{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T09:01:59Z","timestamp":1793178119338,"version":"4.5.0"},"reference-count":223,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017634","name":"Henan University of Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017634","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virus Research"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.virusres.2025.199572","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T11:31:52Z","timestamp":1744284712000},"page":"199572","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Traditional Chinese medicine as a promising choice for future control of PEDV"],"prefix":"10.1016","volume":"356","author":[{"given":"Conghao","family":"Ji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cunhai","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongtong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aifang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sugai","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuying","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.virusres.2025.199572_bib0001","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20231395","article-title":"3-chymotrypsin-like protease in SARS-CoV-2","volume":"44","author":"Al Adem","year":"2024","journal-title":"Biosci Rep"},{"issue":"23","key":"10.1016\/j.virusres.2025.199572_bib0002","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25235672","article-title":"Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery","volume":"25","author":"Almeida","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.virusres.2025.199572_bib0003","article-title":"Efficacy of Jinhua Qinggan Granules Combined With Western Medicine in the Treatment of Confirmed and Suspected COVID-19: A Randomized Controlled Trial","volume":"8","author":"An","year":"2021","journal-title":"Front Med (Lausanne)"},{"issue":"3-4","key":"10.1016\/j.virusres.2025.199572_bib0004","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.vetimm.2015.09.006","article-title":"Age-dependent variation in innate immune responses to porcine epidemic diarrhea virus infection in suckling versus weaned pigs","volume":"168","author":"Annamalai","year":"2015","journal-title":"Vet Immunol Immunopathol"},{"key":"10.1016\/j.virusres.2025.199572_bib0005","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.vetimm.2016.04.009","article-title":"Efficacy of an inactivated genotype 2b porcine epidemic diarrhea virus vaccine in neonatal piglets","volume":"174","author":"Baek","year":"2016","journal-title":"Vet Immunol Immunopathol"},{"issue":"14","key":"10.1016\/j.virusres.2025.199572_bib0006","doi-asserted-by":"crossref","DOI":"10.1002\/jssc.202400274","article-title":"Magnetic materials as adsorbents for the pre-concentration and separation of active ingredients from herbal medicine","volume":"47","author":"Bai","year":"2024","journal-title":"J Sep Sci"},{"key":"10.1016\/j.virusres.2025.199572_bib0007","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.vetmic.2017.12.019","article-title":"Evaluation of a peroxygen-based disinfectant for inactivation of porcine epidemic diarrhea virus at low temperatures on metal surfaces","volume":"214","author":"Baker","year":"2018","journal-title":"Vet Microbiol"},{"issue":"1","key":"10.1016\/j.virusres.2025.199572_bib0008","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1186\/s12917-017-1300-4","article-title":"Evaluation of an accelerated hydrogen peroxide disinfectant to inactivate porcine epidemic diarrhea virus in swine feces on aluminum surfaces under freezing conditions","volume":"13","author":"Baker","year":"2017","journal-title":"BMC Vet Res"},{"issue":"29","key":"10.1016\/j.virusres.2025.199572_bib0009","doi-asserted-by":"crossref","first-page":"31274","DOI":"10.1021\/acsomega.4c02718","article-title":"A Comprehensive Review on Advanced Extraction Techniques for Retrieving Bioactive Components from Natural Sources","volume":"9","author":"Bhadange","year":"2024","journal-title":"ACS Omega"},{"issue":"3-4","key":"10.1016\/j.virusres.2025.199572_bib0011","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.vetmic.2015.05.027","article-title":"Effects of disinfection on the molecular detection of porcine epidemic diarrhea virus","volume":"179","author":"Bowman","year":"2015","journal-title":"Vet Microbiol"},{"issue":"1","key":"10.1016\/j.virusres.2025.199572_bib0012","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.virol.2008.10.021","article-title":"The large form of human 2\u2032,5\u2032-Oligoadenylate Synthetase (OAS3) exerts antiviral effect against Chikungunya virus","volume":"384","author":"Br\u00e9hin","year":"2009","journal-title":"Virology"},{"issue":"2","key":"10.1016\/j.virusres.2025.199572_bib0013","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.molimm.2014.06.037","article-title":"Microbe- and danger-induced inflammation","volume":"63","author":"Broggi","year":"2015","journal-title":"Mol Immunol"},{"issue":"8","key":"10.1016\/j.virusres.2025.199572_bib0014","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms9081731","article-title":"The New Generation hDHODH Inhibitor MEDS433 Hinders the In Vitro Replication of SARS-CoV-2 and Other Human Coronaviruses","volume":"9","author":"Calistri","year":"2021","journal-title":"Microorganisms"},{"issue":"4","key":"10.1016\/j.virusres.2025.199572_bib0015","article-title":"The Aqueous Leaf Extract of M. oleifera Inhibits PEDV Replication through Suppressing Oxidative Stress-Mediated Apoptosis","volume":"12","author":"Cao","year":"2022","journal-title":"Animals (Basel)"},{"issue":"5","key":"10.1016\/j.virusres.2025.199572_bib0016","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0283728","article-title":"Fuzhengjiedu San inhibits porcine reproductive and respiratory syndrome virus by activating the PI3K\/AKT pathway","volume":"19","author":"Chang","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.virusres.2025.199572_bib0017","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.virol.2020.06.008","article-title":"N6-methyladenosine regulates PEDV replication and host gene expression","volume":"548","author":"Chen","year":"2020","journal-title":"Virology"},{"key":"10.1016\/j.virusres.2025.199572_bib0018","article-title":"Traditional Chinese Medicine Prescriptions Decrease Diarrhea Rate by Relieving Colonic Inflammation and Ameliorating Caecum Microbiota in Piglets","volume":"2020","author":"Chen","year":"2020","journal-title":"Evid Based Complement Alternat Med"},{"issue":"17","key":"10.1016\/j.virusres.2025.199572_bib0019","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23179661","article-title":"Antiviral Effect of pIFNLs against PEDV and VSV Infection in Different Cells","volume":"23","author":"Chen","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.virusres.2025.199572_bib0020","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jviromet.2017.01.002","article-title":"Super-oxidized water inactivates major viruses circulating in swine farms","volume":"242","author":"Chen","year":"2017","journal-title":"J Virol Methods"},{"key":"10.1016\/j.virusres.2025.199572_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113009","article-title":"Antiviral activity against porcine epidemic diarrhea virus of Pogostemon cablin polysaccharide","volume":"259","author":"Chen","year":"2020","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.virusres.2025.199572_bib0022","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.rvsc.2021.10.026","article-title":"Inhibition of porcine epidemic diarrhea virus by Alpiniae oxyphyllae fructus polysaccharide 3","volume":"141","author":"Chen","year":"2021","journal-title":"Res Vet Sci"},{"issue":"1","key":"10.1016\/j.virusres.2025.199572_bib0023","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12985-018-1078-4","article-title":"Porcine epidemic diarrhea virus S1 protein is the critical inducer of apoptosis","volume":"15","author":"Chen","year":"2018","journal-title":"Virol J"},{"issue":"4","key":"10.1016\/j.virusres.2025.199572_bib0024","article-title":"Vitro and In Vivo Evaluation of Bacillus Strains as Prophylactic Agents Against Porcine Epidemic Diarrhea Virus","volume":"15","author":"Chen","year":"2025","journal-title":"Animals (Basel)"},{"issue":"3","key":"10.1016\/j.virusres.2025.199572_bib0025","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1007\/s12602-021-09829-w","article-title":"Screening of Lactic Acid Bacterial Strains with Antiviral Activity Against Porcine Epidemic Diarrhea","volume":"14","author":"Chen","year":"2022","journal-title":"Probiotics Antimicrob Proteins"},{"issue":"11","key":"10.1016\/j.virusres.2025.199572_bib0026","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens11111371","article-title":"Antiviral Properties of Pennisetum purpureum Extract against Coronaviruses and Enteroviruses","volume":"11","author":"Chen","year":"2022","journal-title":"Pathogens"},{"issue":"1","key":"10.1016\/j.virusres.2025.199572_bib0061","first-page":"8","article-title":"Study of clinical efficacy on porcine epidemic diarrhea virus infection blocked by Xianglian