{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T17:24:32Z","timestamp":1772558672921,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32230103"],"award-info":[{"award-number":["32230103"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008562","name":"Nanjing Agricultural University","doi-asserted-by":"publisher","award":["090-804125"],"award-info":[{"award-number":["090-804125"]}],"id":[{"id":"10.13039\/501100008562","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virus Research"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.virusres.2022.198989","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T12:20:38Z","timestamp":1666700438000},"page":"198989","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Autophagy induced by Rab1a-ULK1 interaction promotes porcine reproductive and respiratory syndrome virus replication"],"prefix":"10.1016","volume":"323","author":[{"given":"Chenlong","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feifei","family":"Diao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zicheng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Nauwynck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3655-5000","authenticated-orcid":false,"given":"Xing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.virusres.2022.198989_bib0001","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/cdd.2013.187","article-title":"Regulation of autophagy by the Rab GTPase network","volume":"21","author":"Ao","year":"2014","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.virusres.2022.198989_bib0002","first-page":"1","article-title":"Generation of fluorescent HCV pseudoparticles to study early viral entry events- involvement of Rab1a in HCV entry","author":"Bhattacharjee","year":"2022","journal-title":"Virusdisease"},{"key":"10.1016\/j.virusres.2022.198989_bib0003","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.virusres.2011.11.008","article-title":"Induction of autophagy enhances porcine reproductive and respiratory syndrome virus replication","volume":"163","author":"Chen","year":"2012","journal-title":"Virus Res."},{"key":"10.1016\/j.virusres.2022.198989_bib0004","doi-asserted-by":"crossref","first-page":"737","DOI":"10.4161\/auto.7.7.15491","article-title":"ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding","volume":"7","author":"Dunlop","year":"2011","journal-title":"Autophagy"},{"key":"10.1016\/j.virusres.2022.198989_bib0005","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1152\/physrev.00012.2016","article-title":"Ubiquitination and the Regulation of Membrane Proteins","volume":"97","author":"Foot","year":"2017","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.virusres.2022.198989_bib0006","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1242\/jcs.167973","article-title":"A high-content screening microscopy approach to dissect the role of Rab proteins in Golgi-to-ER retrograde trafficking","volume":"128","author":"Galea","year":"2015","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.virusres.2022.198989_bib0007","doi-asserted-by":"crossref","first-page":"12297","DOI":"10.1074\/jbc.M900573200","article-title":"ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy","volume":"284","author":"Ganley","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virusres.2022.198989_bib0008","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1242\/jcs.01114","article-title":"Rab7 is required for the normal progression of the autophagic pathway in mammalian cells","volume":"117","author":"Gutierrez","year":"2004","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.virusres.2022.198989_bib0009","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1083\/jcb.200712064","article-title":"FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells","volume":"181","author":"Hara","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.virusres.2022.198989_bib0010","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1091\/mbc.e08-12-1248","article-title":"Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy","volume":"20","author":"Hosokawa","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.virusres.2022.198989_bib0011","doi-asserted-by":"crossref","first-page":"973","DOI":"10.4161\/auto.5.7.9296","article-title":"Atg101, a novel mammalian autophagy protein interacting with Atg13","volume":"5","author":"Hosokawa","year":"2009","journal-title":"Autophagy"},{"key":"10.1016\/j.virusres.2022.198989_bib0012","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.vetmic.2018.11.016","article-title":"Cellular protein profiles altered by PRRSV infection of porcine monocytes-derived dendritic cells","volume":"228","author":"Hu","year":"2019","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virusres.2022.198989_bib0013","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1091\/mbc.e07-12-1231","article-title":"Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation","volume":"19","author":"Itoh","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.virusres.2022.198989_bib0014","first-page":"5224","article-title":"Dynamic association of the ULK1 complex with omegasomes during autophagy