{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:55:44Z","timestamp":1789865744060,"version":"4.0.1"},"reference-count":89,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vascular Pharmacology"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.vph.2014.08.001","type":"journal-article","created":{"date-parts":[[2014,8,17]],"date-time":"2014-08-17T12:32:29Z","timestamp":1408278749000},"page":"63-70","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Recent developments in the effects of nitric oxide-donating statins on cardiovascular disease through regulation of tetrahydrobiopterin and nitric oxide"],"prefix":"10.1016","volume":"63","author":[{"given":"Sze","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher Cheng-Hwa","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.vph.2014.08.001_bb0005","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s11897-012-0097-5","article-title":"Recoupling the cardiac nitric oxide synthases: tetrahydrobiopterin synthesis and recycling","volume":"9","author":"Alkaitis","year":"2012","journal-title":"Curr Heart Fail Rep"},{"issue":"3","key":"10.1016\/j.vph.2014.08.001_bb0010","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1161\/01.ATV.0000115637.48689.77","article-title":"Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice","volume":"24","author":"Alp","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"5","key":"10.1016\/j.vph.2014.08.001_bb0015","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.phrs.2010.07.006","article-title":"The nitric oxide-donating pravastatin, NCX 6550, inhibits cytokine release and NF-KB activation while enhancing PPARy expression in human monocyte\/macrophages","volume":"62","author":"Amoruso","year":"2010","journal-title":"Pharmacol Res"},{"issue":"17","key":"10.1016\/j.vph.2014.08.001_bb0020","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1161\/CIRCULATIONAHA.111.029272","article-title":"Induction of vascular GTP-cyclohydrolaseI and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis","volume":"124","author":"Antoniades","year":"2011","journal-title":"Circulation"},{"issue":"24","key":"10.1016\/j.vph.2014.08.001_bb0025","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1161\/CIRCULATIONAHA.107.704155","article-title":"Altered plasma versus vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial function, and inflammation","volume":"116","author":"Antoniades","year":"2007","journal-title":"Circulation"},{"issue":"11 Suppl.","key":"10.1016\/j.vph.2014.08.001_bb0030","doi-asserted-by":"crossref","first-page":"S66","DOI":"10.1161\/CIRCULATIONAHA.109.927376","article-title":"Preoperative atorvastatin treatment in CABG patients rapidly improves vein graft redox state by inhibition of Rac 1 and NADPH-oxidase activity","volume":"122","author":"Antoniades","year":"2010","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.vph.2014.08.001_bb0040","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ijcard.2010.10.029","article-title":"Fluvastatin upregulates endothelial nitric oxide synthase activity via enhancement of its phosphorylation and expression and via an increase in tetrahydrobiopterin in vascular endothelial cells","volume":"156","author":"Aoki","year":"2012","journal-title":"Int J Cardiol"},{"issue":"3","key":"10.1016\/j.vph.2014.08.001_bb0045","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s10557-013-6445-1","article-title":"Nitric oxide-donating atorvastatin attenuates neutrophil recruitment during vascular inflammation independent of changes in plasma cholesterol","volume":"27","author":"Baetta","year":"2013","journal-title":"Cardiovasc Drugs Ther"},{"issue":"11","key":"10.1016\/j.vph.2014.08.001_bb0050","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1038\/oby.2003.174","article-title":"Endothelial dysfunction in obesity and insulin resistance: a road to diabetes and heart disease","volume":"11","author":"Caballero","year":"2003","journal-title":"Obes Res"},{"issue":"35","key":"10.1016\/j.vph.2014.08.001_bb0055","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.2174\/138161211798357719","article-title":"Nitric oxide-derived oxidants with a focus on peroxynitrite: molecular targets, cellular responses and therapeutic implications","volume":"17","author":"Calcerrada","year":"2011","journal-title":"Curr