{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:24:40Z","timestamp":1783099480488,"version":"3.54.6"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31771010"],"award-info":[{"award-number":["31771010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672803"],"award-info":[{"award-number":["81672803"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","award":["KYCX25_4333"],"award-info":[{"award-number":["KYCX25_4333"]}],"id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012216","name":"Jiangsu University of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012216","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virus Research"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.virusres.2026.199755","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T15:05:23Z","timestamp":1779721523000},"page":"199755","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Pan-filovirus activity of an IGF2-fused monoclonal antibody: Impairment by IGF1R cross-engagement and rescue via IGF2 Y27L mutation"],"prefix":"10.1016","volume":"369","author":[{"given":"Wen","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaonan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muyang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longlong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youchun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxia","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiannan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guojiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.virusres.2026.199755_bib0001","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-46990-6","article-title":"Activation of the insulin receptor by insulin-like growth factor 2","volume":"15","author":"An","year":"2024","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.virusres.2026.199755_bib0002","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0178885","article-title":"IGF1 and IGF2 specificities to the two insulin receptor isoforms are determined by insulin receptor amino acid 718","volume":"12","author":"Andersen","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.virusres.2026.199755_bib0003","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11010229","article-title":"IGF2: a role in metastasis and tumor evasion from immune surveillance?","volume":"11","author":"Belfiore","year":"2023","journal-title":"Biomedicines"},{"issue":"2","key":"10.1016\/j.virusres.2026.199755_bib0004","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1210\/endo-128-2-1201","article-title":"[Leu27] insulin-like growth factor II is highly selective for the type-II IGF receptor in binding, cross-linking and thymidine incorporation experiments","volume":"128","author":"Beukers","year":"1991","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.virusres.2026.199755_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.chom.2018.12.005","article-title":"A two-antibody pan-Ebolavirus cocktail confers broad therapeutic protection in ferrets and nonhuman primates","volume":"25","author":"Bornholdt","year":"2019","journal-title":"Cell Host Microbe"},{"issue":"1","key":"10.1016\/j.virusres.2026.199755_bib0006","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/s41467-018-08040-w","article-title":"Post-exposure immunotherapy for two ebolaviruses and Marburg virus in nonhuman primates","volume":"10","author":"Brannan","year":"2019","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.virusres.2026.199755_bib0007","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/sj.emboj.7601938","article-title":"Structure and functional analysis of the IGF-II\/IGF2R interaction","volume":"27","author":"Brown","year":"2008","journal-title":"EMBO J."},{"issue":"2","key":"10.1016\/j.virusres.2026.199755_bib0008","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S0021-9258(17)35278-X","article-title":"Mutants of human insulin-like growth factor II with altered affinities for the type 1 and type 2 insulin-like growth factor receptor","volume":"266","author":"B\u00fcrgisser","year":"1991","journal-title":"J. Biol. Chem."},{"issue":"7364","key":"10.1016\/j.virusres.2026.199755_bib0009","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/nature10348","article-title":"Ebola virus entry requires the cholesterol transporter Niemann-Pick C1","volume":"477","author":"Carette","year":"2011","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.virusres.2026.199755_bib0010","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cytogfr.2008.01.005","article-title":"IGF2: epigenetic regulation and role in development and disease","volume":"19","author":"Chao","year":"2008","journal-title":"Cytokine Growth Factor Rev."