{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:49:36Z","timestamp":1791348576598,"version":"4.3.1"},"reference-count":114,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T00:00:00Z","timestamp":1374105600000},"content-version":"vor","delay-in-days":929,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vision Research"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.visres.2010.07.023","type":"journal-article","created":{"date-parts":[[2010,8,5]],"date-time":"2010-08-05T08:47:18Z","timestamp":1280998038000},"page":"296-302","source":"Crossref","is-referenced-by-count":70,"title":["Melanopsin-expressing retinal ganglion cells: implications for human diseases"],"prefix":"10.1016","volume":"51","author":[{"given":"Chiara","family":"La Morgia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred N.","family":"Ross-Cisneros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Hannibal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Montagna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo A.","family":"Sadun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Carelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Pt 5","key":"10.1016\/j.visres.2010.07.023_b0005","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1093\/brain\/awp068","article-title":"The retina in Parkinson\u2019s disease","volume":"132","author":"Archibald","year":"2009","journal-title":"Brain"},{"issue":"1\u20133","key":"10.1016\/j.visres.2010.07.023_b0010","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s12031-008-9059-5","article-title":"PACAP-mediated neuroprotection of neurochemically identified cell types in MSG-induced retinal degeneration","volume":"36","author":"Atlasz","year":"2008","journal-title":"Journal of Molecular Neuroscience"},{"issue":"5","key":"10.1016\/j.visres.2010.07.023_b0015","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1167\/iovs.06-1029","article-title":"Retinal abnormalities in early Alzheimer\u2019s disease","volume":"48","author":"Berisha","year":"2007","journal-title":"Investigative Ophthalmology and Visual Science"},{"issue":"5557","key":"10.1016\/j.visres.2010.07.023_b0020","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1126\/science.1067262","article-title":"Phototransduction by retinal ganglion cells that set the circadian clock","volume":"295","author":"Berson","year":"2002","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.visres.2010.07.023_b0025","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0166-2236(03)00130-9","article-title":"Strange vision: Ganglion cells as circadian photoreceptors","volume":"26","author":"Berson","year":"2003","journal-title":"Trends in Neurosciences"},{"issue":"11","key":"10.1016\/j.visres.2010.07.023_b0030","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1007\/s00702-009-0292-z","article-title":"Retinopathy in Parkinson disease","volume":"116","author":"Bodis-Wollner","year":"2009","journal-title":"Journal of Neural Transmission"},{"issue":"11","key":"10.1016\/j.visres.2010.07.023_b0035","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/s00417-005-0023-6","article-title":"Relative post-mortem sparing of afferent pupil fibers in a patient with 3460 Leber\u2019s hereditary optic neuropathy","volume":"243","author":"Bose","year":"2005","journal-title":"Graefes Archive for Clinical and Experimental Ophthalmology"},{"issue":"16","key":"10.1016\/j.visres.2010.07.023_b0040","doi-asserted-by":"crossref","first-page":"6405","DOI":"10.1523\/JNEUROSCI.21-16-06405.2001","article-title":"Action spectrum for melatonin regulation in humans: Evidence for a novel circadian photoreceptor","volume":"21","author":"Brainard","year":"2001","journal-title":"Journal of Neuroscience"},{"issue":"3","key":"10.1016\/j.visres.2010.07.023_b0045","first-page":"675","article-title":"The pupil in dominant optic atrophy","volume":"42","author":"Bremner","year":"2001","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"10.1016\/j.visres.2010.07.023_b0050","unstructured":"Brown, T. M., Gigg, J., Piggins, H. D., & Lucas, R. J. (2010). Melanopsin-dependent activation of dorsal lateral geniculate neurons. ARVO 2010, poster no. 672\/D736."