{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T18:04:27Z","timestamp":1781805867229,"version":"3.54.5"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T00:00:00Z","timestamp":1748649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004329","name":"Slovenian Research and Innovation Agency","doi-asserted-by":"publisher","award":["L3\\u20132620"],"award-info":[{"award-number":["L3\\u20132620"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"Slovenian Research and Innovation Agency","doi-asserted-by":"publisher","award":["J7\\u20132603"],"award-info":[{"award-number":["J7\\u20132603"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"Slovenian Research and Innovation Agency","doi-asserted-by":"publisher","award":["P3\\u20130387"],"award-info":[{"award-number":["P3\\u20130387"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virus Research"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.virusres.2025.199592","type":"journal-article","created":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T23:39:17Z","timestamp":1748734757000},"page":"199592","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Preparation and pharmacokinetic evaluation of Staphylococcus phage COP-80B for treatment of periprosthetic joint infections in a mouse model"],"prefix":"10.1016","volume":"357","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7304-4560","authenticated-orcid":false,"given":"Vida","family":"\u0160tilec","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Maru\u0161i\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nika","family":"Jane\u017e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urban","family":"Bezeljak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucija","family":"Rebula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Leskovec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rihard","family":"Treb\u0161e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Horvat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matja\u017e","family":"Peterka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virusres.2025.199592_bib0001","unstructured":"Ackermann, H.-W., Tremblay, D., Moineau, S., 2004. Long-term bacteriophage preservation. World Federation for Culture Collections Newsletter 35\u201340."},{"key":"10.1016\/j.virusres.2025.199592_bib0002","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.virol.2012.09.018","article-title":"CIM\u00ae monolithic anion-exchange chromatography as a useful alternative to CsCl gradient purification of bacteriophage particles","volume":"434","author":"Adriaenssens","year":"2012","journal-title":"Virology"},{"key":"10.1016\/j.virusres.2025.199592_bib0003","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01870-19","article-title":"Efficacy of bacteriophages in a staphylococcus aureus nondiabetic or diabetic foot infection murine model","volume":"64","author":"Albac","year":"2020","journal-title":"Antimicrob. Agents Chemother"},{"key":"10.1016\/j.virusres.2025.199592_bib0004","doi-asserted-by":"crossref","DOI":"10.2106\/JBJS.16.00815","article-title":"Quantification of peri-implant bacterial load and in vivo biofilm formation in an innovative, clinically representative mouse model of periprosthetic joint infection","volume":"99","author":"Carli","year":"2017","journal-title":"JBJS"},{"key":"10.1016\/j.virusres.2025.199592_bib0005","article-title":"Pharmacokinetics and time-kill study of inhaled antipseudomonal bacteriophage therapy in mice","volume":"65","author":"Chow","year":"2021","journal-title":"Antimicrob. Agents Chemother"},{"key":"10.1016\/j.virusres.2025.199592_bib0006","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1002\/med.21572","article-title":"Phage therapy: what factors shape phage pharmacokinetics and bioavailability? Systematic and critical review","volume":"39","author":"D\u0105browska","year":"2019","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.virusres.2025.199592_bib0007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/gigascience\/giab008","article-title":"Twelve years of SAMtools and BCFtools","volume":"10","author":"Danecek","year":"2021","journal-title":"Gigascience"},{"key":"10.1016\/j.virusres.2025.199592_bib0008","doi-asserted-by":"crossref","first-page":"pgad406","DOI":"10.1093\/pnasnexus\/pgad406","article-title":"Rapid assessment of changes in phage bioactivity using dynamic light scattering","volume":"2","author":"Dharmaraj","year":"2023","journal-title":"PNAS. Nexus."},{"key":"10.1016\/j.virusres.2025.199592_bib0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcimb.2021.684704","article-title":"Pharmacokinetics and pharmacodynamics of a novel virulent Klebsiella phage Kp_Pokalde_002 in a mouse model","volume":"11","author":"Dhungana","year":"2021","journal-title":"Front. Cell Infect. Microbiol."},{"key":"10.1016\/j.virusres.2025.199592_bib0010","doi-asserted-by":"crossref","first-page":"e1463","DOI":"10.1093\/cid\/ciac694","article-title":"Experience using adjuvant bacteriophage therapy for the treatment of 10 recalcitrant periprosthetic joint infections: a case series","volume":"76","author":"Doub","year":"2022","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.virusres.2025.199592_bib0011","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3390\/antibiotics9050241","article-title":"Salvage bacteriophage therapy for a chronic MRSA prosthetic joint infection","volume":"9","author":"Doub","year":"2020","journal-title":"Antibiotics"},{"key":"10.1016\/j.virusres.2025.199592_bib0012","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3390\/ph14030231","article-title":"Successful treatment of a recalcitrant Staphylococcus epidermidis prosthetic knee infection