{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T16:55:52Z","timestamp":1773939352993,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["22590830"],"award-info":[{"award-number":["22590830"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vascular Pharmacology"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.vph.2014.03.006","type":"journal-article","created":{"date-parts":[[2014,3,29]],"date-time":"2014-03-29T04:47:37Z","timestamp":1396068457000},"page":"49-55","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Stimulation of \u03b17 nicotinic acetylcholine receptor by AR-R17779 suppresses atherosclerosis and aortic aneurysm formation in apolipoprotein E-deficient mice"],"prefix":"10.1016","volume":"61","author":[{"given":"Toru","family":"Hashimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Ichiki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Hurt-Camejo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Micha\u00eblsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiro","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eriko","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohide","family":"Matsuura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomotake","family":"Tokunou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Kitamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Sunagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.vph.2014.03.006_bb0005","doi-asserted-by":"crossref","first-page":"741","DOI":"10.4065\/84.8.741","article-title":"Primary and secondary prevention of cardiovascular diseases: a practical evidence-based approach","volume":"84","author":"O'Keefe","year":"2009","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.vph.2014.03.006_bb0010","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nature01323","article-title":"Inflammation in atherosclerosis","volume":"420","author":"Libby","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.vph.2014.03.006_bb0015","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1016\/j.jacc.2009.09.009","article-title":"Inflammation in atherosclerosis: from pathophysiology to practice","volume":"54","author":"Libby","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.vph.2014.03.006_bb0020","doi-asserted-by":"crossref","first-page":"313","DOI":"10.5551\/jat.11.313","article-title":"The roles of cytokines, inflammation and immunity in vascular diseases","volume":"11","author":"Ohsuzu","year":"2004","journal-title":"J Atheroscler Thromb"},{"key":"10.1016\/j.vph.2014.03.006_bb0025","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/nature01321","article-title":"The inflammatory reflex","volume":"420","author":"Tracey","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.vph.2014.03.006_bb0030","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1172\/JCI30555","article-title":"Physiology and immunology of the cholinergic antiinflammatory pathway","volume":"117","author":"Tracey","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.vph.2014.03.006_bb0035","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/35013070","article-title":"Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin","volume":"405","author":"Borovikova","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.vph.2014.03.006_bb0040","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S1566-0702(00)00233-2","article-title":"Role of vagus nerve signaling in CNI-1493-mediated suppression of acute inflammation","volume":"85","author":"Borovikova","year":"2000","journal-title":"Auton Neurosci"},{"key":"10.1016\/j.vph.2014.03.006_bb0045","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1067\/mva.2002.129643","article-title":"Cholinergic antiinflammatory pathway inhibition of tumor necrosis factor during ischemia reperfusion","volume":"36","author":"Bernik","year":"2002","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.vph.2014.03.006_bb0050","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1097\/01.CCM.0000186762.05301.13","article-title":"Activation of an efferent cholinergic pathway produces strong protection against myocardial ischemia\/reperfusion injury in rats","volume":"33","author":"Mioni","year":"2005","journal-title":"Crit Care Med"},{"key":"10.1016\/j.vph.2014.03.006_bb0055","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1097\/01.shk.0000209539.91553.82","article-title":"Activation of the cholinergic anti-inflammatory pathway reduces NF-kappab activation, blunts TNF-alpha production, and protects against splanchic artery occlusion shock","volume":"25","author":"Altavilla","year":"2006","journal-title":"Shock"},{"key":"10.1016\/j.vph.2014.03.006_bb0060","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1161\/01.CIR.0000050627.90734.ED","article-title":"Efferent vagal fibre stimulation blunts nuclear factor-kappaB activation and protects against hypovolemic hemorrhagic shock","volume":"107","author":"Guarini","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.vph.2014.03.006_bb0065","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/ni1229","article-title":"Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway","volume":"6","author":"de Jonge","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1016\/j.vph.2014.03.006_bb0070","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1084\/jem.20011714","article-title":"Pharmacological stimulation of the cholinergic antiinflammatory