},{"issue":"4","key":"10.1016\/j.visres.2010.07.023_b0055","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1017\/S1041610209008886","article-title":"Bright light therapy for agitation in dementia: A randomized controlled trial","volume":"21","author":"Burns","year":"2009","journal-title":"International Psychogeriatrics"},{"issue":"1\u20132","key":"10.1016\/j.visres.2010.07.023_b0060","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1080\/07420520500545813","article-title":"Age-related changes in the circadian and homeostatic regulation of human sleep","volume":"23","author":"Cajochen","year":"2006","journal-title":"Chronobiology International"},{"issue":"1\u20133","key":"10.1016\/j.visres.2010.07.023_b0065","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s10540-007-9045-0","article-title":"Mitochondrial optic neuropathies: How two genomes may kill the same cell type?","volume":"27","author":"Carelli","year":"2007","journal-title":"Bioscience Reports"},{"key":"10.1016\/j.visres.2010.07.023_b0070","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.preteyeres.2003.10.003","article-title":"Mitochondrial dysfunction as a cause of optic neuropathies","volume":"23","author":"Carelli","year":"2004","journal-title":"Progress in Retinal and Eye Research"},{"issue":"1\u20132","key":"10.1016\/j.visres.2010.07.023_b0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3940(02)00038-1","article-title":"Phase advance of sleep and temperature circadian rhythms in the middle years of life in humans","volume":"320","author":"Carrier","year":"2002","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.visres.2010.07.023_b0080","doi-asserted-by":"crossref","first-page":"c981","DOI":"10.1136\/bmj.c981","article-title":"Age related macular degeneration","volume":"340","author":"Chakravarthy","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.visres.2010.07.023_b0085","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/cne.903380106","article-title":"Neurotoxic effects of neonatal injections of monosodium l-glutamate (l-MSG) on the retinal ganglion cell layer of the golden hamster: Anatomical and functional consequences on the circadian system","volume":"338","author":"Chambille","year":"1993","journal-title":"Journal of Comparative Neurology"},{"key":"10.1016\/j.visres.2010.07.023_b0090","unstructured":"Chen, S. -K., Ecker, J. L., & Hattar, S. (2010). Understanding the complexity of ipRGCs targeting and functions. ARVO meeting, poster no. 664\/D728."},{"issue":"6408","key":"10.1016\/j.visres.2010.07.023_b0095","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/361156a0","article-title":"Ocular regression conceals adaptive progression of the visual system in a blind subterranean mammal","volume":"361","author":"Cooper","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.visres.2010.07.023_b0100","unstructured":"Cooper, H. M., Drouyer, E., Dkhissi-Benyahya, O., Gronfier, C., Chiquet, C., WoldeMussie, E., et al. (2008). Effects of glaucoma on the circadian timing system in mice and men. ARVO meeting, poster no. 182\/A327."},{"issue":"1","key":"10.1016\/j.visres.2010.07.023_b0105","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1056\/NEJM199501053320102","article-title":"Suppression of melatonin secretion in some blind patients by exposure to bright light","volume":"332","author":"Czeisler","year":"1995","journal-title":"New England Journal of Medicine"},{"issue":"7027","key":"10.1016\/j.visres.2010.07.023_b0110","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/nature03387","article-title":"Melanopsin-expressing ganglion cells in primate retina signal colour and irradiance and project to the LGN","volume":"433","author":"Dacey","year":"2005","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.visres.2010.07.023_b0115","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/3656","article-title":"Light detection in a \u2019blind\u2019 mammal","volume":"1","author":"David-Gray","year":"1998","journal-title":"Nature Neuroscience"},{"issue":"3","key":"10.1016\/j.visres.2010.07.023_b0120","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1081\/CBI-100101049","article-title":"Contribution of circadian physiology and sleep homeostasis to age-related changes in human sleep","volume":"17","author":"Dijk","year":"2000","journal-title":"Chronobiology International"},{"issue":"6","key":"10.1016\/j.visres.2010.07.023_b0125","doi-asserted-by":"crossref","first-page":"e1000145","DOI":"10.1371\/journal.pbio.1000145","article-title":"Light, sleep, and circadian rhythms: Together again","volume":"7","author":"Dijk","year":"2009","journal-title":"PLoS Biology"},{"issue":"2","key":"10.1016\/j.visres.2010.07.023_b0130","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1532-5415.2007.01543.x","article-title":"Melatonin and bright-light treatment for rest-activity disruption in institutionalized patients with Alzheimer\u2019s disease","volume":"56","author":"Dowling","year":"2008","journal-title":"Journal of the American Geriatrics Society"},{"issue":"12","key":"10.1016\/j.visres.2010.07.023_b0135","doi-asserted-by":"crossref","first-page":"e3931","DOI":"10.1371\/journal.pone.0003931","article-title":"Glaucoma alters the circadian timing system","volume":"3","author":"Drouyer","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.visres.2010.07.023_b0140","unstructured":"Esquiva, G., Gonzalez-Mendez, I., Fernandez-Sanchez, L., Garcia-Martin, E., Pinilla, I., Garcia-Fernandez, J., et al. (2010). Degeneration of melanopsin photosensitive retinal ganglion cells in human retinas with aging and in animal models of retinitis pigmentosa. ARVO meeting, poster no. 680\/D744."