with intraoperative bacteriophage therapy","volume":"14","author":"Doub","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.virusres.2025.199592_bib0013","doi-asserted-by":"crossref","first-page":"865","DOI":"10.3390\/v13050865","article-title":"Evaluation of the stability of bacteriophages in different solutions suitable for the production of magistral preparations in Belgium","volume":"13","author":"Duyvejonck","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.virusres.2025.199592_bib0014","series-title":"Methods in Molecular Biology","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/978-1-0716-3523-0_14","article-title":"A review of phage therapy for bone and joint infections","author":"Ferry","year":"2024"},{"key":"10.1016\/j.virusres.2025.199592_bib0015","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3389\/fmed.2020.00342","article-title":"The potential innovative use of bacteriophages within the DAC\u00ae hydrogel to treat patients with knee megaprosthesis infection requiring \u201cdebridement antibiotics and implant retention\u201d and soft tissue coverage as salvage therapy","volume":"7","author":"Ferry","year":"2020","journal-title":"Front. Med."},{"key":"10.1016\/j.virusres.2025.199592_bib0016","article-title":"Case report: arthroscopic \u201cdebridement antibiotics and implant retention\u201d with local injection of personalized phage therapy to salvage a relapsing Pseudomonas Aeruginosa prosthetic knee infection","volume":"8","author":"Ferry","year":"2021","journal-title":"Front. Med."},{"key":"10.1016\/j.virusres.2025.199592_bib0017","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02573-17","article-title":"Design of a broad-range bacteriophage cocktail that reduces pseudomonas aeruginosa biofilms and treats acute infections in two animal models","volume":"62","author":"Forti","year":"2018","journal-title":"Antimicrob. Agents Chemother"},{"key":"10.1016\/j.virusres.2025.199592_bib0018","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/264651","article-title":"Development of a broad-range 23S rDNA real-time PCR assay for the detection and quantification of pathogenic bacteria in Human whole blood and plasma specimens","volume":"2013","author":"Gaibani","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.virusres.2025.199592_bib0019","unstructured":"Garrison, E., Marth, G., 2012. Haplotype-based variant detection from short-read sequencing. arXiv preprint arXiv:1207.3907."},{"key":"10.1016\/j.virusres.2025.199592_bib0020","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0301-472X(02)00806-8","article-title":"Gene quantification using real-time quantitative PCR: an emerging technology hits the mainstream","volume":"30","author":"Ginzinger","year":"2002","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.virusres.2025.199592_bib0021","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1084\/jem.192.10.1425","article-title":"Lymph-borne chemokines and other low molecular weight molecules reach high endothelial venules via specialized conduits while a functional barrier limits access to the lymphocyte microenvironments in Lymph node cortex","volume":"192","author":"Gretz","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.virusres.2025.199592_bib0022","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/35047123","article-title":"A toll-like receptor recognizes bacterial DNA","volume":"408","author":"Hemmi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.virusres.2025.199592_bib0023","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep14802","article-title":"Mammalian host-versus-phage immune response determines phage fate in vivo","volume":"5","author":"Hodyra-Stefaniak","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.virusres.2025.199592_bib0024","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1109\/MCSE.2007.55","article-title":"Matplotlib: a 2D graphics environment","volume":"9","author":"Hunter","year":"2007","journal-title":"Comput. Sci. Eng."},{"key":"10.1016\/j.virusres.2025.199592_bib0025","first-page":"173","article-title":"The activity of mouse Kupffer cells following intravenous injection of T4 bacteriophage","volume":"5","author":"Inchley","year":"1969","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.virusres.2025.199592_bib0026","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-018-07641-9","article-title":"High throughput ANI analysis of 90K prokaryotic genomes reveals clear species boundaries","volume":"9","author":"Jain","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.virusres.2025.199592_bib0027","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S1473-3099(18)30482-1","article-title":"Efficacy and tolerability of a cocktail of bacteriophages to treat burn wounds infected by Pseudomonas aeruginosa (PhagoBurn): a randomised, controlled, double-blind phase 1\/2 trial","volume":"19","author":"Jault","year":"2019","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.virusres.2025.199592_bib0028","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2019.01602","article-title":"Interaction between staphylococcal biofilm and bone: how does the presence of biofilm promote prosthesis loosening?","volume":"10","author":"Josse","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.virusres.2025.199592_bib0029","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3390\/v12050559","article-title":"Efficacy of lytic phage cocktails on Staphylococcus aureus and Pseudomonas aeruginosa in mixed-species planktonic cultures and biofilms","volume":"12","author":"Kifelew","year":"2020","journal-title":"Viruses"},{"key":"10.1016\/j.virusres.2025.199592_bib0030","series-title":"Bacteriophages: Methods and Protocols, Volume 