{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T04:21:40Z","timestamp":1783138900981,"version":"3.54.6"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004317","name":"Shihezi University","doi-asserted-by":"publisher","award":["QN202218"],"award-info":[{"award-number":["QN202218"]}],"id":[{"id":"10.13039\/501100004317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005198","name":"Chinese Foundation for Hepatitis Prevention and Control","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005198","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virus Research"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.virusres.2026.199744","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:53:25Z","timestamp":1778579605000},"page":"199744","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["CD72 downregulation is associated with increased CD5+ B cell proliferation and IL-10 production via ERK\/Syk signaling in chronic HBV infection-associated liver disease"],"prefix":"10.1016","volume":"368","author":[{"given":"Bingjie","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luna","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfeng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songsong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.virusres.2026.199744_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2024.103245","article-title":"CD72 is an inhibitory pattern recognition receptor that recognizes ribosomes and suppresses production of anti-ribosome autoantibody","volume":"146","author":"Akatsu","year":"2024","journal-title":"J. Autoimmun."},{"issue":"3","key":"10.1016\/j.virusres.2026.199744_bib0002","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.jhep.2020.10.012","article-title":"IL-2 contributes to cirrhosis-associated immune dysfunction by impairing follicular T helper cells in advanced cirrhosis","volume":"74","author":"Basho","year":"2021","journal-title":"J. Hepatol."},{"issue":"4","key":"10.1016\/j.virusres.2026.199744_bib0003","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.jhep.2022.12.013","article-title":"Activation of CD4 T cells during prime immunization determines the success of a therapeutic hepatitis B vaccine in HBV-carrier mouse models","volume":"78","author":"Brunner","year":"2023","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.virusres.2026.199744_bib0004","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/JLB.MR0618-226R","article-title":"The multiple faces of CD5","volume":"105","author":"Burgue\u00f1o-Bucio","year":"2019","journal-title":"J. Leukoc. Biol."},{"issue":"10","key":"10.1016\/j.virusres.2026.199744_bib0005","doi-asserted-by":"crossref","first-page":"4588","DOI":"10.1172\/JCI121960","article-title":"Circulating and intrahepatic antiviral B cells are defective in hepatitis B","volume":"128","author":"Burton","year":"2018","journal-title":"J. Clin. Invest."},{"issue":"10","key":"10.1016\/j.virusres.2026.199744_bib0006","doi-asserted-by":"crossref","first-page":"4588","DOI":"10.1172\/JCI121960","article-title":"Circulating and intrahepatic antiviral B cells are defective in hepatitis B","volume":"128","author":"Burton","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.virusres.2026.199744_bib0007","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.582292","article-title":"The multiple functions of B cells in chronic HBV infection","volume":"11","author":"Cai","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.virusres.2026.199744_bib0008","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.582292","article-title":"The multiple functions of B cells in chronic HBV infection","volume":"11","author":"Cai","year":"2020","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.virusres.2026.199744_bib0009","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.3390\/antiox14121494","article-title":"Oxidative stress in liver metabolic dysfunction and diseases, with a focus on hepatogenic diabetes: effect of alcohol consumption","volume":"14","author":"Contreras-Zentella","year":"2025","journal-title":"Antioxid. (Basel)"},{"issue":"12","key":"10.1016\/j.virusres.2026.199744_bib0010","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.3390\/antiox14121494","article-title":"Oxidative stress in liver metabolic dysfunction and diseases, with a focus on hepatogenic diabetes: effect of alcohol consumption","volume":"14","author":"Contreras-Zentella","year":"2025","journal-title":"Antioxidants"},{"issue":"11","key":"10.1016\/j.virusres.2026.199744_bib0011","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/j.biocel.2004.05.017","article-title":"The CD5+ B-cell","volume":"36","author":"Dono","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"13","key":"10.1016\/j.virusres.2026.199744_bib0012","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.1080\/10428194.2021.1953010","article-title":"CD5+ diffuse large B-cell lymphoma: a narrative review","volume":"62","author":"Durani","year":"2021","journal-title":"Leuk. Lymphoma"},{"issue":"2","key":"10.1016\/j.virusres.2026.199744_bib0013","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jhep.2017.03.021","article-title":"EASL 2017 clinical practice guidelines on the management of hepatitis B virus infection","volume":"67","year":"2017","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.virusres.2026.199744_bib0014","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1002\/(SICI)1521-4141(200005)30:5<1326::AID-IMMU1326>3.0.CO;2-Q","article-title":"BLNK is associated with the CD72\/SHP-1\/Grb2 complex in the WEHI231 cell line after membrane IgM cross-linking","volume":"30","author":"Fusaki","year":"2000","journal-title":"Eur. J. Immunol."