{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:14:06Z","timestamp":1785510846382,"version":"3.56.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vascular Pharmacology"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1016\/j.vph.2008.08.005","type":"journal-article","created":{"date-parts":[[2008,9,7]],"date-time":"2008-09-07T18:45:23Z","timestamp":1220813123000},"page":"27-33","source":"Crossref","is-referenced-by-count":17,"title":["Activation of muscarinic receptors by a hydroalcoholic extract of Dicksonia sellowiana Presl. HooK (Dicksoniaceae) induces vascular relaxation and hypotension in rats"],"prefix":"10.1016","volume":"50","author":[{"given":"Yanna D.","family":"Rattmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Crestani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda R.","family":"Lapa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Obd\u00falio G.","family":"Miguel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.A.","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Eduardo","family":"da Silva-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adair R.S.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vph.2008.08.005_bib1","doi-asserted-by":"crossref","first-page":"7583","DOI":"10.1073\/pnas.91.16.7583","article-title":"Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase","volume":"91","author":"Archer","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.vph.2008.08.005_bib2","doi-asserted-by":"crossref","first-page":"317S","DOI":"10.1093\/ajcn\/81.1.317S","article-title":"Polyphenols and disease risk in epidemiologic studies","volume":"81","author":"Arts","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.vph.2008.08.005_bib3","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/368850a0","article-title":"Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle","volume":"368","author":"Bolotina","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.vph.2008.08.005_bib4","first-page":"6","article-title":"Determina\u00e7\u00e3o da concentra\u00e7\u00e3o de polifen\u00f3is e do potencial antioxidante das diferentes fra\u00e7\u00f5es do extrato de folhas de Dicksonia sellowiana, (Presl.) Hook, Dicksoniaceae","volume":"6","author":"Bora","year":"2005","journal-title":"Vis\u00e3o Acad\u00eamica"},{"key":"10.1016\/j.vph.2008.08.005_bib5","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1159\/000159147","article-title":"Endothelial dysfunction in atherosclerosis","volume":"33","author":"Busse","year":"1996","journal-title":"J. Vasc. Res."},{"key":"10.1016\/j.vph.2008.08.005_bib6","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0024-3205(03)00235-2","article-title":"Vascular effects of caffeic acid phenethyl ester (CAPE) on isolated rat thoracic aorta","volume":"73","author":"Cicala","year":"2003","journal-title":"Life Sci."},{"key":"10.1016\/j.vph.2008.08.005_bib7","doi-asserted-by":"crossref","first-page":"13767","DOI":"10.1021\/bi00213a002","article-title":"IL-1 beta induces the coexpression of both nitric oxide synthase and cyclooxygenase by islets of Langerhans: activation of cyclooxygenase by nitric oxide","volume":"32","author":"Corbett","year":"1993","journal-title":"Biochemistry"},{"key":"10.1016\/j.vph.2008.08.005_bib8","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/444566a","article-title":"Oenology: red wine procyanidins and vascular health","volume":"444","author":"Corder","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.vph.2008.08.005_bib9","unstructured":"Ferreira, E., 2004. Use of the extraction process to obtain extract, sap, tincture, pulp and by-products from Dicksonia sellowiana-Presl \u2014 Hooker 1844, for using at the human, industrial and pharmacological chemistry, human and animal, medicinal, phytomedicinal, nutriceutic. World Intellectual Property Organization. EUA. WO\/2004\/089387."},{"key":"10.1016\/j.vph.2008.08.005_bib10","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.phymed.2006.11.008","article-title":"Endothelium-dependent vasodilation induced by Hancornia speciosa in rat superior mesenteric artery","volume":"14","author":"Ferreira","year":"2007","journal-title":"Phytomedicine"},{"key":"10.1016\/j.vph.2008.08.005_bib11","first-page":"109","article-title":"Cardioprotective prostacyclin signaling in vascular smooth muscle. Prostaglandins other lipid","volume":"82","author":"Fetalvero","year":"2007","journal-title":"Mediat."