{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T04:45:31Z","timestamp":1788410731398,"version":"build-2803163510"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vascular Pharmacology"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.vph.2015.05.017","type":"journal-article","created":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T00:55:39Z","timestamp":1433465739000},"page":"1-5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"special_numbering":"C","title":["Arterial stiffness and sedentary lifestyle: Role of oxidative stress"],"prefix":"10.1016","volume":"79","author":[{"given":"Gianfranco","family":"Lessiani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Santilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Boccatonda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7167-8917","authenticated-orcid":false,"given":"Pierpaolo","family":"Iodice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Liani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Tripaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul","family":"Saggini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Dav\u00ec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vph.2015.05.017_bb0005","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1161\/01.ATV.0000160548.78317.29","article-title":"Mechanism, pathophysiology, and therapy of arterial stiffness","volume":"25","author":"Zieman","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"4","key":"10.1016\/j.vph.2015.05.017_bb0010","article-title":"Role of arterial stiffness in cardiovascular disease","volume":"1","author":"Cecelja","year":"2012","journal-title":"JRSM Cardiovasc Dis."},{"key":"10.1016\/j.vph.2015.05.017_bb0015","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1161\/01.CIR.0000048892.83521.58","article-title":"Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part I: aging arteries: a \u201cset up\u201d for vascular disease","volume":"107","author":"Lakatta","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.vph.2015.05.017_bb0020","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1161\/01.CIR.0000048893.62841.F7","article-title":"Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part II: the aging heart in health: links to heart disease","volume":"107","author":"Lakatta","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.vph.2015.05.017_bb0025","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1161\/CIRCULATIONAHA.105.535435","article-title":"Acute systemic inflammation increases arterial stiffness and decreases wave reflections in healthy individuals","volume":"112","author":"Vlachopoulos","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.vph.2015.05.017_bb0030","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1161\/HYPERTENSIONAHA.107.089409","article-title":"Proinflammatory profile within the grossly normal aged human aortic wall","volume":"50","author":"Wang","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.vph.2015.05.017_bb0035","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1161\/01.HYP.0000128420.01881.aa","article-title":"Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study","volume":"43","author":"Mitchell","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.vph.2015.05.017_bb0040","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1155\/2012\/386387","article-title":"Systemic vascular function is associated with muscular power in older adults","volume":"2012","author":"Heffernan","year":"2012","journal-title":"J. Aging Res."},{"key":"10.1016\/j.vph.2015.05.017_bb0045","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/jch.12045","article-title":"Oscillometric carotid to femoral pulse wave velocity estimated with the Vicorder device","volume":"15","author":"Muller","year":"2013","journal-title":"J. Clin. Hypertens."},{"key":"10.1016\/j.vph.2015.05.017_bb0050","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1161\/CIRCULATIONAHA.105.555235","article-title":"Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study","volume":"113","author":"Mattace-Raso","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.vph.2015.05.017_bb0055","doi-asserted-by":"crossref","first-page":"582","DOI":"10.2174\/0929867322666141128163739","article-title":"Oxidative stress drivers and modulators in obesity and cardiovascular disease: from biomarkers to therapeutic approach","volume":"22","author":"Santilli","year":"2015","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.vph.2015.05.017_bb0060","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1161\/CIRCULATIONAHA.109.886655","article-title":"Arterial stiffness and cardiovascular events: the Framingham Heart Study","volume":"121","author":"Mitchell","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.vph.2015.05.017_bb0065","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.jss.2014.02.001","article-title":"Short-term physical inactivity impairs vascular function","volume":"190","author":"Nosova","year":"2014","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.vph.2015.05.017_bb0070","doi-asserted-by":"crossref","first-page":"173","DOI":"10.12659\/MSM.883589","article-title":"Sitting and endothelial dysfunction: the role of shear stress","volume":"18","author":"Thosar","year":"2012","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.vph.2015.05.017_bb0075","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1093\/eurheartj\/eht111","article-title":"Role of exercise in the prevention of cardiovascular disease: results, mechanisms, and new perspectives","volume":"34","author":"Schuler","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.vph.2015.05.017_bb0080","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1007\/s11906-013-0336-5","article-title":"Exercise