{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T12:20:44Z","timestamp":1762604444330,"version":"3.44.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,7]],"date-time":"2024-01-07T00:00:00Z","timestamp":1704585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virus Research"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.virusres.2024.199313","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T05:55:33Z","timestamp":1705902933000},"page":"199313","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Increased cAMP-PKA signaling pathway activation is involved in up-regulation of CTLA-4 expression in CD4+ T cells in acute SIVmac239-infected Chinese rhesus macaques"],"prefix":"10.1016","volume":"341","author":[{"given":"Ren-Rong","family":"Tian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben-Bo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Liang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Jun","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5469-0324","authenticated-orcid":false,"given":"Yong-Tang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.virusres.2024.199313_bib0001","doi-asserted-by":"crossref","first-page":"802","DOI":"10.4049\/jimmunol.169.2.802","article-title":"Inhibition of antigen-specific T cell proliferation and cytokine production by protein kinase A type I","volume":"169","author":"Aandahl","year":"2002","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.virusres.2024.199313_bib0002","first-page":"401","article-title":"Expression of immune checkpoint regulators, cytotoxic T-Lymphocyte Antigen-4, and Programmed Death-Ligand 1 in epstein-barr virus-associated nasopharyngeal carcinoma","volume":"29","author":"Ahmed","year":"2021","journal-title":"Appl. Immunohisto. M M"},{"issue":"11","key":"10.1016\/j.virusres.2024.199313_bib0003","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1038\/s41590-019-0512-0","article-title":"Inhibitory receptors and ligands beyond PD-1, PD-L1 and CTLA-4: breakthroughs or backups","volume":"20","author":"Andrews","year":"2019","journal-title":"Nat. Immunol."},{"issue":"2","key":"10.1016\/j.virusres.2024.199313_bib0004","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0014-5793(01)03182-9","article-title":"Modulation of HIV-1 enhancer activity and virus production by cAMP","volume":"509","author":"Banas","year":"2001","journal-title":"FEBS Lett."},{"issue":"2","key":"10.1016\/j.virusres.2024.199313_bib0005","first-page":"703","article-title":"CTLA\u20114 interferes with the HBV\u2011specific T cell immune response (Review)","volume":"42","author":"Cao","year":"2018","journal-title":"Int. J. Mol. Med."},{"issue":"7710","key":"10.1016\/j.virusres.2024.199313_bib0006","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41586-018-0206-z","article-title":"Induction and transcriptional regulation of the co-inhibitory gene module in T cells","volume":"558","author":"Chihara","year":"2018","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.virusres.2024.199313_bib0007","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.4049\/jimmunol.162.3.1392","article-title":"cAMP up-regulates cell surface expression of lymphocyte CXCR4: implications for chemotaxis and HIV-1 infection","volume":"162","author":"Cole","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.virusres.2024.199313_bib0008","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2350-14-46","article-title":"The associations between the polymorphisms in the CTLA-4 gene and the risk of Graves' disease in the Chinese population","volume":"14","author":"Du","year":"2013","journal-title":"BMC. Med. Genet."},{"issue":"9","key":"10.1016\/j.virusres.2024.199313_bib0009","doi-asserted-by":"crossref","first-page":"4074","DOI":"10.4049\/jimmunol.158.9.4074","article-title":"Synergistic induction of CTLA-4 expression by costimulation with TCR plus CD28 signals mediated by increased transcription and messenger ribonucleic acid stability","volume":"158","author":"Finn","year":"1997","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.virusres.2024.199313_bib0010","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.4049\/jimmunol.179.6.3831","article-title":"Induction of the CTLA-4 gene in human lymphocytes is dependent on NFAT binding the proximal promoter","volume":"179","author":"Gibson","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.virusres.2024.199313_bib0011","doi-asserted-by":"crossref","DOI":"10.1186\/1742-4690-10-157","article-title":"HIV-1-associated PKA acts as a cofactor for genome reverse transcription","volume":"10","author":"Giroud","year":"2013","journal-title":"Retrovirology."