pathway","volume":"195","author":"Bernik","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.vph.2014.03.006_bb0075","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1084\/jem.20042397","article-title":"Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve","volume":"202","author":"Luyer","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.vph.2014.03.006_bb0080","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1086\/430323","article-title":"The cholinergic anti-inflammatory pathway regulates the host response during septic peritonitis","volume":"191","author":"van Westerloo","year":"2005","journal-title":"J Infect Dis"},{"key":"10.1016\/j.vph.2014.03.006_bb0085","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1053\/j.gastro.2006.08.016","article-title":"The vagus nerve: a tonic inhibitory influence associated with inflammatory bowel disease in a murine model","volume":"131","author":"Ghia","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.vph.2014.03.006_bb0090","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1053\/j.gastro.2006.02.022","article-title":"The vagus nerve and nicotinic receptors modulate experimental pancreatitis severity in mice","volume":"130","author":"van Westerloo","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.vph.2014.03.006_bb0095","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature01339","article-title":"Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation","volume":"421","author":"Wang","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.vph.2014.03.006_bb0100","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/nm1124","article-title":"Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis","volume":"10","author":"Wang","year":"2004","journal-title":"Nat Med"},{"key":"10.1016\/j.vph.2014.03.006_bb0105","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1161\/01.ATV.0000172631.50972.0f","article-title":"Vitamin E inhibits abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice","volume":"25","author":"Gavrila","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.vph.2014.03.006_bb0110","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1172\/JCI7818","article-title":"Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice","volume":"105","author":"Daugherty","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.vph.2014.03.006_bb0115","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1161\/01.CIR.103.3.448","article-title":"Angiotensin II-induced hypertension accelerates the development of atherosclerosis in apoE-deficient mice","volume":"103","author":"Weiss","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.vph.2014.03.006_bb0120","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1161\/01.ATV.0000118275.60121.2b","article-title":"Monocyte chemoattractant protein-1 is an essential inflammatory mediator in angiotensin II-induced progression of established atherosclerosis in hypercholesterolemic mice","volume":"24","author":"Ni","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.vph.2014.03.006_bb0125","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1161\/01.ATV.0000058404.92759.32","article-title":"Differential effects of doxycycline, a broad-spectrum matrix metalloproteinase inhibitor, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms","volume":"23","author":"Manning","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.vph.2014.03.006_bb0130","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1161\/ATVBAHA.110.203588","article-title":"Atherosclerosis in abdominal aortic aneurysms: a causal event or a process running in parallel?","volume":"30","author":"Johnsen","year":"2010","journal-title":"The Tromso study. Arterioscler Thromb Vasc Biol."},{"key":"10.1016\/j.vph.2014.03.006_bb0135","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.ajpath.2011.05.014","article-title":"Differential roles of endothelin-1 in angiotensin II-induced atherosclerosis and aortic aneurysms in apolipoprotein E-null mice","volume":"179","author":"Suen","year":"2011","journal-title":"Am J Pathol."},{"key":"10.1016\/j.vph.2014.03.006_bb0140","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1084\/jem.20040463","article-title":"Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation","volume":"201","author":"Saeed","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.vph.2014.03.006_bb0145","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1053\/j.gastro.2007.07.022","article-title":"Activation of the cholinergic anti-inflammatory pathway ameliorates postoperative ileus in mice","volume":"133","author":"The","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.vph.2014.03.006_bb0150","doi-asserted-by":"crossref","first-page":"11008","DOI":"10.1073\/pnas.0803237105","article-title":"Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia","volume":"105","author":"Rosas-Ballina","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.vph.2014.03.006_bb0155","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1161\/CIRCRESAHA.111.245563","article-title":"Role of the cholinergic antiinflammatory pathway in murine autoimmune myocarditis","volume":"109","author":"Leib","year":"2011","journal-title":"Circ Res."},{"key":"10.1016\/j.vph.2014.03.006_bb0160","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1111\/j.1572-0241.1999.01059.x","article-title":"Nicotine therapy for ulcerative colitis: a review of rationale, mechanisms, pharmacology, and clinical results","volume":"94","author":"Sandborn","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.vph.2014.03.006_bb0165","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/art.24177","article-title":"Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice","volume":"60","author":"van Maanen","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.vph.2014.03.006_bb0170","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.atherosclerosis.2010.07.027","article-title":"Acetylcholinesterase inhibitors attenuate atherogenesis in apolipoprotein E-knockout mice","volume":"213","author":"Inanaga","year":"2010","journal-title":"Atherosclerosis."