training and cardiometabolic diseases: focus on the vascular system","volume":"15","author":"Roque","year":"2013","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.vph.2015.05.017_bb0085","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1160\/TH13-04-0295","article-title":"Effects of high-amount-high-intensity exercise on invivo platelet activation: modulation by lipid peroxidation and AGE\/RAGE axis","volume":"110","author":"Santilli","year":"2013","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.vph.2015.05.017_bb0090","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.numecd.2005.09.004","article-title":"Effects of moderate-intensity exercise training on plasma biomarkers of inflammation and endothelial dysfunction in older patients with type 2 diabetes","volume":"16","author":"Zoppini","year":"2006","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.vph.2015.05.017_bb0095","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1056\/NEJMoa020194","article-title":"Effects of the amount and intensity of exercise on plasma lipoproteins","volume":"347","author":"Kraus","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.vph.2015.05.017_bb0100","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1161\/01.ATV.0000154579.11213.da","article-title":"Exercise and the prothrombotic state: a paradox of cardiovascular prevention or an enhanced prothrombotic state?","volume":"25","author":"Thrall","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.vph.2015.05.017_bb0105","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1152\/japplphysiol.01004.2002","article-title":"Physical exercise increases urinary excretion of lipoxin A4 and related compounds","volume":"94","author":"Gangemi","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.vph.2015.05.017_bb0110","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1249\/MSS.0b013e3181cfc908","article-title":"Effect of exercise on oxidative stress: a 12-month randomized, controlled trial","volume":"42","author":"Campbell","year":"2010","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.vph.2015.05.017_bb0115","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1001\/jama.2012.128367","article-title":"Physical activity and structured exercise for patients with stable ischemic heart disease","volume":"309","author":"Boden","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.vph.2015.05.017_bb0120","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1161\/CIRCULATIONAHA.108.821736","article-title":"Effects of different types of exercise training followed by detraining on endothelium-dependent dilation in patients with recent myocardial infarction","volume":"119","author":"Vona","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.vph.2015.05.017_bb0125","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1093\/ajh\/hpt080","article-title":"Exercise training reduces peripheral arterial stiffness and myocardial oxygen demand in young prehypertensive subjects","volume":"26","author":"Beck","year":"2013","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.vph.2015.05.017_bb0130","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0022-3565(25)12087-9","article-title":"Immunological characterization of urinary 8-epi-prostaglandin F2 alpha excretion in man","volume":"275","author":"Wang","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.vph.2015.05.017_bb0135","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1161\/01.CIR.85.5.1792","article-title":"Increased thromboxane biosynthesis in type IIa hypercholesterolemia","volume":"85","author":"Davi","year":"1992","journal-title":"Circulation"},{"key":"10.1016\/j.vph.2015.05.017_bb0140","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1093\/eurheartj\/ehl254","article-title":"Expert consensus document on arterial stiffness: methodological issues and clinical applications","volume":"27","author":"Laurent","year":"2006","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.vph.2015.05.017_bb0145","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/hr.2009.154","article-title":"Validity and repeatability of the Vicorder apparatus: a comparison with the SphygmoCor device","volume":"32","author":"Hickson","year":"2009","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.vph.2015.05.017_bb0150","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1161\/01.CIR.102.5.539","article-title":"Effects of vitamin E supplementation on F(2)-isoprostane and thromboxane biosynthesis in healthy cigarette smokers","volume":"102","author":"Patrignani","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.vph.2015.05.017_bb0155","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1093\/eurheartj\/ehr432","article-title":"Physical activity levels, ownership of goods promoting sedentary behaviour and risk of myocardial infarction: results of the INTERHEART study","volume":"33","author":"Held","year":"2012","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.vph.2015.05.017_bb0160","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1161\/STR.0b013e3181fcb238","article-title":"Guidelines for the primary prevention of stroke: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"42","author":"Goldstein","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.vph.2015.05.017_bb0165","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/HJR.0b013e3282f55e09","article-title":"Association of physical activity with all-cause and cardiovascular mortality: a systematic review and meta-analysis","volume":"15","author":"Nocon","year":"2008","journal-title":"Eur. J. Cardiovasc. Prev. Rehabil."