},{"issue":"3","key":"10.1016\/j.virusres.2026.199755_bib0011","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ymgme.2004.06.013","article-title":"Niemann-Pick type C disease: importance of N-glycosylation sites for function and cellular location of the NPC2 protein","volume":"83","author":"Chikh","year":"2004","journal-title":"Mol. Genet. Metab."},{"issue":"6279","key":"10.1016\/j.virusres.2026.199755_bib0012","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1126\/science.aad5224","article-title":"Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody","volume":"351","author":"Corti","year":"2016","journal-title":"Science"},{"issue":"7364","key":"10.1016\/j.virusres.2026.199755_bib0023","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nature10380","article-title":"Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection","volume":"477","author":"C\u00f4t\u00e9","year":"2011","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.virusres.2026.199755_bib0013","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3109\/08977190109001084","article-title":"Contribution of residues A54 and L55 of the human insulin-like growth factor-II (IGF-II) a domain to type 2 IGF receptor binding specificity","volume":"19","author":"Forbe","year":"2001","journal-title":"Growth Factors"},{"key":"10.1016\/j.virusres.2026.199755_bib0014","doi-asserted-by":"crossref","DOI":"10.1038\/srep19193","article-title":"Bispecific antibody affords complete post-exposure protection of mice from both Ebola (Zaire) and Sudan viruses","volume":"6","author":"Frei","year":"2016","journal-title":"Sci. Rep."},{"issue":"22","key":"10.1016\/j.virusres.2026.199755_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2021.09.035","article-title":"Pan-ebolavirus protective therapy by two multifunctional human antibodies","volume":"184","author":"Gilchuk","year":"2021","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.virusres.2026.199755_bib0016","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/s41564-018-0227-2","article-title":"The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses","volume":"3","author":"Goldstein","year":"2018","journal-title":"Nat. Microbiol."},{"issue":"1","key":"10.1016\/j.virusres.2026.199755_bib0017","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00705-012-1454-0","article-title":"Virus nomenclature below the species level: a standardized nomenclature for natural variants of viruses assigned to the family Filoviridae","volume":"158","author":"Kuhn","year":"2013","journal-title":"Arch. Virol."},{"issue":"12","key":"10.1016\/j.virusres.2026.199755_bib0018","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1007\/s00705-010-0814-x","article-title":"Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations","volume":"155","author":"Kuhn","year":"2010","journal-title":"Arch. Virol."},{"key":"10.1016\/j.virusres.2026.199755_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101245","article-title":"Insulin-like growth factors: ligands, binding proteins, and receptors","volume":"52","author":"LeRoith","year":"2021","journal-title":"Mol. Metab."},{"issue":"48","key":"10.1016\/j.virusres.2026.199755_bib0020","doi-asserted-by":"crossref","first-page":"36710","DOI":"10.1074\/jbc.M608743200","article-title":"NPC2, the protein deficient in Niemann-Pick C2 disease, consists of multiple glycoforms that bind a variety of sterols","volume":"281","author":"Liou","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"Suppl 7","key":"10.1016\/j.virusres.2026.199755_bib0021","doi-asserted-by":"crossref","first-page":"S691","DOI":"10.1093\/infdis\/jiad205","article-title":"A pan-Ebolavirus monoclonal antibody cocktail provides protection against Ebola and Sudan viruses","volume":"228","author":"Liu","year":"2023","journal-title":"J. Infect. Dis."},{"issue":"9","key":"10.1016\/j.virusres.2026.199755_bib0022","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.molmed.2017.07.002","article-title":"Clinical evaluation of Ebola virus disease therapeutics","volume":"23","author":"Liu","year":"2017","journal-title":"Trends Mol. Med."},{"issue":"1","key":"10.1016\/j.virusres.2026.199755_bib0024","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1128\/JVI.02265-13","article-title":"Characterization of the envelope glycoprotein of a novel filovirus, Lloviu virus","volume":"88","author":"Maruyama","year":"2014","journal-title":"J. Virol."},{"issue":"22","key":"10.1016\/j.virusres.2026.199755_bib0025","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28227519","article-title":"IGF2 peptide-based LYTACs for targeted degradation of extracellular and transmembrane proteins","volume":"28","author":"Mikitiuk","year":"2023","journal-title":"Molecules"},{"issue":"8","key":"10.1016\/j.virusres.2026.199755_bib0026","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1038\/emboj.2012.53","article-title":"Ebola virus entry requires the host-programmed recognition of an intracellular receptor","volume":"31","author":"Miller","year":"2012","journal-title":"Embo J."