Pharm Des"},{"issue":"11","key":"10.1016\/j.vph.2014.08.001_bb0060","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1021\/ac048192u","article-title":"Direct detection of S-nitrosothiols using planar amperometric nitric oxide sensor modified with polymeric films containing catalytic copper species","volume":"77","author":"Cha","year":"2005","journal-title":"Anal Chem"},{"issue":"10","key":"10.1016\/j.vph.2014.08.001_bb0065","first-page":"3527","article-title":"Endothelial cells in physiology and in the pathophysiology of vascular disorders","volume":"91","author":"Cines","year":"1998","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.vph.2014.08.001_bb0070","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2174\/187152806776383143","article-title":"Nitric oxide and inflammation","volume":"5","author":"Cirino","year":"2006","journal-title":"Inflamm Allergy Drug Targets"},{"issue":"1","key":"10.1016\/j.vph.2014.08.001_bb0075","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1161\/01.CIR.91.1.139","article-title":"Tetrahyrobiopterin and dysfunction of endothelial nitric oxide synthase in coronary arteries","volume":"91","author":"Cosentino","year":"1995","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.vph.2014.08.001_bb0080","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1136\/hrt.2007.122184","article-title":"Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia","volume":"94","author":"Cosentino","year":"2008","journal-title":"Heart"},{"issue":"41","key":"10.1016\/j.vph.2014.08.001_bb0085","doi-asserted-by":"crossref","first-page":"28128","DOI":"10.1074\/jbc.M109.041483","article-title":"Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways","volume":"284","author":"Crabtree","year":"2009","journal-title":"J Biol Chem"},{"issue":"41","key":"10.1016\/j.vph.2014.08.001_bb0090","doi-asserted-by":"crossref","first-page":"28128","DOI":"10.1074\/jbc.M109.041483","article-title":"Critical role for tetrahydrobiopterin recycling by dihydrofolatereductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways","volume":"284","author":"Crabtree","year":"2009","journal-title":"J Biol Chem"},{"issue":"11","key":"10.1016\/j.vph.2014.08.001_bb0095","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1161\/CIRCULATIONAHA.111.038919","article-title":"Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease","volume":"125","author":"Cunnington","year":"2012","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.vph.2014.08.001_bb0100","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/mus.23465","article-title":"Nitricoxide prevents atorvastatin-induced skeletal muscle dysfunction and alterations in mice","volume":"47","author":"D'Antona","year":"2013","journal-title":"Muscle Nerve"},{"issue":"1","key":"10.1016\/j.vph.2014.08.001_bb0105","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1124\/jpet.106.109298","volume":"320","author":"Dever","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"issue":"6","key":"10.1016\/j.vph.2014.08.001_bb0110","first-page":"417","article-title":"The cardio-protective properties of Ncx-6550, a nitric oxide donating pravastatin, in the mouse","volume":"17","author":"Di Filippo","year":"2010","journal-title":"Microcirculation"},{"issue":"Pt 24","key":"10.1016\/j.vph.2014.08.001_bb0115","doi-asserted-by":"crossref","first-page":"5541","DOI":"10.1242\/jcs.115972","article-title":"eNOS-derived nitric oxide regulated endothelial barrier function through VE-cadherin and Rho GTPases","volume":"126","author":"Di Lorenzo","year":"2013","journal-title":"J Cell Sci"},{"issue":"6736","key":"10.1016\/j.vph.2014.08.001_bb0120","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/21224","article-title":"Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation","volume":"399","author":"Dimmeler","year":"1999","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.vph.2014.08.001_bb0125","doi-asserted-by":"crossref","first-page":"C742","DOI":"10.1152\/ajpcell.00138.2009","article-title":"Inhibition of CDKS by roscovitine suppressed LPS-induced *NO production through inhibiting NFkappaB activation and BH4 biosynthesis in macrophages","volume":"297","author":"Du","year":"2009","journal-title":"Am J Physiol Cell