{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:31:59Z","timestamp":1790224319293,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Turkish Scientific Research Council","award":["114s448"],"award-info":[{"award-number":["114s448"]}]},{"name":"Turkish Scientific Research Council","award":["109s453"],"award-info":[{"award-number":["109s453"]}]},{"DOI":"10.13039\/501100000921","name":"COST","doi-asserted-by":"publisher","award":["CA15135"],"award-info":[{"award-number":["CA15135"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Vascular Pharmacology"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.vph.2016.08.003","type":"journal-article","created":{"date-parts":[[2016,8,15]],"date-time":"2016-08-15T22:15:15Z","timestamp":1471299315000},"page":"76-82","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Hydrogen sulfide: A novel mechanism for the vascular protection by resveratrol under oxidative stress in mouse aorta"],"prefix":"10.1016","volume":"87","author":[{"given":"Gunay","family":"Yetik-Anacak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulnur","family":"Sevin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozge","family":"Ozzay\u0131m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Vehbi","family":"Dereli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.vph.2016.08.003_bb0005","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.tips.2013.03.007","article-title":"Oxidative stress in vascular disease and its pharmacological prevention","volume":"34","author":"Li","year":"2013","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.vph.2016.08.003_bb0010","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.vph.2006.08.002","article-title":"Nitric oxide and the endothelium: history and impact on cardiovascular disease","volume":"45","author":"Yetik-Anacak","year":"2006","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.vph.2016.08.003_bb0015","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.tips.2015.05.007","article-title":"The role of H2S bioavailability in endothelial dysfunction","volume":"36","author":"Wang","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.vph.2016.08.003_bb0020","doi-asserted-by":"crossref","first-page":"758358","DOI":"10.1155\/2015\/758358","article-title":"Cardiac H2S generation is reduced in ageing diabetic mice","volume":"2015","author":"Jin","year":"2015","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.vph.2016.08.003_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2119\/molmed.2015.00035","article-title":"Regulation of vascular tone, angiogenesis and cellular bioenergetics by the 3-mercaptopyruvate sulfurtransferase\/H2S pathway: functional impairment by hyperglycemia and restoration by DL-alpha-lipoic acid","volume":"21","author":"Coletta","year":"2015","journal-title":"Mol. Med."},{"key":"10.1016\/j.vph.2016.08.003_bb0030","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.bbrc.2013.02.131","article-title":"Oxidative stress suppresses the cellular bioenergetic effect of the 3-mercaptopyruvate sulfurtransferase\/hydrogen sulfide pathway","volume":"433","author":"Modis","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.vph.2016.08.003_bb0035","doi-asserted-by":"crossref","first-page":"H1215","DOI":"10.1152\/ajpheart.00796.2012","article-title":"Hydrogen sulfide preconditions the db\/db diabetic mouse heart against ischemia-reperfusion injury by activating Nrf2 signaling in an Erk-dependent manner","volume":"304","author":"Peake","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.vph.2016.08.003_bb0040","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1161\/CIRCULATIONAHA.113.001631","article-title":"Dysregulation of hydrogen sulfide producing enzyme cystathionine gamma-lyase contributes to maternal hypertension and placental abnormalities in preeclampsia","volume":"127","author":"Wang","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.vph.2016.08.003_bb0045","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.phrs.2014.08.001","article-title":"Resveratrol and cardiovascular health\u2014promising therapeutic or hopeless illusion?","volume":"90","author":"Tang","year":"2014","journal-title":"Pharmacol. Res."},{"issue":"253","key":"10.1016\/j.vph.2016.08.003_bb0050","first-page":"e10","article-title":"Resveratrol inhibits the release of soluble fms-like tyrosine kinase (sFlt-1) from human placenta","volume":"206","author":"Cudmore","year":"2012","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.vph.2016.08.003_bb0055","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.jnutbio.2011.08.008","article-title":"Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1\/NADPH oxidase-dependent mechanisms","volume":"23","author":"Tang","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.vph.2016.08.003_bb0060","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/j.bcp.2013.02.015","article-title":"SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: implications for vascular