{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T17:21:33Z","timestamp":1783444893222,"version":"3.54.6"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":549,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001116","name":"Foundation Fighting Blindness Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001116","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vision Research"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.visres.2024.108379","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T17:07:31Z","timestamp":1709917651000},"page":"108379","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Retinal response to light exposure in BEST1-mutant dogs evaluated with ultra-high resolution OCT"],"prefix":"10.1016","volume":"218","author":[{"given":"Vivian","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Swider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Sumaroka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie L.","family":"Dufour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph E.","family":"Vance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas S.","family":"Aleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo D.","family":"Aguirre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Beltran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur V.","family":"Cideciyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.visres.2024.108379_b0005","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.ymthe.2005.08.008","article-title":"Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness","volume":"12","author":"Acland","year":"2005","journal-title":"Molecular Therapy"},{"issue":"8","key":"10.1016\/j.visres.2024.108379_b0010","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1016\/j.ymthe.2021.03.021","article-title":"Gene therapy reforms photoreceptor structure and restores vision in NPHP5-associated Leber congenital amaurosis","volume":"29","author":"Aguirre","year":"2021","journal-title":"Molecular Therapy"},{"issue":"11","key":"10.1016\/j.visres.2024.108379_b0015","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.2460\/javma.1974.164.11.1114","article-title":"A survey of ocular findings in eight- to ten-month-old Beagles","volume":"164","author":"Bellhorn","year":"1974","journal-title":"Journal of the American Veterinary Medical Association"},{"issue":"3","key":"10.1016\/j.visres.2024.108379_b0020","article-title":"Canine retina has a primate fovea-like bouquet of cone photoreceptors which is affected by inherited macular degenerations","volume":"9","author":"Beltran","year":"2014","journal-title":"PLoS One1"},{"key":"10.1016\/j.visres.2024.108379_b0025","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/0-387-32442-9_72","article-title":"The retinal pigment epithelium apical microvilli and retinal function","volume":"572","author":"Bonilha","year":"2006","journal-title":"Advances in Experimental Medicine and Biology"},{"issue":"1","key":"10.1016\/j.visres.2024.108379_b0030","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ajhg.2007.08.004","article-title":"Biallelic mutation of BEST1 causes a distinct retinopathy in humans","volume":"82","author":"Burgess","year":"2008","journal-title":"American Journal of Human Genetics"},{"issue":"2","key":"10.1016\/j.visres.2024.108379_b0035","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3109\/02713688808995739","article-title":"Development of hereditary tapetal degeneration in the beagle dog","volume":"7","author":"Burns","year":"1988","journal-title":"Current Eye Research"},{"issue":"12","key":"10.1016\/j.visres.2024.108379_b0040","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1089\/hum.2013.153","article-title":"Human cone visual pigment deletions spare sufficient photoreceptors to warrant gene therapy","volume":"24","author":"Cideciyan","year":"2013","journal-title":"Human Gene Therapy"},{"issue":"5","key":"10.1016\/j.visres.2024.108379_b0045","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1167\/iovs.19-26672","article-title":"Leber congenital amaurosis (LCA): Potential for improvement of vision","volume":"60","author":"Cideciyan","year":"2019","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.visres.2024.108379_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.visres.2022.108157","article-title":"Photoreceptor function and structure in retinal degenerations caused by biallelic BEST1 mutations","volume":"203","author":"Cideciyan","year":"2023","journal-title":"Vision Research"},{"issue":"13","key":"10.1016\/j.visres.2024.108379_b0055","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1167\/iovs.63.13.12","article-title":"Photoreceptor function and structure in autosomal dominant vitelliform macular dystrophy caused by BEST1 mutations","volume":"63","author":"Cideciyan","year":"2022","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"1","key":"10.1016\/j.visres.2024.108379_b0060","doi-asserted-by":"crossref","DOI":"10.1146\/annurev-vision-032321-091738","article-title":"Measures