},{"issue":"4","key":"10.1016\/j.virusres.2024.199313_bib0012","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/eji.201243005","article-title":"Beta2-adrenergic receptor signaling in CD4(+) Foxp3(+) regulatory T cells enhances their suppressive function in a PKA-dependent manner","volume":"43","author":"Guereschi","year":"2013","journal-title":"Eur. J. Immunol."},{"issue":"2","key":"10.1016\/j.virusres.2024.199313_bib0013","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/00002030-200401230-00005","article-title":"Cytokine networks are pre-activated in T cells from HIV-infected patients on HAART and are under the control of cAMP","volume":"18","author":"Johansson","year":"2004","journal-title":"AIDS"},{"key":"10.1016\/j.virusres.2024.199313_bib0014","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1742-4690-10-31","article-title":"Molecular signatures of T-cell inhibition in HIV-1 infection","volume":"10","author":"Larsson","year":"2013","journal-title":"Retrovirology."},{"issue":"4","key":"10.1016\/j.virusres.2024.199313_bib0015","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/00002030-200203080-00002","article-title":"CTLA-4 upregulation during HIV infection: association with anergy and possible target for therapeutic intervention","volume":"16","author":"Leng","year":"2002","journal-title":"AIDS"},{"issue":"1","key":"10.1016\/j.virusres.2024.199313_bib0016","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1165\/rcmb.2012-0155OC","article-title":"Regulation of cytotoxic T lymphocyte antigen 4 by cyclic AMP","volume":"48","author":"Li","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"1","key":"10.1016\/j.virusres.2024.199313_bib0017","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1165\/rcmb.2012-0155OC","article-title":"Regulation of cytotoxic t lymphocyte antigen 4 by cyclic AMP","volume":"48","author":"Li","year":"2013","journal-title":"Am. J. Resp. Cell Mol."},{"issue":"13","key":"10.1016\/j.virusres.2024.199313_bib0018","doi-asserted-by":"crossref","first-page":"11497","DOI":"10.1074\/jbc.M110856200","article-title":"Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation","volume":"277","author":"Mei","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.virusres.2024.199313_bib0019","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1089\/aid.2011.0265","article-title":"cAMP during HIV infection: friend or foe?","volume":"28","author":"Moreno-Fernandez","year":"2012","journal-title":"AIDS Res. Hum. Retroviruses"},{"issue":"3","key":"10.1016\/j.virusres.2024.199313_bib0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0149441","article-title":"Association of Cytotoxic T-Lymphocyte Antigen 4 (CTLA4) and Thyroglobulin (TG) genetic variants with autoimmune hypothyroidism","volume":"11","author":"Patel","year":"2016","journal-title":"PLoS ONE"},{"issue":"12","key":"10.1016\/j.virusres.2024.199313_bib0021","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00469-19","article-title":"Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4)- and programmed Death 1 (PD-1)-mediated regulation of monofunctional and dual functional CD4(+) and CD8(+) T-cell responses in a chronic helminth infection","volume":"87","author":"Rajamanickam","year":"2019","journal-title":"Infect. Immun."},{"issue":"4","key":"10.1016\/j.virusres.2024.199313_bib0022","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1053\/j.gastro.2011.07.004","article-title":"Inhibitory molecules that regulate expansion and restoration of HCV-Specific CD4(+) T cells in patients with chronic infection","volume":"141","author":"Raziorrouh","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.virusres.2024.199313_bib0023","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2147\/TACG.S359158","article-title":"CTLA-4 CT-60 A\/G and CTLA-4 1822 C\/T gene polymorphisms in indonesians with type 1 diabetes mellitus","volume":"15","author":"Rochmah","year":"2022","journal-title":"Appl. Clin. Genet."