},{"issue":"1","key":"10.1016\/j.visres.2010.07.023_b0150","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/BF00198171","article-title":"Circadian photoreception in the retinally degenerate mouse (rd\/rd)","volume":"169","author":"Foster","year":"1991","journal-title":"Journal of Comparative Physiology A"},{"issue":"5413","key":"10.1016\/j.visres.2010.07.023_b0155","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1126\/science.284.5413.502","article-title":"Regulation of mammalian circadian behavior by non-rod, non-cone, ocular photoreceptors","volume":"284","author":"Freedman","year":"1999","journal-title":"Science"},{"issue":"29","key":"10.1016\/j.visres.2010.07.023_b0160","doi-asserted-by":"crossref","first-page":"10339","DOI":"10.1073\/pnas.0501866102","article-title":"Intrinsically photosensitive retinal ganglion cells detect light with a vitamin A-based photopigment, melanopsin","volume":"102","author":"Fu","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.visres.2010.07.023_b0165","unstructured":"Gias, C., Semo, M., Vugler, A. A., & Coffey, P. J. (2010). Melanopsin cortical response in the rodless coneless mouse to light stimulation revealed using optical imaging of intrinsic signals. ARVO meeting, poster no. 673\/D737."},{"issue":"6","key":"10.1016\/j.visres.2010.07.023_b0170","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.biopsych.2005.07.006","article-title":"Light therapy for seasonal affective disorder with blue narrow-band light-emitting diodes (LEDs)","volume":"59","author":"Glickman","year":"2006","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.visres.2010.07.023_b0175","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nature06829","article-title":"Melanopsin cells are the principal conduits for rod\u2013cone input to non-image-forming vision","volume":"453","author":"Guler","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.visres.2010.07.023_b0180","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1177\/074873001129002132","article-title":"Light-dependent induction of cFos during subjective day and night in PACAP-containing ganglion cells of the retinohypothalamic tract","volume":"16","author":"Hannibal","year":"2001","journal-title":"Journal of Biological Rhythms"},{"issue":"RC191","key":"10.1016\/j.visres.2010.07.023_b0185","first-page":"1","article-title":"The photopigment melanopsin is exclusively present in PACAP containing retinal ganglion cells of the retinohypothalamic tract","volume":"22","author":"Hannibal","year":"2002","journal-title":"Journal of Neuroscience"},{"issue":"11","key":"10.1016\/j.visres.2010.07.023_b0190","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1097\/00001756-200208070-00013","article-title":"The circadian photopigment melanopsin is expressed in the blind subterranean mole rat, Spalax","volume":"13","author":"Hannibal","year":"2002","journal-title":"NeuroReport"},{"issue":"11","key":"10.1016\/j.visres.2010.07.023_b0195","doi-asserted-by":"crossref","first-page":"4202","DOI":"10.1167\/iovs.04-0313","article-title":"Melanopsin is expressed in PACAP-containing retinal ganglion cells of the human retinohypothalamic tract","volume":"45","author":"Hannibal","year":"2004","journal-title":"Investigative Ophthalmology and Visual Science"},{"issue":"15","key":"10.1016\/j.visres.2010.07.023_b0200","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1097\/00001756-200410250-00003","article-title":"Melanopsin containing retinal ganglion cells are light responsive from birth","volume":"15","author":"Hannibal","year":"2004","journal-title":"Neuroreport"},{"key":"10.1016\/j.visres.2010.07.023_b0205","first-page":"1","article-title":"Neuronal input pathways to the brain\u2019s biological clock and their functional significance","volume":"182","author":"Hannibal","year":"2006","journal-title":"Advances in Anatomy, Embryology and Cell Biology"},{"issue":"49","key":"10.1016\/j.visres.2010.07.023_b0210","doi-asserted-by":"crossref","first-page":"13468","DOI":"10.1523\/JNEUROSCI.3626-07.2007","article-title":"Light-evoked calcium responses of isolated melanopsin-expressing retinal ganglion cells","volume":"27","author":"Hartwick","year":"2007","journal-title":"Journal of Neuroscience"},{"issue":"5","key":"10.1016\/j.visres.2010.07.023_b0215","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1212\/WNL.50.5.1445","article-title":"Bright light suppresses melatonin in blind patients with neuronal