{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T15:55:52Z","timestamp":1783785352716,"version":"3.55.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"vor","delay-in-days":547,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002974","name":"Daimler and Benz Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002974","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["5719\/1\\u20131"],"award-info":[{"award-number":["5719\/1\\u20131"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vision Research"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.visres.2023.108268","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T21:32:30Z","timestamp":1686173550000},"page":"108268","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Microglial and macroglial dynamics in a model of retinitis pigmentosa"],"prefix":"10.1016","volume":"210","author":[{"given":"Nundehui","family":"D\u00edaz-Lezama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Kajtna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiou","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Ayten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne F.","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.visres.2023.108268_b0005","doi-asserted-by":"crossref","first-page":"9124","DOI":"10.1167\/iovs.11-7736","article-title":"Microglia-mediated IGF-I neuroprotection in the rd10 mouse model of retinitis pigmentosa","volume":"52","author":"Arroba","year":"2011","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"4","key":"10.1016\/j.visres.2023.108268_b0010","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.preteyeres.2006.05.003","article-title":"Muller cells in the healthy and diseased retina","volume":"25","author":"Bringmann","year":"2006","journal-title":"Progress in Retinal and Eye Research"},{"issue":"1","key":"10.1016\/j.visres.2023.108268_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000328979","article-title":"Muller glial cells in retinal disease","volume":"227","author":"Bringmann","year":"2012","journal-title":"Ophthalmologica"},{"issue":"6792","key":"10.1016\/j.visres.2023.108268_b0020","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/35018098","article-title":"A one-hit model of cell death in inherited neuronal degenerations","volume":"406","author":"Clarke","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.visres.2023.108268_b0025","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.preteyeres.2014.07.001","article-title":"Cellular responses following retinal injuries and therapeutic approaches for neurodegenerative diseases","volume":"43","author":"Cuenca","year":"2014","journal-title":"Progress in Retinal and Eye Research"},{"issue":"2","key":"10.1016\/j.visres.2023.108268_b0030","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/cge.12203","article-title":"Genes and mutations causing retinitis pigmentosa","volume":"84","author":"Daiger","year":"2013","journal-title":"Clinical Genetics"},{"issue":"33","key":"10.1016\/j.visres.2023.108268_b0035","doi-asserted-by":"crossref","first-page":"13475","DOI":"10.1523\/JNEUROSCI.0419-13.2013","article-title":"Therapeutic margins in a novel preclinical model of retinitis pigmentosa","volume":"33","author":"Davis","year":"2013","journal-title":"The Journal of Neuroscience"},{"issue":"11","key":"10.1016\/j.visres.2023.108268_b0040","first-page":"1321","article-title":"Muller cell expression of glial fibrillary acidic protein after genetic and experimental photoreceptor degeneration in the rat retina","volume":"25","author":"Eisenfeld","year":"1984","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"Pt A","key":"10.1016\/j.visres.2023.108268_b0045","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.arr.2015.01.003","article-title":"DAMPs as mediators of sterile inflammation in aging-related pathologies","volume":"24","author":"Feldman","year":"2015","journal-title":"Ageing Research Reviews"},{"key":"10.1016\/j.visres.2023.108268_b0050","doi-asserted-by":"crossref","first-page":"484","DOI":"10.3389\/fncel.2015.00484","article-title":"Astrocytes and Muller cell alterations during retinal degeneration in a transgenic rat model of retinitis pigmentosa","volume":"9","author":"Fernandez-Sanchez","year":"2015","journal-title":"Frontiers in Cellular Neuroscience"},{"issue":"1","key":"10.1016\/j.visres.2023.108268_b0055","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1444-0938.2007.00204.x","article-title":"A review of the role of glial cells in understanding retinal disease","volume":"91","author":"Fletcher","year":"2008","journal-title":"Clinical & Experimental Optometry"},{"issue":"20","key":"10.1016\/j.visres.2023.108268_b0060","doi-asserted-by":"crossref","first-page":"8287","DOI":"10.1073\/pnas.0611180104","article-title":"Muller cells are living optical fibers in the vertebrate retina","volume":"104","author":"Franze","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2","key":"10.1016\/j.visres.2023.108268_b0065","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0304-3940(94)11239-F","article-title":"Expression of glial fibrillary acidic protein (GFAP), glutamine synthetase (GS), and Bcl-2 protooncogene protein by Muller (glial) cells in retinal light damage of rats","volume":"185","author":"Grosche","year":"1995","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.visres.2023.108268_b0070","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.815347","article-title":"Microglia polarization from M1 to M2 in neurodegenerative diseases","volume":"14","author":"Guo","year":"2022","journal-title":"Frontiers in Aging Neuroscience"},{"issue":"4","key":"10.1016\/j.visres.2023.108268_b0075","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0014-4835(02)00332-9","article-title":"Activated