},{"issue":"1","key":"10.1016\/j.virusres.2026.199744_bib0015","doi-asserted-by":"crossref","first-page":"uxag001","DOI":"10.1093\/cei\/uxag001","article-title":"CD40L and IL-4 lymph node-associated signals protect B cells from rituximab-induced ADCC via KIR and NKG2A","volume":"220","author":"Graham","year":"2026","journal-title":"Clin. Exp. Immunol."},{"issue":"4","key":"10.1016\/j.virusres.2026.199744_bib0016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/etm.2026.13090","article-title":"Senescent hepatic stellate cells drive inflammation and disease progression in MASH (Review)","volume":"31","author":"Han","year":"2026","journal-title":"Exp. Ther. Med."},{"issue":"11","key":"10.1016\/j.virusres.2026.199744_bib0017","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1002\/eji.201445146","article-title":"Perspectives on fetal derived CD5+ B1 B cells","volume":"45","author":"Hardy","year":"2015","journal-title":"Eur. J. Immunol."},{"issue":"2","key":"10.1016\/j.virusres.2026.199744_bib0018","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1365-2249.1993.tb03387.x","article-title":"Expression of CD5 and CD72 on T and B cell subsets in rheumatoid arthritis and Sj\u00f6gren's syndrome","volume":"92","author":"Jamin","year":"2008","journal-title":"Clin. Exp. Immunol."},{"issue":"1","key":"10.1016\/j.virusres.2026.199744_bib0019","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1515\/folmed-2017-0008","article-title":"Immune cell subsets evaluation as a predictive tool for hepatitis B infection outcome and treatment responsiveness","volume":"59","author":"Kandilarova","year":"2017","journal-title":"Folia Med. (Plovdiv)"},{"issue":"1","key":"10.1016\/j.virusres.2026.199744_bib0020","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1515\/folmed-2017-0008","article-title":"Immune cell subsets evaluation as a predictive tool for Hepatitis B infection outcome and treatment responsiveness","volume":"59","author":"Kandilarova","year":"2017","journal-title":"Folia Med. (Plovdiv)"},{"issue":"5","key":"10.1016\/j.virusres.2026.199744_bib0021","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1007\/s12185-019-02788-7","article-title":"Pathophysiology of chronic lymphocytic leukemia and human B1 cell development","volume":"111","author":"Kikushige","year":"2020","journal-title":"Int. J. Hematol."},{"issue":"1","key":"10.1016\/j.virusres.2026.199744_bib0022","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1177\/0300060516676136","article-title":"Interferon-\u03b1-induced CD100 on na\u00efve CD8(+) T cells enhances antiviral responses to hepatitis C infection through CD72 signal transduction","volume":"45","author":"Li","year":"2017","journal-title":"J. Int. Med. Res."},{"issue":"10","key":"10.1016\/j.virusres.2026.199744_bib0023","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/s41575-019-0197-8","article-title":"Clinical utility of HBV surface antigen quantification in HBV e antigen-negative chronic HBV infection","volume":"16","author":"Liaw","year":"2019","journal-title":"Nat. Rev. Gastroenterol Hepatol."},{"issue":"10","key":"10.1016\/j.virusres.2026.199744_bib0024","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/cmi.2017.48","article-title":"Human immunodeficiency virus type-1 induces a regulatory B cell-like phenotype in vitro","volume":"15","author":"Lopez-Abente","year":"2018","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.virusres.2026.199744_bib0025","doi-asserted-by":"crossref","first-page":"853","DOI":"10.3389\/fimmu.2020.00853","article-title":"Diverse virus and host-dependent mechanisms influence the systemic and intrahepatic immune responses in the Woodchuck model of Hepatitis B","volume":"11","author":"Michalak","year":"2020","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.virusres.2026.199744_bib0026","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.jhep.2023.12.023","article-title":"Single-cell, single-nucleus, and spatial transcriptomics characterization of the immunological landscape in the healthy and PSC human liver","volume":"80","author":"Nakib","year":"2024","journal-title":"J. Hepatol."},{"issue":"8","key":"10.1016\/j.virusres.2026.199744_bib0027","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007923","article-title":"Toxoplasma gondii activates a Syk-CARD9-NF-\u03baB signaling axis and gasdermin D-independent release of IL-1\u03b2 during infection of primary human monocytes","volume":"15","author":"Pandori","year":"2019","journal-title":"PLoS Pathog."