ceroid-lipofuscinoses","volume":"50","author":"H\u00e4t\u00f6nen","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.visres.2010.07.023_b0220","doi-asserted-by":"crossref","first-page":"e2451","DOI":"10.1371\/journal.pone.0002451","article-title":"Inducible ablation of melanopsin-expressing retinal ganglion cells reveals their central role in non-image forming visual responses","volume":"3","author":"Hatori","year":"2008","journal-title":"PLoS ONE"},{"issue":"5557","key":"10.1016\/j.visres.2010.07.023_b0225","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1126\/science.1069609","article-title":"Melanopsin-containing retinal ganglion cells: Architecture, projections, and intrinsic photosensitivity","volume":"295","author":"Hattar","year":"2002","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.visres.2010.07.023_b0230","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/cne.20970","article-title":"Central projections of melanopsin-expressing retinal ganglion cells in the mouse","volume":"497","author":"Hattar","year":"2006","journal-title":"Journal of Comparative Neurology"},{"key":"10.1016\/j.visres.2010.07.023_b0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00307084","article-title":"An autoradiographic and electron microscopic study of retino-hypothalamic connections","volume":"135","author":"Hendrickson","year":"1972","journal-title":"Zeitschrift f\u00fcr Zellforschung und Mikroskopische Anatomie"},{"issue":"8","key":"10.1016\/j.visres.2010.07.023_b0240","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1056\/NEJM198608213150804","article-title":"Optic-nerve degeneration in Alzheimer\u2019s disease","volume":"315","author":"Hinton","year":"1986","journal-title":"New England Journal of Medicine"},{"issue":"2","key":"10.1016\/j.visres.2010.07.023_b0245","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1083\/jcb.200506099","article-title":"Retinal ganglion cell degeneration is topological but not cell type specific in DBA\/2J mice","volume":"171","author":"Jakobs","year":"2005","journal-title":"Journal of Cell Biology"},{"issue":"6","key":"10.1016\/j.visres.2010.07.023_b0580","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1740-3391-6-1","article-title":"Circadian rhythm dysfunction in glaucoma: A hypothesis","volume":"10","author":"Jean-Louis","year":"2008","journal-title":"J Circadian Rhythms"},{"key":"10.1016\/j.visres.2010.07.023_b0255","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/BF02431765","article-title":"Age-related decline of human optic nerve axon populations","volume":"10","author":"Johnson","year":"1987","journal-title":"Age"},{"issue":"10","key":"10.1016\/j.visres.2010.07.023_b0260","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.1111\/j.1460-9568.2007.05924.x","article-title":"Characterization and synaptic connectivity of melanopsin-containing ganglion cells in the primate retina","volume":"26","author":"Jusuf","year":"2007","journal-title":"European Journal of Neuroscience"},{"issue":"5","key":"10.1016\/j.visres.2010.07.023_b0265","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1755-3768.2006.00863.x","article-title":"Relative afferent pupillary defect in glaucoma: A pupillometric study","volume":"85","author":"Kalaboukhova","year":"2007","journal-title":"Acta Ophthalmologica Scandinavica"},{"issue":"3","key":"10.1016\/j.visres.2010.07.023_b0270","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1442-9071.2010.02212.x","article-title":"Selective wavelength pupillometry in Leber hereditary optic neuropathy","volume":"38","author":"Kawasaki","year":"2010","journal-title":"Clinical and Experimental Ophthalmology"},{"issue":"2","key":"10.1016\/j.visres.2010.07.023_b0275","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1562\/2006-07-11-RA-964","article-title":"Melanopsin triggers the release of internal calcium stores in response to light","volume":"83","author":"Kumbalasiri","year":"2007","journal-title":"Photochemistry and Photobiology"},{"key":"10.1016\/j.visres.2010.07.023_b0280","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1093\/brain\/awq155","article-title":"Melanopsin retinal ganglion cells are resistant to neurodegeneration in mitochondrial optic neuropathies","volume":"133","author":"La Morgia","year":"2010","journal-title":"Brain"},{"issue":"6","key":"10.1016\/j.visres.2010.07.023_b0285","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s11920-009-0070-5","article-title":"Circadian misalignment in mood disturbances","volume":"11","author":"Lewy","year":"2009","journal-title":"Current Psychiatry Reports"},{"issue":"2","key":"10.1016\/j.visres.2010.07.023_b0290","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jsmc.2009.02.003","article-title":"Winter depression: Integrating mood, circadian rhythms, and