solution","volume":"54","author":"Chang","year":"2018","journal-title":"Chinese Journal of Veterinary Medicine"},{"issue":"10","key":"10.1016\/j.virusres.2025.199572_bib0172","first-page":"4403","article-title":"Effect of pulsatilla powder prescription decoction ferments on intestinal barrier function of piglets infected with porcine epidemic diarrhea virus","volume":"54","author":"Chang","year":"2023","journal-title":"Acta Veterinaria et Zootechnica Sinica"},{"issue":"12","key":"10.1016\/j.virusres.2025.199572_bib0027","doi-asserted-by":"crossref","DOI":"10.3390\/v13122527","article-title":"Antiviral Activities of Carbazole Derivatives against Porcine Epidemic Diarrhea Virus In Vitro","volume":"13","author":"Chen","year":"2021","journal-title":"Viruses"},{"issue":"5660","key":"10.1016\/j.virusres.2025.199572_bib0028","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1126\/science.1092734","article-title":"Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis","volume":"303","author":"Chipuk","year":"2004","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.virusres.2025.199572_bib0029","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1021\/acs.jnatprod.8b00435","article-title":"Prenylated Phenolic Compounds from the Leaves of Sabia limoniacea and Their Antiviral Activities against Porcine Epidemic Diarrhea Virus","volume":"82","author":"Cho","year":"2019","journal-title":"J Nat Prod"},{"key":"10.1016\/j.virusres.2025.199572_bib0030","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/985151","article-title":"Epimedium koreanum Nakai Water Extract Exhibits Antiviral Activity against Porcine Epidermic Diarrhea Virus In Vitro and In Vivo","volume":"2012","author":"Cho","year":"2012","journal-title":"Evid Based Complement Alternat Med"},{"issue":"1","key":"10.1016\/j.virusres.2025.199572_bib0031","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.antiviral.2008.10.002","article-title":"Antiviral activity of quercetin 7-rhamnoside against porcine epidemic diarrhea virus","volume":"81","author":"Choi","year":"2009","journal-title":"Antiviral Res"},{"issue":"3-4","key":"10.1016\/j.virusres.2025.199572_bib0032","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ejps.2009.03.002","article-title":"Inhibitory effects of quercetin 3-rhamnoside on influenza A virus replication","volume":"37","author":"Choi","year":"2009","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.virusres.2025.199572_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2021.105630","article-title":"Continuous and pulsed ultrasound-assisted extraction of carob's antioxidants: Processing parameters optimization and identification of polyphenolic composition","volume":"76","author":"Christou","year":"2021","journal-title":"Ultrason Sonochem"},{"issue":"06","key":"10.1016\/j.virusres.2025.199572_bib0070","first-page":"173","article-title":"Study and application the hyperimmunized yolk antibodies of TGEV and PEDV in piglets","volume":"39","author":"Cui","year":"2012","journal-title":"China Animal Husbandry & Veterinary Medicine"},{"issue":"2","key":"10.1016\/j.virusres.2025.199572_bib0034","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jep.2012.07.005","article-title":"Life or death: neuroprotective and anticancer effects of quercetin","volume":"143","author":"Dajas","year":"2012","journal-title":"J Ethnopharmacol"},{"issue":"8","key":"10.1016\/j.virusres.2025.199572_bib0035","first-page":"2293","article-title":"Preparation, Purification and Activity Factors Analysis of IgY Against Variant of Porcine Epidemic Diarrhea Virus","volume":"45","author":"Dan","year":"2018","journal-title":"China Animal Husbandry & Veterinary Medicine"},{"issue":"7","key":"10.1016\/j.virusres.2025.199572_bib0036","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1439-0450.1979.tb00845.x","article-title":"Experimental infection of pigs with Belgian isolates of the porcine rotavirus","volume":"26","author":"Debouck","year":"1979","journal-title":"Zentralbl Veterinarmed B"},{"issue":"5","key":"10.1016\/j.virusres.2025.199572_bib0037","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.nut.2009.06.013","article-title":"Bioavailability of catechins from ready-to-drink tea","volume":"26","author":"Del Rio","year":"2010","journal-title":"Nutrition"},{"issue":"17","key":"10.1016\/j.virusres.2025.199572_bib0038","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00565-20","article-title":"Inactivating Three Interferon Antagonists Attenuates Pathogenesis of an Enteric Coronavirus","volume":"94","author":"Deng","year":"2020","journal-title":"J Virol"},{"issue":"1","key":"10.1016\/j.virusres.2025.199572_bib0039","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13567-019-0712-5","article-title":"Nanoparticle-based vaccine development and evaluation against viral infections in pigs","volume":"50","author":"Dhakal","year":"2019","journal-title":"Vet Res"},{"issue":"11","key":"10.1016\/j.virusres.2025.199572_bib0040","doi-asserted-by":"crossref","DOI":"10.3390\/v10110601","article-title":"The Natural Compound Homoharringtonine Presents Broad Antiviral Activity In Vitro and In Vivo","volume":"10","author":"Dong","year":"2018","journal-title":"Viruses"},{"issue":"8","key":"10.1016\/j.virusres.2025.199572_bib0041","first-page":"2603","article-title":"Immunization against porcine epidemic diarrhea virus and vaccine development","volume":"37","author":"Dong","year":"2021","journal-title":"Chinese Journal of Biotechnology"},{"issue":"6","key":"10.1016\/j.virusres.2025.199572_bib0042","doi-asserted-by":"crossref","DOI":"10.3390\/v14061231","article-title":"Bis-Benzylisoquinoline Alkaloids Inhibit Porcine Epidemic Diarrhea Virus In Vitro and In Vivo","volume":"14","author":"Dong","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.virusres.2025.199572_bib0043","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2021.771411","article-title":"Alterations of Suckling Piglet Jejunal Microbiota Due to Infection With Porcine Epidemic Diarrhea Virus and Protection Against Infection by Lactobacillus salivarius","volume":"8","author":"Dong","year":"2021","journal-title":"Front Vet Sci"},{"issue":"5","key":"10.1016\/j.virusres.2025.199572_bib0044","doi-asserted-by":"crossref","first-page":"4369","DOI":"10.1021\/acsami.7b13811","article-title":"Glutathione-Capped Ag(2)S Nanoclusters Inhibit Coronavirus Proliferation through Blockage of Viral RNA Synthesis and Budding","volume":"10","author":"Du","year":"2018","journal-title":"ACS Appl Mater Interfaces"},{"issue":"1","key":"10.1016\/j.virusres.2025.199572_bib0045","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1186\/s12917-017-1218-x","article-title":"Curcumin is a promising inhibitor of genotype 2 porcine reproductive and respiratory syndrome virus infection","volume":"13","author":"Du","year":"2017","journal-title":"BMC Vet Res"},{"issue":"1","key":"10.1016\/j.virusres.2025.199572_bib0046","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13567-021-00955-5","article-title":"Antiviral effects of ergosterol peroxide in a pig model of porcine deltacoronavirus (PDCoV) infection involves modulation of apoptosis and tight junction in the small intestine","volume":"52","author":"Duan","year":"2021","journal-title":"Vet Res"},{"issue":"3","key":"10.1016\/j.virusres.2025.199572_bib0047","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1111\/tbed.13444","article-title":"Origin and epidemic status of porcine epidemic diarrhea virus variants in China","volume":"67","author":"Fan","year":"2020","journal-title":"Transbound Emerg Dis"},{"issue":"7","key":"10.1016\/j.virusres.2025.199572_bib0048","doi-asserted-by":"crossref","first-page":"821","DOI":"10.2174\/1389557523666221220142911","article-title":"Antiviral Activity of Pyrimidine Containing Compounds: Patent Review","volume":"23","author":"Farghaly","year":"2023","journal-title":"Mini Rev Med Chem"},{"issue":"6","key":"10.1016\/j.virusres.2025.199572_bib0049","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1097\/00002030-200204120-00020","article-title":"Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea as a candidate anti-HIV agent","volume":"16","author":"Fassina","year":"2002","journal-title":"Aids"},{"key":"10.1016\/j.virusres.2025.199572_bib0050","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.antiviral.2018.07.012","article-title":"Multiple antiviral approaches of (-)-epigallocatechin-3-gallate (EGCG) against porcine reproductive and respiratory syndrome virus infection in vitro","volume":"158","author":"Ge","year":"2018","journal-title":"Antiviral Res"},{"issue":"10","key":"10.1016\/j.virusres.2025.199572_bib0051","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1093\/jas\/sky295","article-title":"Evaluation of the effects of flushing feed manufacturing equipment with chemically treated rice hulls on porcine epidemic diarrhea virus cross-contamination during feed manufacturing","volume":"96","author":"Gebhardt","year":"2018","journal-title":"J Anim Sci"},{"issue":"1-2","key":"10.1016\/j.virusres.2025.199572_bib0052","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.vetmic.2014.12.019","article-title":"Previous