microglia in human retinitis pigmentosa, late-onset retinal degeneration, and age-related macular degeneration","volume":"76","author":"Gupta","year":"2003","journal-title":"Experimental Eye Research"},{"issue":"3","key":"10.1016\/j.visres.2023.108268_b0080","doi-asserted-by":"crossref","first-page":"e0120415","DOI":"10.1371\/journal.pone.0120415","article-title":"Muller glia activation in response to inherited retinal degeneration is highly varied and disease-specific","volume":"10","author":"Hippert","year":"2015","journal-title":"PLoS One1"},{"key":"10.1016\/j.visres.2023.108268_b0085","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.exer.2016.03.018","article-title":"Retinal remodeling in human retinitis pigmentosa","volume":"150","author":"Jones","year":"2016","journal-title":"Experimental Eye Research"},{"key":"10.1016\/j.visres.2023.108268_b0090","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3389\/fncel.2020.00198","article-title":"Overview of general and discriminating markers of differential microglia phenotypes","volume":"14","author":"Jurga","year":"2020","journal-title":"Frontiers in Cellular Neuroscience"},{"issue":"3","key":"10.1016\/j.visres.2023.108268_b0095","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s00018-022-04161-0","article-title":"Late-stage rescue of visually guided behavior in the context of a significantly remodeled retinitis pigmentosa mouse model","volume":"79","author":"Kajtna","year":"2022","journal-title":"Cellular and Molecular Life Sciences"},{"issue":"9","key":"10.1016\/j.visres.2023.108268_b0100","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1172\/JCI82462","article-title":"Halting progressive neurodegeneration in advanced retinitis pigmentosa","volume":"125","author":"Koch","year":"2015","journal-title":"The Journal of Clinical Investigation"},{"issue":"5","key":"10.1016\/j.visres.2023.108268_b0105","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.preteyeres.2012.04.004","article-title":"Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease","volume":"31","author":"Kur","year":"2012","journal-title":"Progress in Retinal and Eye Research"},{"key":"10.1016\/j.visres.2023.108268_b0110","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.exer.2016.03.027","article-title":"Astrocyte structural reactivity and plasticity in models of retinal detachment","volume":"150","author":"Luna","year":"2016","journal-title":"Experimental Eye Research"},{"issue":"5","key":"10.1016\/j.visres.2023.108268_b0115","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S1350-9462(03)00039-9","article-title":"Neural remodeling in retinal degeneration","volume":"22","author":"Marc","year":"2003","journal-title":"Progress in Retinal and Eye Research"},{"issue":"8","key":"10.1016\/j.visres.2023.108268_b0120","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1073\/pnas.92.8.3249","article-title":"Mutation spectrum of the gene encoding the beta subunit of rod phosphodiesterase among patients with autosomal recessive retinitis pigmentosa","volume":"92","author":"McLaughlin","year":"1995","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.visres.2023.108268_b0125","doi-asserted-by":"crossref","first-page":"1006897","DOI":"10.3389\/fimmu.2022.1006897","article-title":"More than meets the eye: The role of microglia in healthy and diseased retina","volume":"13","author":"Murenu","year":"2022","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.visres.2023.108268_b0130","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s12974-014-0186-3","article-title":"Microglia activation in a model of retinal degeneration and TUDCA neuroprotective effects","volume":"11","author":"Noailles","year":"2014","journal-title":"Journal of Neuroinflammation"},{"issue":"24","key":"10.1016\/j.visres.2023.108268_b0135","doi-asserted-by":"crossref","first-page":"8139","DOI":"10.1523\/JNEUROSCI.5200-13.2014","article-title":"Suppression of microglial activation is neuroprotective in a mouse model of human retinitis pigmentosa","volume":"34","author":"Peng","year":"2014","journal-title":"The Journal of Neuroscience"},{"key":"10.1016\/j.visres.2023.108268_b0140","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.3389\/fimmu.2019.01975","article-title":"Microglia in Retinal Degeneration","volume":"10","author":"Rashid","year":"2019","journal-title":"Frontiers in Immunology"},{"issue":"8","key":"10.1016\/j.visres.2023.108268_b0145","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.1167\/iovs.13-12557","article-title":"Relationship between foveal cone structure and clinical measures of visual function in patients with inherited retinal degenerations","volume":"54","author":"Ratnam","year":"2013","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"5","key":"10.1016\/j.visres.2023.108268_b0150","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1002\/glia.22477","article-title":"New functions of Muller cells","volume":"61","author":"Reichenbach","year":"2013","journal-title":"Glia"},{"issue":"4","key":"10.1016\/j.visres.2023.108268_b0155","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/glia.23727","article-title":"Glia of the human retina","volume":"68","author":"Reichenbach","year":"2020","journal-title":"Glia"},{"issue":"1","key":"10.1016\/j.visres.2023.108268_b0160","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1167\/iovs.03-0518","article-title":"Glial remodeling and neural plasticity in human retinal detachment with proliferative vitreoretinopathy","volume":"46","author":"Sethi","year":"2005","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.visres.2023.108268_b0165","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev-vision-091517-034425","article-title":"Microglia in the Retina: Roles in development, maturity, and disease","volume":"4","author":"Silverman","year":"2018","journal-title":"Annu Rev Vis Sci."