the sleep\/wake and light\/dark cycles into a bio-psycho-social\u2013environmental model","volume":"4","author":"Lewy","year":"2009","journal-title":"Sleep Medicine Clinics"},{"issue":"7","key":"10.1016\/j.visres.2010.07.023_b0295","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1167\/iovs.05-1295","article-title":"Melanopsin-expressing retinal ganglion cells are more injury-resistant in a chronic ocular hypertension model","volume":"47","author":"Li","year":"2006","journal-title":"Investigative Ophthalmology and Visual Science"},{"issue":"8","key":"10.1016\/j.visres.2010.07.023_b0300","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1007\/s10571-008-9286-x","article-title":"Enhanced survival of melanopsin-expressing retinal ganglion cells after injury is associated with the PI3 K\/Akt pathway","volume":"28","author":"Li","year":"2008","journal-title":"Cellular and Molecular Neurobiology"},{"issue":"41","key":"10.1016\/j.visres.2010.07.023_b0305","doi-asserted-by":"crossref","first-page":"16009","DOI":"10.1073\/pnas.0806114105","article-title":"Restoration of visual function in retinal degeneration mice by ectopic expression of melanopsin","volume":"105","author":"Lin","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"5413","key":"10.1016\/j.visres.2010.07.023_b0310","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1126\/science.284.5413.505","article-title":"Regulation of the mammalian pineal by non-rod, non-cone, ocular photoreceptors","volume":"284","author":"Lucas","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.visres.2010.07.023_b0315","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1126\/science.1077293","article-title":"Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice","volume":"299","author":"Lucas","year":"2003","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.visres.2010.07.023_b0320","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/nn.2179","article-title":"The acute light-induction of sleep is mediated by OPN4-based photoreception","volume":"11","author":"Lupi","year":"2008","journal-title":"Nature Neuroscience"},{"key":"10.1016\/j.visres.2010.07.023_b0325","unstructured":"Matynia, A., Parikh, S., Chen, B., Nusinowitz, S., & Gorin, M. B. (2010). Behavioral and pharmacological analysis of light associated allodynia. ARVO meeting, poster no. 675\/D739."},{"issue":"2","key":"10.1016\/j.visres.2010.07.023_b0330","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1365-2869.2006.00532.x","article-title":"Circadian and homeostatic sleep regulation in morningness\u2013eveningness","volume":"15","author":"Mongrain","year":"2006","journal-title":"Journal of Sleep Research"},{"issue":"6","key":"10.1016\/j.visres.2010.07.023_b0335","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1093\/sleep\/30.6.773","article-title":"Increased homeostatic response to behavioral sleep fragmentation in morning types compared to evening types","volume":"30","author":"Mongrain","year":"2007","journal-title":"Sleep"},{"key":"10.1016\/j.visres.2010.07.023_b0340","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.901460102","article-title":"A retinohypothalamic projection in the rat","volume":"146","author":"Moore","year":"1972","journal-title":"Journal of Comparative Neurology"},{"issue":"11","key":"10.1016\/j.visres.2010.07.023_b0345","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1093\/sleep\/30.11.1445","article-title":"Practice parameters for the clinical evaluation and treatment of circadian rhythm sleep disorders. An American academy of sleep medicine report. Standards of practice committee of the American academy of sleep medicine","volume":"30","author":"Morgenthaler","year":"2007","journal-title":"Sleep"},{"issue":"5","key":"10.1016\/j.visres.2010.07.023_b0350","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1177\/0748730407306043","article-title":"Melanopsin-dependent nonvisual responses: Evidence for photopigment bistability in vivo","volume":"22","author":"Mure","year":"2007","journal-title":"Journal of Biological Rhythms"},{"issue":"2","key":"10.1016\/j.visres.2010.07.023_b0355","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nn.2475","article-title":"A neural mechanism for exacerbation of headache by light","volume":"13","author":"Noseda","year":"2010","journal-title":"Nature Neuroscience"},{"key":"10.1016\/j.visres.2010.07.023_b0360","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1111\/j.1471-4159.2008.05320.x","article-title":"Light affects mitochondria to cause apoptosis to cultured cells: Possible relevance to ganglion cell death in certain optic neuropathies","volume":"105","author":"Osborne","year":"2008","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.visres.2010.07.023_b0365","unstructured":"Park, J. C., Moura, A. L., Raza, A. S., Palmer, N., Gavazi, E., Tsang, S. H., et al. (2010). Toward a clinical protocol for assessing rod, cone and melanopsin contributions to the human pupil response. ARVO meeting, poster no. 1453\/A602."