{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T09:49:34Z","timestamp":1793180974816,"version":"4.5.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virus Research"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.virusres.2023.199240","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T21:26:31Z","timestamp":1697232391000},"page":"199240","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["HMGB1 Release Induced by EV71 Infection Exacerbates Blood-Brain Barrier Disruption via VE-cadherin Phosphorylation"],"prefix":"10.1016","volume":"338","author":[{"given":"Qiao","family":"You","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enhui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruining","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.virusres.2023.199240_bib0001","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s10020-020-00172-4","article-title":"Extracellular HMGB1: a therapeutic target in severe pulmonary inflammation including COVID-19?","volume":"26","author":"Andersson","year":"2020","journal-title":"Mol Med"},{"key":"10.1016\/j.virusres.2023.199240_bib0002","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1146\/annurev-immunol-030409-101323","article-title":"HMGB1 is a therapeutic target for sterile inflammation and infection","volume":"29","author":"Andersson","year":"2011","journal-title":"Annu Rev Immunol"},{"issue":"12","key":"10.1016\/j.virusres.2023.199240_bib0003","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1056\/NEJMoa065954","article-title":"Neurodevelopment and cognition in children after enterovirus 71 infection","volume":"356","author":"Chang","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.virusres.2023.199240_bib0004","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.3389\/fimmu.2018.01268","article-title":"Promyelocytic Leukemia Restricts Enterovirus 71 Replication by Inhibiting Autophagy","volume":"9","author":"Chen","year":"2018","journal-title":"Front Immunol"},{"issue":"9","key":"10.1016\/j.virusres.2023.199240_bib0005","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.it.2016.06.006","article-title":"Astrocytes: Key Regulators of Neuroinflammation","volume":"37","author":"Colombo","year":"2016","journal-title":"Trends Immunol"},{"key":"10.1016\/j.virusres.2023.199240_bib0006","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev-immunol-051116-052358","article-title":"Microglia Function in the Central Nervous System During Health and Neurodegeneration","volume":"35","author":"Colonna","year":"2017","journal-title":"Annu Rev Immunol"},{"issue":"23","key":"10.1016\/j.virusres.2023.199240_bib0007","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1001\/jama.2018.17288","article-title":"Hand, Foot, and Mouth Disease","volume":"320","author":"Cox","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.virusres.2023.199240_bib0008","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ijid.2017.04.005","article-title":"A prospective, comparative study of severe neurological and uncomplicated hand, foot and mouth forms of paediatric enterovirus 71 infections","volume":"59","author":"Crabol","year":"2017","journal-title":"Int J Infect Dis"},{"issue":"Pt 12","key":"10.1016\/j.virusres.2023.199240_bib0009","first-page":"2545","article-title":"Endothelial adherens junctions at a glance","volume":"126","author":"Dejana","year":"2013","journal-title":"J Cell Sci"},{"issue":"3","key":"10.1016\/j.virusres.2023.199240_bib0010","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/s41401-021-00676-7","article-title":"Targeting HMGB1 for the treatment of sepsis and sepsis-induced organ injury","volume":"43","author":"Deng","year":"2022","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.virusres.2023.199240_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.cytogfr.2021.08.003","article-title":"Potential effects of HMGB1 on viral replication and virus infection-induced inflammatory responses: A promising therapeutic target for virus infection-induced inflammatory diseases","author":"Ding","year":"2021","journal-title":"Cytokine Growth Factor Rev"},{"issue":"6","key":"10.1016\/j.virusres.2023.199240_bib0012","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/2211-5463.12197","article-title":"miR-127-5p negatively regulates enterovirus 71 replication by directly targeting SCARB2","volume":"7","author":"Feng","year":"2017","journal-title":"FEBS Open Bio"},{"issue":"6","key":"10.1016\/j.virusres.2023.199240_bib0013","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1128\/JVI.02712-13","article-title":"Enterovirus 2Apro targets MDA5 and MAVS in infected cells","volume":"88","author":"Feng","year":"2014","journal-title":"J