{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:45:20Z","timestamp":1758905120017},"reference-count":48,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Stein Family Foundation"},{"DOI":"10.13039\/501100011085","name":"David R. Bloom Center for Pharmacy","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011085","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Dr. Adolf and Klara Brettler Center for Research in Molecular Pharmacology and Therapeutics at The Hebrew University of Jerusalem, Israel"},{"name":"Israeli Ministry of Science and Technology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vascular Pharmacology"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1016\/j.vph.2010.04.005","type":"journal-article","created":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T09:15:46Z","timestamp":1272705346000},"page":"107-114","source":"Crossref","is-referenced-by-count":12,"title":["Transient signaling of Erk1\/2, Akt and PLC\u03b3 induced by nerve growth factor in brain capillary endothelial cells"],"prefix":"10.1016","volume":"53","author":[{"given":"Shimon","family":"Lecht","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadar","family":"Arien-Zakay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoav","family":"Wagenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cezary","family":"Marcinkiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter I.","family":"Lelkes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Lazarovici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vph.2010.04.005_bib1","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.vph.2010.04.005_bib2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s12031-008-9123-1","article-title":"Quantitative assessment of neuronal differentiation in three-dimensional collagen gels using enhanced green fluorescence protein expressing PC12 pheochromocytoma cells","volume":"37","author":"Arien-Zakay","year":"2009","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.vph.2010.04.005_bib3","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1001\/archneur.62.4.563","article-title":"Interferon beta promotes nerve growth factor secretion early in the course of multiple sclerosis","volume":"62","author":"Biernacki","year":"2005","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.vph.2010.04.005_bib4","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1073\/pnas.64.2.787","article-title":"The nerve growth factor: purification as a 30,000-molecular-weight protein","volume":"64","author":"Bocchini","year":"1969","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.vph.2010.04.005_bib5","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1152\/physrev.00007.2008","article-title":"Cardiovascular actions of neurotrophins","volume":"89","author":"Caporali","year":"2009","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.vph.2010.04.005_bib6","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/sj.cdd.4402263","article-title":"Identification of the prosurvival activity of nerve growth factor on cardiac myocytes","volume":"15","author":"Caporali","year":"2008","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.vph.2010.04.005_bib7","doi-asserted-by":"crossref","first-page":"14563","DOI":"10.1016\/S0021-9258(18)42077-7","article-title":"Phosphatidylinositol 3-kinase is activated by nerve growth factor and epidermal growth factor in PC12 cells","volume":"267","author":"Carter","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vph.2010.04.005_bib8","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1006\/excr.1998.4204","article-title":"Arterial nerve growth factor (NGF) mRNA, protein, and vascular smooth muscle cell NGF secretion in hypertensive and hyperactive rats","volume":"244","author":"Clemow","year":"1998","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.vph.2010.04.005_bib9","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.cellsig.2006.12.011","article-title":"Shp2 in PC12 cells: NGF versus EGF signalling","volume":"19","author":"D'Alessio","year":"2007","journal-title":"Cell Signal."},{"key":"10.1016\/j.vph.2010.04.005_bib10","first-page":"2248","article-title":"Expression and activation of the nerve growth factor receptor TrkA in serous ovarian carcinoma","volume":"9","author":"Davidson","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.vph.2010.04.005_bib11","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1124\/jpet.105.093252","article-title":"Nerve growth factor-induced migration of endothelial cells","volume":"315","author":"Dolle","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.vph.2010.04.005_bib12","first-page":"309","article-title":"Neurotrophin and neurotrophin receptors in vascular smooth muscle cells. Regulation of expression in response to injury","volume":"147","author":"Donovan","year":"1995","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.vph.2010.04.005_bib13","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1161\/01.CIR.0000033971.56802.C5","article-title":"Nerve growth factor promotes angiogenesis and arteriogenesis in ischemic hindlimbs","volume":"106","author":"Emanueli","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.vph.2010.04.005_bib14","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/978-1-4613-0361-9_34","article-title":"Purification and characterization of nerve growth factors (NGFs) from the snake