infection of sows with a \"mild\" strain of porcine epidemic diarrhea virus confers protection against infection with a \"severe\" strain","volume":"176","author":"Goede","year":"2015","journal-title":"Veterinary microbiology"},{"key":"10.1016\/j.virusres.2025.199572_bib0053","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3389\/fvets.2019.00273","article-title":"The Role of Non-animal Origin Feed Ingredients in Transmission of Viral Pathogens of Swine: A Review of Scientific Literature","volume":"6","author":"Gordon","year":"2019","journal-title":"Front Vet Sci"},{"key":"10.1016\/j.virusres.2025.199572_bib0056","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2024.1407182","article-title":"Research progress on pharmacological properties and application of probiotics in the fermentation of Scutellaria baicalensis Georgi","volume":"11","author":"Guo","year":"2024","journal-title":"Front Nutr"},{"issue":"7","key":"10.1016\/j.virusres.2025.199572_bib0057","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nm.3893","article-title":"Inflammasomes: mechanism of action, role in disease, and therapeutics","volume":"21","author":"Guo","year":"2015","journal-title":"Nat Med"},{"issue":"15","key":"10.1016\/j.virusres.2025.199572_bib0058","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1056\/NEJMoa2118542","article-title":"Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19","volume":"386","author":"Hammond","year":"2022","journal-title":"N Engl J Med"},{"issue":"8","key":"10.1016\/j.virusres.2025.199572_bib0059","doi-asserted-by":"crossref","first-page":"8852","DOI":"10.3390\/cimb46080523","article-title":"ROS Chronicles in HIV Infection: Genesis of Oxidative Stress, Associated Pathologies, and Therapeutic Strategies","volume":"46","author":"Harshithkumar","year":"2024","journal-title":"Curr Issues Mol Biol"},{"issue":"2","key":"10.1016\/j.virusres.2025.199572_bib0060","first-page":"100","article-title":"Efficacy of an accelerated hydrogen peroxide disinfectant to inactivate porcine epidemic diarrhea virus in swine feces on metal surfaces","volume":"81","author":"Holtkamp","year":"2017","journal-title":"Can J Vet Res"},{"issue":"15","key":"10.1016\/j.virusres.2025.199572_bib0062","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00406-19","article-title":"Engineering a Live Attenuated Porcine Epidemic Diarrhea Virus Vaccine Candidate via Inactivation of the Viral 2\u2032-O-Methyltransferase and the Endocytosis Signal of the Spike Protein","volume":"93","author":"Hou","year":"2019","journal-title":"J Virol"},{"issue":"2","key":"10.1016\/j.virusres.2025.199572_bib0063","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01758-18","article-title":"Deletion of both the Tyrosine-Based Endocytosis Signal and the Endoplasmic Reticulum Retrieval Signal in the Cytoplasmic Tail of Spike Protein Attenuates Porcine Epidemic Diarrhea Virus in Pigs","volume":"93","author":"Hou","year":"2019","journal-title":"J Virol"},{"key":"10.1016\/j.virusres.2025.199572_bib0064","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.628526","article-title":"Epigallocatechin-3-Gallate, the Main Polyphenol in Green Tea, Inhibits Porcine Epidemic Diarrhea Virus In Vitro","volume":"12","author":"Huan","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.virusres.2025.199572_bib0203","doi-asserted-by":"crossref","DOI":"10.1016\/j.scp.2023.101267","article-title":"Comparative analysis of flavonoids extracted from Dendrobium chrysotoxum flowers by supercritical fluid extraction and ultrasonic cold extraction","volume":"36","author":"Hu","year":"2023","journal-title":"Sustainable Chemistry and Pharmacy"},{"issue":"46","key":"10.1016\/j.virusres.2025.199572_bib0065","doi-asserted-by":"crossref","first-page":"75064","DOI":"10.18632\/oncotarget.11991","article-title":"Porcine epidemic diarrhea virus nucleoprotein contributes to HMGB1 transcription and release by interacting with C\/EBP-\u03b2","volume":"7","author":"Huan","year":"2016","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.virusres.2025.199572_bib0066","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1007\/s00705-017-3259-7","article-title":"Glycyrrhizin inhibits porcine epidemic diarrhea virus infection and attenuates the proinflammatory responses by inhibition of high mobility group box-1 protein","volume":"162","author":"Huan","year":"2017","journal-title":"Arch Virol"},{"key":"10.1016\/j.virusres.2025.199572_bib0067","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2021.105184","article-title":"Ergosterol peroxide inhibits HBV infection by inhibiting the binding of the pre-S1 domain of LHBsAg to NTCP","volume":"195","author":"Huang","year":"2021","journal-title":"Antiviral Res"},{"key":"10.1016\/j.virusres.2025.199572_bib0068","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107843","article-title":"Traditional Chinese Medicine (TCM) in the treatment of COVID-19 and other viral infections: Efficacies and mechanisms","volume":"225","author":"Huang","year":"2021","journal-title":"Pharmacol Ther"},{"issue":"6","key":"10.1016\/j.virusres.2025.199572_bib0069","doi-asserted-by":"crossref","DOI":"10.3390\/v15061317","article-title":"Molnupiravir Inhibits Porcine Epidemic Diarrhea Virus Infection In Vitro","volume":"15","author":"Huang","year":"2023","journal-title":"Viruses"},{"issue":"4","key":"10.1016\/j.virusres.2025.199572_bib0071","doi-asserted-by":"crossref","first-page":"e58","DOI":"10.4142\/jvs.23090","article-title":"Porcine epidemic diarrhea virus: an update overview of virus epidemiology, vaccines, and control strategies in South Korea","volume":"24","author":"Jang","year":"2023","journal-title":"J Vet Sci"},{"issue":"11","key":"10.1016\/j.virusres.2025.199572_bib0072","doi-asserted-by":"crossref","DOI":"10.3390\/v12111242","article-title":"Curcumin as an Antiviral Agent","volume":"12","author":"Jennings","year":"2020","journal-title":"Viruses"},{"key":"10.1016\/j.virusres.2025.199572_bib0073","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114760","article-title":"Advanced applications of mass spectrometry imaging technology in quality control and safety assessments of traditional Chinese medicines","volume":"284","author":"Jiang","year":"2022","journal-title":"J Ethnopharmacol"},{"issue":"10","key":"10.1016\/j.virusres.2025.199572_bib0074","first-page":"2117","article-title":"Research progress on porcine epidemic diarrhea virus vaccines","volume":"42","author":"Jing","year":"2022","journal-title":"Chinese Journal of Veterinary Science"},{"issue":"2","key":"10.1016\/j.virusres.2025.199572_bib0076","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.tvjl.2015.02.017","article-title":"Porcine epidemic diarrhea virus infection: Etiology, epidemiology, pathogenesis and immunoprophylaxis","volume":"204","author":"Jung","year":"2015","journal-title":"Vet J"},{"key":"10.1016\/j.virusres.2025.199572_bib0077","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2020.198045","article-title":"Porcine epidemic diarrhea virus (PEDV): An update on etiology, transmission, pathogenesis, and prevention and control","volume":"286","author":"Jung","year":"2020","journal-title":"Virus research"},{"issue":"3","key":"10.1016\/j.virusres.2025.199572_bib0078","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/bab.1617","article-title":"Progress in biopharmaceutical development","volume":"65","author":"Kesik-Brodacka","year":"2018","journal-title":"Biotechnol Appl Biochem"},{"issue":"9","key":"10.1016\/j.virusres.2025.199572_bib0079","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23092300","article-title":"Antiviral Activities of Oleanolic Acid and Its Analogues","volume":"23","author":"Khwaza","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.virusres.2025.199572_bib0080","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s40781-015-0065-1","article-title":"Medicinal herb extracts ameliorate impaired growth performance and intestinal lesion of newborn piglets challenged with the virulent porcine epidemic diarrhea virus","volume":"57","author":"Kim","year":"2015","journal-title":"J Anim Sci Technol"},{"issue":"13","key":"10.1016\/j.virusres.2025.199572_bib0081","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1016\/j.bmcl.2017.05.022","article-title":"Antiviral escin derivatives from the seeds of Aesculus turbinata Blume (Japanese horse chestnut)","volume":"27","author":"Kim","year":"2017","journal-title":"Bioorg Med Chem Lett"},{"issue":"1","key":"10.1016\/j.virusres.2025.199572_bib0082","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1556\/004.2021.00001","article-title":"Application of chitosan as a natural disinfectant against porcine epidemic diarrhoea virus","volume":"69","author":"Kim","year":"2021","journal-title":"Acta Vet Hung"},{"key":"10.1016\/j.virusres.2025.199572_bib0083","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.virol.2014.04.040","article-title":"Porcine epidemic diarrhea virus induces caspase-independent apoptosis through activation of mitochondrial apoptosis-inducing