{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:29:49Z","timestamp":1792643389566,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003345","name":"Chinese Academy of Meteorological Sciences","doi-asserted-by":"publisher","award":["2019-12M-5-032"],"award-info":[{"award-number":["2019-12M-5-032"]}],"id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2023NSFSC1661"],"award-info":[{"award-number":["2023NSFSC1661"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2023ZYD0172"],"award-info":[{"award-number":["2023ZYD0172"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371083"],"award-info":[{"award-number":["82371083"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82121003"],"award-info":[{"award-number":["82121003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vision Research"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.visres.2024.108509","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T23:36:42Z","timestamp":1731022602000},"page":"108509","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Lack of retinal degeneration in a Dram2 knockout mouse model"],"prefix":"10.1016","volume":"226","author":[{"given":"Kuanxiang","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudi","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinrui","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.visres.2024.108509_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2019.107752","article-title":"Characterization of the cone-rod dystrophy retinal phenotype caused by novel homozygous DRAM2 mutations","volume":"187","author":"Abad-Morales","year":"2019","journal-title":"Experimental Eye Research"},{"key":"10.1016\/j.visres.2024.108509_b0010","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1038\/eye.2016.189","article-title":"MicroRNA-125b promotes tumor growth and suppresses apoptosis by targeting DRAM2 in retinoblastoma","volume":"30","author":"Bai","year":"2016","journal-title":"Eye"},{"key":"10.1016\/j.visres.2024.108509_b0015","doi-asserted-by":"crossref","first-page":"3752","DOI":"10.1111\/febs.16365","article-title":"DRAM-4 and DRAM-5 are compensatory regulators of autophagy and cell survival in nutrient-deprived conditions","volume":"289","author":"Barthet","year":"2022","journal-title":"The FEBS Journal"},{"key":"10.1016\/j.visres.2024.108509_b0020","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1080\/27694127.2022.2062965","article-title":"DRAMs and autophagy: A family affair","volume":"1","author":"Barthet","year":"2022","journal-title":"Autophagy Reports"},{"key":"10.1016\/j.visres.2024.108509_b0025","doi-asserted-by":"crossref","first-page":"7035","DOI":"10.1021\/bi050226k","volume":"44","author":"Belyaeva","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.visres.2024.108509_b0030","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a028274","article-title":"Photoreceptor Cilia and Retinal Ciliopathies","volume":"9","author":"Bujakowska","year":"2017","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"key":"10.1016\/j.visres.2024.108509_b0035","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.ajhg.2015.04.006","article-title":"Biallelic mutations in the autophagy regulator DRAM2 cause retinal dystrophy with early macular involvement","volume":"96","author":"El-Asrag","year":"2015","journal-title":"American Journal of Human Genetics"},{"key":"10.1016\/j.visres.2024.108509_b0040","doi-asserted-by":"crossref","first-page":"238","DOI":"10.2174\/138920211795860107","article-title":"Retinitis pigmentosa: Genes and disease mechanisms","volume":"12","author":"Ferrari","year":"2011","journal-title":"Current Genomics"},{"key":"10.1016\/j.visres.2024.108509_b0045","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1750-1172-1-40","article-title":"Retinitis pigmentosa","volume":"1","author":"Hamel","year":"2006","journal-title":"Orphanet Journal of Rare Diseases"},{"key":"10.1016\/j.visres.2024.108509_b0050","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1750-1172-2-7","article-title":"Cone rod dystrophies","volume":"2","author":"Hamel","year":"2007","journal-title":"Orphanet Journal of Rare Diseases"},{"key":"10.1016\/j.visres.2024.108509_b0055","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/S0140-6736(06)69740-7","article-title":"Retinitis pigmentosa","volume":"368","author":"Hartong","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.visres.2024.108509_b0060","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.878350","article-title":"Patterning and Development of Photoreceptors in the Human Retina","volume":"10","author":"Hussey","year":"2022","journal-title":"Frontiers in Cell and Development Biology"},{"key":"10.1016\/j.visres.2024.108509_b0065","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/ng0904-1024c","article-title":"Correction: Corrigendum: Mutations in RDH12 encoding a photoreceptor cell retinol dehydrogenase cause severe childhood-onset retinal dystrophy","volume":"36","author":"Janecke","year":"2004","journal-title":"Nature Genetics"},{"key":"10.1016\/j.visres.2024.108509_b0070","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23137398","article-title":"The Clinical Spectrum and Disease Course of DRAM2 