},{"key":"10.1016\/j.vph.2014.03.006_bb0175","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/89961","article-title":"Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis","volume":"7","author":"Heeschen","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.vph.2014.03.006_bb0180","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1161\/01.ATV.0000193510.19000.10","article-title":"Nicotine induces proinflammatory responses in macrophages and the aorta leading to acceleration of atherosclerosis in low-density lipoprotein receptor(\u2212\/\u2212) mice","volume":"26","author":"Lau","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.vph.2014.03.006_bb0185","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.neuropharm.2010.01.013","article-title":"Structural differences determine the relative selectivity of nicotinic compounds for native alpha 4 beta 2*-, alpha 6 beta 2*-, alpha 3 beta 4*- and alpha 7-nicotine acetylcholine receptors","volume":"58","author":"Grady","year":"2010","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.vph.2014.03.006_bb0190","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/j.bmcl.2003.09.104","article-title":"Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes","volume":"14","author":"Papke","year":"2004","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.vph.2014.03.006_bb0195","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s002130000444","article-title":"The alpha4beta2 agonist SIB 1765F, but not the alpha7 agonist AR-R 17779, cross-sensitises to the psychostimulant effects of nicotine","volume":"150","author":"Grottick","year":"2000","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.vph.2014.03.006_bb0200","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0014-2999(02)01819-8","article-title":"Characterization of functional nicotinic acetylcholine receptors involved in catecholamine release from the isolated rat adrenal gland","volume":"446","author":"Yokotani","year":"2002","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.vph.2014.03.006_bb0205","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1210\/endo.136.5.7720663","article-title":"Interleukin-6 stimulates hepatic triglyceride secretion in rats","volume":"136","author":"Nonogaki","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.vph.2014.03.006_bb0210","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00395-011-0179-7","article-title":"Role of endothelial Nox2 NADPH oxidase in angiotensin II-induced hypertension and vasomotor dysfunction","volume":"106","author":"Murdoch","year":"2011","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.vph.2014.03.006_bb0215","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1161\/CIRCRESAHA.107.158295","article-title":"Endothelial NF-kappaB as a mediator of kidney damage: the missing link between systemic vascular and renal disease?","volume":"101","author":"Guzik","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.vph.2014.03.006_bb0220","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1161\/01.ATV.19.7.1623","article-title":"Angiotensin induces inflammatory activation of human vascular smooth muscle cells","volume":"19","author":"Kranzhofer","year":"1999","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.vph.2014.03.006_bb0225","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1084\/jem.20070657","article-title":"Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction","volume":"204","author":"Guzik","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.vph.2014.03.006_bb0230","doi-asserted-by":"crossref","first-page":"H1660","DOI":"10.1152\/ajpheart.00028.2009","article-title":"ANG II infusion promotes abdominal aortic aneurysms independent of increased blood pressure in hypercholesterolemic mice","volume":"296","author":"Cassis","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.vph.2014.03.006_bb0235","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.1021\/jm000249r","article-title":"(-)-Spiro[1-azabicyclo[2.2.2]octane-3,5\u2032-oxazolidin-2\u2032-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the alpha 7 nicotinic acetylcholine receptor","volume":"43","author":"Mullen","year":"2000","journal-title":"J Med Chem"}],"container-title":["Vascular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189114000597?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189114000597?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T01:17:11Z","timestamp":1761527831000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1537189114000597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":47,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S1537189114000597"],"URL":"https:\/\/doi.org\/10.1016\/j.vph.2014.03.006","relation":{},"ISSN":["1537-1891"],"issn-type":[{"value":"1537-1891","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stimulation of \u03b17 nicotinic acetylcholine receptor by AR-R17779 suppresses atherosclerosis and aortic aneurysm formation in apolipoprotein E-deficient mice","name":"articletitle","label":"Article Title"},{"value":"Vascular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vph.2014.03.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}