factor","volume":"460-461","author":"Kim","year":"2014","journal-title":"Virology"},{"issue":"21","key":"10.1016\/j.virusres.2025.199572_bib0084","doi-asserted-by":"crossref","first-page":"11754","DOI":"10.1128\/JVI.01348-12","article-title":"Broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronaviruses","volume":"86","author":"Kim","year":"2012","journal-title":"J Virol"},{"issue":"1","key":"10.1016\/j.virusres.2025.199572_bib0085","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1186\/s12917-017-1283-1","article-title":"Trypsin-independent porcine epidemic diarrhea virus US strain with altered virus entry mechanism","volume":"13","author":"Kim","year":"2017","journal-title":"BMC Vet Res"},{"issue":"1","key":"10.1016\/j.virusres.2025.199572_bib0086","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12917-017-1017-4","article-title":"Evaluation of biosecurity measures to prevent indirect transmission of porcine epidemic diarrhea virus","volume":"13","author":"Kim","year":"2017","journal-title":"BMC Vet Res"},{"key":"10.1016\/j.virusres.2025.199572_bib0087","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.antiviral.2017.08.010","article-title":"Rapamycin-induced autophagy restricts porcine epidemic diarrhea virus infectivity in porcine intestinal epithelial cells","volume":"146","author":"Ko","year":"2017","journal-title":"Antiviral research"},{"issue":"12","key":"10.1016\/j.virusres.2025.199572_bib0088","first-page":"128","article-title":"Application of microecological preparations of Chinese medicine in animal production","volume":"49","author":"Kun","year":"2017","journal-title":"Animal Husbandry & Veterinary Medicine"},{"key":"10.1016\/j.virusres.2025.199572_bib0123","first-page":"1","article-title":"Identification of Recombinant PRRSV Live Vector Vaccine Strains Expressing The Dominant Antigenic Region of PEDV S Protein","author":"Lao","year":"2025","journal-title":"Chin J Animal Infect Dis"},{"key":"10.1016\/j.virusres.2025.199572_bib0089","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1472-6882-6-10","article-title":"Dose escalation of a curcuminoid formulation","volume":"6","author":"Lao","year":"2006","journal-title":"BMC Complement Altern Med"},{"key":"10.1016\/j.virusres.2025.199572_bib0090","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/s12985-015-0421-2","article-title":"Porcine epidemic diarrhea virus: An emerging and re-emerging epizootic swine virus","volume":"12","author":"Lee","year":"2015","journal-title":"Virol J"},{"issue":"9","key":"10.1016\/j.virusres.2025.199572_bib0091","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1007\/s00705-015-2494-z","article-title":"Immunoprophylactic effect of chicken egg yolk antibody (IgY) against a recombinant S1 domain of the porcine epidemic diarrhea virus spike protein in piglets","volume":"160","author":"Lee","year":"2015","journal-title":"Arch Virol"},{"key":"10.1016\/j.virusres.2025.199572_bib0092","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.virusres.2014.09.013","article-title":"Porcine epidemic diarrhea virus infection: inhibition by polysaccharide from Ginkgo biloba exocarp and mode of its action","volume":"195","author":"Lee","year":"2015","journal-title":"Virus Res"},{"key":"10.1016\/j.virusres.2025.199572_bib0093","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175260","article-title":"Deep learning and machine intelligence: New computational modeling techniques for discovery of the combination rules and pharmacodynamic characteristics of Traditional Chinese Medicine","volume":"933","author":"Li","year":"2022","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"10.1016\/j.virusres.2025.199572_bib0094","doi-asserted-by":"crossref","DOI":"10.3390\/v12020176","article-title":"Antiviral Effect of Epigallocatechin Gallate via Impairing Porcine Circovirus Type 2 Attachment to Host Cell Receptor","volume":"12","author":"Li","year":"2020","journal-title":"Viruses"},{"issue":"4","key":"10.1016\/j.virusres.2025.199572_bib0095","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1142\/S0192415X20500433","article-title":"The Application of Fermentation Technology in Traditional Chinese Medicine: A Review","volume":"48","author":"Li","year":"2020","journal-title":"Am J Chin Med"},{"issue":"2","key":"10.1016\/j.virusres.2025.199572_bib0096","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s11262-019-01633-7","article-title":"In vitro antiviral activity of Griffithsin against porcine epidemic diarrhea virus","volume":"55","author":"Li","year":"2019","journal-title":"Virus Genes"},{"key":"10.1016\/j.virusres.2025.199572_bib0097","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2023.106185","article-title":"Insights and progress on epidemic characteristics, genotyping, and preventive measures of PEDV in China: A review","volume":"181","author":"Li","year":"2023","journal-title":"Microb Pathog"},{"issue":"5","key":"10.1016\/j.virusres.2025.199572_bib0098","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1007\/s12272-001-1206-5","article-title":"Quercetin in a lotus leaves extract may be responsible for antibacterial activity","volume":"31","author":"Li","year":"2008","journal-title":"Arch Pharm Res"},{"issue":"6","key":"10.1016\/j.virusres.2025.199572_bib0099","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.01486-15","article-title":"Complete Genome Sequence of the Porcine Epidemic Diarrhea Virus Variant CH\/HNYF\/2014","volume":"3","author":"Li","year":"2015","journal-title":"Genome Announc"},{"issue":"1","key":"10.1016\/j.virusres.2025.199572_bib0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.antiviral.2012.10.006","article-title":"Traditional Chinese herbal medicine as a source of molecules with antiviral activity","volume":"97","author":"Li","year":"2013","journal-title":"Antiviral Res"},{"key":"10.1016\/j.virusres.2025.199572_bib0101","article-title":"Opportunities and challenges of traditional Chinese medicine doctors in the era of artificial intelligence","volume":"10","author":"Li","year":"2023","journal-title":"Front Med (Lausanne)"},{"issue":"8","key":"10.1016\/j.virusres.2025.199572_bib0102","doi-asserted-by":"crossref","DOI":"10.3390\/v14081746","article-title":"Development of a Genetically Engineered Bivalent Vaccine against Porcine Epidemic Diarrhea Virus and Porcine Rotavirus","volume":"14","author":"Li","year":"2022","journal-title":"Viruses"},{"issue":"10","key":"10.1016\/j.virusres.2025.199572_bib0010","first-page":"68","article-title":"Preparation and application of immunoglobin of yolk against porcine epidemic diarrhea virus","volume":"41","author":"Li","year":"2014","journal-title":"China Animal Husbandry Vet Med"},{"issue":"9","key":"10.1016\/j.virusres.2025.199572_bib0103","doi-asserted-by":"crossref","DOI":"10.3390\/v13091866","article-title":"Construction of a Recombinant Porcine Epidemic Diarrhea Virus Encoding Nanoluciferase for High-Throughput Screening of Natural Antiviral Products","volume":"13","author":"Li","year":"2021","journal-title":"Viruses"},{"issue":"11","key":"10.1016\/j.virusres.2025.199572_bib0055","first-page":"3","article-title":"Study and clinical application of egg yolk antibody against porcine epidemic diarrhea virus","volume":"54","author":"Li","year":"2018","journal-title":"Chin J Vet Sci Med"},{"issue":"10","key":"10.1016\/j.virusres.2025.199572_bib0104","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1099\/jgv.0.001466","article-title":"Antiviral and virucidal effects of curcumin on transmissible gastroenteritis virus in vitro","volume":"101","author":"Li","year":"2020","journal-title":"J Gen Virol"},{"issue":"1","key":"10.1016\/j.virusres.2025.199572_bib0105","doi-asserted-by":"crossref","first-page":"3811","DOI":"10.1038\/s41467-018-06056-w","article-title":"An alternative pathway of enteric PEDV dissemination from nasal cavity to intestinal mucosa in swine","volume":"9","author":"Li","year":"2018","journal-title":"Nat Commun"},{"issue":"21","key":"10.1016\/j.virusres.2025.199572_bib0106","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21218095","article-title":"Inhibition of Porcine Epidemic Diarrhea Virus Replication and Viral 3C-Like Protease by Quercetin","volume":"21","author":"Li","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.virusres.2025.199572_bib0107","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2020.104553","article-title":"Porcine epidemic diarrhea virus: Molecular mechanisms of attenuation and vaccines","volume":"149","author":"Li","year":"2020","journal-title":"Microb Pathog"},{"issue":"8","key":"10.1016\/j.virusres.2025.199572_bib0108","doi-asserted-by":"crossref","DOI":"10.3390\/v14081744","article-title":"PEDV: Insights and Advances into Types, Function, Structure, and Receptor Recognition","volume":"14","author":"Lin","year":"2022","journal-title":"Viruses"},{"issue":"04","key":"10.1016\/j.virusres.2025.199572_bib0186","first-page":"18","article-title":"Therapeutic effect and mechanism of Andrographis paniculata compound on piglet epidemic diarrhea","volume":"58","author":"Liu","year":"2022","journal-title":"Chin J Vet Sci Med"},{"key":"10.1016\/j.virusres.2025.199572_bib0109","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/8358151","article-title":"Structural