Virol"},{"key":"10.1016\/j.virusres.2023.199240_bib0014","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3389\/fmicb.2019.00625","article-title":"Enterovirus 71 Suppresses miR-17-92 Cluster Through Up-Regulating Methylation of the miRNA Promoter","volume":"10","author":"Fu","year":"2019","journal-title":"Front Microbiol"},{"issue":"3","key":"10.1016\/j.virusres.2023.199240_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109419","article-title":"Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer's disease and frontotemporal dementia","volume":"36","author":"Gaikwad","year":"2021","journal-title":"Cell Rep"},{"issue":"2","key":"10.1016\/j.virusres.2023.199240_bib0016","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.01048-20","article-title":"Pathogenesis Study of Enterovirus 71 Using a Novel Human SCARB2 Knock-In Mouse Model","volume":"6","author":"Jin","year":"2021","journal-title":"mSphere"},{"issue":"18","key":"10.1016\/j.virusres.2023.199240_bib0017","doi-asserted-by":"crossref","first-page":"9359","DOI":"10.1128\/JVI.00682-11","article-title":"Hepatitis C virus infection is blocked by HMGB1 released from virus-infected cells","volume":"85","author":"Jung","year":"2011","journal-title":"J Virol"},{"issue":"2","key":"10.1016\/j.virusres.2023.199240_bib0018","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.virol.2011.12.010","article-title":"Analysis of the interactions of viral and cellular factors with human cytomegalovirus lytic origin of replication, oriLyt","volume":"424","author":"Kagele","year":"2012","journal-title":"Virology"},{"issue":"4","key":"10.1016\/j.virusres.2023.199240_bib0019","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.chom.2013.03.010","article-title":"Virus infections in the nervous system","volume":"13","author":"Koyuncu","year":"2013","journal-title":"Cell Host Microbe"},{"issue":"9","key":"10.1016\/j.virusres.2023.199240_bib0020","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.2174\/1570159X16666180222164809","article-title":"The Role of VE-cadherin in Blood-brain Barrier Integrity Under Central Nervous System Pathological Conditions","volume":"16","author":"Li","year":"2018","journal-title":"Curr Neuropharmacol"},{"issue":"3","key":"10.1016\/j.virusres.2023.199240_bib0021","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00401-018-1815-1","article-title":"Functional morphology of the blood-brain barrier in health and disease","volume":"135","author":"Liebner","year":"2018","journal-title":"Acta Neuropathol"},{"issue":"4","key":"10.1016\/j.virusres.2023.199240_bib0022","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.neuron.2020.08.012","article-title":"Astrocyte Crosstalk in CNS Inflammation","volume":"108","author":"Linnerbauer","year":"2020","journal-title":"Neuron"},{"issue":"7","key":"10.1016\/j.virusres.2023.199240_bib0023","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1128\/JVI.06687-11","article-title":"Enterovirus 71 disrupts interferon signaling by reducing the level of interferon receptor 1","volume":"86","author":"Lu","year":"2012","journal-title":"J Virol"},{"issue":"3","key":"10.1016\/j.virusres.2023.199240_bib0024","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/mi.2016.82","article-title":"ROS-dependent HMGB1 secretion upregulates IL-8 in upper airway epithelial cells under hypoxic condition","volume":"10","author":"Min","year":"2017","journal-title":"Mucosal Immunol"},{"issue":"17","key":"10.1016\/j.virusres.2023.199240_bib0025","doi-asserted-by":"crossref","first-page":"9122","DOI":"10.1128\/JVI.00789-12","article-title":"HMGB1 protein binds to influenza virus nucleoprotein and promotes viral replication","volume":"86","author":"Moisy","year":"2012","journal-title":"J Virol"},{"issue":"10336","key":"10.1016\/j.virusres.2023.199240_bib0026","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1016\/S0140-6736(22)00313-0","article-title":"Efficacy, safety, and immunogenicity of an inactivated, adjuvanted enterovirus 71 vaccine in infants and children: a multiregion, double-blind, randomised, placebo-controlled, phase 3 trial","volume":"399","author":"Nguyen","year":"2022","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.virusres.2023.199240_bib0027","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jphs.2019.04.006","article-title":"Anti-HMGB1 monoclonal antibody therapy for a wide range of CNS and PNS diseases","volume":"140","author":"Nishibori","year":"2019","journal-title":"J Pharmacol Sci"},{"issue":"12","key":"10.1016\/j.virusres.2023.199240_bib0028","doi-asserted-by":"crossref","DOI":"10.3390\/cells9122650","article-title":"High Mobility Group Box-1 and Blood-Brain Barrier