{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:49:01Z","timestamp":1777859341231,"version":"3.51.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008880","name":"Kanae Foundation for the Promotion of Medical Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008880","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007263","name":"Astellas Foundation for Research on Metabolic Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP24fm0208101"],"award-info":[{"award-number":["JP24fm0208101"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP25fm0208101"],"award-info":[{"award-number":["JP25fm0208101"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["24jk0210001h0001"],"award-info":[{"award-number":["24jk0210001h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virus Research"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.virusres.2026.199684","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T07:26:13Z","timestamp":1767425173000},"page":"199684","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Identification of novel small chemical compounds that inhibit Ebola virus VP40-mediated virus-like particle production"],"prefix":"10.1016","volume":"364","author":[{"given":"Tomoko","family":"Tsuruta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Mizuta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Izumisawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiro","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0710-2272","authenticated-orcid":false,"given":"Shuzo","family":"Urata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.virusres.2026.199684_bib0001","doi-asserted-by":"crossref","first-page":"5779","DOI":"10.1074\/jbc.M112.443960","article-title":"The Ebola virus matrix protein penetrates into the plasma membrane: a key step in viral protein 40 (VP40) oligomerization and viral egress","volume":"288","author":"Adu-Gyamfi","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.virusres.2026.199684_bib0002","doi-asserted-by":"crossref","DOI":"10.3390\/v13010052","article-title":"A novel Ebola Virus VP40 matrix protein-based screening for identification of novel candidate medical countermeasures","volume":"13","author":"Bennett","year":"2020","journal-title":"Viruses"},{"key":"10.1016\/j.virusres.2026.199684_bib0003","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s00705-023-05834-2","article-title":"Renaming of genera Ebolavirus and Marburgvirus to Orthoebolavirus and Orthomarburgvirus, respectively, and introduction of binomial species names within family Filoviridae","volume":"168","author":"Biedenkopf","year":"2023","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virusres.2026.199684_bib0004","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.cell.2013.07.015","article-title":"Structural rearrangement of ebola virus VP40 begets multiple functions in the virus life cycle","volume":"154","author":"Bornholdt","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.virusres.2026.199684_bib0005","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24076298","article-title":"Cheminformatics-based study identifies potential Ebola VP40 inhibitors","volume":"24","author":"Broni","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"Suppl 2","key":"10.1016\/j.virusres.2026.199684_bib0006","doi-asserted-by":"crossref","first-page":"S167","DOI":"10.1093\/infdis\/jiv090","article-title":"High-resolution crystal structure of dimeric VP40 from sudan ebolavirus","volume":"212","author":"Clifton","year":"2015","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.virusres.2026.199684_bib0007","doi-asserted-by":"crossref","first-page":"4228","DOI":"10.1093\/emboj\/19.16.4228","article-title":"Crystal structure of the matrix protein VP40 from Ebola virus","volume":"19","author":"Dessen","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.virusres.2026.199684_bib0008","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1012038","article-title":"Recent advances in the treatment of Ebola disease: a brief overview","volume":"20","author":"El Ayoubi","year":"2024","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virusres.2026.199684_bib0009","doi-asserted-by":"crossref","DOI":"10.3390\/v17071016","article-title":"Development of a novel, highly sensitive system for evaluating ebola virus particle formation","volume":"17","author":"Furuyama","year":"2025","journal-title":"Viruses"},{"key":"10.1016\/j.virusres.2026.199684_bib0010","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0969-2126(03)00050-9","article-title":"The matrix protein VP40 from Ebola virus octamerizes into pore-like structures with specific RNA binding