},{"issue":"10","key":"10.1016\/j.visres.2010.07.023_b0370","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1002\/mds.21542","article-title":"Bright light therapy in Parkinson\u2019s disease: A pilot study","volume":"22","author":"Paus","year":"2007","journal-title":"Movement Disorders"},{"issue":"1531","key":"10.1016\/j.visres.2010.07.023_b0375","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1098\/rstb.2009.0050","article-title":"The evolution of irradiance detection: Melanopsin and the non-visual opsins","volume":"364","author":"Peirson","year":"2009","journal-title":"Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences"},{"issue":"5","key":"10.1016\/j.visres.2010.07.023_b0380","first-page":"251","article-title":"Alterations in nocturnal melatonin secretion in patients with optic neuropathies","volume":"84","author":"P\u00e9rez-Rico","year":"2009","journal-title":"Archivos de la Sociedad Espanola de Oftalmologia"},{"key":"10.1016\/j.visres.2010.07.023_b0385","unstructured":"Perez Rico, C., de la Villa, P., & Blanco, R. (2010). Multifocal erg and light-induced melatonin suppression evaluation of the functional integrity of the retinohypothalamic tract in advanced glaucoma. ARVO 2010, poster no. 5490\/A545."},{"issue":"4","key":"10.1016\/j.visres.2010.07.023_b0390","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1074\/jbc.M807321200","article-title":"Respiratory complex I dysfunction due to mitochondrial DNA mutations shifts the voltage threshold for opening of the permeability transition pore toward resting levels","volume":"284","author":"Porcelli","year":"2009","journal-title":"Journal of Biological Chemistry"},{"issue":"2","key":"10.1016\/j.visres.2010.07.023_b0395","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1523\/JNEUROSCI.20-02-00600.2000","article-title":"A novel human opsin in the inner retina","volume":"20","author":"Provencio","year":"2000","journal-title":"Journal of Neuroscience"},{"issue":"6871","key":"10.1016\/j.visres.2010.07.023_b0400","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/415493a","article-title":"Photoreceptive net in the mammalian retina. This mesh of cells may explain how some blind mice can still tell day from night","volume":"415","author":"Provencio","year":"2002","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.visres.2010.07.023_b0405","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"British Journal of Ophthalmology"},{"issue":"6901","key":"10.1016\/j.visres.2010.07.023_b0410","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/nature00965","article-title":"Coordination of circadian timing in mammals","volume":"418","author":"Reppert","year":"2002","journal-title":"Nature"},{"issue":"23","key":"10.1016\/j.visres.2010.07.023_b0415","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1016\/j.visres.2004.06.010","article-title":"Axotomized mouse retinal ganglion cells containing melanopsin show enhanced survival, but not enhanced axon regrowth into a peripheral nerve graft","volume":"44","author":"Robinson","year":"2004","journal-title":"Vision Research"},{"issue":"1\u20133","key":"10.1016\/j.visres.2010.07.023_b0420","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jad.2008.08.005","article-title":"A missense variant (P10L) of the melanopsin (OPN4) gene in seasonal affective disorder","volume":"114","author":"Roecklein","year":"2009","journal-title":"Journal of Affective Disorders"},{"issue":"6","key":"10.1016\/j.visres.2010.07.023_b0425","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.smrv.2007.07.005","article-title":"Epidemiology of the human circadian clock","volume":"11","author":"Roenneberg","year":"2007","journal-title":"Sleep Medicine Reviews"},{"issue":"3","key":"10.1016\/j.visres.2010.07.023_b0430","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1053\/smrv.2000.0147","article-title":"Circadian rhythm sleep disorders: Lessons from the blind","volume":"5","author":"Sack","year":"2001","journal-title":"Sleep Medicine Reviews"},{"issue":"2","key":"10.1016\/j.visres.2010.07.023_b0435","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0006-8993(84)90252-X","article-title":"A retinohypothalamic pathway in man: Light mediation of circadian rhythms","volume":"302","author":"Sadun","year":"1984","journal-title":"Brain Research"},{"key":"10.1016\/j.visres.2010.07.023_b0440","first-page":"223","article-title":"Leber\u2019s hereditary optic neuropathy differentially affects smaller axons in the optic nerve","volume":"98","author":"Sadun","year":"2000","journal-title":"Transactions