Physiol"},{"issue":"7","key":"10.1016\/j.vph.2014.08.001_bb0130","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/sj.bjp.0707142","article-title":"Nitropravastatin stimulates neovascularisation and improves recovery from limb ischaemia in type-1 diabetic mice","volume":"150","author":"Emanueli","year":"2007","journal-title":"Br J Pharmacol 150 (7)"},{"issue":"4","key":"10.1016\/j.vph.2014.08.001_bb0135","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.cardiores.2004.11.003","article-title":"Oxidized low-density lipoprotein increase superoxide production by endothelial nitric oxide synthase by inhibiting PKCalpha","volume":"65","author":"Fleming","year":"2005","journal-title":"Cardiovasc Res"},{"issue":"7","key":"10.1016\/j.vph.2014.08.001_bb0140","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/eurheartj\/ehr304","article-title":"Nitric oxide synthases: regulation and function","volume":"33","author":"F\u00f6rstermann","year":"2012","journal-title":"Eur Heart J."},{"issue":"36","key":"10.1016\/j.vph.2014.08.001_bb0145","doi-asserted-by":"crossref","first-page":"25722","DOI":"10.1016\/S0021-9258(18)35667-9","article-title":"Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle","volume":"267","author":"Gross","year":"1992","journal-title":"J Biol Chem"},{"issue":"5113","key":"10.1016\/j.vph.2014.08.001_bb0150","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1126\/science.8502995","article-title":"Feedback regulation mechanisms for the control of GTP cyclohydrolase I activity","volume":"260","author":"Harada","year":"1993","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.vph.2014.08.001_bb0155","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/MOL.0b013e32825a6773","article-title":"The broad spectrum of statin myopathy: from myalgia to rhabdomyolysis","volume":"18","author":"Harper","year":"2007","journal-title":"Curr Opin Lipidol"},{"issue":"2","key":"10.1016\/j.vph.2014.08.001_bb0160","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1161\/01.ATV.0000054659.72231.A1","article-title":"HMG-CoA reductase inhibitor increase GTP cyclohydrolase I mRNA and tetrahydrobiopterin in vascular endothelial cells","volume":"23","author":"Hattori","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"11","key":"10.1016\/j.vph.2014.08.001_bb0165","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1007\/s001250051551","article-title":"Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus","volume":"43","author":"Heitzer","year":"2000","journal-title":"Diabetologia"},{"issue":"18","key":"10.1016\/j.vph.2014.08.001_bb0170","doi-asserted-by":"crossref","first-page":"12030","DOI":"10.1074\/jbc.272.18.12030","article-title":"Calmodulin promotes dimerization of the oxygenase domain of human endothelial nitric-oxide synthase","volume":"272","author":"Hellemann","year":"1997","journal-title":"J Biol Chem"},{"issue":"2 Suppl. 4","key":"10.1016\/j.vph.2014.08.001_bb0175","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1524-6175.2006.06032.x","article-title":"Nitricoxide in hypertension","volume":"8","author":"Hermann","year":"2006","journal-title":"J Clin Hypertens (Greenwich)"},{"issue":"6","key":"10.1016\/j.vph.2014.08.001_bb0180","doi-asserted-by":"crossref","first-page":"417","DOI":"10.2174\/138161280506230110111042","article-title":"Current trends in the development of nitric oxide donors","volume":"5","author":"Hou","year":"1999","journal-title":"Curr Pharm Des"},{"issue":"5","key":"10.1016\/j.vph.2014.08.001_rf0155","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1001\/jama.2013.284657","article-title":"More than a billion people taking statins?: Potential implications of the new cardiovascular guidelines","volume":"311","author":"Ioannidis","year":"2014","journal-title":"JAMA"},{"issue":"11","key":"10.1016\/j.vph.2014.08.001_rf0445","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1111\/j.1538-7836.2005.01605.x","volume":"3","year":"2005","journal-title":"J Thromb Haemost"},{"issue":"1","key":"10.1016\/j.vph.2014.08.001_bb0195","first-page":"147","article-title":"Vascular nitric oxide: formation and function","volume":"2010","author":"Jin","year":"2010","journal-title":"J Blood Med"},{"issue":"1","key":"10.1016\/j.vph.2014.08.001_bb0200","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jvs.2007.09.005","article-title":"Nitric oxide and nanotechnology: a novel