of function and structure to determine phenotypic features, natural history, and treatment outcomes in inherited retinal diseases","volume":"7","author":"Cideciyan","year":"2021","journal-title":"Annual Review of Vision Science"},{"issue":"36","key":"10.1016\/j.visres.2024.108379_b0065","first-page":"E8547","article-title":"Mutation-independent rhodopsin gene therapy by knockdown and replacement with a single AAV vector","volume":"115","author":"Cideciyan","year":"2018","journal-title":"Proceedings of the National academy of Sciences of the United States of America"},{"issue":"1","key":"10.1016\/j.visres.2024.108379_b0070","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-13112-w","article-title":"Variabilities in retinal function and structure in a canine model of cone-rod dystrophy associated with RPGRIP1 support multigenic etiology","volume":"7","author":"Das","year":"2017","journal-title":"Scientific Reports"},{"issue":"Pt 2","key":"10.1016\/j.visres.2024.108379_b0075","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1113\/jphysiol.2004.075622","article-title":"Volume sensitivity of the bestrophin family of chloride channels","volume":"562","author":"Fischmeister","year":"2005","journal-title":"The Journal of Physiology"},{"issue":"9","key":"10.1016\/j.visres.2024.108379_b0080","doi-asserted-by":"crossref","first-page":"6486","DOI":"10.1364\/OE.16.006486","article-title":"Measuring retinal contributions to the optical Stiles-Crawford effect with optical coherence tomography","volume":"16","author":"Gao","year":"2008","journal-title":"Optics Express"},{"issue":"12","key":"10.1016\/j.visres.2024.108379_b0085","first-page":"E2839","article-title":"BEST1 gene therapy corrects a diffuse retina-wide microdetachment modulated by light exposure","volume":"115","author":"Guziewicz","year":"2018","journal-title":"Proceedings of the National academy of Sciences of the United States of America"},{"key":"10.1016\/j.visres.2024.108379_b0090","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.preteyeres.2017.01.005","article-title":"Bestrophinopathy: An RPE-photoreceptor interface disease","volume":"58","author":"Guziewicz","year":"2017","journal-title":"Progress in Retinal and Eye Research"},{"issue":"5","key":"10.1016\/j.visres.2024.108379_b0095","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1167\/iovs.06-1374","article-title":"Bestrophin gene mutations cause canine multifocal retinopathy: A novel animal model for best disease","volume":"48","author":"Guziewicz","year":"2007","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"2","key":"10.1016\/j.visres.2024.108379_b0100","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1152\/physrev.00022.2007","article-title":"Molecular physiology of bestrophins: Multifunctional membrane proteins linked to best disease and other retinopathies","volume":"88","author":"Hartzell","year":"2008","journal-title":"Physiological Reviews"},{"key":"10.1016\/j.visres.2024.108379_b0105","first-page":"157","article-title":"Fine structure of the canine tapetum lucidem","volume":"136","author":"Lesiuk","year":"1983","journal-title":"Journal of Anatomy"},{"issue":"23","key":"10.1016\/j.visres.2024.108379_b0110","doi-asserted-by":"crossref","first-page":"12758","DOI":"10.1073\/pnas.220402097","article-title":"Bestrophin, the product of the best vitelliform macular dystrophy gene (VMD2), localizes to the basolateral plasma membrane of the retinal pigment epithelium","volume":"97","author":"Marmorstein","year":"2000","journal-title":"Proceedings of the National academy of Sciences of the United States of America"},{"issue":"20","key":"10.1016\/j.visres.2024.108379_b0115","first-page":"E2630","article-title":"Bestrophin 1 is indispensable for volume regulation in human retinal pigment epithelium cells","volume":"112","author":"Milenkovic","year":"2015","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.visres.2024.108379_b0120","first-page":"2518","article-title":"Topographical characterization of cone photoreceptors and the area centralis of the canine retina","volume":"14","author":"Mowat","year":"2008","journal-title":"Molecular Vision"},{"issue":"7","key":"10.1016\/j.visres.2024.108379_b0125","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1167\/iovs.06-0868","article-title":"Differential macular and peripheral expression of bestrophin in human eyes and its implication for best disease","volume":"48","author":"Mullins","year":"2007","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"1","key":"10.1016\/j.visres.2024.108379_b0130","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00424-010-0840-2","article-title":"The presence of bestrophin-1 modulates the Ca2+ recruitment from Ca2+ stores in the ER","volume":"460","author":"Neussert","year":"2010","journal-title":"Pfl\u00fcgers