aging","volume":"85","author":"Zarzuelo","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.vph.2016.08.003_bb0065","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature01960","article-title":"Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan","volume":"425","author":"Howitz","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.vph.2016.08.003_bb0070","doi-asserted-by":"crossref","first-page":"9161","DOI":"10.1073\/pnas.1202916109","article-title":"Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation","volume":"109","author":"Coletta","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.vph.2016.08.003_bb0075","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.niox.2013.04.001","article-title":"Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol","volume":"32","author":"Xia","year":"2013","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.vph.2016.08.003_bb0080","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.3892\/mmr.2013.1417","article-title":"Hydrogen sulfide prevents H2O2-induced senescence in human umbilical vein endothelial cells through SIRT1 activation","volume":"7","author":"Suo","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.vph.2016.08.003_bb0085","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00210-013-0920-x","article-title":"Hydrogen sulfide protects endothelial nitric oxide function under conditions of acute oxidative stress in vitro","volume":"387","author":"Al-Magableh","year":"2014","journal-title":"Naunyn Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.vph.2016.08.003_bb0090","article-title":"Transcriptional regulation of cystathionine-gamma-lyase in endothelial cells by NADPH oxidase 4-dependent signaling","author":"Mistry","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vph.2016.08.003_bb0095","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1159\/000430266","article-title":"Exogenous hydrogen sulfide attenuates cardiac fibrosis through reactive oxygen species signal pathways in experimental diabetes mellitus models","volume":"36","author":"Zheng","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.vph.2016.08.003_bb0100","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1210\/jc.2010-1812","article-title":"A resveratrol and polyphenol preparation suppresses oxidative and inflammatory stress response to a high-fat, high-carbohydrate meal","volume":"96","author":"Ghanim","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.vph.2016.08.003_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113305","article-title":"The role of miR-34a in the hepatoprotective effect of hydrogen sulfide on ischemia\/reperfusion injury in young and old rats","volume":"9","author":"Huang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.vph.2016.08.003_bb0110","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1111\/jcmm.12254","article-title":"Inhibitory effects of hydrogen sulphide on pulmonary fibrosis in smoking rats via attenuation of oxidative stress and inflammation","volume":"18","author":"Zhou","year":"2014","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.vph.2016.08.003_bb0115","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1161\/01.ATV.0000034022.11764.EC","article-title":"Detection of superoxide in vascular tissue","volume":"22","author":"Munzel","year":"2002","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.vph.2016.08.003_bb1115","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1515\/jbcpp-2013-0095","article-title":"Methylglyoxal causes endothelial dysfunction: the role of endothelial nitric oxide synthase and AMP-activated protein kinase alpha","volume":"25","author":"Turkseven","year":"2014","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"10.1016\/j.vph.2016.08.003_bb0120","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1172\/JCI116491","article-title":"Hypercholesterolemia increases endothelial superoxide anion production","volume":"91","author":"Ohara","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.vph.2016.08.003_bb0125","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1042\/bj2060267","article-title":"Characterization of the enzymic capacity for cysteine desulphhydration in liver and kidney of the rat","volume":"206","author":"Stipanuk","year":"1982","journal-title":"Biochem. J."},{"key":"10.1016\/j.vph.2016.08.003_bb0130","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1111\/jsm.12993","article-title":"Resveratrol stimulates hydrogen sulfide (H2 S) formation to relax murine corpus cavernosum","volume":"12","author":"Yetik-Anacak","year":"2015","journal-title":"J. Sex. Med."