Disruption","volume":"9","author":"Nishibori","year":"2020","journal-title":"Cells"},{"issue":"7","key":"10.1016\/j.virusres.2023.199240_bib0029","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1002\/jmv.25076","article-title":"Anti-high mobility group box-1 monoclonal antibody treatment of brain edema induced by influenza infection and lipopolysaccharide","volume":"90","author":"Nosaka","year":"2018","journal-title":"J Med Virol"},{"issue":"12","key":"10.1016\/j.virusres.2023.199240_bib0030","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/nm.3407","article-title":"Development, maintenance and disruption of the blood-brain barrier","volume":"19","author":"Obermeier","year":"2013","journal-title":"Nat Med"},{"issue":"11","key":"10.1016\/j.virusres.2023.199240_bib0031","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/S1474-4422(10)70209-X","article-title":"Clinical features, diagnosis, and management of enterovirus 71","volume":"9","author":"Ooi","year":"2010","journal-title":"The Lancet Neurology"},{"key":"10.1016\/j.virusres.2023.199240_bib0032","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1038\/ncomms2199","article-title":"Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo","volume":"3","author":"Orsenigo","year":"2012","journal-title":"Nat Commun"},{"key":"10.1016\/j.virusres.2023.199240_bib0033","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.virol.2018.09.001","article-title":"Newcastle disease virus infection triggers HMGB1 release to promote the inflammatory response","volume":"525","author":"Qu","year":"2018","journal-title":"Virology"},{"issue":"3","key":"10.1016\/j.virusres.2023.199240_bib0034","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2500\/ajra.2016.30.4300","article-title":"HMGB1-TLR4 signaling contributes to the secretion of interleukin 6 and interleukin 8 by nasal epithelial cells","volume":"30","author":"Shimizu","year":"2016","journal-title":"Am J Rhinol Allergy"},{"issue":"11","key":"10.1016\/j.virusres.2023.199240_bib0035","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S1473-3099(10)70194-8","article-title":"Virology, epidemiology, pathogenesis, and control of enterovirus 71","volume":"10","author":"Solomon","year":"2010","journal-title":"The Lancet Infectious Diseases"},{"issue":"1-2","key":"10.1016\/j.virusres.2023.199240_bib0036","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bbagrm.2009.09.008","article-title":"HMGB proteins: interactions with DNA and chromatin","volume":"1799","author":"Stros","year":"2010","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"10.1016\/j.virusres.2023.199240_bib0037","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1007\/s10753-015-0298-7","article-title":"Enolase of Streptococcus Suis Serotype 2 Enhances Blood-Brain Barrier Permeability by Inducing IL-8 Release","volume":"39","author":"Sun","year":"2016","journal-title":"Inflammation"},{"issue":"3","key":"10.1016\/j.virusres.2023.199240_bib0038","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrneurol.2017.188","article-title":"Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders","volume":"14","author":"Sweeney","year":"2018","journal-title":"Nat Rev Neurol"},{"issue":"1","key":"10.1016\/j.virusres.2023.199240_bib0039","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1152\/physrev.00050.2017","article-title":"Blood-Brain Barrier: From Physiology to Disease and Back","volume":"99","author":"Sweeney","year":"2019","journal-title":"Physiol Rev"},{"key":"10.1016\/j.virusres.2023.199240_bib0040","doi-asserted-by":"crossref","first-page":"46243","DOI":"10.1038\/srep46243","article-title":"Anti-high mobility group box-1 (HMGB1) antibody inhibits hemorrhage-induced brain injury and improved neurological deficits in rats","volume":"7","author":"Wang","year":"2017","journal-title":"Sci Rep."},{"key":"10.1016\/j.virusres.2023.199240_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173189","article-title":"HMGB1 promoted P-glycoprotein at the blood-brain barrier in MCAO rats via TLR4\/NF-\u03baB signaling pathway","volume":"880","author":"Wang","year":"2020","journal-title":"Eur J Pharmacol"},{"issue":"5425","key":"10.1016\/j.virusres.2023.199240_bib0042","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1126\/science.285.5425.248","article-title":"HMG-1 as a late mediator of endotoxin lethality in mice","volume":"285","author":"Wang","year":"1999","journal-title":"Science"},{"issue":"19","key":"10.1016\/j.virusres.2023.199240_bib0043","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20194870","article-title":"STAT3 Regulates the Type I IFN-Mediated Antiviral Response by Interfering with the Nuclear Entry of