{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:42:08Z","timestamp":1790206928237,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T00:00:00Z","timestamp":1705708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005196","name":"Chinese Academy of Agricultural Sciences","doi-asserted-by":"publisher","award":["CAAS-CSLPDCP-202301"],"award-info":[{"award-number":["CAAS-CSLPDCP-202301"]}],"id":[{"id":"10.13039\/501100005196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virus Research"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.virusres.2024.199329","type":"journal-article","created":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T06:15:55Z","timestamp":1706336155000},"page":"199329","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["A novel antigenic epitope identified on the accessory protein NS6 of porcine deltacoronavirus"],"prefix":"10.1016","volume":"341","author":[{"given":"Qiuge","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxiao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingze","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longjun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virusres.2024.199329_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2019.197834","article-title":"Identification of the immunodominant neutralizing regions in the spike glycoprotein of porcine deltacoronavirus","volume":"276","author":"Chen","year":"2020","journal-title":"Virus Res."},{"issue":"Pt 4","key":"10.1016\/j.virusres.2024.199329_bib0002","article-title":"Identification of an immunodominant neutralizing epitope of porcine Deltacoronavirus spike protein","volume":"242","author":"Chen","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"2","key":"10.1016\/j.virusres.2024.199329_bib0003","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1099\/jgv.0.000690","article-title":"Discovery of a novel accessory protein NS7a encoded by porcine deltacoronavirus","volume":"98","author":"Fang","year":"2017","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virusres.2024.199329_bib0004","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.virol.2016.09.015","article-title":"Identification and subcellular localization of porcine deltacoronavirus accessory protein NS6","volume":"499","author":"Fang","year":"2016","journal-title":"Virology"},{"issue":"15","key":"10.1016\/j.virusres.2024.199329_bib0005","doi-asserted-by":"crossref","first-page":"e00712","DOI":"10.1128\/JVI.00712-18","article-title":"Porcine deltacoronavirus accessory protein NS6 antagonizes interferon beta production by interfering with the binding of RIG-I\/MDA5 to double-stranded RNA","volume":"92","author":"Fang","year":"2018","journal-title":"J. Virol."},{"issue":"10","key":"10.1016\/j.virusres.2024.199329_bib0006","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00957-23","article-title":"Porcine deltacoronavirus accessory protein NS6 harnesses VPS35-mediated retrograde trafficking to facilitate efficient viral infection","volume":"97","author":"Fang","year":"2023","journal-title":"J. Virol."},{"issue":"10","key":"10.1016\/j.virusres.2024.199329_bib0007","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.3390\/v13101991","article-title":"Construction, characterization and application of recombinant porcine deltacoronavirus expressing nanoluciferase","volume":"13","author":"Fang","year":"2021","journal-title":"Viruses"},{"issue":"2","key":"10.1016\/j.virusres.2024.199329_bib0008","doi-asserted-by":"crossref","first-page":"648","DOI":"10.3390\/ijms21020648","article-title":"Identification of a novel linear B-cell epitope on the nucleocapsid protein of porcine deltacoronavirus","volume":"21","author":"Fu","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"2\u20133","key":"10.1016\/j.virusres.2024.199329_bib0009","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s00253-022-12348-5","article-title":"Identification of a novel linear B-cell epitope in porcine deltacoronavirus nucleocapsid protein","volume":"107","author":"He","year":"2023","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.virusres.2024.199329_bib0010","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.antiviral.2014.06.013","article-title":"Accessory proteins of SARS-CoV and other coronaviruses","volume":"109","author":"Liu","year":"2014","journal-title":"Antiviral Res."