approach to inhibit neointimal hyperplasia","volume":"47","author":"Kapadia","year":"2008","journal-title":"J Vasc Surg"},{"issue":"1","key":"10.1016\/j.vph.2014.08.001_bb0205","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1161\/01.ATV.18.1.27","article-title":"Cytokines stimulate GTP cyclohydrolase I gene expression in cultured human umbilical vein endothelial cells","volume":"18","author":"Katusic","year":"1998","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"6","key":"10.1016\/j.vph.2014.08.001_bb0210","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1161\/01.RES.66.6.1561","article-title":"Control of coronary vascular tone by nitric oxide","volume":"66","author":"Kelm","year":"1990","journal-title":"Circ Res"},{"issue":"6 Pt 1","key":"10.1016\/j.vph.2014.08.001_bb0215","first-page":"G1138","article-title":"Nitric oxide modulates epithelial permeability in the feline small intestine","volume":"262","author":"Kubes","year":"1992","journal-title":"Am J Physiol"},{"issue":"3","key":"10.1016\/j.vph.2014.08.001_bb0225","first-page":"167","article-title":"Recent development in pleiotropic effects of statins on cardiovascular disease through regulation of transforming growth factor-beta superfamily","volume":"22","author":"Ma","year":"2011","journal-title":"Cytokine Growth Factor Rev"},{"issue":"2b","key":"10.1016\/j.vph.2014.08.001_bb0230","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/j.1476-5381.2011.01423.x","article-title":"Nitric oxide-donating statin improves multiple functions of circulating angiogenic cells","volume":"164","author":"Mangialardi","year":"2011","journal-title":"Br J Pharmacol"},{"issue":"1","key":"10.1016\/j.vph.2014.08.001_bb0235","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/09629359791875","article-title":"Nitric oxide function in atherosclerosis","volume":"6","author":"Matthys","year":"1997","journal-title":"Mediat Inflamm"},{"issue":"8A","key":"10.1016\/j.vph.2014.08.001_bb0240","doi-asserted-by":"crossref","first-page":"89C","DOI":"10.1016\/j.amjcard.2006.02.030","article-title":"Final conclusions and recommendations of the National Lipid Association Statin Safety Assessment Task Force","volume":"97","author":"Mckenney","year":"2006","journal-title":"Am J Cardiol"},{"issue":"5","key":"10.1016\/j.vph.2014.08.001_bb0245","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1160\/TH12-06-0424","article-title":"The role of tetrahydrobiopterin in inflammation and cardiovascular disease","volume":"108","author":"McNeill","year":"2012","journal-title":"Thromb Haemost"},{"issue":"3","key":"10.1016\/j.vph.2014.08.001_bb0250","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/sj.bjp.0707224","article-title":"Recent developments in nitric oxide donor drugs","volume":"151","author":"Miller","year":"2007","journal-title":"Br J Pharmacol"},{"issue":"3","key":"10.1016\/j.vph.2014.08.001_bb0255","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/sj.bjp.0707224","article-title":"Recent developments in nitric oxide donor drugs","volume":"151","author":"Miller","year":"2007","journal-title":"Br J Pharmacol"},{"issue":"1\u20133","key":"10.1016\/j.vph.2014.08.001_bb0260","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ejphar.2007.05.014","article-title":"NCX 6560, a nitric-releasing derivative of atorvastatin, inhibits cholesterol biosynthesis and shows anti-inflammatory and anti-thrombotic properties","volume":"570","author":"Momi","year":"2007","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"10.1016\/j.vph.2014.08.001_bb0265","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1093\/cvr\/cvs100","article-title":"Nitric oxide enhances the anti-inflammatory and anti-atherogenic activity of atorvastatin in a mouse model of accelerated atherosclerosis","volume":"94","author":"Momi","year":"2012","journal-title":"Cardiovasc Res"},{"issue":"3","key":"10.1016\/j.vph.2014.08.001_bb0270","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1161\/01.HYP.0000255954.80025.34","article-title":"Mechanism of endothelial nitric oxide synthase phosphorylation and activation by