of the American Ophthalmological Society"},{"key":"10.1016\/j.visres.2010.07.023_b0445","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.tins.2004.12.009","article-title":"The hypothalamic integrator for circadian rhythms","volume":"28","author":"Saper","year":"2005","journal-title":"Trends in Neurosciences"},{"issue":"1\u20133","key":"10.1016\/j.visres.2010.07.023_b0450","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s12031-008-9091-5","article-title":"Suppression of ganglion cell death by PACAP following optic nerve transection in the rat","volume":"36","author":"Seki","year":"2008","journal-title":"Journal of Molecular Neuroscience"},{"issue":"June 29","key":"10.1016\/j.visres.2010.07.023_b0455","article-title":"Suppression of rat retinal ganglion cell death by PACAP following transient ischemia induced by high intraocular pressure","author":"Seki","year":"2010","journal-title":"Journal of Molecular Neuroscience"},{"issue":"11","key":"10.1016\/j.visres.2010.07.023_b0460","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1111\/j.1460-9568.2003.03061.x","article-title":"Light-induced c-fos in melanopsin retinal ganglion cells of young and aged rodless\/coneless (rd\/rd cl) mice","volume":"18","author":"Semo","year":"2003","journal-title":"European Journal of Neuroscience"},{"issue":"8","key":"10.1016\/j.visres.2010.07.023_b0465","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1111\/j.1460-9568.2007.05461.x","article-title":"Paradoxical opsin expressing cells in the inner retina that are augmented following retinal degeneration","volume":"25","author":"Semo","year":"2007","journal-title":"European Journal of Neuroscience"},{"key":"10.1016\/j.visres.2010.07.023_b0470","unstructured":"Semo, M., Gias, C., Lawrence, J. M., Ahmado, A., Coffey, P. J., & Vugler, A. A. (2010). Melanopsin mediated photophobia in adult rodless and coneless mice. ARVO 2010, poster no. 674\/D738."},{"issue":"6","key":"10.1016\/j.visres.2010.07.023_b0475","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.sleep.2006.11.013","article-title":"Circadian rhythm sleep disorders in the blind and their treatment with melatonin","volume":"8","author":"Skene","year":"2007","journal-title":"Sleep Medicine"},{"issue":"3","key":"10.1016\/j.visres.2010.07.023_b0480","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0014-4835(02)00300-7","article-title":"Expression of opsin genes early in ocular development of humans and mice","volume":"76","author":"Tarttelin","year":"2003","journal-title":"Experimental Eye Research"},{"issue":"Pt. 1","key":"10.1016\/j.visres.2010.07.023_b0485","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1469-7793.2001.t01-1-00261.x","article-title":"An action spectrum for melatonin suppression: Evidence for a novel non-rod, non-cone photoreceptor system in humans","volume":"535","author":"Thapan","year":"2001","journal-title":"Journal of Physiology"},{"issue":"2","key":"10.1016\/j.visres.2010.07.023_b0490","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1365-2796.2007.01905.x","article-title":"Mitochondrial dysfunction as a cause of ageing","volume":"263","author":"Trifunovic","year":"2008","journal-title":"Journal of Internal Medicine"},{"issue":"6","key":"10.1016\/j.visres.2010.07.023_b0495","doi-asserted-by":"crossref","first-page":"e1000125","DOI":"10.1371\/journal.pbio.1000125","article-title":"Melanopsin as a sleep modulator: Circadian gating of the direct effects of light on sleep and altered sleep homeostasis in Opn4(\u2212\/\u2212) mice","volume":"7","author":"Tsai","year":"2009","journal-title":"PLoS Biology"},{"issue":"6","key":"10.1016\/j.visres.2010.07.023_b0500","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.neuron.2005.09.031","article-title":"Physiologic diversity and development of intrinsically photosensitive retinal ganglion cells","volume":"48","author":"Tu","year":"2005","journal-title":"Neuron"},{"issue":"11","key":"10.1016\/j.visres.2010.07.023_b0505","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1136\/bjo.2008.141747","article-title":"Circadian photoreception: Ageing and the eye\u2019s important role in systemic health","volume":"92","author":"Turner","year":"2008","journal-title":"British Journal of Ophthalmology"},{"issue":"10","key":"10.1016\/j.visres.2010.07.023_b0510","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.tics.2009.07.004","article-title":"Light as a modulator of cognitive brain function","volume":"13","author":"Vandewalle","year":"2009","journal-title":"Trends in Cognitive Sciences"},{"issue":"11","key":"10.1016\/j.visres.2010.07.023_b0515","doi-asserted-by":"crossref","first-page":"e1247","DOI":"10.1371\/journal.pone.0001247","article-title":"Brain responses to violet, blue, and