{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:06:33Z","timestamp":1785215193907,"version":"3.55.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":550,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100008071","name":"Glaucoma Research Society of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010630","name":"Faculty of Medicine, Memorial University of Newfoundland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010630","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008071","name":"Glaucoma Research Society of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vision Research"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.visres.2019.01.008","type":"journal-article","created":{"date-parts":[[2019,2,2]],"date-time":"2019-02-02T16:42:48Z","timestamp":1549125768000},"page":"66-72","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Loss of foxc1 in zebrafish reduces optic nerve size and cell number in the retinal ganglion cell layer"],"prefix":"10.1016","volume":"156","author":[{"given":"Jurgienne","family":"Umali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexia","family":"Hawkey-Noble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis R.","family":"French","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.visres.2019.01.008_b0005","unstructured":"Beckman, S. (2017). Using Acridine Orange to Measure Cell Death in Ethanol Treated Zebrafish Embryos. Biotek Application Note, Cell Imaging."},{"issue":"4","key":"10.1016\/j.visres.2019.01.008_b0010","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1093\/hmg\/ddm326","article-title":"FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A","volume":"17","author":"Berry","year":"2008","journal-title":"Human Molecular Genetics"},{"issue":"2","key":"10.1016\/j.visres.2019.01.008_b0015","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.ydbio.2012.03.006","article-title":"Math5 defines the ganglion cell competence state in a subpopulation of retinal progenitor cells exiting the cell cycle","volume":"365","author":"Brzezinski","year":"2012","journal-title":"Developmental Biology"},{"issue":"1","key":"10.1016\/j.visres.2019.01.008_b0020","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0959-4388(99)80005-1","article-title":"The roles of intrinsic and extrinsic cues and bHLH genes in the determination of retinal cell fates","volume":"9","author":"Cepko","year":"1999","journal-title":"Current Opinion in Neurobiology"},{"issue":"2","key":"10.1016\/j.visres.2019.01.008_b0025","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/cr.2012.150","article-title":"Defective FGF signaling causes coloboma formation and disrupts retinal neurogenesis","volume":"23","author":"Chen","year":"2013","journal-title":"Cell Research"},{"issue":"2","key":"10.1016\/j.visres.2019.01.008_b0030","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1167\/iovs.11-8277","article-title":"Interactive effects of ATOH7 and RFTN1 in association with adult-onset primary open-angle glaucoma","volume":"53","author":"Chen","year":"2012","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"23","key":"10.1016\/j.visres.2019.01.008_b0035","doi-asserted-by":"crossref","first-page":"9495","DOI":"10.1073\/pnas.0903264106","article-title":"Development and diversification of retinal amacrine interneurons at single cell resolution","volume":"106","author":"Cherry","year":"2009","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"10.1016\/j.visres.2019.01.008_b0040","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.coph.2012.09.008","article-title":"Oxidative stress and mitochondrial dysfunction in glaucoma","volume":"13","author":"Chrysostomou","year":"2013","journal-title":"Current Opinion in Pharmacology"},{"issue":"1","key":"10.1016\/j.visres.2019.01.008_b0045","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.devbrainres.2004.12.011","article-title":"Expression of Fgf19 in the developing chick eye","volume":"156","author":"Francisco-Morcillo","year":"2005","journal-title":"Brain Research. Developmental Brain Research"},{"issue":"11","key":"10.1016\/j.visres.2019.01.008_b0050","doi-asserted-by":"crossref","first-page":"4877","DOI":"10.1172\/JCI75109","article-title":"Mutation of FOXC1 and PITX2 induces cerebral small-vessel disease","volume":"124","author":"French","year":"2014","journal-title":"J Clin Invest"},{"issue":"22","key":"10.1016\/j.visres.2019.01.008_b0055","first-page":"3933","article-title":"Opposing Shh and Fgf signals initiate nasotemporal patterning of the zebrafish retina","volume":"142","author":"Hernandez-Bejarano","year":"2015","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.visres.2019.01.008_b0060","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nbt.2501","article-title":"Efficient genome editing in zebrafish using a CRISPR-Cas system","volume":"31","author":"Hwang","year":"2013","journal-title":"Nature Biotechnology"},{"key":"10.1016\/j.visres.2019.01.008_b0065","doi-asserted-by":"crossref","first-page":"e1069","DOI":"10.1038\/cddis.2014.8","article-title":"Dysfunction of the stress-responsive FOXC1 transcription factor contributes to the earlier-onset glaucoma observed in Axenfeld-Rieger syndrome patients","volume":"5","author":"Ito","year":"2014","journal-title":"Cell Death and Disease"},{"issue":"Pt 2","key":"10.1016\/j.visres.2019.01.008_b0070","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/brain\/awt292","article-title":"Identification