thrombin","volume":"49","author":"Motley","year":"2007","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.vph.2014.08.001_bb0275","doi-asserted-by":"crossref","first-page":"691","DOI":"10.2337\/diabetes.55.03.06.db05-0771","article-title":"Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance","volume":"55","author":"Naruse","year":"2006","journal-title":"Diabetes"},{"issue":"6","key":"10.1016\/j.vph.2014.08.001_bb0280","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1073\/pnas.80.6.1546","article-title":"Biosynthesis of tetrahydrobiopterin by de novo and salvage pathways in adrenal medulla extracts, mammalian cell cultures, and rat brain in vivo","volume":"80","author":"Nichol","year":"1983","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3\u20134","key":"10.1016\/j.vph.2014.08.001_rf0475","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.vph.2013.07.001","article-title":"Propionyl-L-carnitine induces eNOS activation and nitric oxide synthesis in endothelial cells via PI3 and Akt kinases","volume":"59","author":"Ning","year":"2013","journal-title":"Vascul Pharmacol"},{"issue":"7","key":"10.1016\/j.vph.2014.08.001_rf0480","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/sj.bjp.0707142","article-title":"Nitropravastatin stimulates reparative neovascularisation and improves recovery from limb ischaemia in type-1 diabetic mice","volume":"150","year":"2007","journal-title":"Br J Pharmacol"},{"issue":"3","key":"10.1016\/j.vph.2014.08.001_bb0295","doi-asserted-by":"crossref","first-page":"H721","DOI":"10.1152\/ajpheart.01089.2010","article-title":"Increasing dihydrobiopterin causes dysfunction of endothelial nitric oxide synthase in rats in vivo","volume":"301","author":"Noguchi","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"10.1016\/j.vph.2014.08.001_bb0300","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.atherosclerosis.2008.12.023","article-title":"Statins inhibit Rho kinase activity in patients with atherosclerosis","volume":"205","author":"Nohria","year":"2009","journal-title":"Atherosclerosis"},{"issue":"22","key":"10.1016\/j.vph.2014.08.001_bb0305","doi-asserted-by":"crossref","first-page":"8497","DOI":"10.1073\/pnas.0401996101","article-title":"Nitric oxide (NO)-releasing statin derivatives, a class of drugs showing enhanced antiproliferative and antiinflammatory properties","volume":"101","author":"Ongini","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.vph.2014.08.001_rf0485","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1152\/physrev.00029.2006","article-title":"Nitric oxide and peroxynitrite in health and disease","volume":"87","author":"Pacher","year":"2007","journal-title":"Physiol Rev"},{"issue":"3","key":"10.1016\/j.vph.2014.08.001_rf0490","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1161\/CIRCULATIONAHA.110.985150","article-title":"Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling","volume":"124","year":"2011","journal-title":"Circulation"},{"issue":"16","key":"10.1016\/j.vph.2014.08.001_bb0320","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1128\/MCB.00506-13","article-title":"Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells","volume":"33","author":"Park","year":"2013","journal-title":"Mol Cell Biol"},{"issue":"2","key":"10.1016\/j.vph.2014.08.001_bb0325","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.atherosclerosis.2006.09.016","article-title":"Short-term high glucose exposure induces monocyte-endothelial cells adhesion and transmigration by increasing VCAM-1 and MCP-expression in human aortic endothelial cells","volume":"193","author":"Piga","year":"2007","journal-title":"Atherosclerosis"},{"issue":"8","key":"10.1016\/j.vph.2014.08.001_bb0330","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1161\/01.CIR.0000058702.69484.A0","article-title":"Peripheral blood \u201cendothelial progenitor cells\u201d are derived from monocyte\/macrophages and secrete angiogenic growth factors","volume":"107","author":"Rehman","year":"2003","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.vph.2014.08.001_bb0335","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1111\/j.1538-7836.2005.01605.x","article-title":"A novel nitric oxide-releasing statin derivative exerts an antiplatelet\/antithrombotic activity and inhibits tissue factor expression","volume":"3","author":"Rossiello","year":"2005","journal-title":"J Thromb Haemost"},{"issue":"3","key":"10.1016\/j.vph.2014.08.001_bb0340","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/00004872-199715030-00009","article-title":"Dual