1: Isolation, Characterization, and Interactions","first-page":"69","article-title":"Enumeration of bacteriophages by double agar overlay plaque assay","author":"Kropinski","year":"2009"},{"key":"10.1016\/j.virusres.2025.199592_bib0031","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.bbrc.2009.08.062","article-title":"Toll-like receptors and innate immunity","volume":"388","author":"Kumar","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.virusres.2025.199592_bib0032","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nmeth.1455","article-title":"Coding of facial expressions of pain in the laboratory mouse","volume":"7","author":"Langford","year":"2010","journal-title":"Nat. Methods"},{"key":"10.1016\/j.virusres.2025.199592_bib0033","doi-asserted-by":"crossref","DOI":"10.3390\/v13071268","article-title":"The safety and toxicity of phage therapy: a review of animal and clinical studies","volume":"13","author":"Liu","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.virusres.2025.199592_bib0034","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1038\/s41596-020-0346-0","article-title":"Standardized bacteriophage purification for personalized phage therapy","volume":"15","author":"Luong","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.virusres.2025.199592_bib0035","series-title":"Methods in Molecular Biology","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/978-1-60327-164-6_9","article-title":"Enumeration of bacteriophages using the small drop plaque assay system","author":"Mazzocco","year":"2009"},{"key":"10.1016\/j.virusres.2025.199592_bib0036","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/s41434-024-00444-2","article-title":"Analytical characterization of full, intermediate, and empty AAV capsids","volume":"31","author":"McColl-Carboni","year":"2024","journal-title":"Gene Ther."},{"key":"10.1016\/j.virusres.2025.199592_bib0037","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3390\/antibiotics14020114","article-title":"Phage therapy for orthopaedic infections: the first three cases from the United Kingdom","volume":"14","author":"Munteanu","year":"2025","journal-title":"Antibiotics"},{"key":"10.1016\/j.virusres.2025.199592_bib0038","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis","volume":"399","author":"Murray","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.virusres.2025.199592_bib0039","doi-asserted-by":"crossref","first-page":"728","DOI":"10.3382\/ps.2008-00378","article-title":"The influence of the mode of administration in the dissemination of three coliphages in chickens","volume":"88","author":"Oliveira","year":"2009","journal-title":"Poult. Sci."},{"key":"10.1016\/j.virusres.2025.199592_bib0040","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/cis803","article-title":"Diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America","volume":"56","author":"Osmon","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.virusres.2025.199592_bib0041","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1056\/NEJMra2203477","article-title":"Periprosthetic joint infection","volume":"388","author":"Patel","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.virusres.2025.199592_bib0042","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13520","article-title":"Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months","volume":"7","author":"Pelliccia","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.virusres.2025.199592_bib0043","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s00216-021-03648-2","article-title":"Monitoring process-related impurities in biologics\u2013host cell protein analysis","volume":"414","author":"Pilely","year":"2022","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.virusres.2025.199592_bib0044","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1146\/annurev.biochem.71.110601.135414","article-title":"Lipopolysaccharide endotoxins","volume":"71","author":"Raetz","year":"2002","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.virusres.2025.199592_bib0045","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.3390\/v13061182","article-title":"Successful treatment of Staphylococcus aureus prosthetic joint infection with bacteriophage therapy","volume":"13","author":"Ramirez-Sanchez","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.virusres.2025.199592_bib0046","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/ni.3101","article-title":"The endothelial protein PLVAP in lymphatics controls the entry of lymphocytes and antigens into lymph nodes","volume":"16","author":"Rantakari","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.virusres.2025.199592_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2023.123606","article-title":"CIM monolithic chromatography as a useful tool for endotoxin reduction and purification of bacteriophage particles supported with PAT analytics","volume":"1217","author":"Rebula","year":"2023","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.virusres.2025.199592_bib0048","doi-asserted-by":"crossref","first-page":"e75","DOI":"10.1002\/jex2.75","article-title":"Comparison of interferometric light microscopy with nanoparticle tracking analysis for the study of extracellular vesicles and bacteriophages","volume":"2","author":"Sausset","year":"2023","journal-title":"J. ExtraCell Biol."},{"key":"10.1016\/j.virusres.2025.199592_bib0049","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1099\/00221287-128-2-307","article-title":"Successful treatment of experimental Escherichia coli infections in mice using phage: its general superiority over antibiotics","volume":"128","author":"Smith","year":"1982","journal-title":"Microbiol"},{"key":"10.1016\/j.virusres.2025.199592_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12866-021-02117-1","article-title":"Potential of bacteriophages as disinfectants to control of Staphylococcus aureus biofilms","volume":"21","author":"Song","year":"2021","journal-title":"BMC. Microbiol."