},{"issue":"1","key":"10.1016\/j.virusres.2024.199313_bib0024","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1182\/blood-2017-06-741033","article-title":"CTLA-4: a moving target in immunotherapy","volume":"131","author":"Rowshanravan","year":"2018","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.virusres.2024.199313_bib0025","doi-asserted-by":"crossref","DOI":"10.3390\/v14030581","article-title":"Expression Profile and Biological Role of Immune Checkpoints in Disease Progression of HIV\/SIV Infection","volume":"14","author":"Sun","year":"2022","journal-title":"Viruses."},{"key":"10.1016\/j.virusres.2024.199313_bib0026","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.2741\/2022","article-title":"Negative regulation of T-cell receptor activation by the cAMP-PKA-Csk signalling pathway in T-cell lipid rafts","volume":"11","author":"Tasken","year":"2006","journal-title":"Front. Biosci."},{"key":"10.1016\/j.virusres.2024.199313_bib0027","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.antiviral.2018.07.004","article-title":"CD24 and Fc fusion protein protects SIVmac239-infected Chinese rhesus macaque against progression to AIDS","volume":"157","author":"Tian","year":"2018","journal-title":"Antiviral Res."},{"issue":"8","key":"10.1016\/j.virusres.2024.199313_bib0028","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1007\/s00705-015-2455-6","article-title":"High immune activation and abnormal expression of cytokines contribute to death of SHIV89.6-infected Chinese rhesus macaques","volume":"160","author":"Tian","year":"2015","journal-title":"Arch. Virol."},{"issue":"11","key":"10.1016\/j.virusres.2024.199313_bib0029","doi-asserted-by":"crossref","first-page":"6231","DOI":"10.4049\/jimmunol.169.11.6231","article-title":"Cyclic adenosine 5 '-monophosphate and calcium induce CD152 (CTLA-4) up-regulation in resting CD4(+) T lymphocytes","volume":"169","author":"Vendetti","year":"2002","journal-title":"J. Immunol."},{"issue":"9","key":"10.1016\/j.virusres.2024.199313_bib0030","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nchembio.1611","article-title":"Endosomal generation of cAMP in GPCR signaling","volume":"10","author":"Vilardaga","year":"2014","journal-title":"Nat. Chem. Biol."},{"issue":"3","key":"10.1016\/j.virusres.2024.199313_bib0031","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.pharmthera.2004.12.005","article-title":"Sensitization of adenylate cyclase by G alpha(i\/o)-coupled receptors","volume":"106","author":"Watts","year":"2005","journal-title":"Pharmacol. Therapeut."},{"issue":"1","key":"10.1016\/j.virusres.2024.199313_bib0032","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/sj.jid.5700029","article-title":"Increased expression of CTLA-4 in malignant T-cells from patients with mycosis fungoides \u2013 cutaneous T cell lymphoma","volume":"126","author":"Wong","year":"2006","journal-title":"J. Invest. Dermatol."},{"issue":"4","key":"10.1016\/j.virusres.2024.199313_bib0033","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/JLB.4MR1019-189R","article-title":"Incomplete immune reconstitution in HIV\/AIDS patients on antiretroviral therapy: challenges of immunological non-responders","volume":"107","author":"Yang","year":"2020","journal-title":"J. Leukoc. Biol."},{"issue":"3","key":"10.1016\/j.virusres.2024.199313_bib0034","first-page":"7","article-title":"Study on treatment of monkey immunodeficiency virus infected rhesus monkeys with Jianpi Yiqi Fang","volume":"43","author":"Zhao","year":"2022","journal-title":"Yunnan J. Tradition. Chinese Med. Materia Medica"}],"container-title":["Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170224000066?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170224000066?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T14:23:30Z","timestamp":1759155810000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168170224000066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":34,"alternative-id":["S0168170224000066"],"URL":"https:\/\/doi.org\/10.1016\/j.virusres.2024.199313","relation":{},"ISSN":["0168-1702"],"issn-type":[{"type":"print","value":"0168-1702"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased cAMP-PKA signaling pathway activation is involved in up-regulation of CTLA-4 expression in CD4+ T cells in acute SIVmac239-infected Chinese rhesus macaques","name":"articletitle","label":"Article Title"},{"value":"Virus Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virusres.2024.199313","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"199313"}}