},{"key":"10.1016\/j.visres.2023.108268_b0170","doi-asserted-by":"crossref","first-page":"494","DOI":"10.3389\/fncel.2015.00494","article-title":"A survey of retinal remodeling","volume":"9","author":"Strettoi","year":"2015","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"10.1016\/j.visres.2023.108268_b0175","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3390\/ijms23031138","article-title":"Retinal Plasticity","volume":"23","author":"Strettoi","year":"2022","journal-title":"International Journal of Molecular Sciences"},{"issue":"13","key":"10.1016\/j.visres.2023.108268_b0180","doi-asserted-by":"crossref","first-page":"5492","DOI":"10.1523\/JNEUROSCI.22-13-05492.2002","article-title":"Morphological and functional abnormalities in the inner retina of the rd\/rd mouse","volume":"22","author":"Strettoi","year":"2002","journal-title":"The Journal of Neuroscience"},{"key":"10.1016\/j.visres.2023.108268_b0185","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.preteyeres.2018.03.005","article-title":"Non-syndromic retinitis pigmentosa","volume":"66","author":"Verbakel","year":"2018","journal-title":"Progress in Retinal and Eye Research"},{"key":"10.1016\/j.visres.2023.108268_b0190","doi-asserted-by":"crossref","first-page":"334","DOI":"10.3389\/fncel.2019.00334","article-title":"A defective crosstalk between neurons and Muller glial cells in the rd1 retina impairs the regenerative potential of glial stem cells","volume":"13","author":"Volonte","year":"2019","journal-title":"Frontiers in Cellular Neuroscience"},{"issue":"1","key":"10.1016\/j.visres.2023.108268_b0195","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/IIO.0000000000000256","article-title":"Retinitis pigmentosa: Review of current treatment","volume":"59","author":"Wang","year":"2019","journal-title":"International Ophthalmology Clinics"},{"key":"10.1016\/j.visres.2023.108268_b0200","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/1742-2094-8-173","article-title":"Adaptive Muller cell responses to microglial activation mediate neuroprotection and coordinate inflammation in the retina","volume":"8","author":"Wang","year":"2011","journal-title":"Journal of Neuroinflammation"},{"issue":"12","key":"10.1016\/j.visres.2023.108268_b0205","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1523\/JNEUROSCI.2717-16.2017","article-title":"Tamoxifen Provides Structural and Functional Rescue in Murine Models of Photoreceptor Degeneration","volume":"37","author":"Wang","year":"2017","journal-title":"The Journal of Neuroscience"},{"key":"10.1016\/j.visres.2023.108268_b0210","first-page":"1073","article-title":"Minocycline delayed photoreceptor death in rds mice through iNOS-dependent mechanism","volume":"13","author":"Yang","year":"2007","journal-title":"Molecular Vision"},{"issue":"1","key":"10.1016\/j.visres.2023.108268_b0215","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ophtha.2012.07.006","article-title":"Clinical evidence of sustained chronic inflammatory reaction in retinitis pigmentosa","volume":"120","author":"Yoshida","year":"2013","journal-title":"Ophthalmology"},{"issue":"9","key":"10.1016\/j.visres.2023.108268_b0220","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1002\/glia.23016","article-title":"Microglial phagocytosis and activation underlying photoreceptor degeneration is regulated by CX3CL1-CX3CR1 signaling in a mouse model of retinitis pigmentosa","volume":"64","author":"Zabel","year":"2016","journal-title":"Glia"},{"issue":"8","key":"10.1016\/j.visres.2023.108268_b0225","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1167\/iovs.05-0118","article-title":"Identification of sequential events and factors associated with microglial activation, migration, and cytotoxicity in retinal degeneration in rd mice","volume":"46","author":"Zeng","year":"2005","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"8","key":"10.1016\/j.visres.2023.108268_b0230","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1016\/j.ymthe.2018.06.014","article-title":"Genetic rescue reverses microglial activation in preclinical models of retinitis pigmentosa","volume":"26","author":"Zhang","year":"2018","journal-title":"Molecular Therapy"},{"issue":"9","key":"10.1016\/j.visres.2023.108268_b0235","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.15252\/emmm.201505298","article-title":"Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration","volume":"7","author":"Zhao","year":"2015","journal-title":"EMBO Molecular Medicine"},{"key":"10.1016\/j.visres.2023.108268_b0240","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/fnana.2017.00077","article-title":"Microglia polarization with M1\/M2 phenotype changes in rd1 mouse model of retinal degeneration","volume":"11","author":"Zhou","year":"2017","journal-title":"Frontiers in Neuroanatomy"}],"container-title":["Vision Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042698923000925?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042698923000925?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:13:28Z","timestamp":1777396408000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042698923000925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":48,"alternative-id":["S0042698923000925"],"URL":"https:\/\/doi.org\/10.1016\/j.visres.2023.108268","relation":{},"ISSN":["0042-6989"],"issn-type":[{"value":"0042-6989","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microglial and macroglial dynamics in a model of retinitis pigmentosa","name":"articletitle","label":"Article Title"},{"value":"Vision Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.visres.2023.108268","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108268"}}