Modulation of Gut Microbiota during Alleviation of Suckling Piglets Diarrhoea with Herbal Formula","volume":"2017","author":"Liu","year":"2017","journal-title":"Evid Based Complement Alternat Med"},{"issue":"18","key":"10.1016\/j.virusres.2025.199572_bib0187","first-page":"155","article-title":"The Efficacy of Traditional Chinese Medicine Compounds on the Treatment of Piglets Artificially Infected with Porcine Epidemic Diarrhea Virus","author":"Liu","year":"2016","journal-title":"Heilongjiang Animal Sci Vet Med"},{"key":"10.1016\/j.virusres.2025.199572_bib0110","doi-asserted-by":"crossref","first-page":"825","DOI":"10.3389\/fmicb.2019.00825","article-title":"Gegen Qinlian Decoction Treats Diarrhea in Piglets by Modulating Gut Microbiota and Short-Chain Fatty Acids","volume":"10","author":"Liu","year":"2019","journal-title":"Frontiers in microbiology"},{"issue":"2","key":"10.1016\/j.virusres.2025.199572_bib0111","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1021\/acs.jnatprod.6b00694","article-title":"Sesquiterpenoids with Various Carbocyclic Skeletons from the Flowers of Chrysanthemum indicum","volume":"80","author":"Liu","year":"2017","journal-title":"J Nat Prod"},{"issue":"2-3","key":"10.1016\/j.virusres.2025.199572_bib0112","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s11259-021-09808-0","article-title":"Porcine enteric coronaviruses: an updated overview of the pathogenesis, prevalence, and diagnosis","volume":"45","author":"Liu","year":"2021","journal-title":"Vet Res Commun"},{"key":"10.1016\/j.virusres.2025.199572_bib0113","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.cis.2015.04.006","article-title":"Nanocarriers for the delivery of active ingredients and fractions extracted from natural products used in traditional Chinese medicine (TCM)","volume":"221","author":"Liu","year":"2015","journal-title":"Adv Colloid Interface Sci"},{"issue":"2","key":"10.1016\/j.virusres.2025.199572_bib0114","doi-asserted-by":"crossref","DOI":"10.3390\/v14020402","article-title":"Ergosterol Peroxide Inhibits Porcine Epidemic Diarrhea Virus Infection in Vero Cells by Suppressing ROS Generation and p53 Activation","volume":"14","author":"Liu","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.virusres.2025.199572_bib0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2021.104832","article-title":"Antiviral activity of portulaca oleracea L. extracts against porcine epidemic diarrhea virus by partial suppression on myd88\/NF-\u03bab activation in vitro","volume":"154","author":"Liu","year":"2021","journal-title":"Microb Pathog"},{"issue":"05","key":"10.1016\/j.virusres.2025.199572_bib0178","first-page":"641","article-title":"Inhibitory effect of Curcumin on PEDV-infected Vero cells","volume":"53","author":"Liu","year":"2023","journal-title":"Chin Vet Sci"},{"issue":"5","key":"10.1016\/j.virusres.2025.199572_bib0116","doi-asserted-by":"crossref","first-page":"872","DOI":"10.3201\/eid2005.131628","article-title":"Role of transportation in spread of porcine epidemic diarrhea virus infection, United States","volume":"20","author":"Lowe","year":"2014","journal-title":"Emerg Infect Dis"},{"issue":"08","key":"10.1016\/j.virusres.2025.199572_bib0117","first-page":"1066","article-title":"Inhibitory effect of Portulaca oleracea polysaccharide on porcine epidemic diarrhea virus","volume":"50","author":"Lu","year":"2020","journal-title":"Chinese Veterinary Science"},{"issue":"07","key":"10.1016\/j.virusres.2025.199572_bib0146","first-page":"2931","article-title":"Research Progress on Porcine Epidemic Diarrhea Virus Vaccines","volume":"50","author":"Lu","year":"2023","journal-title":"China Animal Husbandry Vet Med"},{"key":"10.1016\/j.virusres.2025.199572_bib0118","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.rvsc.2022.09.011","article-title":"Alpiniae oxyphyllae fructus polysaccharide 3 inhibits porcine epidemic diarrhea virus entry into IPEC-J2 cells","volume":"152","author":"Luo","year":"2022","journal-title":"Res Vet Sci"},{"key":"10.1016\/j.virusres.2025.199572_bib0119","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107658","article-title":"The birth of artemisinin","volume":"216","author":"Ma","year":"2020","journal-title":"Pharmacol Ther"},{"issue":"1","key":"10.1016\/j.virusres.2025.199572_bib0120","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/mc.20695","article-title":"Curcumin suppresses human papillomavirus oncoproteins, restores p53, Rb, and PTPN13 proteins and inhibits benzo[a]pyrene-induced upregulation of HPV E7","volume":"50","author":"Maher","year":"2011","journal-title":"Mol Carcinog"},{"issue":"1","key":"10.1016\/j.virusres.2025.199572_bib0121","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41580-021-00432-z","article-title":"Structures and functions of coronavirus replication-transcription complexes and their relevance for SARS-CoV-2 drug design","volume":"23","author":"Malone","year":"2022","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"14","key":"10.1016\/j.virusres.2025.199572_bib0122","doi-asserted-by":"crossref","first-page":"4820","DOI":"10.1016\/j.bmcl.2012.05.055","article-title":"Potent inhibition of norovirus 3CL protease by peptidyl \u03b1-ketoamides and \u03b1-ketoheterocycles","volume":"22","author":"Mandadapu","year":"2012","journal-title":"Bioorg Med Chem Lett"},{"issue":"1","key":"10.1016\/j.virusres.2025.199572_bib0124","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.tplants.2016.08.002","article-title":"ROS Are Good","volume":"22","author":"Mittler","year":"2017","journal-title":"Trends Plant Sci"},{"issue":"3","key":"10.1016\/j.virusres.2025.199572_bib0125","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/tbed.12823","article-title":"Swine enteric coronavirus disease: A review of 4 years with porcine epidemic diarrhoea virus and porcine deltacoronavirus in the United States and Canada","volume":"65","author":"Niederwerder","year":"2018","journal-title":"Transbound Emerg Dis"},{"issue":"6","key":"10.1016\/j.virusres.2025.199572_bib0126","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1177\/1040638716663251","article-title":"Tissue localization, shedding, virus carriage, antibody response, and aerosol transmission of Porcine epidemic diarrhea virus following inoculation of 4-week-old feeder pigs","volume":"28","author":"Niederwerder","year":"2016","journal-title":"J Vet Diagn Invest"},{"key":"10.1016\/j.virusres.2025.199572_bib0127","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.3389\/fmicb.2020.01159","article-title":"Interleukin-8 Release Inhibitors Generated by Fermentation of Artemisia princeps Pampanini Herb Extract With Lactobacillus plantarum SN13T","volume":"11","author":"Okamoto","year":"2020","journal-title":"Front Microbiol"},{"issue":"8","key":"10.1016\/j.virusres.2025.199572_bib0128","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1080\/10408347.2023.2207652","article-title":"Applications of Hyperspectral Imaging Technology Combined with Machine Learning in Quality Control of Traditional Chinese Medicine from the Perspective of Artificial Intelligence: A Review","volume":"54","author":"Pan","year":"2024","journal-title":"Crit Rev Anal Chem"},{"key":"10.1016\/j.virusres.2025.199572_bib0129","first-page":"1","article-title":"Microwave-assisted extraction of chrysin from propolis and its encapsulation feasibility analysis in casein micelles","volume":"111","author":"Parappa","year":"2024","journal-title":"Materials Today: Proceedings"},{"issue":"2","key":"10.1016\/j.virusres.2025.199572_bib0130","article-title":"Porcine Epidemic Diarrhea: Insights and Progress on Vaccines","volume":"12","author":"Park","year":"2024","journal-title":"Vaccines (Basel)"},{"issue":"6","key":"10.1016\/j.virusres.2025.199572_bib0131","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1007\/s13346-024-01517-w","article-title":"Research progress on nanotechnology of traditional Chinese medicine to enhance the therapeutic effect of osteoarthritis","volume":"14","author":"Peng","year":"2024","journal-title":"Drug Deliv Transl Res"},{"issue":"3","key":"10.1016\/j.virusres.2025.199572_bib0132","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/BF01317606","article-title":"A new coronavirus-like particle associated with diarrhea in swine","volume":"58","author":"Pensaert","year":"1978","journal-title":"Arch Virol"},{"key":"10.1016\/j.virusres.2025.199572_bib0133","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.prevetmed.2017.12.009","article-title":"An epidemiological investigation of the early phase of the porcine epidemic diarrhea (PED) outbreak in Canadian swine herds in 2014: A case-control study","volume":"150","author":"Perri","year":"2018","journal-title":"Prev Vet Med"},{"issue":"6","key":"10.1016\/j.virusres.2025.199572_bib0134","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1128\/JVI.75.6.2848-2856.2001","article-title":"Differences in cytokine and chemokine responses during neurological disease induced by polytropic murine retroviruses Map to separate regions of the viral envelope gene","volume":"75","author":"Peterson","year":"2001","journal-title":"J