Archiv"},{"issue":"1","key":"10.1016\/j.visres.2024.108379_b0135","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1463-5224.2004.00318.x","article-title":"Comparative morphology of the tapetum lucidum (among selected species)","volume":"7","author":"Ollivier","year":"2004","journal-title":"Veterinary Ophthalmology"},{"issue":"10","key":"10.1016\/j.visres.2024.108379_b0140","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.1074\/jbc.RA118.006180","article-title":"A G86R mutation in the calcium-sensor protein GCAP1 alters regulation of retinal guanylyl cyclase and causes dominant cone-rod degeneration","volume":"294","author":"Peshenko","year":"2019","journal-title":"Journal of Biological Chemistry"},{"issue":"3","key":"10.1016\/j.visres.2024.108379_b0145","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/915","article-title":"Identification of the gene responsible for best macular dystrophy","volume":"19","author":"Petrukhin","year":"1998","journal-title":"Nature Genetics"},{"issue":"2","key":"10.1016\/j.visres.2024.108379_b0150","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0014-4835(02)00280-4","article-title":"In vivo micropathology of best macular dystrophy with optical coherence tomography","volume":"76","author":"Pianta","year":"2003","journal-title":"Experimental Eye Research"},{"issue":"1","key":"10.1016\/j.visres.2024.108379_b0155","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/vop.12243","article-title":"Retinal dysplasia in American pit bull terriers \u2013 Phenotypic characterization and breeding study","volume":"19","author":"Rodarte-Almeida","year":"2016","journal-title":"Veterinary Ophthalmology"},{"issue":"2","key":"10.1016\/j.visres.2024.108379_b0160","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/13816810600677990","article-title":"Variant phenotype of best vitelliform macular dystrophy associated with compound heterozygous mutations in VMD2","volume":"27","author":"Schatz","year":"2006","journal-title":"Ophthalmic Genetics"},{"issue":"4","key":"10.1016\/j.visres.2024.108379_b0165","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1167\/iovs.07-0838","article-title":"Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography","volume":"49","author":"Srinivasan","year":"2008","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"1089","key":"10.1016\/j.visres.2024.108379_b0170","first-page":"461","article-title":"Pigment epithelial cell ensheathment of cone outer segments in the retina of the domestic cat","volume":"187","author":"Steinberg","year":"1974","journal-title":"Proceedings of the Royal Society of London - Series B: Biological Sciences"},{"key":"10.1016\/j.visres.2024.108379_b0175","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/978-1-4614-3209-8_15","article-title":"The role of bestrophin-1 in intracellular Ca(2+) signaling","volume":"801","author":"Strauss","year":"2014","journal-title":"Advances in Experimental Medicine and Biology"},{"issue":"6","key":"10.1016\/j.visres.2024.108379_b0180","doi-asserted-by":"crossref","first-page":"4008","DOI":"10.1073\/pnas.052692999","article-title":"The vitelliform macular dystrophy protein defines a new family of chloride channels","volume":"99","author":"Sun","year":"2002","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2","key":"10.1016\/j.visres.2024.108379_b0185","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1292\/jvms.14-0447","article-title":"Spatial relationships among the cellular tapetum, visual streak and rod density in dogs","volume":"77","author":"Yamaue","year":"2015","journal-title":"The Journal of Veterinary Medical Science"},{"key":"10.1016\/j.visres.2024.108379_b0190","first-page":"2791","article-title":"Assessment of canine BEST1 variations identifies new mutations and establishes an independent bestrophinopathy model (cmr3)","volume":"16","author":"Zangerl","year":"2010","journal-title":"Molecular Vision"}],"updated-by":[{"DOI":"10.1016\/j.visres.2024.108437","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000}}],"container-title":["Vision Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042698924000233?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042698924000233?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T21:58:08Z","timestamp":1762034288000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042698924000233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":38,"alternative-id":["S0042698924000233"],"URL":"https:\/\/doi.org\/10.1016\/j.visres.2024.108379","relation":{},"ISSN":["0042-6989"],"issn-type":[{"value":"0042-6989","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Retinal response to light exposure in BEST1-mutant dogs evaluated with ultra-high resolution OCT","name":"articletitle","label":"Article Title"},{"value":"Vision Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.visres.2024.108379","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108379"}}