4161\/auto.26843","article-title":"Autophagy enhances the replication of classical swine fever virus in vitro","volume":"10","author":"Pei","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.virusres.2022.198905_bib0024","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.biologicals.2012.07.006","article-title":"BVDV: a pestivirus inducing tolerance of the innate immune response","volume":"41","author":"Peterhans","year":"2013","journal-title":"Biologicals"},{"key":"10.1016\/j.virusres.2022.198905_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetimm.2017.09.006","article-title":"Both cytopathic and non-cytopathic bovine viral diarrhea virus (BVDV) induced autophagy at a similar rate","volume":"193-194","author":"Rajput","year":"2017","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.virusres.2022.198905_bib0026","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.589537","article-title":"Mosaic bovine viral diarrhea virus antigens elicit cross-protective immunity in calves","volume":"11","author":"Sangewar","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.virusres.2022.198905_bib0027","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1002\/jcb.27522","article-title":"Berbamine ameliorates isoproterenol-induced myocardial infarction by inhibiting mitochondrial dysfunction and apoptosis in rats","volume":"120","author":"Saranya","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.virusres.2022.198905_bib35","doi-asserted-by":"crossref","first-page":"702","DOI":"10.3389\/fvets.2021.702730","article-title":"Eradication of Bovine Viral Diarrhoea (BVD) in Cattle in Switzerland: Lessons Taught by the Complex Biology of the Virus","volume":"8","author":"Schweizer","year":"2021","journal-title":"Front. Vet Sci."},{"key":"10.1016\/j.virusres.2022.198905_bib0028","doi-asserted-by":"crossref","first-page":"8705","DOI":"10.1128\/JVI.00616-12","article-title":"Hepatitis C virus upregulates Beclin1 for induction of autophagy and activates mTOR signaling","volume":"86","author":"Shrivastava","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2022.198905_bib0029","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1099\/jgv.0.000672","article-title":"ICTV virus taxonomy profile: flaviviridae","volume":"98","author":"Simmonds","year":"2017","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virusres.2022.198905_bib0030","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.vetmic.2013.03.010","article-title":"Bovine viral diarrhea virus (BVDV) infections in pigs","volume":"165","author":"Tao","year":"2013","journal-title":"Vet. Microbiol."},{"issue":"8","key":"10.1016\/j.virusres.2022.198905_bib0031","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1080\/15548627.2020.1798064","article-title":"Autophagy in farm animals: current knowledge and future challenges","volume":"17","author":"Tesseraud","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.virusres.2022.198905_bib0032","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.molimm.2016.01.009","article-title":"Transcriptomic analysis of responses to cytopathic bovine viral diarrhea virus-1 (BVDV-1) infection in MDBK cells","volume":"71","author":"Villalba","year":"2016","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.virusres.2022.198905_bib0033","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.3390\/v13091810","article-title":"Gypenoside inhibits bovine viral diarrhea virus replication by interfering with viral attachment and internalization and activating apoptosis of infected cells","volume":"13","author":"Yang","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.virusres.2022.198905_bib0034","doi-asserted-by":"crossref","first-page":"e2577","DOI":"10.1038\/cddis.2017.7","article-title":"Berbamine postconditioning protects the heart from ischemia\/reperfusion injury through modulation of autophagy","volume":"8","author":"Zheng","year":"2017","journal-title":"Cell Death & Dis"}],"container-title":["Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170222002337?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170222002337?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T14:17:23Z","timestamp":1759155443000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168170222002337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":34,"alternative-id":["S0168170222002337"],"URL":"https:\/\/doi.org\/10.1016\/j.virusres.2022.198905","relation":{},"ISSN":["0168-1702"],"issn-type":[{"value":"0168-1702","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Berbamine hydrochloride inhibits bovine viral diarrhea virus replication via interfering in late-stage autophagy","name":"articletitle","label":"Article Title"},{"value":"Virus Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virusres.2022.198905","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"198905"}}