},{"issue":"4","key":"10.1016\/j.virusres.2024.199329_bib0011","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00665-17","article-title":"MERS-CoV accessory ORFs play key role for infection and pathogenesis","volume":"8","author":"Menachery","year":"2017","journal-title":"mBio"},{"key":"10.1016\/j.virusres.2024.199329_bib0012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virol.2021.01.011","article-title":"The porcine deltacoronavirus accessory protein NS6 is expressed in vivo and incorporated into virions","volume":"556","author":"Qin","year":"2021","journal-title":"Virology"},{"issue":"8","key":"10.1016\/j.virusres.2024.199329_bib0013","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.vaccine.2018.01.017","article-title":"Recombinant live attenuated avian coronavirus vaccines with deletions in the accessory genes 3ab and\/or 5ab protect against infectious bronchitis in chickens","volume":"36","author":"van Beurden","year":"2018","journal-title":"Vaccine"},{"issue":"7","key":"10.1016\/j.virusres.2024.199329_bib0014","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.3201\/eid2007.140296","article-title":"Detection and genetic characterization of deltacoronavirus in pigs, Ohio, USA, 2014","volume":"20","author":"Wang","year":"2014","journal-title":"Emerging Infect. Dis."},{"key":"10.1016\/j.virusres.2024.199329_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2021.198497","article-title":"Identification of a novel B cell epitope on the nucleocapsid protein of porcine deltacoronavirus","volume":"302","author":"Wei","year":"2021","journal-title":"Virus Res."},{"key":"10.1016\/j.virusres.2024.199329_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.126327","article-title":"Identification of potential SLA-I-specific T-cell epitopes within the structural proteins of porcine deltacoronavirus","volume":"251","author":"Wen","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"7","key":"10.1016\/j.virusres.2024.199329_bib0017","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1128\/JVI.06540-11","volume":"86","author":"Woo","year":"2012","journal-title":"J. Virol."},{"issue":"18","key":"10.1016\/j.virusres.2024.199329_bib0018","doi-asserted-by":"crossref","first-page":"13934","DOI":"10.3390\/ijms241813934","article-title":"Identification of a monoclonal antibody against porcine deltacoronavirus membrane protein","volume":"24","author":"Wu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.virusres.2024.199329_bib0019","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/tbed.13369","article-title":"Pathogenicity of porcine deltacoronavirus (PDCoV) strain NH and immunization of pregnant sows with an inactivated PDCoV vaccine protects 5-day-old neonatal piglets from virulent challenge","volume":"67","author":"Zhang","year":"2020","journal-title":"Transbound. Emerg. Dis."},{"issue":"25","key":"10.1016\/j.virusres.2024.199329_bib0020","doi-asserted-by":"crossref","first-page":"9830","DOI":"10.1074\/jbc.RA119.007779","article-title":"Porcine deltacoronavirus enters cells via two pathways: a protease-mediated one at the cell surface and another facilitated by cathepsins in the endosome","volume":"294","author":"Zhang","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.virusres.2024.199329_bib0021","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1080\/22221751.2019.1701391","article-title":"Genetic manipulation of porcine deltacoronavirus reveals insights into NS6 and NS7 functions: a novel strategy for vaccine design","volume":"9","author":"Zhang","year":"2019","journal-title":"Emerg. Microbes Infect."},{"issue":"8","key":"10.1016\/j.virusres.2024.199329_bib0022","first-page":"e74","article-title":"Identification of a natural recombinant transmissible gastroenteritis virus between Purdue and Miller clusters in China","volume":"6","author":"Zhang","year":"2017","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.virusres.2024.199329_bib0023","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/1743-422X-9-225","article-title":"Identification of a conserved linear B-cell epitope in the M protein of porcine epidemic diarrhea virus","volume":"9","author":"Zhang","year":"2012","journal-title":"Virol. J."},{"key":"10.1016\/j.virusres.2024.199329_bib0024","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.virusres.2016.07.003","article-title":"Virulence factors in porcine coronaviruses and vaccine design","volume":"226","author":"Zu\u00f1iga","year":"2016","journal-title":"Virus Res."}],"container-title":["Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170224000224?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170224000224?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T14:23:47Z","timestamp":1759155827000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168170224000224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":24,"alternative-id":["S0168170224000224"],"URL":"https:\/\/doi.org\/10.1016\/j.virusres.2024.199329","relation":{},"ISSN":["0168-1702"],"issn-type":[{"value":"0168-1702","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel antigenic epitope identified on the accessory protein NS6 of porcine deltacoronavirus","name":"articletitle","label":"Article Title"},{"value":"Virus Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virusres.2024.199329","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"199329"}}