},{"key":"10.1016\/j.virusres.2025.199592_bib0051","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.3390\/antibiotics11101340","article-title":"The safety and efficacy of phage therapy: a systematic review of clinical and safety trials","volume":"11","author":"Stacey","year":"2022","journal-title":"Antibiotics"},{"key":"10.1016\/j.virusres.2025.199592_bib0052","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1169135","article-title":"Isolation and in vitro characterization of novel S. epidermidis phages for therapeutic applications","volume":"13","author":"\u0160trancar","year":"2023","journal-title":"Front. Cell Infect. Microbiol."},{"key":"10.1016\/j.virusres.2025.199592_bib0053","doi-asserted-by":"crossref","DOI":"10.1128\/aac.02071-21","article-title":"Considerations for the use of phage therapy in clinical practice","volume":"66","author":"Suh","year":"2022","journal-title":"Antimicrob. Agents Chemother"},{"key":"10.1016\/j.virusres.2025.199592_bib0054","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01359-23","article-title":"Evaluation of the impact of repeated intravenous phage doses on mammalian host\u2013phage interactions","volume":"98","author":"Tan","year":"2024","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2025.199592_bib0055","article-title":"Pharmacokinetic assessment of staphylococcal phage K following parenteral and intra-articular administration in rabbits","volume":"13","author":"Totten","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.virusres.2025.199592_bib0056","doi-asserted-by":"crossref","first-page":"544","DOI":"10.4049\/jimmunol.94.4.544","article-title":"Intracellular distribution and degradation of bacteriophage in mammalian tissues","volume":"94","author":"Uhr","year":"1965","journal-title":"J. Immunol."},{"key":"10.1016\/j.virusres.2025.199592_bib0057","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-08336-9","article-title":"Pro- and anti-inflammatory responses of peripheral blood mononuclear cells induced by Staphylococcus aureus and Pseudomonas aeruginosa phages","volume":"7","author":"Van Belleghem","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.virusres.2025.199592_bib0058","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3390\/v11010010","article-title":"Interactions between bacteriophage, bacteria, and the mammalian immune system","volume":"11","author":"Van Belleghem","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.virusres.2025.199592_bib0059","article-title":"Pharmacokinetics and safety evaluation of intravenously administered Pseudomonas phage PA_LZ7 in a mouse model","volume":"12","author":"Wang","year":"2024","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.virusres.2025.199592_bib0060","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.21105\/joss.03021","article-title":"seaborn: statistical data visualization","volume":"6","author":"Waskom","year":"2021","journal-title":"J. Open. Source Softw."},{"key":"10.1016\/j.virusres.2025.199592_bib0061","doi-asserted-by":"crossref","first-page":"254","DOI":"10.4315\/JFP-21-292","article-title":"Evaluation of a preharvest bacteriophage therapy for control of Salmonella within bovine peripheral lymph nodes","volume":"85","author":"Wottlin","year":"2022","journal-title":"J. Food Prot."},{"key":"10.1016\/j.virusres.2025.199592_bib0062","unstructured":"Wunderli, P., Lu, J., Ames, M., Wolman, M., Finger, J., Gacheru, S., 2020. Viral vector API characterization of product-related impurities. Pharmaceutical technology regulatory sourcebook eBook (October 2020)."},{"key":"10.1016\/j.virusres.2025.199592_bib0063","doi-asserted-by":"crossref","first-page":"155","DOI":"10.5731\/pdajpst.2013.00910","article-title":"Establishing acceptable limits of residual DNA","volume":"67","author":"Yang","year":"2013","journal-title":"PDa J. Pharm. Sci. Technol."},{"key":"10.1016\/j.virusres.2025.199592_bib0064","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.3390\/v16111800","article-title":"Assessment of bacteriophage pharmacokinetic parameters after intra-articular delivery in a rat prosthetic joint infection model","volume":"16","author":"Young","year":"2024","journal-title":"Viruses"},{"key":"10.1016\/j.virusres.2025.199592_bib0065","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.cmpb.2010.01.007","article-title":"PKSolver: an add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel","volume":"99","author":"Zhang","year":"2010","journal-title":"Comput. Methods Programs Biomed."}],"container-title":["Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170225000693?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170225000693?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T00:17:18Z","timestamp":1749860238000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168170225000693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":65,"alternative-id":["S0168170225000693"],"URL":"https:\/\/doi.org\/10.1016\/j.virusres.2025.199592","relation":{},"ISSN":["0168-1702"],"issn-type":[{"value":"0168-1702","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preparation and pharmacokinetic evaluation of Staphylococcus phage COP-80B for treatment of periprosthetic joint infections in a mouse model","name":"articletitle","label":"Article Title"},{"value":"Virus Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virusres.2025.199592","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"199592"}}