{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T16:02:03Z","timestamp":1772121723863,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virus Research"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.virusres.2024.199336","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T18:58:20Z","timestamp":1707850700000},"page":"199336","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Inhibition of EV71 replication by an interferon-stimulated gene product L3HYPDH"],"prefix":"10.1016","volume":"342","author":[{"given":"Jian","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Logen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinuan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobin","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanfeng","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runcai","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Mu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2929-7461","authenticated-orcid":false,"given":"Xuemin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.virusres.2024.199336_bib0001","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1261\/rna.469707","article-title":"Differential factor requirement to assemble translation initiation complexes at the alternative start codons of foot-and-mouth disease virus RNA","volume":"13","author":"Andreev","year":"2007","journal-title":"RNA"},{"key":"10.1016\/j.virusres.2024.199336_bib0002","doi-asserted-by":"crossref","first-page":"9969","DOI":"10.1128\/JVI.73.12.9969-9975.1999","article-title":"Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998","volume":"73","author":"Brown","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2024.199336_bib0003","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1007\/s13238-014-0087-3","article-title":"Molecular mechanism of SCARB2-mediated attachment and uncoating of EV71","volume":"5","author":"Dang","year":"2014","journal-title":"Protein Cell"},{"key":"10.1016\/j.virusres.2024.199336_bib0004","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s10096-018-3206-x","article-title":"Hand, foot and mouth disease: current knowledge on clinical manifestations, epidemiology, aetiology and prevention","volume":"37","author":"Esposito","year":"2018","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.virusres.2024.199336_bib0005","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1002\/2211-5463.13400","article-title":"Picornavirus translation strategies","volume":"12","author":"Francisco-Velilla","year":"2022","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.virusres.2024.199336_bib0006","article-title":"Type I interferon-induced TMEM106A blocks attachment of EV-A71 virus by interacting with the membrane protein SCARB2","volume":"13","author":"Guo","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.virusres.2024.199336_bib0007","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1006\/viro.1996.0395","article-title":"Structural Requirements for initiation of translation by internal ribosome entry within genome-length hepatitis C virus RNA","volume":"222","author":"Honda","year":"1996","journal-title":"Virology"},{"key":"10.1016\/j.virusres.2024.199336_bib0008","doi-asserted-by":"crossref","first-page":"4531","DOI":"10.4049\/jimmunol.168.9.4531","article-title":"Quantitative expression of toll-like receptor 1\u201310 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides","volume":"168","author":"Hornung","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.virusres.2024.199336_bib0009","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.virusres.2014.05.007","article-title":"Distribution of EV71 receptors SCARB2 and PSGL-1 in human tissues","volume":"190","author":"Jiao","year":"2014","journal-title":"Virus Res."},{"key":"10.1016\/j.virusres.2024.199336_bib0010","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12929-019-0607-9","article-title":"Translation control of enterovirus A71 gene expression","volume":"27","author":"Lai","year":"2020","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.virusres.2024.199336_bib0011","doi-asserted-by":"crossref","first-page":"8051","DOI":"10.1128\/JVI.02491-09","article-title":"The 3C protein of enterovirus 71 inhibits retinoid acid-inducible gene I-mediated interferon regulatory factor 3 activation and type I interferon responses","volume":"84","author":"Lei","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2024.199336_bib0012","doi-asserted-by":"crossref","first-page":"8811","DOI":"10.1128\/JVI.00447-11","article-title":"Cleavage of the adaptor protein TRIF by enterovirus 71 3C inhibits antiviral responses mediated by toll-like receptor 3","volume":"85","author":"Lei","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2024.199336_bib0013","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1261\/rna.058651.116","article-title":"The eIF3 complex of Trypanosoma brucei : composition conservation does not imply the conservation of structural assembly and subunits function","volume":"23","author":"Li","year":"2017","journal-title":"RNA"},{"key":"10.1016\/j.virusres.2024.199336_bib0014","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.1007\/s00705-016-3012-7","article-title":"Efficacy and safety of interferon-\u03b12b spray in the treatment of hand, foot, and mouth disease: a multicenter, randomized, double-blind trial","volume":"161","author":"Lin","year":"2016","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virusres.2024.199336_bib0015","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/1423-0127-16-103","article-title":"Viral and host proteins involved in picornavirus life cycle","volume":"16","author":"Lin","year":"2009","journal-title":"J. Biomed. Sci."