{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T02:31:23Z","timestamp":1789698683271,"version":"4.0.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T00:00:00Z","timestamp":1439251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005617","name":"BHF Centre of Research Excellence","doi-asserted-by":"publisher","award":["RE\/13\/1\/30181"],"award-info":[{"award-number":["RE\/13\/1\/30181"]}],"id":[{"id":"10.13039\/501100005617","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RG\/10\/15\/28578"],"award-info":[{"award-number":["RG\/10\/15\/28578"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RG\/12\/5\/29576"],"award-info":[{"award-number":["RG\/12\/5\/29576"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wellcome Trust Core","award":["090532\/Z\/09\/Z"],"award-info":[{"award-number":["090532\/Z\/09\/Z"]}]},{"name":"National Institute for Health Research (NIHR) Oxford Biomedical Research Centre"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vascular Pharmacology"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.vph.2015.08.009","type":"journal-article","created":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T19:28:19Z","timestamp":1439321299000},"page":"69-79","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Endothelial cell tetrahydrobiopterin deficiency attenuates LPS-induced vascular dysfunction and hypotension"],"prefix":"10.1016","volume":"77","author":[{"given":"Surawee","family":"Chuaiphichai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Starr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manasi","family":"Nandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith M.","family":"Channon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0971-9858","authenticated-orcid":false,"given":"Eileen","family":"McNeill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vph.2015.08.009_bb0005","doi-asserted-by":"crossref","first-page":"R182","DOI":"10.1186\/cc11666","article-title":"Angiopoietin-1 variant reduces LPS-induced microvascular dysfunction in a murine model of sepsis","volume":"16","author":"Alfieri","year":"2012","journal-title":"Crit. Care"},{"key":"10.1016\/j.vph.2015.08.009_bb0010","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/jlb.48.6.565","article-title":"Modulation of nitrogen oxide synthesis in vivo: NG-monomethyl-l-arginine inhibits endotoxin-induced nitrate\/nitrate biosynthesis while promoting hepatic damage","volume":"48","author":"Billiar","year":"1990","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.vph.2015.08.009_bb0015","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1006\/bbrc.1996.0348","article-title":"Inhibition of tetrahydrobiopterin synthesis reduces in vivo nitric oxide production in experimental endotoxic shock","volume":"220","author":"Bune","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.vph.2015.08.009_bb0020","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/S0008-6363(02)00460-1","article-title":"GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: effects on nitric oxide synthase activity, protein levels and dimerization","volume":"55","author":"Cai","year":"2002","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.vph.2015.08.009_bb0025","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1096\/fj.02-0668fje","article-title":"Protection against lipopolysaccharide-induced endothelial dysfunction in resistance and conduit vasculature of iNOS knockout mice","volume":"17","author":"Chauhan","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.vph.2015.08.009_bb0030","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1042\/CS20120479","article-title":"P2X7 receptor activation contributes to an initial upstream mechanism of lipopolysaccharide-induced vascular dysfunction","volume":"125","author":"Chiao","year":"2013","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.vph.2015.08.009_bb0035","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1161\/HYPERTENSIONAHA.114.03089","article-title":"Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation","volume":"64","author":"Chuaiphichai","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.vph.2015.08.009_bb0040","doi-asserted-by":"crossref","first-page":"10040","DOI":"10.1074\/jbc.M411991200","article-title":"Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knock-out mice: a pro-inflammatory role for eNOS-derived no in vivo","volume":"280","author":"Connelly","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vph.2015.08.009_bb0045","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1074\/jbc.M805403200","article-title":"Quantitative regulation of intracellular endothelial nitric oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression","volume":"284","author":"Crabtree","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vph.2015.08.009_bb0050","first-page":"211","article-title":"Differential induction of nitric oxide synthase in various organs of the mouse during endotoxaemia: role of TNF-alpha and IL-1-beta","volume":"81","author":"Cunha","year":"1994","journal-title":"Immunology"},{"key":"10.1016\/j.vph.2015.08.009_bb0055","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1161\/CIRCULATIONAHA.111.038919","article-title":"Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease","volume":"125","author":"Cunnington","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.vph.2015.08.009_bb0060","doi-asserted-by":"crossref","first-page":"4031","DOI":"10.4049\/jimmunol.0900105","article-title":"A pivotal role of endothelial-specific NF-kappaB signaling in the pathogenesis of septic shock and septic vascular dysfunction","volume":"183","author":"Ding","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.vph.2015.08.009_bb0065","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/infdis\/171.1.153","article-title":"Protective effects of a recombinant amino-terminal fragment of human bactericidal\/permeability-increasing protein in an animal model of gram-negative sepsis","volume":"171","author":"Evans","year":"1995","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.vph.2015.08.009_bb0070","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1093\/bja\/86.4.578","article-title":"Circulating tetrahydrobiopterin concentrations in patients with septic