},{"issue":"6","key":"10.1016\/j.virusres.2026.199744_bib0028","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S2468-1253(18)30056-6","article-title":"Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study","volume":"3","year":"2018","journal-title":"Lancet Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.virusres.2026.199744_bib0029","doi-asserted-by":"crossref","first-page":"77","DOI":"10.4049\/jimmunol.2001173","article-title":"CD40L-Stimulated B lymphocytes are polarized toward APC functions after exposure to IL-4 and IL-21","volume":"207","author":"Possama\u00ef","year":"2021","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.virusres.2026.199744_bib0030","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S2468-1253(19)30119-0","article-title":"A global scientific strategy to cure hepatitis B","volume":"4","author":"Revill","year":"2019","journal-title":"Lancet Gastroenterol. Hepatol."},{"issue":"9","key":"10.1016\/j.virusres.2026.199744_bib0031","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/imcb.12283","article-title":"BAFF, IL-4 and IL-21 separably program germinal center-like phenotype acquisition, BCL6 expression, proliferation and survival of CD40L-activated B cells in vitro","volume":"97","author":"Robinson","year":"2019","journal-title":"Immunol. Cell Biol."},{"issue":"10","key":"10.1016\/j.virusres.2026.199744_bib0032","doi-asserted-by":"crossref","first-page":"4573","DOI":"10.1172\/JCI121957","article-title":"PD-1 blockade partially recovers dysfunctional virus-specific B cells in chronic hepatitis B infection","volume":"128","author":"Salimzadeh","year":"2018","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.virusres.2026.199744_bib0033","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12865-020-00351-2","article-title":"A regulatory role for CD72 expression on B cells and increased soluble CD72 in primary Sjogren's syndrome","volume":"21","author":"Shen","year":"2020","journal-title":"BMC. Immunol."},{"issue":"7","key":"10.1016\/j.virusres.2026.199744_bib0034","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009708","article-title":"Antibody-independent functions of B cells during viral infections","volume":"17","author":"Upasani","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virusres.2026.199744_bib0035","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.clim.2016.02.004","article-title":"Increased soluble CD72 in systemic lupus erythematosus is in association with disease activity and lupus nephritis","volume":"164","author":"Vadasz","year":"2016","journal-title":"Clin. Immunol."},{"issue":"6","key":"10.1016\/j.virusres.2026.199744_bib0036","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.semarthrit.2013.11.010","article-title":"A regulatory role for CD72 expression on B cells in systemic lupus erythematosus","volume":"43","author":"Vadasz","year":"2014","journal-title":"Sem. Arthritis Rheu."},{"issue":"8","key":"10.1016\/j.virusres.2026.199744_bib0037","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1053\/j.gastro.2018.03.021","article-title":"Dysregulated response of follicular helper T cells to Hepatitis B surface antigen promotes HBV persistence in mice and associates with outcomes of patients","volume":"154","author":"Wang","year":"2018","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.virusres.2026.199744_bib0038","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s10875-008-9264-6","article-title":"CD72, a coreceptor with both positive and negative effects on B lymphocyte development and function","volume":"29","author":"Wu","year":"2009","journal-title":"J. Clin. Immunol."},{"issue":"4","key":"10.1016\/j.virusres.2026.199744_bib0039","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.jhep.2019.05.013","article-title":"MMP2\/MMP9-mediated CD100 shedding is crucial for inducing intrahepatic anti-HBV CD8 T cell responses and HBV clearance","volume":"71","author":"Yang","year":"2019","journal-title":"J. Hepatol."},{"issue":"4","key":"10.1016\/j.virusres.2026.199744_bib0040","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1089\/vim.2020.0311","article-title":"Imbalance between soluble and membrane-bound CD100 regulates monocytes activity in Hepatitis B virus-associated acute-on-chronic liver failure","volume":"34","author":"Zhang","year":"2021","journal-title":"Viral. Immunol."},{"issue":"11","key":"10.1016\/j.virusres.2026.199744_bib0041","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2017.183","article-title":"IL-33 promotes IL-10 production in macrophages: a role for IL-33 in macrophage foam cell formation","volume":"49","author":"Zhang","year":"2017","journal-title":"Exp. Mol. Med."}],"container-title":["Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170226000638?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170226000638?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T04:14:06Z","timestamp":1783138446000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168170226000638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":41,"alternative-id":["S0168170226000638"],"URL":"https:\/\/doi.org\/10.1016\/j.virusres.2026.199744","relation":{},"ISSN":["0168-1702"],"issn-type":[{"value":"0168-1702","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CD72 downregulation is associated with increased CD5+ B cell proliferation and IL-10 production via ERK\/Syk signaling in chronic HBV infection-associated liver disease","name":"articletitle","label":"Article Title"},{"value":"Virus Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virusres.2026.199744","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"199744"}}