Virol"},{"issue":"08","key":"10.1016\/j.virusres.2025.199572_bib0136","first-page":"116","article-title":"Effects of biological fermentation on active components of compound Chinese herbal medicine","author":"Qiufeng","year":"2023","journal-title":"Heilongjiang Animal Science and Veterinary"},{"issue":"07","key":"10.1016\/j.virusres.2025.199572_bib0135","first-page":"2262","article-title":"Research progress on fermented traditional Chinese medicine and its theoretical exploration of \u201cfermentation compatibility\u201d","volume":"54","author":"Qu","year":"2023","journal-title":"Chin Tradit Herb Drugs"},{"key":"10.1016\/j.virusres.2025.199572_bib0137","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1112610","article-title":"Hypericum japonicum extract inhibited porcine epidemic diarrhea virus in vitro and in vivo","volume":"14","author":"Rao","year":"2023","journal-title":"Front Pharmacol"},{"issue":"8","key":"10.1016\/j.virusres.2025.199572_bib0138","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/s41423-020-0485-9","article-title":"The ORF3a protein of SARS-CoV-2 induces apoptosis in cells","volume":"17","author":"Ren","year":"2020","journal-title":"Cell Mol Immunol"},{"issue":"10","key":"10.1016\/j.virusres.2025.199572_bib0139","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.cellbi.2007.04.009","article-title":"Antioxidative and prooxidative effects of quercetin on A549 cells","volume":"31","author":"Robaszkiewicz","year":"2007","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.virusres.2025.199572_bib0140","article-title":"Transplacental Transmission of Porcine Epidemic Diarrhea Virus","volume":"8","author":"Ryu","year":"2021","journal-title":"Front Vet Sci"},{"issue":"1","key":"10.1016\/j.virusres.2025.199572_bib0141","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12985-018-0940-8","article-title":"Efficacy of genogroup 1 based porcine epidemic diarrhea live vaccine against genogroup 2 field strain in Japan","volume":"15","author":"Sato","year":"2018","journal-title":"Virol J"},{"issue":"7344","key":"10.1016\/j.virusres.2025.199572_bib0142","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature09907","article-title":"A diverse range of gene products are effectors of the type I interferon antiviral response","volume":"472","author":"Schoggins","year":"2011","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.virusres.2025.199572_bib0143","doi-asserted-by":"crossref","first-page":"5111","DOI":"10.2527\/jas.2015-9136","article-title":"Assessment of the economic impacts of porcine epidemic diarrhea virus in the United States","volume":"93","author":"Schulz","year":"2015","journal-title":"J Anim Sci"},{"issue":"12","key":"10.1016\/j.virusres.2025.199572_bib0144","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00023-19","article-title":"High-Throughput Screening and Identification of Potent Broad-Spectrum Inhibitors of Coronaviruses","volume":"93","author":"Shen","year":"2019","journal-title":"J Virol"},{"issue":"2","key":"10.1016\/j.virusres.2025.199572_bib0147","doi-asserted-by":"crossref","first-page":"166","DOI":"10.7774\/cevr.2015.4.2.166","article-title":"Porcine epidemic diarrhea: a review of current epidemiology and available vaccines","volume":"4","author":"Song","year":"2015","journal-title":"Clin Exp Vaccine Res"},{"issue":"5","key":"10.1016\/j.virusres.2025.199572_bib0148","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1021\/acs.analchem.6b04919","article-title":"Biosynthesis-Based Quantitative Analysis of 151 Secondary Metabolites of Licorice To Differentiate Medicinal Glycyrrhiza Species and Their Hybrids","volume":"89","author":"Song","year":"2017","journal-title":"Anal Chem"},{"issue":"4","key":"10.1016\/j.virusres.2025.199572_bib0149","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0278-6915(93)90080-I","article-title":"Glycyrrhizic acid in liquorice\u2013evaluation of health hazard","volume":"31","author":"St\u00f8rmer","year":"1993","journal-title":"Food Chem Toxicol"},{"issue":"3","key":"10.1016\/j.virusres.2025.199572_bib0150","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1111\/tbed.13439","article-title":"A molecular epidemiological investigation of PEDV in China: Characterization of co-infection and genetic diversity of S1-based genes","volume":"67","author":"Su","year":"2020","journal-title":"Transbound Emerg Dis"},{"key":"10.1016\/j.virusres.2025.199572_bib0151","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2020.108959","article-title":"Porcine epidemic diarrhea virus infections induce autophagy in Vero cells via ROS-dependent endoplasmic reticulum stress through PERK and IRE1 pathways","volume":"253","author":"Sun","year":"2021","journal-title":"Vet Microbiol"},{"key":"10.1016\/j.virusres.2025.199572_bib0152","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2022.109516","article-title":"Inhibitory effect of Buddlejasaponin IVb on porcine epidemic diarrhea virus in vivo and in vitro","volume":"272","author":"Sun","year":"2022","journal-title":"Vet Microbiol"},{"key":"10.1016\/j.virusres.2025.199572_bib0153","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2024.106719","article-title":"Study on the immune-enhancing and inhabiting transmissible gastroenteritis virus effects of polysaccharides from Cimicifuga rhizoma","volume":"192","author":"Tan","year":"2024","journal-title":"Microb Pathog"},{"key":"10.1016\/j.virusres.2025.199572_bib0154","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1298471","article-title":"Boosting the immunogenicity of the CoronaVac SARS-CoV-2 inactivated vaccine with Huoxiang Suling Shuanghua Decoction: a randomized, double-blind, placebo-controlled study","volume":"15","author":"Tang","year":"2024","journal-title":"Front Immunol"},{"issue":"6","key":"10.1016\/j.virusres.2025.199572_bib0155","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19061578","article-title":"Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery","volume":"19","author":"Thomford","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.virusres.2025.199572_bib0156","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbad027","article-title":"Exploring pharmacological active ingredients of traditional Chinese medicine by pharmacotranscriptomic map in ITCM","volume":"24","author":"Tian","year":"2023","journal-title":"Brief Bioinform"},{"issue":"18","key":"10.1016\/j.virusres.2025.199572_bib0157","doi-asserted-by":"crossref","first-page":"5315","DOI":"10.1016\/j.bmcl.2011.07.016","article-title":"Design, synthesis, and evaluation of inhibitors of Norwalk virus 3C protease","volume":"21","author":"Tiew","year":"2011","journal-title":"Bioorganic & medicinal chemistry letters"},{"issue":"13","key":"10.1016\/j.virusres.2025.199572_bib0158","article-title":"Glycyrrhizic-Acid-Based Carbon Dots with High Antiviral Activity by Multisite Inhibition Mechanisms","volume":"16","author":"Tong","year":"2020","journal-title":"Small"},{"issue":"6","key":"10.1016\/j.virusres.2025.199572_bib0159","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0158128","article-title":"Comparison of Thermal and Non-Thermal Processing of Swine Feed and the Use of Selected Feed Additives on Inactivation of Porcine Epidemic Diarrhea Virus (PEDV)","volume":"11","author":"Trudeau","year":"2016","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.virusres.2025.199572_bib0160","doi-asserted-by":"crossref","first-page":"6499","DOI":"10.1021\/acs.jmedchem.2c00117","article-title":"Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19","volume":"65","author":"Unoh","year":"2022","journal-title":"J Med Chem"},{"key":"10.1016\/j.virusres.2025.199572_bib0161","article-title":"Applications of Artificial Intelligence in Drug Repurposing","author":"Wan","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.virusres.2025.199572_bib0162","article-title":"In silico and in vitro evaluation of antiviral activity of wogonin against main protease of porcine epidemic diarrhea virus","volume":"13","author":"Wang","year":"2023","journal-title":"Front Cell Infect Microbiol"},{"issue":"4","key":"10.1016\/j.virusres.2025.199572_bib0163","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.febslet.2012.01.005","article-title":"PEDV ORF3 encodes an ion channel protein and regulates virus production","volume":"586","author":"Wang","year":"2012","journal-title":"FEBS Lett"},{"issue":"1","key":"10.1016\/j.virusres.2025.199572_bib0164","doi-asserted-by":"crossref","first-page":"226","DOI":"10.4103\/1673-5374.344841","article-title":"Lactoferrin modification of berberine nanoliposomes enhances the neuroprotective effects in a mouse model of Alzheimer's disease","volume":"18","author":"Wang","year":"2023","journal-title":"Neural Regen Res"},{"issue":"1","key":"10.1016\/j.virusres.2025.199572_bib0165","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s13567-020-00865-y","article-title":"Tomatidine inhibits porcine epidemic diarrhea virus replication by targeting 3CL protease","volume":"51","author":"Wang","year":"2020","journal-title":"Vet Res"},{"key":"10.1016\/j.virusres.2025.199572_bib0166","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.coviro.2018.12.001","article-title":"Emerging