properties","volume":"11","author":"Gomis-Ruth","year":"2003","journal-title":"Structure"},{"key":"10.1016\/j.virusres.2026.199684_bib0011","doi-asserted-by":"crossref","first-page":"7294","DOI":"10.1128\/JVI.00591-14","article-title":"Small-molecule probes targeting the viral PPxY-host Nedd4 interface block egress of a broad range of RNA viruses","volume":"88","author":"Han","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2026.199684_bib0012","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.virol.2005.03.027","article-title":"Functional characterization of Ebola virus L-domains using VSV recombinants","volume":"336","author":"Irie","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.virusres.2026.199684_bib0013","doi-asserted-by":"crossref","first-page":"5205","DOI":"10.1128\/JVI.75.11.5205-5214.2001","article-title":"Ebola virus VP40-induced particle formation and association with the lipid bilayer","volume":"75","author":"Jasenosky","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2026.199684_bib0014","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.apjtm.2016.03.002","article-title":"Determination of ligand cluster and binding site within VP40 of Ebola virus: clue for drug development","volume":"9","author":"Joob","year":"2016","journal-title":"Asian Pac. J. Trop. Med."},{"key":"10.1016\/j.virusres.2026.199684_bib0015","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40249-016-0105-1","article-title":"Virtual screening of the inhibitors targeting at the viral protein 40 of Ebola virus","volume":"5","author":"Karthick","year":"2016","journal-title":"Infect. Dis. Poverty."},{"key":"10.1016\/j.virusres.2026.199684_bib0016","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00894-021-04682-8","article-title":"Targeting ebola virus VP40 protein through novel inhibitors: exploring the structural and dynamic perspectives on molecular landscapes","volume":"27","author":"Khan","year":"2021","journal-title":"J. Mol. Model."},{"key":"10.1016\/j.virusres.2026.199684_bib0017","series-title":"Herbicidal Azole Derivative having Dihydrobenzoquinone Skeleton","author":"Komai","year":"1998"},{"key":"10.1016\/j.virusres.2026.199684_bib0018","doi-asserted-by":"crossref","first-page":"e84","DOI":"10.1038\/emi.2014.88","article-title":"Identification of 53 compounds that block Ebola virus-like particle entry via a repurposing screen of approved drugs","volume":"3","author":"Kouznetsova","year":"2014","journal-title":"Emerg. Microbes. Infect."},{"key":"10.1016\/j.virusres.2026.199684_bib0019","article-title":"Filoviridae","volume":"1","author":"Kuhn Jens","year":"2021","journal-title":"Fields Virol."},{"key":"10.1016\/j.virusres.2026.199684_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.108986","article-title":"Cellular mRNA triggers structural transformation of Ebola virus matrix protein VP40 to its essential regulatory form","volume":"35","author":"Landeras-Bueno","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.virusres.2026.199684_bib0021","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1128\/JVI.77.3.1812-1819.2003","article-title":"Overlapping motifs (PTAP and PPEY) within the Ebola virus VP40 protein function independently as late budding domains: involvement of host proteins TSG101 and VPS-4","volume":"77","author":"Licata","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2026.199684_bib0022","doi-asserted-by":"crossref","DOI":"10.3390\/v12010105","article-title":"Reporter assays for Ebola Virus nucleoprotein oligomerization, virion-like particle budding, and minigenome activity reveal the importance of nucleoprotein amino acid position 111","volume":"12","author":"Lin","year":"2020","journal-title":"Viruses"},{"key":"10.1016\/j.virusres.2026.199684_bib0023","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1146\/annurev-med-052915-015604","article-title":"Ebola: anatomy of an epidemic","volume":"68","author":"Lo","year":"2017","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.virusres.2026.199684_bib0024","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jviromet.2006.06.007","article-title":"A luciferase-based budding assay for Ebola virus","volume":"137","author":"McCarthy","year":"2006","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.virusres.2026.199684_bib0025","doi-asserted-by":"crossref","first-page":"4855","DOI":"10.1128\/JVI.76.10.4855-4865.2002","article-title":"Ebola virus VP40 drives the formation of virus-like filamentous particles along with GP","volume":"76","author":"Noda","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2026.199684_bib0026","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1006\/jmbi.2000.3822","article-title":"Structural characterization and membrane binding properties of the matrix protein VP40 of Ebola virus","volume":"300","author":"Ruigrok","year":"2000","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.virusres.2026.199684_bib0027","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.cell.2020.03.011","article-title":"A vaccine against Ebola Virus","volume":"181","author":"Saphire","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.virusres.2026.199684_bib0028","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1016\/j.bpj.2013.03.021","article-title":"The Ebola virus matrix protein deeply penetrates the plasma membrane: an important step in viral egress","volume":"104","author":"Soni","year":"2013","journal-title":"Biophys. J."