induction","volume":"126","author":"Karanasios","year":"2013","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.virusres.2022.198989_bib0015","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ncb2152","article-title":"AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1","volume":"13","author":"Kim","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.virusres.2022.198989_bib0016","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/tbed.12530","article-title":"Outbreak Investigation of NADC30-Like PRRSV in South-East China","volume":"63","author":"Li","year":"2016","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.virusres.2022.198989_bib0017","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.virol.2017.11.002","article-title":"Rab1A is required for assembly of classical swine fever virus particle","volume":"514","author":"Lin","year":"2018","journal-title":"VirologyVirology"},{"key":"10.1016\/j.virusres.2022.198989_bib0018","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.virol.2012.03.022","article-title":"Autophagy sustains the replication of porcine reproductive and respiratory virus in host cells","volume":"429","author":"Liu","year":"2012","journal-title":"VirologyVirology"},{"key":"10.1016\/j.virusres.2022.198989_bib0019","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009446","article-title":"The herpesvirus accessory protein gamma134.5 facilitates viral replication by disabling mitochondrial translocation of RIG-I","volume":"17","author":"Liu","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virusres.2022.198989_bib0020","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1021\/pr201266z","volume":"11","author":"Lu","year":"2012","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.virusres.2022.198989_bib0021","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.30819","article-title":"Expanding the view of the molecular mechanisms of autophagy pathway","author":"Majeed","year":"2022","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.virusres.2022.198989_bib0022","doi-asserted-by":"crossref","first-page":"649","DOI":"10.4161\/auto.5.5.8249","article-title":"A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy","volume":"5","author":"Mercer","year":"2009","journal-title":"Autophagy"},{"key":"10.1016\/j.virusres.2022.198989_bib0023","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1146\/annurev-biochem-052810-093700","article-title":"GTPase networks in membrane traffic","volume":"81","author":"Mizuno-Yamasaki","year":"2012","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.virusres.2022.198989_bib0024","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1034\/j.1600-0854.2002.30704.x","article-title":"Induction of autophagy causes dramatic changes in the subcellular distribution of GFP-Rab24","volume":"3","author":"Munafo","year":"2002","journal-title":"Traffic"},{"key":"10.1016\/j.virusres.2022.198989_bib0025","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1742-4690-9-7","article-title":"Human immunodeficiency virus type 1 envelope proteins traffic toward virion assembly sites via a TBC1D20\/Rab1-regulated pathway","volume":"9","author":"Nachmias","year":"2012","journal-title":"Retrovirology"},{"key":"10.1016\/j.virusres.2022.198989_bib0026","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2460\/javma.2005.227.385","article-title":"Assessment of the economic impact of porcine reproductive and respiratory syndrome on swine production in the United States","volume":"227","author":"Neumann","year":"2005","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.virusres.2022.198989_bib0027","doi-asserted-by":"crossref","first-page":"6491","DOI":"10.1128\/JVI.00496-12","article-title":"Role for TBC1D20 and Rab1 in hepatitis C virus replication via interaction with lipid droplet-bound nonstructural protein 5A","volume":"86","author":"Nevo-Yassaf","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2022.198989_bib0028","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1111\/j.1462-5822.2012.01792.x","article-title":"The small GTPases Rab9A and Rab23 function at distinct steps in autophagy during Group A Streptococcus infection","volume":"14","author":"Nozawa","year":"2012","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.virusres.2022.198989_bib0029","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1080\/15548627.2016.1140293","article-title":"The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14","volume":"12","author":"Park","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.virusres.2022.198989_bib0030","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.virol.2014.11.007","article-title":"RAB1A promotes Vaccinia virus replication by facilitating the production of intracellular enveloped virions","volume":"475","author":"Pechenick Jowers","year":"2015","journal-title":"VirologyVirology"},{"key":"10.1016\/j.virusres.2022.198989_bib0031","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1084\/jem.20150956","article-title":"Therapeutic targeting of autophagy in neurodegenerative and infectious