cell cycle-specific mechanisms mediate the antimitogenic effects of nitric oxide in vascular smooth muscle cells","volume":"15","author":"Sarkar","year":"1997","journal-title":"J Hypertens"},{"issue":"4","key":"10.1016\/j.vph.2014.08.001_bb0345","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1525-1594.2008.00540.x","article-title":"Antithrombogenicpolynitrosated polyester\/poly(methyl methacrylate) blend for the coating of blood-contacting surfaces","volume":"32","author":"Seabra","year":"2008","journal-title":"Artif Organs"},{"issue":"5","key":"10.1016\/j.vph.2014.08.001_bb0350","doi-asserted-by":"crossref","first-page":"C803","DOI":"10.1152\/ajpcell.00457.2005","article-title":"Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression","volume":"291","author":"Searles","year":"2006","journal-title":"Am J Physiol Cell Physiol"},{"issue":"3","key":"10.1016\/j.vph.2014.08.001_bb0355","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/00005344-200203000-00007","article-title":"Tetrahydrobiopterin improves impaired endothelium-dependent forearm vasodilation in patients with heart failure","volume":"39","author":"Setoguchi","year":"2002","journal-title":"J Cardiovasc Pharmacol"},{"issue":"3","key":"10.1016\/j.vph.2014.08.001_bb0360","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/FJC.0b013e31802f5895","article-title":"Pitavastatin restores vascular dysfunction in insulin-resistant state by inhibiting NAD(P)H oxidase activity and uncoupled endothelial nitric oxide synthase-dependent superoxide production","volume":"49","author":"Shinozaki","year":"2007","journal-title":"J Cardiovasc Pharmacol"},{"issue":"8","key":"10.1016\/j.vph.2014.08.001_bb0365","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/S0891-5849(02)01015-8","article-title":"Hypercholesterolemia promotes inflammation and microvascular dysfunction: role of nitric oxide superoxide","volume":"33","author":"Stokes","year":"2002","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"10.1016\/j.vph.2014.08.001_bb0370","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1172\/JCI119131","article-title":"Tetrahydrobiopterin restores endothelial function in hypercholesterolemia","volume":"99","author":"Stroes","year":"1997","journal-title":"J Clin Invest"},{"issue":"19","key":"10.1016\/j.vph.2014.08.001_bb0375","doi-asserted-by":"crossref","first-page":"12691","DOI":"10.1074\/jbc.M809295200","article-title":"Tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells","volume":"284","author":"Sugiyama","year":"2009","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.vph.2014.08.001_bb0380","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s11154-010-9134-4","article-title":"Endothelial dysfunction in diabetes mellitus: molecular mechanisms and clinical implications","volume":"11","author":"Tabit","year":"2010","journal-title":"Rev Endocr Metab Disord"},{"issue":"3","key":"10.1016\/j.vph.2014.08.001_bb0385","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1161\/01.ATV.0000109171.50229.33","article-title":"Endothelial nitric oxide synthase: a new paradigm for gene regulation in the injured blood vessel","volume":"24","author":"Tai","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"20","key":"10.1016\/j.vph.2014.08.001_bb0390","doi-asserted-by":"crossref","first-page":"13660","DOI":"10.1074\/jbc.M807959200","article-title":"GTP cyclohyrdolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression","volume":"284","author":"Tatham","year":"2009","journal-title":"J Biol Chem"},{"issue":"2 Pt 2","key":"10.1016\/j.vph.2014.08.001_bb0395","first-page":"H321","article-title":"Free radicals mediate endothelial cells dysfunction caused by elevated glucose","volume":"263","author":"Tesfamariam","year":"1992","journal-title":"Am J Physiol"},{"issue":"Pt 1","key":"10.1016\/j.vph.2014.08.001_bb0400","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/0264-6021:3470001","article-title":"Tetrahydrobiopterin biosynthesis, regeneration and functions","volume":"347","author":"Th\u00f6ny","year":"2000","journal-title":"Biochem J"},{"issue":"4","key":"10.1016\/j.vph.2014.08.001_bb0405","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S1734-1140(11)70601-6","article-title":"Statin-induced