STAT1","volume":"20","author":"Wang","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.virusres.2023.199240_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2021.136049","article-title":"Enterovirus 71 infection induced Aquaporin-4 depolarization by increasing matrix metalloproteinase-9 activity","volume":"759","author":"Wang","year":"2021","journal-title":"Neurosci Lett"},{"issue":"2","key":"10.1016\/j.virusres.2023.199240_bib0045","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/nen.0b013e318163a990","article-title":"The distribution of inflammation and virus in human enterovirus 71 encephalomyelitis suggests possible viral spread by neural pathways","volume":"67","author":"Wong","year":"2008","journal-title":"J Neuropathol Exp Neurol"},{"issue":"5","key":"10.1016\/j.virusres.2023.199240_bib0046","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009587","article-title":"Infection of humanized mice with a novel phlebovirus presented pathogenic features of severe fever with thrombocytopenia syndrome","volume":"17","author":"Xu","year":"2021","journal-title":"PLoS Pathog"},{"issue":"5","key":"10.1016\/j.virusres.2023.199240_bib0047","doi-asserted-by":"crossref","first-page":"3406","DOI":"10.1002\/jcp.30125","article-title":"HMGB1 as a therapeutic target in disease","volume":"236","author":"Xue","year":"2021","journal-title":"J Cell Physiol"},{"issue":"5","key":"10.1016\/j.virusres.2023.199240_bib0048","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1128\/JVI.02795-15","article-title":"HMGB1 Promotes Hepatitis C Virus Replication by Interaction with Stem-Loop 4 in the Viral 5\u2032 Untranslated Region","volume":"90","author":"Yu","year":"2015","journal-title":"J Virol"},{"issue":"1","key":"10.1016\/j.virusres.2023.199240_bib0049","doi-asserted-by":"crossref","first-page":"154","DOI":"10.20892\/j.issn.2095-3941.2019.0353","article-title":"Neutrophil extracellular traps mediate the crosstalk between glioma progression and the tumor microenvironment via the HMGB1\/RAGE\/IL-8 axis","volume":"17","author":"Zha","year":"2020","journal-title":"Cancer Biol Med"},{"issue":"5","key":"10.1016\/j.virusres.2023.199240_bib0050","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1161\/STROKEAHA.110.598334","article-title":"Anti-high mobility group box-1 monoclonal antibody protects the blood-brain barrier from ischemia-induced disruption in rats","volume":"42","author":"Zhang","year":"2011","journal-title":"Stroke"},{"issue":"5","key":"10.1016\/j.virusres.2023.199240_bib0051","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.cell.2015.10.067","article-title":"Establishment and Dysfunction of the Blood-Brain Barrier","volume":"163","author":"Zhao","year":"2015","journal-title":"Cell"},{"issue":"17","key":"10.1016\/j.virusres.2023.199240_bib0052","doi-asserted-by":"crossref","first-page":"e6764","DOI":"10.1097\/MD.0000000000006764","article-title":"Alteration of serum high-mobility group protein 1 (HMGB1) levels in children with enterovirus 71-induced hand, foot, and mouth disease","volume":"96","author":"Zheng","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.virusres.2023.199240_bib0053","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104457","article-title":"Zika virus leads to olfactory disorders in mice by targeting olfactory ensheathing cells","volume":"89","author":"Zhou","year":"2023","journal-title":"EBioMedicine"},{"issue":"9","key":"10.1016\/j.virusres.2023.199240_bib0054","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1056\/NEJMoa1304923","article-title":"Efficacy, safety, and immunogenicity of an enterovirus 71 vaccine in China","volume":"370","author":"Zhu","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.virusres.2023.199240_bib0055","article-title":"Interleukins and Ischemic Stroke","volume":"13","author":"Zhu","year":"2022","journal-title":"Front Immunol"}],"container-title":["Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170223002022?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170223002022?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T14:21:04Z","timestamp":1759155664000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168170223002022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":55,"alternative-id":["S0168170223002022"],"URL":"https:\/\/doi.org\/10.1016\/j.virusres.2023.199240","relation":{},"ISSN":["0168-1702"],"issn-type":[{"value":"0168-1702","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HMGB1 Release Induced by EV71 Infection Exacerbates Blood-Brain Barrier Disruption via VE-cadherin Phosphorylation","name":"articletitle","label":"Article Title"},{"value":"Virus Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virusres.2023.199240","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"199240"}}