of retinal ganglion cell neuroprotection conferred by platelet-derived growth factor through analysis of the mesenchymal stem cell secretome","volume":"137","author":"Johnson","year":"2014","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.visres.2019.01.008_b0075","doi-asserted-by":"crossref","first-page":"336","DOI":"10.3109\/02713683.2011.556301","article-title":"Platelet-derived growth factor receptor alpha is associated with oxidative stress-induced retinal cell death","volume":"36","author":"Kanamoto","year":"2011","journal-title":"Current Eye Research"},{"issue":"3","key":"10.1016\/j.visres.2019.01.008_b0080","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0896-6273(01)00312-9","article-title":"Retinal ganglion cell genesis requires lakritz, a Zebrafish atonal Homolog","volume":"30","author":"Kay","year":"2001","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.visres.2019.01.008_b0085","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Developmental Dynamics"},{"issue":"2","key":"10.1016\/j.visres.2019.01.008_b0090","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/35053522","article-title":"Vertebrate neural cell-fate determination: Lessons from the retina","volume":"2","author":"Livesey","year":"2001","journal-title":"Nature Reviews Neuroscience"},{"issue":"13","key":"10.1016\/j.visres.2019.01.008_b0095","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1093\/hmg\/ddq144","article-title":"Genome-wide association identifies ATOH7 as a major gene determining human optic disc size","volume":"19","author":"Macgregor","year":"2010","journal-title":"Human Molecular Genetics"},{"issue":"5","key":"10.1016\/j.visres.2019.01.008_b0100","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/ejhg.2015.169","article-title":"Rare FOXC1 variants in congenital glaucoma: Identification of translation regulatory sequences","volume":"24","author":"Medina-Trillo","year":"2016","journal-title":"European Journal of Human Genetics"},{"issue":"7","key":"10.1016\/j.visres.2019.01.008_b0105","doi-asserted-by":"crossref","first-page":"e0160016","DOI":"10.1371\/journal.pone.0160016","article-title":"A Novel Homozygous Mutation in FOXC1 Causes Axenfeld Rieger Syndrome with Congenital Glaucoma","volume":"11","author":"Micheal","year":"2016","journal-title":"PLoS ONE"},{"issue":"2","key":"10.1016\/j.visres.2019.01.008_b0110","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.ydbio.2007.11.013","article-title":"Fgf19 is required for zebrafish lens and retina development","volume":"313","author":"Nakayama","year":"2008","journal-title":"Developmental Biology"},{"issue":"1","key":"10.1016\/j.visres.2019.01.008_b0115","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1167\/iovs.16-19891","article-title":"A genome-wide association study of vertical cup-disc ratio in a Latino population","volume":"58","author":"Nannini","year":"2017","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"3","key":"10.1016\/j.visres.2019.01.008_b0120","doi-asserted-by":"crossref","first-page":"e0119703","DOI":"10.1371\/journal.pone.0119703","article-title":"Genetic association of SNPs near ATOH7, CARD10, CDKN2B, CDC7 and SIX1\/SIX6 with the endophenotypes of primary open angle glaucoma in Indian population","volume":"10","author":"Philomenadin","year":"2015","journal-title":"PLoS ONE"},{"issue":"20","key":"10.1016\/j.visres.2019.01.008_b0125","doi-asserted-by":"crossref","first-page":"5002","DOI":"10.1002\/j.1460-2075.1994.tb06827.x","article-title":"Cloning and characterization of seven human forkhead proteins: Binding site specificity and DNA bending","volume":"13","author":"Pierrou","year":"1994","journal-title":"EMBO Journal"},{"issue":"16","key":"10.1016\/j.visres.2019.01.008_b0130","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.1093\/hmg\/dds197","article-title":"ATOH7 mutations cause autosomal recessive persistent hyperplasia of the primary vitreous","volume":"21","author":"Prasov","year":"2012","journal-title":"Human Molecular Genetics"},{"issue":"3","key":"10.1016\/j.visres.2019.01.008_b0135","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"British Journal of Ophthalmology"},{"issue":"2","key":"10.1016\/j.visres.2019.01.008_b0140","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/cne.20134","article-title":"Timing and topography of cell genesis in the rat retina","volume":"474","author":"Rapaport","year":"2004","journal-title":"The Journal of Comparative Neurology"},{"issue":"5","key":"10.1016\/j.visres.2019.01.008_b0145","doi-asserted-by":"crossref","first-page":"e78","DOI":"10.1371\/journal.pgen.0030078","article-title":"p53 activation by knockdown technologies","volume":"3","author":"Robu","year":"2007","journal-title":"PLoS Genetics"},{"issue":"3","key":"10.1016\/j.visres.2019.01.008_b0150","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1086\/318792","article-title":"Analyses of the effects that disease-causing missense mutations have on the structure and function of the winged-helix protein FOXC1","volume":"68","author":"Saleem","year":"2001","journal-title":"American Journal of Human