{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T14:25:09Z","timestamp":1783002309309,"version":"3.54.5"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000015","name":"U.S. Department of Energy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100021177","name":"CDC Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100021177","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006225","name":"Oak Ridge Associated Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI151006"],"award-info":[{"award-number":["R01AI151006"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI109008"],"award-info":[{"award-number":["R01AI109008"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007917","name":"Agricultural Research Service","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006229","name":"Oak Ridge Institute for Science and Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006229","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virus Research"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.virusres.2024.199398","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T18:51:10Z","timestamp":1716231070000},"page":"199398","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Evaluation of two inoculation routes of an adenovirus-mediated viral protein inhibitor in a Crimean-Congo hemorrhagic fever mouse model"],"prefix":"10.1016","volume":"345","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2110-3087","authenticated-orcid":false,"given":"Florine E.M.","family":"Scholte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica R.","family":"Spengler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R.","family":"Welch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica R.","family":"Harmon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JoAnn D.","family":"Coleman-McCray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D.","family":"Pegan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel M.","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina F.","family":"Spiropoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9ric","family":"Bergeron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.virusres.2024.199398_bib0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41392-021-00487-6","article-title":"Viral vector platforms within the gene therapy landscape","volume":"6","author":"Bulcha","year":"2021","journal-title":"Sig. Transduct. Target. Ther."},{"issue":"23","key":"10.1016\/j.virusres.2024.199398_bib0018","doi-asserted-by":"crossref","first-page":"13271","DOI":"10.1128\/JVI.01647-07","article-title":"Crimean-Congo Hemorrhagic Fever Virus Glycoprotein Processing by the Endoprotease SKI-1\/S1P Is Critical for Virus Infectivity","volume":"81","author":"Bergeron","year":"2007","journal-title":"Journal of Virology"},{"issue":"1","key":"10.1016\/j.virusres.2024.199398_bib0007","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.4110\/in.2021.21.e6","article-title":"Adenovirus Vectors: Excellent Tools for Vaccine Development","volume":"21","author":"Chang","year":"2021","journal-title":"Immune Netw."},{"issue":"1","key":"10.1016\/j.virusres.2024.199398_bib0020","doi-asserted-by":"crossref","first-page":"19384","DOI":"10.1038\/s41598-023-45740-w","article-title":"Optimal reference genes for RNA tissue analysis in small animal models of hemorrhagic fever viruses","volume":"13","author":"Davies","year":"2023","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.virusres.2024.199398_bib0022","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1038\/sj.gt.3301030","article-title":"Expression of Coxsackie adenovirus receptor and alphav-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers","volume":"6","author":"Fechner","year":"1999","journal-title":"Gene Ther."},{"issue":"6","key":"10.1016\/j.virusres.2024.199398_bib0002","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.chom.2007.09.014","article-title":"Ovarian tumor domain-containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses","volume":"2","author":"Frias-Staheli","year":"2007","journal-title":"Cell host & microbe"},{"issue":"24","key":"10.1016\/j.virusres.2024.199398_bib0025","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1002\/cbic.201800649","article-title":"Enhanced Delivery of Synthetic Labelled Ubiquitin into Live Cells by Using Next-Generation Ub-TAT Conjugates","volume":"19","author":"Hameed","year":"2018","journal-title":"Chembiochem"},{"issue":"5","key":"10.1016\/j.virusres.2024.199398_bib0017","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1073\/pnas.95.5.2509","article-title":"Vogelstein B. A simplified system for generating recombinant adenoviruses","volume":"95","author":"He","year":"1998","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.virusres.2024.199398_bib0016","first-page":"JVI.01083","article-title":"Exploring Crimean-Congo hemorrhagic fever virus-induced hepatic injury using antibody-mediated type I interferon blockade in mice","author":"Lindquist","year":"2018","journal-title":"J. Virol."},{"issue":"1","key":"10.1016\/j.virusres.2024.199398_bib0023","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0168-1702(93)90090-A","article-title":"Monitoring foreign gene expression by a human adenovirus-based vector using the firefly luciferase gene as a reporter","volume":"28","author":"Mittal","year":"1993","journal-title":"Virus Res."},{"issue":"1","key":"10.1016\/j.virusres.2024.199398_bib0011","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1080\/22221751.2020.1838955","article-title":"Comparison of transgenic and adenovirus hACE2 mouse models for SARS-CoV-2 infection","volume":"9","author":"Rathnasinghe","year":"2020","journal-title":"Emerg. Microbes Infect."