shock","volume":"86","author":"Galley","year":"2001","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.vph.2015.08.009_bb0075","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1042\/cs0880131","article-title":"Nitric oxide synthase activity is increased in patients with sepsis syndrome","volume":"88","author":"Goode","year":"1995","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.vph.2015.08.009_bb0080","doi-asserted-by":"crossref","first-page":"25722","DOI":"10.1016\/S0021-9258(18)35667-9","article-title":"Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle","volume":"267","author":"Gross","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vph.2015.08.009_bb0085","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1097\/CCM.0b013e31825b88ba","article-title":"Administration of tetrahydrobiopterin improves the microcirculation and outcome in an ovine model of septic shock","volume":"40","author":"He","year":"2012","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.vph.2015.08.009_bb0090","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/0006-291X(90)91565-A","article-title":"Reversal of endotoxin-mediated shock by NG-methyl-l-arginine, an inhibitor of nitric oxide synthesis","volume":"172","author":"Kilbourn","year":"1990","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.vph.2015.08.009_bb0095","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1093\/cvr\/cvs246","article-title":"Glucose-independent improvement of vascular dysfunction in experimental sepsis by dipeptidyl-peptidase 4 inhibition","volume":"96","author":"Kroller-Schon","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.vph.2015.08.009_bb0100","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/0092-8674(95)90085-3","article-title":"Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase","volume":"81","author":"MacMicking","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.vph.2015.08.009_bb0105","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.freeradbiomed.2014.10.575","article-title":"Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation","volume":"79","author":"McNeill","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.vph.2015.08.009_bb0110","doi-asserted-by":"crossref","first-page":"10043","DOI":"10.1073\/pnas.87.24.10043","article-title":"Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells","volume":"87","author":"Radomski","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.vph.2015.08.009_bb0115","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/j.1476-5381.1990.tb14151.x","article-title":"Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo","volume":"101","author":"Rees","year":"1990","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.vph.2015.08.009_bb0120","doi-asserted-by":"crossref","first-page":"9909","DOI":"10.1073\/pnas.1301026110","article-title":"Protein kinase G oxidation is a major cause of injury during sepsis","volume":"110","author":"Rudyk","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.vph.2015.08.009_bb0125","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1152\/japplphysiol.00793.2014","article-title":"Quantification of microcirculatory blood flow: a sensitive and clinically relevant prognostic marker in murine models of sepsis","volume":"118","author":"Sand","year":"2015","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.vph.2015.08.009_bb0130","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/S0024-3205(98)00427-5","article-title":"Protective effects of tetrahydrobiopterin against nitric oxide-induced endothelial cell death","volume":"63","author":"Shimizu","year":"1998","journal-title":"Life Sci."},{"key":"10.1016\/j.vph.2015.08.009_bb0135","doi-asserted-by":"crossref","first-page":"R412","DOI":"10.1152\/ajpregu.00823.2010","article-title":"Disruption of COX-2 and eNOS does not confer protection from cardiovascular failure in lipopolysaccharide-treated conscious mice and isolated vascular rings","volume":"301","author":"Staehr","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.vph.2015.08.009_bb0140","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/SHK.0000000000000235","article-title":"Overexpression of GTP cyclohydrolase 1 feedback regulatory protein is protective in a murine model of septic shock","volume":"42","author":"Starr","year":"2014","journal-title":"Shock"},{"key":"10.1016\/j.vph.2015.08.009_bb0145","first-page":"104","article-title":"Effect of superoxide dismutase on hemorrhagic hypotension and retransfusion-evoked middle cerebral artery endothelial dysfunction","volume":"44","author":"Szabo","year":"1994","journal-title":"Circ. Shock."},{"key":"10.1016\/j.vph.2015.08.009_bb0150","doi-asserted-by":"crossref","first-page":"13660","DOI":"10.1074\/jbc.M807959200","article-title":"GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression","volume":"284","author":"Tatham","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vph.2015.08.009_bb0155","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/S0006-2952(96)00511-4","article-title":"Effect of septicaemia on the plasma levels of biopterin and nitric oxide metabolites in rats and rabbits","volume":"52","author":"van Amsterdam","year":"1996","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.vph.2015.08.009_bb0160","doi-asserted-by":"crossref","first-page":"7236","DOI":"10.1074\/jbc.M411317200","article-title":"Autoregulatory role of endothelium-derived nitric oxide (NO) on lipopolysaccharide-induced vascular inducible NO synthase expression and function","volume":"280","author":"Vo","year":"2005","journal-title":"J. Biol. Chem."}],"container-title":["Vascular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189115001950?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189115001950?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T05:55:55Z","timestamp":1653026155000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1537189115001950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":32,"alternative-id":["S1537189115001950"],"URL":"https:\/\/doi.org\/10.1016\/j.vph.2015.08.009","relation":{},"ISSN":["1537-1891"],"issn-type":[{"value":"1537-1891","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endothelial cell tetrahydrobiopterin deficiency attenuates LPS-induced vascular dysfunction and hypotension","name":"articletitle","label":"Article Title"},{"value":"Vascular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vph.2015.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}