Genetics"},{"issue":"6","key":"10.1016\/j.visres.2019.01.008_b0155","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1073\/pnas.1109540109","article-title":"Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth","volume":"109","author":"Seo","year":"2012","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"11","key":"10.1016\/j.visres.2019.01.008_b0160","doi-asserted-by":"crossref","first-page":"5026","DOI":"10.1167\/iovs.09-3447","article-title":"FoxC1 is essential for vascular basement membrane integrity and hyaloid vessel morphogenesis","volume":"50","author":"Skarie","year":"2009","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"7","key":"10.1016\/j.visres.2019.01.008_b0165","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1093\/hmg\/9.7.1021","article-title":"Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development","volume":"9","author":"Smith","year":"2000","journal-title":"Human Molecular Genetics"},{"issue":"3","key":"10.1016\/j.visres.2019.01.008_b0170","first-page":"143","article-title":"The role of oxidative stress and vascular insufficiency in primary open angle glaucoma","volume":"87","author":"Ster","year":"2014","journal-title":"Clujul Medical"},{"issue":"1","key":"10.1016\/j.visres.2019.01.008_b0175","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1167\/iovs.06-0472","article-title":"Genotype-phenotype correlations in Axenfeld-Rieger malformation and glaucoma patients with FOXC1 and PITX2 mutations","volume":"48","author":"Strungaru","year":"2007","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"21","key":"10.1016\/j.visres.2019.01.008_b0180","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1093\/hmg\/ddl400","article-title":"FGF19 is a target for FOXC1 regulation in ciliary body-derived cells","volume":"15","author":"Tamimi","year":"2006","journal-title":"Human Molecular Genetics"},{"issue":"1","key":"10.1016\/j.visres.2019.01.008_b0185","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nprot.2007.514","article-title":"High-resolution in situ hybridization to whole-mount zebrafish embryos","volume":"3","author":"Thisse","year":"2008","journal-title":"Nature Protocols"},{"issue":"18","key":"10.1016\/j.visres.2019.01.008_b0190","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1101\/gad.907401","article-title":"The winged helix transcription factor Foxc1a is essential for somitogenesis in zebrafish","volume":"15","author":"Topczewska","year":"2001","journal-title":"Genes & Development"},{"issue":"4","key":"10.1016\/j.visres.2019.01.008_b0195","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1136\/bjophthalmol-2013-304080","article-title":"Wellcome Trust Case Control Consortium BGG: Clarifying the role of ATOH7 in glaucoma endophenotypes","volume":"98","author":"Venturini","year":"2014","journal-title":"British Journal of Ophthalmology"},{"issue":"1","key":"10.1016\/j.visres.2019.01.008_b0200","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ydbio.2007.11.034","article-title":"Sequential and cooperative action of FGFS and SHH in the zebrafish retina","volume":"314","author":"Vinothkumar","year":"2008","journal-title":"Developmental Biology"},{"key":"10.1016\/j.visres.2019.01.008_b0205","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.mod.2013.10.003","article-title":"The ETS transcription factor Etv1 mediates FGF signaling to initiate proneural gene expression during Xenopus laevis retinal development","volume":"131","author":"Willardsen","year":"2014","journal-title":"Mechanisms of Development"},{"issue":"2","key":"10.1016\/j.visres.2019.01.008_b0210","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.ydbio.2008.10.046","article-title":"Temporal regulation of Ath5 gene expression during eye development","volume":"326","author":"Willardsen","year":"2009","journal-title":"Developmental Biology"},{"issue":"2","key":"10.1016\/j.visres.2019.01.008_b0215","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/bdrc.21095","article-title":"Neural crest derivatives in ocular development: Discerning the eye of the storm","volume":"105","author":"Williams","year":"2015","journal-title":"Birth Defects Res C Embryo Today"},{"issue":"13","key":"10.1016\/j.visres.2019.01.008_b0220","first-page":"E1559","article-title":"Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate","volume":"112","author":"Wu","year":"2015","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"10.1016\/j.visres.2019.01.008_b0225","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ydbio.2003.08.005","article-title":"Math5 determines the competence state of retinal ganglion cell progenitors","volume":"264","author":"Yang","year":"2003","journal-title":"Developmental Biology"}],"container-title":["Vision Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042698919300203?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042698919300203?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T01:15:06Z","timestamp":1758590106000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042698919300203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":45,"alternative-id":["S0042698919300203"],"URL":"https:\/\/doi.org\/10.1016\/j.visres.2019.01.008","relation":{},"ISSN":["0042-6989"],"issn-type":[{"value":"0042-6989","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of foxc1 in zebrafish reduces optic nerve size and cell number in the retinal ganglion cell layer","name":"articletitle","label":"Article Title"},{"value":"Vision Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.visres.2019.01.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}