and re-emerging coronaviruses in pigs","volume":"34","author":"Wang","year":"2019","journal-title":"Curr Opin Virol"},{"issue":"4","key":"10.1016\/j.virusres.2025.199572_bib0054","first-page":"357","article-title":"Research advance of probiotics in the fermentation of Chinese herbal medicine","volume":"46","author":"Wang","year":"2024","journal-title":"J Univ Shanghai Sci Technol"},{"key":"10.1016\/j.virusres.2025.199572_bib0167","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2020.108729","article-title":"Identification of host cell proteins that interact with the M protein of porcine epidemic diarrhea virus","volume":"246","author":"Wang","year":"2020","journal-title":"Vet Microbiol"},{"key":"10.1016\/j.virusres.2025.199572_bib0168","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1323231","article-title":"Functional features of a novel interferon-stimulated gene SHFL: a comprehensive review","volume":"14","author":"Wang","year":"2023","journal-title":"Front Microbiol"},{"issue":"2","key":"10.1016\/j.virusres.2025.199572_bib0188","first-page":"518","article-title":"The Prevalence and Prevention of PEDV, TGEV and PoRV in Porcine Viral Diarrhea","volume":"45","author":"Wang","year":"2018","journal-title":"China Animal Husbandry Vet Med"},{"issue":"1","key":"10.1016\/j.virusres.2025.199572_bib0169","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12943-021-01311-z","article-title":"mRNA vaccine: a potential therapeutic strategy","volume":"20","author":"Wang","year":"2021","journal-title":"Mol Cancer"},{"issue":"16","key":"10.1016\/j.virusres.2025.199572_bib0170","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1039\/D2TB00225F","article-title":"Nano-traditional Chinese medicine: a promising strategy and its recent advances","volume":"10","author":"Wei","year":"2022","journal-title":"J Mater Chem B"},{"issue":"06","key":"10.1016\/j.virusres.2025.199572_bib0171","first-page":"11","article-title":"The antiviral activity of four phenolic components of Myrtle against porcine epidemic diarrhea virus in vitro","author":"Wei","year":"2020","journal-title":"Modern Journal of Animal Husbandry and Veterinary Medicine"},{"issue":"1","key":"10.1016\/j.virusres.2025.199572_bib0173","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1021\/acs.analchem.8b05112","article-title":"Accelerating Metabolite Identification in Natural Product Research: Toward an Ideal Combination of Liquid Chromatography-High-Resolution Tandem Mass Spectrometry and NMR Profiling, in Silico Databases, and Chemometrics","volume":"91","author":"Wolfender","year":"2019","journal-title":"Anal Chem"},{"issue":"4","key":"10.1016\/j.virusres.2025.199572_bib0174","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.4142\/jvs.2019.20.e32","article-title":"Generation and protective efficacy of a cold-adapted attenuated genotype 2b porcine epidemic diarrhea virus","volume":"20","author":"Won","year":"2019","journal-title":"J Vet Sci"},{"key":"10.1016\/j.virusres.2025.199572_bib0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.virol.2023.109848","article-title":"Inhibiting mechanism of Alpiniae oxyphyllae fructus polysaccharide 3 against the replication of porcine epidemic diarrhea virus","volume":"587","author":"Wu","year":"2023","journal-title":"Virology"},{"key":"10.1016\/j.virusres.2025.199572_bib0176","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3389\/fimmu.2020.00169","article-title":"Quantitative Proteomic Analysis Reveals Antiviral and Anti-inflammatory Effects of Puerarin in Piglets Infected With Porcine Epidemic Diarrhea Virus","volume":"11","author":"Wu","year":"2020","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.virusres.2025.199572_bib0177","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s12985-019-1232-7","article-title":"Characterization and pathogenicity of Vero cell-attenuated porcine epidemic diarrhea virus CT strain","volume":"16","author":"Wu","year":"2019","journal-title":"Virol J"},{"key":"10.1016\/j.virusres.2025.199572_bib0179","article-title":"Medicinal plants and natural compounds against acyclovir-resistant HSV infections","volume":"13","author":"Xu","year":"2022","journal-title":"Front Microbiol"},{"key":"10.1016\/j.virusres.2025.199572_bib0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetmic.2019.03.028","article-title":"Porcine epidemic diarrhea virus infections induce apoptosis in Vero cells via a reactive oxygen species (ROS)\/p53, but not p38 MAPK and SAPK\/JNK signalling pathways","volume":"232","author":"Xu","year":"2019","journal-title":"Vet Microbiol"},{"key":"10.1016\/j.virusres.2025.199572_bib0181","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1743-422X-10-26","article-title":"Porcine epidemic diarrhea virus E protein causes endoplasmic reticulum stress and up-regulates interleukin-8 expression","volume":"10","author":"Xu","year":"2013","journal-title":"Virol J"},{"issue":"20","key":"10.1016\/j.virusres.2025.199572_bib0182","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70180","article-title":"Puerarin alleviates apoptosis and inflammation in kidney stone cells via the PI3K\/AKT pathway: Network pharmacology and experimental verification","volume":"28","author":"Xu","year":"2024","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.virusres.2025.199572_bib0183","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/5686929","article-title":"Optimization of Rare Ginsenosides and Antioxidant Activity Quality of Ginseng Jiaosu Based on Probiotic Strains and Fermentation Technology","author":"Xu","year":"2023","journal-title":"Journal of Food Quality"},{"key":"10.1016\/j.virusres.2025.199572_bib0184","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2020.108849","article-title":"Aloe extract inhibits porcine epidemic diarrhea virus in vitro and in vivo","volume":"249","author":"Xu","year":"2020","journal-title":"Vet Microbiol"},{"issue":"04","key":"10.1016\/j.virusres.2025.199572_bib0185","first-page":"1661","article-title":"Preparation and application of immunoglobin of yolk against porcine epidemic diarrhea virus","volume":"55","author":"Yajuan","year":"2024","journal-title":"Acta Veterinaria et Zootechnica Sinica"},{"issue":"09","key":"10.1016\/j.virusres.2025.199572_bib0075","first-page":"20","article-title":"The Efficacy of Traditional Chinese Medicine Compounds on the Treatment of Piglets Artificially Infected with Porcine Epidemic Diarrhea Virus","volume":"40","author":"Yang","year":"2019","journal-title":"Jilin Animal Husbandry Vet Med"},{"issue":"2","key":"10.1016\/j.virusres.2025.199572_bib0189","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s11596-021-2346-x","article-title":"A Network Pharmacology Study to Uncover the Multiple Molecular Mechanism of the Chinese Patent Medicine Toujiequwen Granules in the Treatment of Corona Virus Disease 2019 (COVID-19)","volume":"41","author":"Yang","year":"2021","journal-title":"Curr Med Sci"},{"key":"10.1016\/j.virusres.2025.199572_bib0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2021.145666","article-title":"Nano-realgar suppresses lung cancer stem cell growth by repressing metabolic reprogramming","volume":"788","author":"Yang","year":"2021","journal-title":"Gene"},{"issue":"1","key":"10.1016\/j.virusres.2025.199572_bib0191","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1038\/s41467-019-09830-6","article-title":"Hydrophobic carbon dots with blue dispersed emission and red aggregation-induced emission","volume":"10","author":"Yang","year":"2019","journal-title":"Nat Commun"},{"issue":"5","key":"10.1016\/j.virusres.2025.199572_bib0192","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1142\/S0192415X23500519","article-title":"Probiotic Fermentation of Herbal Medicine: Progress, Challenges, and Opportunities","volume":"51","author":"Yang","year":"2023","journal-title":"Am J Chin Med"},{"issue":"28","key":"10.1016\/j.virusres.2025.199572_bib0193","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.1016\/j.tet.2015.04.092","article-title":"Three new coumarins from Saposhnikovia divaricata and their porcine epidemic diarrhea virus (PEDV) inhibitory activity","volume":"71","author":"Yang","year":"2015","journal-title":"Tetrahedron"},{"issue":"3","key":"10.1016\/j.virusres.2025.199572_bib0194","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1021\/jm501567f","article-title":"Oleanane triterpenes from the flowers of Camellia japonica inhibit porcine epidemic diarrhea virus (PEDV) replication","volume":"58","author":"Yang","year":"2015","journal-title":"J Med Chem"},{"issue":"12","key":"10.1016\/j.virusres.2025.199572_bib0195","first-page":"28","article-title":"Study on the therapeutic effect of compound Chinese herbal medicine on porcine epidemic diarrhea","author":"Yaxin","year":"2020","journal-title":"China Feed"},{"issue":"2","key":"10.1016\/j.virusres.2025.199572_bib0196","doi-asserted-by":"crossref","DOI":"10.3390\/v12020240","article-title":"Structural Basis for Inhibiting Porcine Epidemic Diarrhea Virus Replication with the 3C-Like Protease Inhibitor