Retinopathy","volume":"23","author":"Kra\u0161ovec","year":"2022","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.visres.2024.108509_b0075","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21041331","article-title":"Clinical Course and Electron Microscopic Findings in Lymphocytes of Patients with DRAM2-Associated Retinopathy","volume":"21","author":"Kuniyoshi","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.visres.2024.108509_b0080","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1128\/MCB.01486-06","article-title":"Targeted disruption of the murine retinal dehydrogenase gene Rdh12 does not limit visual cycle function","volume":"27","author":"Kurth","year":"2007","journal-title":"Molecular Cell. Biology"},{"key":"10.1016\/j.visres.2024.108509_b0085","doi-asserted-by":"crossref","first-page":"21381","DOI":"10.1038\/s41598-020-78554-1","article-title":"TMEM150B is dispensable for oocyte maturation and female fertility in mouse","volume":"10","author":"Liu","year":"2020","journal-title":"Scientific Reports"},{"key":"10.1016\/j.visres.2024.108509_b0090","doi-asserted-by":"crossref","first-page":"19565","DOI":"10.1073\/pnas.0707477104","article-title":"Redundant and unique roles of retinol dehydrogenases in the mouse retina","volume":"104","author":"Maeda","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.visres.2024.108509_b0095","doi-asserted-by":"crossref","first-page":"652","DOI":"10.4161\/cc.6.6.4029","article-title":"Programmed cell death in retinal degeneration: Targeting apoptosis in photoreceptors as potential therapy for retinal degeneration","volume":"6","author":"Marigo","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.visres.2024.108509_b0100","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.1242\/jcs.175687","article-title":"Photoreceptors at a glance","volume":"128","author":"Molday","year":"2015","journal-title":"Journal of Cell Science"},{"key":"10.1016\/j.visres.2024.108509_b0105","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1080\/15548627.2015.1137412","article-title":"Another DRAM involved in autophagy and cell death","volume":"12","author":"Mrschtik","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.visres.2024.108509_b0110","doi-asserted-by":"crossref","first-page":"13158","DOI":"10.1073\/pnas.0705963104","article-title":"Photoreceptor outer segment phagocytosis attenuates oxidative stress-induced apoptosis with concomitant neuroprotectin D1 synthesis","volume":"104","author":"Mukherjee","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.visres.2024.108509_b0115","first-page":"24","article-title":"Retinitis pigmentosa: current clinical management and emerging therapies","author":"Nguyen","year":"2023","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.visres.2024.108509_b0120","series-title":"Encyclopedia of the Eye","article-title":"Primary Photoreceptor Degenerations: Retinitis Pigmentosa","author":"Pennesi","year":"2010"},{"key":"10.1016\/j.visres.2024.108509_b0125","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1086\/424889","article-title":"Retinal dehydrogenase 12 (RDH12) mutations in leber congenital amaurosis","volume":"75","author":"Perrault","year":"2004","journal-title":"American Journal of Human Genetics"},{"key":"10.1016\/j.visres.2024.108509_b0130","doi-asserted-by":"crossref","first-page":"8083","DOI":"10.1167\/iovs.15-17604","article-title":"Disease Expression in Autosomal Recessive Retinal Dystrophy Associated With Mutations in the DRAM2 Gene","volume":"56","author":"Sergouniotis","year":"2015","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/j.visres.2024.108509_b0135","doi-asserted-by":"crossref","first-page":"41186","DOI":"10.1074\/jbc.M112.403717","article-title":"Low activation and fast inactivation of transducin in carp cones","volume":"287","author":"Tachibanaki","year":"2012","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.visres.2024.108509_b0140","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s13046-019-1068-4","article-title":"DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53","volume":"38","author":"Wudu","year":"2019","journal-title":"Journal of Experimental & Clinical Cancer Research"},{"key":"10.1016\/j.visres.2024.108509_b0145","doi-asserted-by":"crossref","first-page":"7951","DOI":"10.1073\/pnas.1816360116","article-title":"Cone photoreceptor classification in the living human eye from photostimulation-induced phase dynamics","volume":"116","author":"Zhang","year":"2019","journal-title":"Proceedings of the National Academy of Sciences"}],"container-title":["Vision Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042698924001536?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042698924001536?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:54:39Z","timestamp":1777460079000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042698924001536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":29,"alternative-id":["S0042698924001536"],"URL":"https:\/\/doi.org\/10.1016\/j.visres.2024.108509","relation":{},"ISSN":["0042-6989"],"issn-type":[{"value":"0042-6989","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lack of retinal degeneration in a Dram2 knockout mouse model","name":"articletitle","label":"Article Title"},{"value":"Vision Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.visres.2024.108509","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108509"}}