},{"issue":"6","key":"10.1016\/j.virusres.2026.199755_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2022.02.023","article-title":"Asymmetric and non-stoichiometric glycoprotein recognition by two distinct antibodies results in broad protection against ebolaviruses","volume":"185","author":"Milligan","year":"2022","journal-title":"Cell"},{"issue":"24","key":"10.1016\/j.virusres.2026.199755_bib0028","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1056\/NEJMoa1910993","article-title":"A randomized, controlled trial of Ebola virus disease therapeutics","volume":"381","author":"Mulangu","year":"2019","journal-title":"N. Engl. J. Med."},{"issue":"10","key":"10.1016\/j.virusres.2026.199755_bib0029","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002304","article-title":"Discovery of an ebolavirus-like filovirus in Europe","volume":"7","author":"Negredo","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virusres.2026.199755_bib0030","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.virol.2014.08.019","article-title":"Cell entry by a novel European filovirus requires host endosomal cysteine proteases and Niemann-Pick C1","volume":"468\u2013470","author":"Ng","year":"2014","journal-title":"Virology"},{"issue":"16","key":"10.1016\/j.virusres.2026.199755_bib0031","doi-asserted-by":"crossref","first-page":"6201","DOI":"10.1074\/jbc.RA117.001627","article-title":"Design and evaluation of bi- and trispecific antibodies targeting multiple filovirus glycoproteins","volume":"293","author":"Nyakatura","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.virusres.2026.199755_bib0032","doi-asserted-by":"crossref","DOI":"10.1002\/pro.70051","article-title":"Engineering IGF2 for lysosome-targeting chimeras development to target drug-resistant membrane proteins in tumor therapy","volume":"34","author":"Pan","year":"2025","journal-title":"Protein Sci."},{"issue":"suppl_5","key":"10.1016\/j.virusres.2026.199755_bib0033","doi-asserted-by":"crossref","first-page":"S612","DOI":"10.1093\/infdis\/jiy285","article-title":"Development of clinical-stage human monoclonal antibodies that treat advanced Ebola virus disease in nonhuman primates","volume":"218","author":"Pascal","year":"2018","journal-title":"J. Infect. Dis."},{"issue":"2","key":"10.1016\/j.virusres.2026.199755_bib0034","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/0006-291X(91)91277-J","article-title":"Mutants of human insulin-like growth factor II: expression and characterization of analogs with a substitution of TYR27 and\/or a deletion of residues 62-67","volume":"181","author":"Roth","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"Pt 1","key":"10.1016\/j.virusres.2026.199755_bib0035","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1101\/SQB.1988.053.01.062","article-title":"Insulin and insulin-like growth factor receptors and responses","volume":"53","author":"Roth","year":"1988","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1016\/j.virusres.2026.199755_bib0036","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jcv.2015.01.014","article-title":"Ebola and Marburg haemorrhagic fever","volume":"64","author":"Rougeron","year":"2015","journal-title":"J. Clin. Virol."},{"issue":"31","key":"10.1016\/j.virusres.2026.199755_bib0037","doi-asserted-by":"crossref","first-page":"20626","DOI":"10.1016\/S0021-9258(18)54755-4","article-title":"The design, expression, and characterization of human insulin-like growth factor II (IGF-II) mutants specific for either the IGF-II\/cation-independent mannose 6-phosphate receptor or IGF-I receptor","volume":"266","author":"Sakano","year":"1991","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.virusres.2026.199755_bib0038","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01857-15","article-title":"Direct visualization of Ebola virus fusion triggering in the endocytic pathway","volume":"7","author":"Spence","year":"2016","journal-title":"MBio"},{"issue":"1","key":"10.1016\/j.virusres.2026.199755_bib0039","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009275","article-title":"Ebola virus triggers receptor tyrosine kinase-dependent signaling to promote the delivery of viral particles to entry-conducive intracellular compartments","volume":"17","author":"Stewart","year":"2021","journal-title":"PLoS Pathog."},{"issue":"5","key":"10.1016\/j.virusres.2026.199755_bib0040","article-title":"Insulin-like growth factor 2-tagged aptamer chimeras (ITACs) modular assembly for targeted and efficient degradation of two membrane proteins","volume":"63","author":"Tian","year":"2024","journal-title":"Angew. Chem. Int. Engl."