GC376","volume":"12","author":"Ye","year":"2020","journal-title":"Viruses"},{"issue":"09","key":"10.1016\/j.virusres.2025.199572_bib0202","first-page":"1829","article-title":"Berberine inhibits porcine epidemic diarrhea virus replication and assembly","volume":"39","author":"Ye","year":"2019","journal-title":"Chin J Vet Sci"},{"issue":"3","key":"10.1016\/j.virusres.2025.199572_bib0197","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s11262-015-1257-y","article-title":"Porcine epidemic diarrhea virus ORF3 gene prolongs S-phase, facilitates formation of vesicles and promotes the proliferation of attenuated PEDV","volume":"51","author":"Ye","year":"2015","journal-title":"Virus Genes"},{"issue":"6","key":"10.1016\/j.virusres.2025.199572_bib0198","doi-asserted-by":"crossref","first-page":"867","DOI":"10.2460\/ajvr.1993.54.06.867","article-title":"Detection of passage and absorption of chicken egg yolk immunoglobulins in the gastrointestinal tract of pigs by use of enzyme-linked immunosorbent assay and fluorescent antibody testing","volume":"54","author":"Yokoyama","year":"1993","journal-title":"Am J Vet Res"},{"key":"10.1016\/j.virusres.2025.199572_bib0199","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/3687486","article-title":"Effect of Modified Pulsatilla Powder on Enterotoxigenic Escherichia coli O101-Induced Diarrhea in Mice","volume":"2017","author":"Yu","year":"2017","journal-title":"Evid Based Complement Alternat Med"},{"issue":"28","key":"10.1016\/j.virusres.2025.199572_bib0200","doi-asserted-by":"crossref","first-page":"4578","DOI":"10.3748\/wjg.v12.i28.4578","article-title":"Anti-inflammatory effect of Diammonium Glycyrrhizinate in a rat model of ulcerative colitis","volume":"12","author":"Yuan","year":"2006","journal-title":"World J Gastroenterol"},{"issue":"21","key":"10.1016\/j.virusres.2025.199572_bib0201","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00809-18","article-title":"Surfactin Inhibits Membrane Fusion during Invasion of Epithelial Cells by Enveloped Viruses","volume":"92","author":"Yuan","year":"2018","journal-title":"J Virol"},{"issue":"7","key":"10.1016\/j.virusres.2025.199572_bib0204","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms10071294","article-title":"The Advances of Broad-Spectrum and Hot Anti-Coronavirus Drugs","volume":"10","author":"Zeng","year":"2022","journal-title":"Microorganisms"},{"issue":"2","key":"10.1016\/j.virusres.2025.199572_bib0205","doi-asserted-by":"crossref","DOI":"10.3390\/v14020258","article-title":"Levistolide A Inhibits PEDV Replication via Inducing ROS Generation","volume":"14","author":"Zeng","year":"2022","journal-title":"Viruses"},{"issue":"8","key":"10.1016\/j.virusres.2025.199572_bib0206","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1080\/15548627.2023.2181615","article-title":"N protein of PEDV plays chess game with host proteins by selective autophagy","volume":"19","author":"Zhai","year":"2023","journal-title":"Autophagy"},{"issue":"6","key":"10.1016\/j.virusres.2025.199572_bib0207","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens12060845","article-title":"Bis-Benzylisoquinoline Alkaloids Inhibit Porcine Epidemic Diarrhea Virus by Disrupting Virus Entry","volume":"12","author":"Zhang","year":"2023","journal-title":"Pathogens"},{"issue":"3","key":"10.1016\/j.virusres.2025.199572_bib0208","doi-asserted-by":"crossref","DOI":"10.1093\/molbev\/msad052","article-title":"Global Dynamics of Porcine Enteric Coronavirus PEDV Epidemiology, Evolution, and Transmission","volume":"40","author":"Zhang","year":"2023","journal-title":"Mol Biol Evol"},{"issue":"1","key":"10.1016\/j.virusres.2025.199572_bib0209","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-56391-1","article-title":"Microarray analysis reveals the inhibition of intestinal expression of nutrient transporters in piglets infected with porcine epidemic diarrhea virus","volume":"9","author":"Zhang","year":"2019","journal-title":"Scientific reports"},{"key":"10.1016\/j.virusres.2025.199572_bib0210","article-title":"Monolaurin Confers a Protective Effect Against Porcine Epidemic Diarrhea Virus Infection in Piglets by Regulating the Interferon Pathway","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Immunol"},{"issue":"5","key":"10.1016\/j.virusres.2025.199572_bib0211","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1142\/S0192415X23500490","article-title":"Advances in the Application of Traditional Chinese Medicine Using Artificial Intelligence: A Review","volume":"51","author":"Zhang","year":"2023","journal-title":"Am J Chin Med"},{"key":"10.1016\/j.virusres.2025.199572_bib0212","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.vetmic.2019.01.003","article-title":"Lactobacillus acidophilus S-layer protein-mediated inhibition of PEDV-induced apoptosis of Vero cells","volume":"229","author":"Zhang","year":"2019","journal-title":"Vet Microbiol"},{"issue":"9","key":"10.1016\/j.virusres.2025.199572_bib0213","doi-asserted-by":"crossref","DOI":"10.3390\/v13091825","article-title":"Hypericin Inhibit Alpha-Coronavirus Replication by Targeting 3CL Protease","volume":"13","author":"Zhang","year":"2021","journal-title":"Viruses"},{"issue":"9","key":"10.1016\/j.virusres.2025.199572_bib0214","article-title":"Evaluation of Cross-Protection between G1a- and G2a-Genotype Porcine Epidemic Diarrhea Viruses in Suckling Piglets","volume":"10","author":"Zhang","year":"2020","journal-title":"Animals (Basel)"},{"issue":"11","key":"10.1016\/j.virusres.2025.199572_bib0215","doi-asserted-by":"crossref","DOI":"10.3390\/v14112434","article-title":"Porcine Epidemic Diarrhea Virus: An Updated Overview of Virus Epidemiology, Virulence Variation Patterns and Virus-Host Interactions","volume":"14","author":"Zhang","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.virusres.2025.199572_bib0216","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.2147\/IJN.S21373","article-title":"Effect of size and processing method on the cytotoxicity of realgar nanoparticles in cancer cell lines","volume":"6","author":"Zhao","year":"2011","journal-title":"Int J Nanomedicine"},{"issue":"05","key":"10.1016\/j.virusres.2025.199572_bib0145","first-page":"907","article-title":"Inhibitory Effect of Xanthohumol on the Porcine Epidemic Diarrhea Virus In Vitro","volume":"36","author":"Zhao","year":"2020","journal-title":"Chin J Virol"},{"issue":"2","key":"10.1016\/j.virusres.2025.199572_bib0217","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.02958-23","article-title":"PEDV-spike-protein-expressing mRNA vaccine protects piglets against PEDV challenge","volume":"15","author":"Zhao","year":"2024","journal-title":"mBio"},{"key":"10.1016\/j.virusres.2025.199572_bib0218","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153308","article-title":"Prevention and treatment of COVID-19 using Traditional Chinese Medicine: A review","volume":"85","author":"Zhao","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.virusres.2025.199572_bib0219","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2021.108994","article-title":"Porcine epidemic diarrhea virus E protein suppresses RIG-I signaling-mediated interferon-\u03b2 production","volume":"254","author":"Zheng","year":"2021","journal-title":"Veterinary microbiology"},{"key":"10.1016\/j.virusres.2025.199572_bib0220","article-title":"In vivo investigation of PEDV transmission via nasal infection: mechanisms of CD4(+) T-cell-mediated intestinal infection","author":"Zhong","year":"2025","journal-title":"J Virol"},{"key":"10.1016\/j.virusres.2025.199572_bib0221","article-title":"Integrating artificial intelligence into the modernization of traditional Chinese medicine industry: a review","volume":"15","author":"Zhou","year":"2024","journal-title":"Front Pharmacol"},{"issue":"6","key":"10.1016\/j.virusres.2025.199572_bib0222","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.immuni.2014.05.007","article-title":"Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor","volume":"40","author":"Zhu","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.virusres.2025.199572_bib0223","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.virusres.2016.07.003","article-title":"Virulence factors in porcine coronaviruses and vaccine design","volume":"226","author":"Zu\u00f1iga","year":"2016","journal-title":"Virus Res"}],"container-title":["Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170225000498?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170225000498?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T12:12:03Z","timestamp":1762258323000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168170225000498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":223,"alternative-id":["S0168170225000498"],"URL":"https:\/\/doi.org\/10.1016\/j.virusres.2025.199572","relation":{},"ISSN":["0168-1702"],"issn-type":[{"value":"0168-1702","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Traditional Chinese medicine as a promising choice for future control of PEDV","name":"articletitle","label":"Article Title"},{"value":"Virus Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virusres.2025.199572","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"199572"}}