},{"key":"10.1016\/j.vph.2008.08.005_bib12","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1073\/pnas.91.2.539","article-title":"Role of nitric oxide in eicosanoid synthesis and uterine motility in estrogen-treated rat uteri","volume":"91","author":"Franchi","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.vph.2008.08.005_bib13","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/288373a0","article-title":"The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine","volume":"288","author":"Furchgott","year":"1980","journal-title":"Nature"},{"key":"10.1016\/j.vph.2008.08.005_bib14","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/0090-6980(77)90132-0","article-title":"Prostaglandins H1 and H2. Convenient biochemical synthesis and isolation. Further biological and spectroscopic characterization","volume":"13","author":"Gorman","year":"1977","journal-title":"Prostaglandins"},{"key":"10.1016\/j.vph.2008.08.005_bib15","first-page":"107","article-title":"Evaluation of clonal herbs of Lamiaceae species for management of diabetes and hypertension","volume":"15","author":"Kwon","year":"2006","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"10.1016\/j.vph.2008.08.005_bib16","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0014-2999(99)00747-5","article-title":"Dioclein, a new nitric oxide- and endothelium-dependent vasodilator flavonoid","volume":"386","author":"Lemos","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.vph.2008.08.005_bib17","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1097\/00005344-199406243-00003","article-title":"Endothelium dysfunction in the coronary circulation","volume":"24","author":"Luscher","year":"1994","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.vph.2008.08.005_bib18","unstructured":"Marquesini, N.R., 1995. Plantas usadas como medicinais pelos \u00edndios do Paran\u00e1 e Santa Catarina, Sul do Brasil: Guarani, Kaing\u00e3ng, Xokleng, Ava-Guarani, Kra\u00f4 e Cayua. Universidade Federal do Paran\u00e1. Curitiba, Brasil."},{"key":"10.1016\/j.vph.2008.08.005_bib19","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ejphar.2006.09.051","article-title":"Chronic pretreatment with American ginseng berry and its polyphenolic constituents attenuate oxidant stress in cardiomyocytes","volume":"553","author":"Mehendale","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.vph.2008.08.005_bib20","unstructured":"Mielke, E.J., 2002. An\u00e1lise da Cadeia Produtiva e Comercializa\u00e7\u00e3o do Xaxim, Dicksonia sellowiana no Estado do Paran\u00e1. Universidade Federal do Paran\u00e1. Curitiba, Brasil."},{"key":"10.1016\/j.vph.2008.08.005_bib21","unstructured":"MMA, 1998. Primeiro relat\u00f3rio nacional para a Conven\u00e7\u00e3o sobre Diversidade Biol\u00f3gica: Brasil. Minist\u00e9rio do Meio Ambiente, dos Recursos H\u00eddricos e da Amaz\u00f4nia Legal. Bras\u00edlia, Brasil."},{"key":"10.1016\/j.vph.2008.08.005_bib22","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0049-3848(77)90185-2","article-title":"Differential formation of prostacyclin (PGX or PGI2) by layers of the arterial wall. An explanation for the anti-thrombotic properties of vascular endothelium","volume":"11","author":"Moncada","year":"1977","journal-title":"Thromb. Res."},{"key":"10.1016\/j.vph.2008.08.005_bib23","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1096\/fasebj.6.12.1381691","article-title":"Nitric oxide as a secretory product of mammalian cells","volume":"6","author":"Nathan","year":"1992","journal-title":"Faseb J."},{"key":"10.1016\/j.vph.2008.08.005_bib24","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1152\/ajpcell.1995.268.4.C799","article-title":"Physiological roles and properties of potassium channels in arterial smooth muscle","volume":"268","author":"Nelson","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.vph.2008.08.005_bib25","unstructured":"Pio Corr\u00eaa, 1984. Dicion\u00e1rio de plantas \u00fateis do Brasil e das ex\u00f3ticas cultivadas. Imprensa Nacional, Brasil."},{"key":"10.1016\/j.vph.2008.08.005_bib26","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.jep.2005.09.026","article-title":"Nitric oxide-dependent vasorelaxation induced by extractive solutions and fractions of Maytenus ilicifolia Mart ex Reissek (Celastraceae) leaves","volume":"104","author":"Rattmann","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.vph.2008.08.005_bib27","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.vph.2006.08.411","article-title":"Endothelium-dependent vasodilator effect of Euterpe oleracea Mart. (a\u00e7a\u00ed) extracts in mesenteric vascular bed of the rat","volume":"46","author":"Rocha","year":"2007","journal-title":"Vascul. Pharmacol."},{"key":"10.1016\/j.vph.2008.08.005_bib28","first-page":"223","article-title":"Cryopreservation of spores of Dicksonia sellowiana: an endangered tree fern indigenous to South and Central America","volume":"21","author":"Rogge","year":"2000","journal-title":"Cryo-Lett."