},{"key":"10.1016\/j.virusres.2026.199684_bib0029","first-page":"300","article-title":"Membrane binding and bending in Ebola VP40 assembly and egress","volume":"5","author":"Stahelin","year":"2014","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.virusres.2026.199684_bib0030","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0022-2836(02)01406-7","article-title":"Ebola virus matrix protein VP40 interaction with human cellular factors Tsg101 and Nedd4","volume":"326","author":"Timmins","year":"2003","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.virusres.2026.199684_bib0031","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/viro.2001.0860","article-title":"Vesicular release of ebola virus matrix protein VP40","volume":"283","author":"Timmins","year":"2001","journal-title":"Virology"},{"key":"10.1016\/j.virusres.2026.199684_bib0032","doi-asserted-by":"crossref","first-page":"4895","DOI":"10.1128\/JVI.02829-06","article-title":"Interaction of Tsg101 with Marburg virus VP40 depends on the PPPY motif, but not the PT\/SAP motif as in the case of Ebola virus, and Tsg101 plays a critical role in the budding of Marburg virus-like particles induced by VP40, NP, and GP","volume":"81","author":"Urata","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.virusres.2026.199684_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2022.105267","article-title":"Identification of novel chemical compounds targeting filovirus VP40-mediated particle production","volume":"199","author":"Urata","year":"2022","journal-title":"Antiviral Res."},{"key":"10.1016\/j.virusres.2026.199684_bib0034","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1099\/vir.0.015495-0","article-title":"Regulation of Marburg virus (MARV) budding by Nedd4.1: a different WW domain of Nedd4.1 is critical for binding to MARV and Ebola virus VP40","volume":"91","author":"Urata","year":"2010","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.virusres.2026.199684_bib0035","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.59225","article-title":"Ebola and Marburg virus matrix layers are locally ordered assemblies of VP40 dimers","volume":"9","author":"Wan","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.virusres.2026.199684_bib0036","doi-asserted-by":"crossref","first-page":"5587","DOI":"10.1016\/j.cell.2024.08.044","article-title":"Intracellular Ebola virus nucleocapsid assembly revealed by in situ cryo-electron tomography","volume":"187","author":"Watanabe","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.virusres.2026.199684_bib0037","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.str.2023.06.004","article-title":"The C-terminus of Sudan ebolavirus VP40 contains a functionally important CX(n)C motif, a target for redox modifications","volume":"31","author":"Werner","year":"2023","journal-title":"Structure"},{"key":"10.1016\/j.virusres.2026.199684_bib0038","doi-asserted-by":"crossref","first-page":"9987","DOI":"10.1128\/JVI.77.18.9987-9992.2003","article-title":"Nedd4 regulates egress of Ebola virus-like particles from host cells","volume":"77","author":"Yasuda","year":"2003","journal-title":"J. Virol."}],"container-title":["Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170226000018?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170226000018?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:29:11Z","timestamp":1777508951000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168170226000018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":38,"alternative-id":["S0168170226000018"],"URL":"https:\/\/doi.org\/10.1016\/j.virusres.2026.199684","relation":{},"ISSN":["0168-1702"],"issn-type":[{"value":"0168-1702","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of novel small chemical compounds that inhibit Ebola virus VP40-mediated virus-like particle production","name":"articletitle","label":"Article Title"},{"value":"Virus Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virusres.2026.199684","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"199684"}}