},{"issue":"5","key":"10.1016\/j.virusres.2024.199398_bib0008","first-page":"468","volume":"100","author":"Rosengart","year":"1999","journal-title":"Angiogenesis Gene Therapy. Circulation."},{"issue":"4","key":"10.1016\/j.virusres.2024.199398_bib0014","doi-asserted-by":"crossref","first-page":"574","DOI":"10.3390\/vaccines8040574","article-title":"Adenoviral Vector-Based Vaccine Platforms for Developing the Next Generation of Influenza Vaccines","volume":"8","author":"Sayedahmed","year":"2020","journal-title":"Vaccines (Basel)"},{"issue":"4","key":"10.1016\/j.virusres.2024.199398_bib0005","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01065-19","article-title":"Stable Occupancy of the Crimean-Congo Hemorrhagic Fever Virus-Encoded Deubiquitinase Blocks Viral Infection","volume":"10","author":"Scholte","year":"2019","journal-title":"mBio"},{"issue":"10","key":"10.1016\/j.virusres.2024.199398_bib0003","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1016\/j.celrep.2017.08.040","article-title":"Crimean-Congo Hemorrhagic Fever Virus Suppresses Innate Immune Responses via a Ubiquitin and ISG15 Specific Protease","volume":"20","author":"Scholte","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.virusres.2024.199398_bib0009","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.omtm.2019.11.001","article-title":"Immunology of Adenoviral Vectors in Cancer Therapy","volume":"15","author":"Shaw","year":"2019","journal-title":"Mol. Ther. Methods Clin. Dev."},{"issue":"6869","key":"10.1016\/j.virusres.2024.199398_bib0012","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/415331a","article-title":"Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity","volume":"415","author":"Shiver","year":"2002","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.virusres.2024.199398_bib0001","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1128\/JVI.06277-11","article-title":"Arterivirus and nairovirus ovarian tumor domain-containing Deubiquitinases target activated RIG-I to control innate immune signaling","volume":"86","author":"van Kasteren","year":"2012","journal-title":"Journal of virology"},{"key":"10.1016\/j.virusres.2024.199398_bib0019","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.antiviral.2017.10.008","article-title":"Identification of 2\u2032-deoxy-2\u2032-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus","volume":"147","author":"Welch","year":"2017","journal-title":"Antivir. Res."},{"issue":"1","key":"10.1016\/j.virusres.2024.199398_bib0013","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.1038\/s41467-020-17972-1","article-title":"A single dose of an adenovirus-vectored vaccine provides protection against SARS-CoV-2 challenge","volume":"11","author":"Wu","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.virusres.2024.199398_bib0024","doi-asserted-by":"crossref","first-page":"697","DOI":"10.3389\/fphar.2020.00697","article-title":"Cell-Penetrating Peptides in Diagnosis and Treatment of Human Diseases: From Preclinical Research to Clinical Application","volume":"11","author":"Xie","year":"2020","journal-title":"Front Pharmacol"},{"issue":"2","key":"10.1016\/j.virusres.2024.199398_bib0010","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0092-8674(93)80063-K","article-title":"Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis","volume":"75","author":"Zabner","year":"1993","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.virusres.2024.199398_bib0004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.ppat.1006372","article-title":"Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants","volume":"13","author":"Zhang","year":"2017","journal-title":"PLoS Pathogens"},{"issue":"10069","key":"10.1016\/j.virusres.2024.199398_bib0015","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0140-6736(16)32617-4","article-title":"Safety and immunogenicity of a recombinant adenovirus type-5 vector-based Ebola vaccine in healthy adults in Sierra Leone: a single-centre, randomised, double-blind, placebo-controlled, phase 2 trial","volume":"389","author":"Zhu","year":"2017","journal-title":"The Lancet"},{"issue":"12","key":"10.1016\/j.virusres.2024.199398_bib0021","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1093\/infdis\/jit061","article-title":"Lethal Crimean-Congo hemorrhagic fever virus infection in interferon \u03b1\/\u03b2 receptor knockout mice is associated with high viral loads, proinflammatory responses, and coagulopathy","volume":"207","author":"Zivcec","year":"2013","journal-title":"J. Infect. Dis."}],"container-title":["Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170224000911?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170224000911?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T12:04:47Z","timestamp":1778673887000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168170224000911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":25,"alternative-id":["S0168170224000911"],"URL":"https:\/\/doi.org\/10.1016\/j.virusres.2024.199398","relation":{},"ISSN":["0168-1702"],"issn-type":[{"value":"0168-1702","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of two inoculation routes of an adenovirus-mediated viral protein inhibitor in a Crimean-Congo hemorrhagic fever mouse model","name":"articletitle","label":"Article Title"},{"value":"Virus Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virusres.2024.199398","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"199398"}}