},{"key":"10.1016\/j.vph.2015.05.017_bb0170","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1177\/1359786810382057","article-title":"Mortality trends in the general population: the importance of cardiorespiratory fitness","volume":"24","author":"Lee","year":"2010","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.vph.2015.05.017_bb0175","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1161\/CIR.0b013e318235eb4d","article-title":"AHA\/ACCF secondary prevention and risk reduction therapy for patients with coronary and other atherosclerotic vascular disease: 2011 update: a guideline from the American Heart Association and American College of Cardiology Foundation","volume":"124","author":"Smith","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.vph.2015.05.017_bb0180","doi-asserted-by":"crossref","first-page":"e110034","DOI":"10.1371\/journal.pone.0110034","article-title":"Effects of exercise modalities on arterial stiffness and wave reflection: a systematic review and meta-analysis of randomized controlled trials","volume":"9","author":"Ashor","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.vph.2015.05.017_bb0185","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ijcard.2015.04.020","article-title":"Brachial-ankle pulse wave velocity is associated with coronary calcification among 1131 healthy middle-aged men","volume":"189","author":"Vishnu","year":"2015","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.vph.2015.05.017_bb0190","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1093\/oxfordjournals.aje.a117315","article-title":"Arterial stiffness: a new cardiovascular risk factor?","volume":"140","author":"Arnett","year":"1994","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.vph.2015.05.017_bb0195","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1161\/01.CIR.102.11.1270","article-title":"Aging, habitual exercise, and dynamic arterial compliance","volume":"102","author":"Tanaka","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.vph.2015.05.017_bb0200","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.jacc.2011.11.082","article-title":"Endothelial dysfunction, arterial stiffness, and heart failure","volume":"60","author":"Marti","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.vph.2015.05.017_bb0205","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.coph.2004.11.003","article-title":"Isoprostane formation and inhibition in atherothrombosis","volume":"5","author":"Patrono","year":"2005","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.vph.2015.05.017_bb0210","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1161\/01.ATV.0000158311.24443.af","article-title":"Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis","volume":"25","author":"Laufs","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.vph.2015.05.017_bb0215","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1055\/s-0032-1301891","article-title":"Nitro-oxidative stress biomarkers in active and inactive men","volume":"33","author":"Bjork","year":"2012","journal-title":"Int. J. Sports Med."},{"key":"10.1016\/j.vph.2015.05.017_bb0220","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1080\/17461391.2013.823466","article-title":"Physical inactivity and muscle oxidative capacity in humans","volume":"14","author":"Gram","year":"2014","journal-title":"Eur. J. Sport Sci."},{"key":"10.1016\/j.vph.2015.05.017_bb0225","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1191\/0961203305lu2216oa","article-title":"Oxidant stress, inflammation and atherogenesis","volume":"14","author":"Dav\u00ec","year":"2005","journal-title":"Lupus"},{"key":"10.1016\/j.vph.2015.05.017_bb0230","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.288.16.2008","article-title":"Platelet activation in obese women: role of inflammation and oxidant stress","volume":"288","author":"Dav\u00ec","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.vph.2015.05.017_bb0235","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/HJH.0000000000000473","article-title":"Joint scientific statement of the European Association for the Study of Obesity and the European Society of Hypertension: obesity and early vascular ageing","volume":"33","author":"Jordan","year":"2015","journal-title":"J. Hypertens."},{"key":"10.1016\/j.vph.2015.05.017_bb0240","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1055\/s-0033-1363266","article-title":"Effect of a single bout of resistance exercise on arterial stiffness following a high-fat meal","volume":"35","author":"Augustine","year":"2014","journal-title":"Int. J. Sports Med."},{"key":"10.1016\/j.vph.2015.05.017_bb0245","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1097\/HJH.0000000000000520","article-title":"Non-hemodynamic predictors of arterial stiffness after 17years of follow-up: the Malmo Diet and cancer study","volume":"33","author":"Gottsater","year":"2015","journal-title":"J. Hypertens."}],"container-title":["Vascular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189115001317?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189115001317?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T10:24:13Z","timestamp":1748427853000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1537189115001317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":49,"alternative-id":["S1537189115001317"],"URL":"https:\/\/doi.org\/10.1016\/j.vph.2015.05.017","relation":{},"ISSN":["1537-1891"],"issn-type":[{"value":"1537-1891","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Arterial stiffness and sedentary lifestyle: Role of oxidative stress","name":"articletitle","label":"Article Title"},{"value":"Vascular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vph.2015.05.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}