},{"issue":"1","key":"10.1016\/j.virusres.2024.199336_bib0016","doi-asserted-by":"crossref","first-page":"15234","DOI":"10.1038\/s41598-020-71970-3","article-title":"Autophagy is induced and supports virus replication in enterovirus A71-infected human primary neuronal cells","volume":"10","author":"Lin","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.virusres.2024.199336_bib0017","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1128\/JVI.06687-11","article-title":"Enterovirus 71 disrupts interferon signaling by reducing the level of interferon receptor 1","volume":"86","author":"Lu","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2024.199336_bib0018","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.3389\/fmicb.2017.02629","article-title":"Insights into structural and mechanistic features of viral IRES elements","volume":"8","author":"Martinez-Salas","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.virusres.2024.199336_bib0019","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.virusres.2015.01.012","article-title":"Picornavirus IRES elements: RNA structure and host protein interactions","volume":"206","author":"Mart\u00ednez-Salas","year":"2015","journal-title":"Virus Res."},{"key":"10.1016\/j.virusres.2024.199336_bib0020","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1073\/pnas.2235688100","article-title":"Electroporation and RNA interference in the rodent retina in vivo and in vitro","volume":"101","author":"Matsuda","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.virusres.2024.199336_bib0021","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.3390\/v14102129","article-title":"Foot-and-mouth disease virus: molecular interplays with IFN response and the importance of the model","volume":"14","author":"Sarry","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.virusres.2024.199336_bib0022","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1146\/annurev-virology-092818-015756","article-title":"Interferon-stimulated genes: what do they all do?","volume":"6","author":"Schoggins","year":"2019","journal-title":"Annu. Rev. Virol."},{"key":"10.1016\/j.virusres.2024.199336_bib0023","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.coviro.2011.10.008","article-title":"Interferon-stimulated genes and their antiviral effector functions","volume":"1","author":"Schoggins","year":"2011","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.virusres.2024.199336_bib0024","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.3390\/v14102190","article-title":"Activation of host cellular signaling and mechanism of enterovirus 71 viral proteins associated with hand, foot and mouth disease","volume":"14","author":"Swain","year":"2022","journal-title":"Viruses"},{"issue":"1","key":"10.1016\/j.virusres.2024.199336_bib0025","doi-asserted-by":"crossref","first-page":"9719","DOI":"10.1038\/s41598-021-89271-8","article-title":"Novel capsid binder and PI4KIIIbeta inhibitors for EV-A71 replication inhibition","volume":"11","author":"Tan","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.virusres.2024.199336_bib0026","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1128\/JVI.02143-15","article-title":"Host MicroRNA miR-197 plays a negative regulatory role in the enterovirus 71 infectious cycle by targeting the RAN protein","volume":"90","author":"Tang","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2024.199336_bib0027","doi-asserted-by":"crossref","first-page":"21654","DOI":"10.1074\/jbc.M112.363218","article-title":"Identification of a human trans-3-hydroxy-l-proline dehydratase, the first characterized member of a novel family of proline racemase-like enzymes","volume":"287","author":"Visser","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virusres.2024.199336_bib0028","article-title":"Enterovirus A71 utilizes host cell lipid \u03b2-oxidation to promote its replication","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.virusres.2024.199336_bib0029","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3851\/IMP1720","article-title":"Potent inhibition of human enterovirus 71 replication by type I interferon subtypes","volume":"16","author":"Yi","year":"2011","journal-title":"Antivir. Ther."},{"key":"10.1016\/j.virusres.2024.199336_bib0030","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.ijantimicag.2018.12.009","article-title":"Spiramycin and azithromycin, safe for administration to children, exert antiviral activity against enterovirus A71 in vitro and in vivo","volume":"53","author":"Zeng","year":"2019","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.virusres.2024.199336_bib0031","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1007\/s13238-017-0405-7","article-title":"The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection","volume":"8","author":"Zhang","year":"2017","journal-title":"Protein Cell"},{"key":"10.1016\/j.virusres.2024.199336_bib0032","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s13238-018-0511-1","article-title":"Identification of new type I interferon-stimulated genes and investigation of their involvement in IFN-\u03b2 activation","volume":"9","author":"Zhang","year":"2018","journal-title":"Protein Cell"},{"key":"10.1016\/j.virusres.2024.199336_bib0033","doi-asserted-by":"crossref","first-page":"8976","DOI":"10.1038\/srep08976","article-title":"``Roar\u201d of blaNDM-1 and \u201csilence\u201d of blaOXA-58 co-exist in Acinetobacter pittii","volume":"5","author":"Zhou","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.virusres.2024.199336_bib0034","doi-asserted-by":"crossref","first-page":"4236","DOI":"10.1038\/emboj.2012.271","article-title":"Translational repression precedes and is required for ZAP-mediated mRNA decay: ZAP-mediated translational repression versus mRNA decay","volume":"31","author":"Zhu","year":"2012","journal-title":"EMBO J."}],"container-title":["Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170224000297?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170224000297?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T14:22:11Z","timestamp":1759155731000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168170224000297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":34,"alternative-id":["S0168170224000297"],"URL":"https:\/\/doi.org\/10.1016\/j.virusres.2024.199336","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/304345","asserted-by":"object"}]},"ISSN":["0168-1702"],"issn-type":[{"value":"0168-1702","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of EV71 replication by an interferon-stimulated gene product L3HYPDH","name":"articletitle","label":"Article Title"},{"value":"Virus Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virusres.2024.199336","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"199336"}}