venoms","volume":"391","author":"Hayashi","year":"1996","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.vph.2010.04.005_bib15","doi-asserted-by":"crossref","first-page":"18169","DOI":"10.1074\/jbc.M008870200","article-title":"Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells","volume":"276","author":"Kao","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vph.2010.04.005_bib16","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0959-4388(00)00092-1","article-title":"Neurotrophin signal transduction in the nervous system","volume":"10","author":"Kaplan","year":"2000","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.vph.2010.04.005_bib17","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0041-0101(03)00225-3","article-title":"Characterization of nerve growth factors (NGFs) from snake venoms by use of a novel, quantitative bioassay utilizing pheochromocytoma (PC12) cells overexpressing human trkA receptors","volume":"42","author":"Katzir","year":"2003","journal-title":"Toxicon"},{"key":"10.1016\/j.vph.2010.04.005_bib18","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S1016-8478(23)13124-4","article-title":"A positive role of the PI3-K\/Akt signaling pathway in PC12 cell differentiation","volume":"18","author":"Kim","year":"2004","journal-title":"Mol. Cells"},{"key":"10.1016\/j.vph.2010.04.005_bib19","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0167-4838(92)90090-Z","article-title":"Purification and amino-acid sequence of a nerve growth factor from the venom of Vipera russelli russelli","volume":"1160","author":"Koyama","year":"1992","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.vph.2010.04.005_bib20","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/10623320600669053","article-title":"Nerve growth factor (NGF) promotes angiogenesis in the quail chorioallantoic membrane","volume":"13","author":"Lazarovici","year":"2006","journal-title":"Endothelium"},{"key":"10.1016\/j.vph.2010.04.005_bib21","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.2174\/138161206777698738","article-title":"Cross talk between the cardiovascular and nervous systems: neurotrophic effects of vascular endothelial growth factor (VEGF) and angiogenic effects of nerve growth factor (NGF)\u2014implications in drug development","volume":"12","author":"Lazarovici","year":"2006","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.vph.2010.04.005_bib22","series-title":"Angiogenesis: Basic Science and Clinical Applications","first-page":"99","article-title":"Nerve growth factor \u2014 a neurotrophin with angiogenic activity","author":"Lecht","year":"2007"},{"key":"10.1016\/j.vph.2010.04.005_bib24","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s12031-009-9318-0","article-title":"Nerve growth factor-induced protection of brain capillary endothelial cells exposed to oxygen-glucose deprivation involves attenuation of Erk phosphorylation","volume":"41","author":"Lecht","year":"2010","journal-title":"J. Mol. Neurosci"},{"key":"10.1016\/j.vph.2010.04.005_bib23","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s11626-009-9267-5","article-title":"Cardiac microvascular endothelial cells express and release nerve growth factor but not fibroblast growth factor-2","volume":"46","author":"Lecht","year":"2010","journal-title":"Vitro Cell Dev Biol Anim"},{"key":"10.1016\/j.vph.2010.04.005_bib25","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1083\/jcb.200309036","article-title":"SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase","volume":"163","author":"Marsh","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.vph.2010.04.005_bib26","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0092-8674(95)90401-8","article-title":"Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation","volume":"80","author":"Marshall","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.vph.2010.04.005_bib27","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/0092-8674(90)90009-4","article-title":"Increased proteolytic activity is responsible for the aberrant morphogenetic behavior of endothelial cells expressing the middle T oncogene","volume":"62","author":"Montesano","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.vph.2010.04.005_bib28","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.brainres.2004.05.013","article-title":"Brain capillary endothelial cells proliferate in response to NGF, express NGF receptors and secrete NGF after inflammation","volume":"1017","author":"Moser","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.vph.2010.04.005_bib29","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.mvr.2007.07.004","article-title":"Nerve growth factor as an angiogenic factor","volume":"75","author":"Nico","year":"2008","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.vph.2010.04.005_bib30","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1750-2187-1-4","article-title":"Tyrosine-specific MAPK phosphatases and the control of ERK signaling in PC12 cells","volume":"1","author":"Noordman","year":"2006","journal-title":"J. Mol. Signal."},{"key":"10.1016\/j.vph.2010.04.005_bib31","first-page":"909","article-title":"Amino acid sequence of nerve growth factor purified from the venom of the Formosan cobra Naja naja atra","volume":"19","author":"Oda","year":"1989","journal-title":"Biochem. Int."},{"key":"10.1016\/j.vph.2010.04.005_bib32","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1440-169x.2004.00756.x","article-title":"Sustained MAPK activation is dependent on continual NGF receptor regeneration","volume":"46","author":"Qiu","year":"2004","journal-title":"Dev. Growth Differ."