},{"key":"10.1016\/j.vph.2008.08.005_bib29","doi-asserted-by":"crossref","unstructured":"Russo, G., Leopold, J. A., Loscalzo, J., 2002. Vasoactive substances: Nitric oxide and endothelial dysfunction in atherosclerosis. 38, 259\u2013269.","DOI":"10.1016\/S1537-1891(02)00250-1"},{"key":"10.1016\/j.vph.2008.08.005_bib30","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1172\/JCI117185","article-title":"Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammation","volume":"93","author":"Salvemini","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.vph.2008.08.005_bib31","unstructured":"Sehnem, A., 1978. Flora Ilustrada Catarinense. Herb\u00e1rio Barbosa Rodrigues, Itaja\u00ed, Brasil."},{"key":"10.1016\/j.vph.2008.08.005_bib32","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ejphar.2004.07.034","article-title":"Vascular protection by dietary polyphenols","volume":"500","author":"Stoclet","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.vph.2008.08.005_bib33","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1097\/01.hjh.0000226196.67052.c0","article-title":"Chlorogenic acid attenuates hypertension and improves endothelial function in spontaneously hypertensive rats","volume":"24","author":"Suzuki","year":"2006","journal-title":"J. Hypertens."},{"key":"10.1016\/j.vph.2008.08.005_bib34","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.amjhyper.2006.11.008","article-title":"Ferulic acid restores endothelium-dependent vasodilation in aortas of spontaneously hypertensive rats","volume":"20","author":"Suzuki","year":"2007","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.vph.2008.08.005_bib35","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0090-6980(77)90019-3","article-title":"Effects of prostacyclin (PGX) on cyclic AMP concentrations in human platelets","volume":"13","author":"Tateson","year":"1977","journal-title":"Prostaglandins"},{"key":"10.1016\/j.vph.2008.08.005_bib36","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1001\/jama.298.1.49","article-title":"Effects of low habitual cocoa intake on blood pressure and bioactive nitric oxide: a randomized controlled trial","volume":"298","author":"Taubert","year":"2007","journal-title":"Jama"},{"key":"10.1016\/j.vph.2008.08.005_bib37","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0378-8741(02)00055-7","article-title":"Cardiovascular effects of Urtica dioica L. (Urticaceae) roots extracts: in vitro and in vivo pharmacological studies","volume":"81","author":"Testai","year":"2002","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.vph.2008.08.005_bib38","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1126\/science.170.3957.547","article-title":"Pre-Cretaceous floweringplants: further evidence from Utah","volume":"170","author":"Tidwell","year":"1970","journal-title":"Science"},{"key":"10.1016\/j.vph.2008.08.005_bib39","series-title":"Ferns and Allied Plants. With Special Reference to Tropical America","author":"Tryon","year":"1982"},{"key":"10.1016\/j.vph.2008.08.005_bib40","first-page":"329","article-title":"Vascular endothelium and the relaxation effect of histamine on aorta of the rat","volume":"256","author":"Van de Voorde","year":"1982","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.vph.2008.08.005_bib41","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.cardiores.2006.11.008","article-title":"Tea polyphenols in preventing cardiovascular diseases","volume":"73","author":"Yamada","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.vph.2008.08.005_bib42","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1093\/ajcn\/72.2.476","article-title":"Intake of antioxidant vitamins and risk of death from stroke in postmenopausal women","volume":"72","author":"Yochum","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.vph.2008.08.005_bib43","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1007\/BF02345308","article-title":"Inhibition of TNF-e induced cell death in human umbilical vein endothelial cells and Jurkat cells by protocatechuic acid","volume":"40","author":"Zhou-Stache","year":"2002","journal-title":"Med. Biol. Eng. Comput."}],"container-title":["Vascular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189108001109?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189108001109?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T17:31:13Z","timestamp":1557768673000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1537189108001109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":43,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["S1537189108001109"],"URL":"https:\/\/doi.org\/10.1016\/j.vph.2008.08.005","relation":{},"ISSN":["1537-1891"],"issn-type":[{"value":"1537-1891","type":"print"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}