},{"issue":"1","key":"10.1016\/j.virusres.2026.199755_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.chom.2018.12.004","article-title":"Development of a human antibody cocktail that deploys multiple functions to confer pan-Ebolavirus protection","volume":"25","author":"Wec","year":"2019","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.virusres.2026.199755_bib0042","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1126\/science.aag3267","article-title":"A \"Trojan horse\" bispecific-antibody strategy for broad protection against ebolaviruses","author":"Wec","year":"2016","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.virusres.2026.199755_bib0043","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1012134","article-title":"Design and characterization of protective pan-ebolavirus and pan-filovirus bispecific antibodies","volume":"20","author":"Wirchnianski","year":"2024","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.virusres.2026.199755_bib0044","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.729851","article-title":"Two distinct lysosomal targeting strategies afford trojan horse antibodies with pan-filovirus activity","volume":"12","author":"Wirchnianski","year":"2021","journal-title":"Front. Immunol."},{"issue":"13","key":"10.1016\/j.virusres.2026.199755_bib0045","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2320053121","article-title":"Directed evolution of genetically encoded LYTACs for cell-mediated delivery","volume":"121","author":"Yang","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.virusres.2026.199755_bib0046","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/s41564-018-0328-y","article-title":"Characterization of a filovirus (M\u011bngl\u00e0 virus) from Rousettus bats in China","volume":"4","author":"Yang","year":"2019","journal-title":"Nat. Microbiol."},{"issue":"2","key":"10.1016\/j.virusres.2026.199755_bib0047","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jmb.2006.03.046","article-title":"Kinetics of insulin-like growth factor II (IGF-II) interaction with domain 11 of the human IGF-II\/mannose 6-phosphate receptor: function of CD and AB loop solvent-exposed residues","volume":"359","author":"Zaccheo","year":"2006","journal-title":"J. Mol. Biol."},{"issue":"44","key":"10.1016\/j.virusres.2026.199755_bib0048","doi-asserted-by":"crossref","first-page":"24272","DOI":"10.1021\/jacs.3c08886","article-title":"Insulin-like growth factor 2 (IGF2)-fused lysosomal targeting chimeras for degradation of extracellular and membrane proteins","volume":"145","author":"Zhang","year":"2023","journal-title":"J. Am. Chem. Soc"},{"issue":"3","key":"10.1016\/j.virusres.2026.199755_bib0049","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02212-21","article-title":"TIM-1 Augments cellular entry of Ebola virus species and mutants, which is blocked by recombinant TIM-1 protein","volume":"10","author":"Zhang","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.virusres.2026.199755_bib0050","first-page":"12","article-title":"A novel MARV glycoprotein-specific antibody with potentials of broad-spectrum neutralization to filovirus","author":"Zhang","year":"2024","journal-title":"ELife"},{"issue":"9","key":"10.1016\/j.virusres.2026.199755_bib0051","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00685-24","article-title":"Afucosylated anti-EBOV antibody MIL77-3 engages sGP to elicit NK cytotoxicity","volume":"98","author":"Zhang","year":"2024","journal-title":"J. Virol."},{"issue":"11","key":"10.1016\/j.virusres.2026.199755_bib0052","doi-asserted-by":"crossref","DOI":"10.3390\/biom12111557","article-title":"Insulin-like growth factor-2 (IGF-2) in fibrosis","volume":"12","author":"Zhu","year":"2022","journal-title":"Biomolecules"}],"container-title":["Virus Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170226000742?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168170226000742?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:12:39Z","timestamp":1783098759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168170226000742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":52,"alternative-id":["S0168170226000742"],"URL":"https:\/\/doi.org\/10.1016\/j.virusres.2026.199755","relation":{},"ISSN":["0168-1702"],"issn-type":[{"value":"0168-1702","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pan-filovirus activity of an IGF2-fused monoclonal antibody: Impairment by IGF1R cross-engagement and rescue via IGF2 Y27L mutation","name":"articletitle","label":"Article Title"},{"value":"Virus Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.virusres.2026.199755","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"199755"}}