},{"key":"10.1016\/j.vph.2010.04.005_bib33","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00424-005-1436-0","article-title":"Nerve growth factor activates aorta endothelial cells causing PI3K\/Akt- and ERK-dependent migration","volume":"450","author":"Rahbek","year":"2005","journal-title":"Pflugers. Arch."},{"key":"10.1016\/j.vph.2010.04.005_bib34","doi-asserted-by":"crossref","first-page":"845","DOI":"10.2174\/092986730609220401151459","article-title":"Role of neurotrophin-trk interactions in oncology: the anti-tumor efficacy of potent and selective trk tyrosine kinase inhibitors in pre-clinical tumor models","volume":"6","author":"Ruggeri","year":"1999","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.vph.2010.04.005_bib35","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/s00125-004-1424-5","article-title":"Nerve growth factor supplementation reverses the impairment, induced by Type 1 diabetes, of hindlimb post-ischaemic recovery in mice","volume":"47","author":"Salis","year":"2004","journal-title":"Diabetologia"},{"key":"10.1016\/j.vph.2010.04.005_bib36","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/ncb1543","article-title":"Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate","volume":"9","author":"Santos","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.vph.2010.04.005_bib37","doi-asserted-by":"crossref","first-page":"20175","DOI":"10.1074\/jbc.271.33.20175","article-title":"Differential utilization of Trk autophosphorylation sites","volume":"271","author":"Segal","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vph.2010.04.005_bib38","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1242\/jcs.000232","article-title":"Integrin alpha9 beta1 is a receptor for nerve growth factor and other neurotrophins","volume":"121","author":"Staniszewska","year":"2008","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.vph.2010.04.005_bib39","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1385\/JMN:22:3:237","article-title":"Nerve growth factor pretreatment attenuates oxygen and glucose deprivation-induced c-Jun amino-terminal kinase 1 and stress-activated kinases p38alpha and p38beta activation and confers neuroprotection in the pheochromocytoma PC12 Model","volume":"22","author":"Tabakman","year":"2004","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.vph.2010.04.005_bib40","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1042\/bj2880351","article-title":"Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor","volume":"288","author":"Traverse","year":"1992","journal-title":"Biochem. J."},{"key":"10.1016\/j.vph.2010.04.005_bib41","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/(SICI)1097-4547(19980215)51:4<442::AID-JNR4>3.0.CO;2-C","article-title":"Duration and magnitude of nerve growth factor signaling depend on the ratio of p75LNTR to TrkA","volume":"51","author":"Twiss","year":"1998","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.vph.2010.04.005_bib42","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/303821a0","article-title":"Human beta-nerve growth factor gene sequence highly homologous to that of mouse","volume":"303","author":"Ullrich","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.vph.2010.04.005_bib43","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1126\/science.1071552","article-title":"Signaling pathways for PC12 cell differentiation: making the right connections","volume":"296","author":"Vaudry","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.vph.2010.04.005_bib44","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/43705","article-title":"Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor","volume":"401","author":"Wiesmann","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.vph.2010.04.005_bib45","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0031-6865(99)00036-9","article-title":"Neurotrophin receptor structure and interactions","volume":"74","author":"Yano","year":"2000","journal-title":"Pharm. Acta Helv."},{"key":"10.1016\/j.vph.2010.04.005_bib46","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nrn2336","article-title":"Neurovascular signalling defects in neurodegeneration","volume":"9","author":"Zacchigna","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.vph.2010.04.005_bib47","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1042\/bst0311171","article-title":"VEGF signalling: integration and multi-tasking in endothelial cell biology","volume":"31","author":"Zachary","year":"2003","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.vph.2010.04.005_bib48","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/(SICI)1097-4547(19961201)46:5<581::AID-JNR7>3.0.CO;2-F","article-title":"Detection of increased tissue concentrations of nerve growth factor with an improved extraction procedure","volume":"46","author":"Zettler","year":"1996","journal-title":"J. Neurosci. Res."}],"container-title":["Vascular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189110000868?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189110000868?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T10:12:47Z","timestamp":1711447967000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1537189110000868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":48,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S1537189110000868"],"URL":"https:\/\/doi.org\/10.1016\/j.vph.2010.04.005","relation":{},"ISSN":["1537-1891"],"issn-type":[{"value":"1537-1891","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]}}}