myopathies","volume":"63","author":"Tomaszewski","year":"2011","journal-title":"Pharmacol Rep"},{"issue":"Pt 3","key":"10.1016\/j.vph.2014.08.001_bb0410","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1042\/0264-6021:3620733","article-title":"The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study","volume":"362","author":"Vasquez-Vivar","year":"2002","journal-title":"Biochem J"},{"issue":"1","key":"10.1016\/j.vph.2014.08.001_bb0415","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.atherosclerosis.2007.10.003","article-title":"Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus","volume":"198","author":"Wenzel","year":"2008","journal-title":"Atherosclerosis"},{"issue":"11","key":"10.1016\/j.vph.2014.08.001_bb0420","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1161\/01.ATV.17.11.2479","article-title":"Expression of multiple isoforms of nitric oxide synthase in normal and atherosclerotic vessels","volume":"17","author":"Wilcox","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"10.1016\/j.vph.2014.08.001_bb0425","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.talanta.2007.06.022","article-title":"Nitric oxide-releasing\/generating polymers for the development of implantable chemical sensors with enhanced biocompatibility","volume":"75","author":"Wu","year":"2008","journal-title":"Talanta"},{"issue":"8","key":"10.1016\/j.vph.2014.08.001_bb0430","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1038\/mt.2010.109","article-title":"Oral tetrahydrobiopterin improves the beneficial effect of adenoviral-mediated eNOS gene transfer after induction of hindlimb ischemia","volume":"18","author":"Yan","year":"2010","journal-title":"Mol Ther"},{"issue":"1","key":"10.1016\/j.vph.2014.08.001_bb0435","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10557-011-6351-3","article-title":"Simvastatin ameliorates angiotensin II-induced endothelial dysfunction through restoration of Rho-BH4-eNOS-NO pathway","volume":"26","author":"Zhang","year":"2012","journal-title":"Cardiovasc Drugs Ther"},{"issue":"6","key":"10.1016\/j.vph.2014.08.001_bb0440","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.3892\/ijmm.2013.1513","article-title":"ox-LDL downregulates eNOS activity via LOX-1-mediated endoplasmic reticulum stress","volume":"32","author":"Zhou","year":"2013","journal-title":"Int J Mol Med"},{"issue":"2","key":"10.1016\/j.vph.2014.08.001_bb9000","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/00005344-200002000-00001","article-title":"Tetrahydrobiopterin improves endothelial function in patients with coronary artery disease","volume":"35","author":"Maier","year":"2000","journal-title":"J Cardiovasc Pharmacol"},{"issue":"5","key":"10.1016\/j.vph.2014.08.001_bb9005","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1253\/circj.CJ-08-0850","article-title":"Plasma tetrahydrobiopterin\/dihydrobiopterin ratio: a possible marker of endothelial dysfunction","volume":"73","author":"Takeda","year":"2009","journal-title":"Circ J"},{"issue":"8A","key":"10.1016\/j.vph.2014.08.001_bb9010","doi-asserted-by":"crossref","first-page":"52C","DOI":"10.1016\/j.amjcard.2005.12.010","article-title":"Statin safety: a systemic review","volume":"97","author":"Law","year":"2006","journal-title":"Am J Cardiol"}],"container-title":["Vascular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189114001268?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189114001268?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,16]],"date-time":"2023-07-16T02:51:51Z","timestamp":1689475911000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1537189114001268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":89,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S1537189114001268"],"URL":"https:\/\/doi.org\/10.1016\/j.vph.2014.08.001","relation":{},"ISSN":["1537-1891"],"issn-type":[{"value":"1537-1891","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recent developments in the effects of nitric oxide-donating statins on cardiovascular disease through regulation of tetrahydrobiopterin and nitric oxide","name":"articletitle","label":"Article Title"},{"value":"Vascular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vph.2014.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown copyright \u00a9 2014 Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}