green monochromatic light exposures in humans: Prominent role of blue light and the brainstem","volume":"2","author":"Vandewalle","year":"2007","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.visres.2010.07.023_b0520","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1093\/cercor\/bhm007","article-title":"Wavelength-dependent modulation of brain responses to a working memory task by daytime light exposure","volume":"17","author":"Vandewalle","year":"2007","journal-title":"Cerebral Cortex"},{"issue":"3","key":"10.1016\/j.visres.2010.07.023_b0525","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/00001756-199303000-00005","article-title":"Injury-resistant retinal ganglion cells that are rich in cytochrome oxidase","volume":"4","author":"von Bussmann","year":"1993","journal-title":"NeuroReport"},{"issue":"1","key":"10.1016\/j.visres.2010.07.023_b0530","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.expneurol.2007.01.032","article-title":"Dopamine neurones form a discrete plexus with melanopsin cells in normal and degenerating retina","volume":"205","author":"Vugler","year":"2007","journal-title":"Experimental Neurology"},{"issue":"2","key":"10.1016\/j.visres.2010.07.023_b0535","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1017\/S0952523808080309","article-title":"Survival and remodeling of melanopsin cells during retinal dystrophy","volume":"25","author":"Vugler","year":"2008","journal-title":"Visual Neuroscience"},{"issue":"5","key":"10.1016\/j.visres.2010.07.023_b0540","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1136\/bjo.79.5.442","article-title":"Evidence for preserved direct pupillary light response in Leber\u2019s hereditary optic neuropathy","volume":"79","author":"Wakakura","year":"1995","journal-title":"British Journal of Ophthalmology"},{"issue":"11","key":"10.1016\/j.visres.2010.07.023_b0545","first-page":"1015","article-title":"Loss of melanopsin-containing retinal ganglion cells in a rat glaucoma model","volume":"121","author":"Wang","year":"2008","journal-title":"Chinese Medical Journal (English Edition)"},{"issue":"2","key":"10.1016\/j.visres.2010.07.023_b0550","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ophtha.2003.05.014","article-title":"Sleep disturbances in young subjects with visual dysfunction","volume":"111","author":"Wee","year":"2004","journal-title":"Ophthalmology"},{"issue":"1","key":"10.1016\/j.visres.2010.07.023_b0555","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bbr.2008.04.017","article-title":"Compromised circadian function in Parkinson\u2019s disease: Enucleation augments disease severity in the unilateral model","volume":"193","author":"Willis","year":"2008","journal-title":"Behavioural Brain Research"},{"issue":"6","key":"10.1016\/j.visres.2010.07.023_b0560","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.sleep.2006.11.010","article-title":"Disturbance and strategies for reactivation of the circadian rhythm system in aging and Alzheimer\u2019s disease","volume":"8","author":"Wu","year":"2007","journal-title":"Sleep Medicine"},{"issue":"24","key":"10.1016\/j.visres.2010.07.023_b0565","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1016\/j.cub.2007.11.034","article-title":"Short-wavelength light sensitivity of circadian, pupillary, and visual awareness in humans lacking an outer retina","volume":"17","author":"Zaidi","year":"2007","journal-title":"Current Biology"},{"issue":"Pt. 2","key":"10.1016\/j.visres.2010.07.023_b0570","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1093\/brain\/awm335","article-title":"OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion","volume":"131","author":"Zanna","year":"2008","journal-title":"Brain"},{"issue":"18","key":"10.1016\/j.visres.2010.07.023_b0575","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1080\/15287390600630203","article-title":"Neurodegeneration produced by rotenone in the mouse retina: A potential model to investigate environmental pesticide contributions to neurodegenerative diseases","volume":"69","author":"Zhang","year":"2006","journal-title":"Journal of Toxicology and Environmental Health, Part A"}],"container-title":["Vision Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042698910003706?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042698910003706?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T15:41:37Z","timestamp":1635954097000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042698910003706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":114,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S0042698910003706"],"URL":"https:\/\/doi.org\/10.1016\/j.visres.2010.07.023","relation":{},"ISSN":["0042-6989"],"issn-type":[{"value":"0042-6989","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}