diseases","volume":"212","author":"Rubinsztein","year":"2015","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.virusres.2022.198989_bib0032","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.virusres.2022.198989_bib0033","doi-asserted-by":"crossref","first-page":"36354","DOI":"10.1074\/jbc.M705221200","article-title":"TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication","volume":"282","author":"Sklan","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virusres.2022.198989_bib0034","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1099\/vir.0.056341-0","article-title":"Arterivirus molecular biology and pathogenesis","volume":"94","author":"Snijder","year":"2013","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virusres.2022.198989_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2019.108498","article-title":"S100A9 regulates porcine reproductive and respiratory syndrome virus replication by interacting with the viral nucleocapsid protein","volume":"239","author":"Song","year":"2019","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virusres.2022.198989_bib0036","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nrm2728","article-title":"Rab GTPases as coordinators of vesicle traffic","volume":"10","author":"Stenmark","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.virusres.2022.198989_bib0037","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.4161\/auto.21159","article-title":"Porcine reproductive and respiratory syndrome virus induces autophagy to promote virus replication","volume":"8","author":"Sun","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.virusres.2022.198989_bib0038","doi-asserted-by":"crossref","first-page":"e526","DOI":"10.1371\/journal.pone.0000526","article-title":"Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark","volume":"2","author":"Tian","year":"2007","journal-title":"PLoS ONE"},{"key":"10.1016\/j.virusres.2022.198989_bib0039","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1093\/jxb\/ern240","article-title":"Post-transcriptional regulation of auxin transport proteins: cellular trafficking, protein phosphorylation, protein maturation, ubiquitination, and membrane composition","volume":"60","author":"Titapiwatanakun","year":"2009","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.virusres.2022.198989_bib0040","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.15252\/embj.201694401","article-title":"The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy","volume":"35","author":"Webster","year":"2016","journal-title":"EMBO J."},{"key":"10.1016\/j.virusres.2022.198989_bib0041","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1080\/21541248.2016.1240495","article-title":"C9orf72 plays a central role in Rab GTPase-dependent regulation of autophagy","volume":"9","author":"Webster","year":"2018","journal-title":"Small GTPases"},{"key":"10.1016\/j.virusres.2022.198989_bib0042","doi-asserted-by":"crossref","first-page":"8012","DOI":"10.1128\/JVI.00500-11","article-title":"Analysis of Rab GTPase-activating proteins indicates that Rab1a\/b and Rab43 are important for herpes simplex virus 1 secondary envelopment","volume":"85","author":"Zenner","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2022.198989_bib0043","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1743-422X-10-135","article-title":"Comparative expression of Toll-like receptors and inflammatory cytokines in pigs infected with different virulent porcine reproductive and respiratory syndrome virus isolates","volume":"10","author":"Zhang","year":"2013","journal-title":"Virol. J."},{"key":"10.1016\/j.virusres.2022.198989_bib0044","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.vetmic.2017.07.028","article-title":"A novel recombinant porcine reproductive and respiratory syndrome virus with significant variation in cell adaption and pathogenicity","volume":"208","author":"Zhang","year":"2017","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.virusres.2022.198989_bib0045","doi-asserted-by":"crossref","first-page":"194","DOI":"10.4049\/jimmunol.1800777","article-title":"The GTPase Rab1 Is Required for NLRP3 inflammasome activation and inflammatory lung injury","volume":"202","author":"Zhang","year":"2019","journal-title":"J. Immunol."},{"key":"10.1016\/j.virusres.2022.198989_bib0046","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.3201\/eid2112.150360","article-title":"NADC30-like strain of porcine reproductive and respiratory syndrome virus, China","volume":"21","author":"Zhou","year":"2015","journal-title":"Emerg. Infect. Dis."}],"container-title":["Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170222003185?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170222003185?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T14:19:26Z","timestamp":1759155566000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168170222003185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":46,"alternative-id":["S0168170222003185"],"URL":"https:\/\/doi.org\/10.1016\/j.virusres.2022.198989","relation":{},"ISSN":["0168-1702"],"issn-type":[{"value":"0168-1702","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autophagy induced by Rab1a-ULK1 interaction promotes porcine reproductive and respiratory syndrome virus replication","name":"articletitle","label":"Article Title"},{"value":"Virus Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virusres.2022.198989","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"198989"}}