},{"key":"10.1016\/j.vph.2016.08.003_bb1135","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2016.08.015","article-title":"Hydrogen sulfide compensates nitric oxide deficiency in murine corpus cavernosum","author":"Yetik-Anacak","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.vph.2016.08.003_bb0900","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1111\/bph.12700","article-title":"Gas what: NO is not the only answer to sexual function","volume":"172","author":"Yetik-Anacak","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.vph.2016.08.003_bb0135","doi-asserted-by":"crossref","first-page":"13829","DOI":"10.1073\/pnas.1105121108","article-title":"Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function","volume":"108","author":"Suzuki","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.vph.2016.08.003_bb0140","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/bjp.2008.296","article-title":"Biosynthesis of H2S is impaired in non-obese diabetic (NOD) mice","volume":"155","author":"Brancaleone","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.vph.2016.08.003_bb0145","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s11010-012-1435-3","article-title":"Exogenous hydrogen sulfide attenuates diabetic myocardial injury through cardiac mitochondrial protection","volume":"371","author":"Zhong","year":"2012","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.vph.2016.08.003_bb0150","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1161\/ATVBAHA.108.179333","article-title":"Role of hydrogen sulfide in the development of atherosclerotic lesions in apolipoprotein E knockout mice","volume":"29","author":"Wang","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.vph.2016.08.003_bb0155","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/bph.12171","article-title":"Selectivity of commonly used pharmacological inhibitors for cystathionine beta synthase (CBS) and cystathionine gamma lyase (CSE)","volume":"169","author":"Asimakopoulou","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.vph.2016.08.003_bb0160","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1074\/jbc.M805459200","article-title":"Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S","volume":"284","author":"Sun","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.vph.2016.08.003_bb0165","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/aja.2013.32","article-title":"Further evidence of endogenous hydrogen sulphide as a mediator of relaxation in human and rat bladder","volume":"15","author":"Gai","year":"2013","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.vph.2016.08.003_bb0170","doi-asserted-by":"crossref","first-page":"4513","DOI":"10.1073\/pnas.0807974105","article-title":"Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation","volume":"106","author":"di Villa Bianca","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.vph.2016.08.003_bb0175","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s00210-011-0608-z","article-title":"Mechanism of vasorelaxation and role of endogenous hydrogen sulfide production in mouse aorta","volume":"383","author":"Al-Magableh","year":"2011","journal-title":"Naunyn Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.vph.2016.08.003_bb0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0053319","article-title":"cGMP-dependent protein kinase contributes to hydrogen sulfide-stimulated vasorelaxation","volume":"7","author":"Bucci","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.vph.2016.08.003_bb0185","doi-asserted-by":"crossref","first-page":"H2693","DOI":"10.1152\/ajpheart.00853.2007","article-title":"S-allylcysteine mediates cardioprotection in an acute myocardial infarction rat model via a hydrogen sulfide-mediated pathway","volume":"293","author":"Chuah","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.vph.2016.08.003_bb0190","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s00395-015-0510-9","article-title":"Hydrogen sulfide and PKG in ischemia-reperfusion injury: sources, signaling, accelerators and brakes","volume":"110","author":"Andreadou","year":"2015","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.vph.2016.08.003_bb0195","doi-asserted-by":"crossref","first-page":"5501","DOI":"10.1111\/bph.12900","article-title":"Emerging role of hydrogen sulfide in hypertension and related cardiovascular diseases","volume":"172","author":"Meng","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.vph.2016.08.003_bb0200","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3109\/13685538.2012.668722","article-title":"Endogenous hydrogen sulfide insufficiency as a predictor of sexual dysfunction in aging rats","volume":"15","author":"Srilatha","year":"2012","journal-title":"Aging Male"},{"key":"10.1016\/j.vph.2016.08.003_bb0205","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2174\/157489007780832560","article-title":"Resveratrol: a therapeutic promise for cardiovascular diseases","volume":"2","author":"Das","year":"2007","journal-title":"Recent Pat. Cardiovasc. Drug Discov."},{"key":"10.1016\/j.vph.2016.08.003_bb0210","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ejphar.2011.05.026","article-title":"Resveratrol prevents endothelial nitric oxide synthase uncoupling and attenuates development of hypertension in spontaneously hypertensive rats","volume":"667","author":"Bhatt","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.vph.2016.08.003_bb0215","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jsxm.2015.12.002","article-title":"Resveratrol protects and restores endothelium-dependent relaxation in hypercholesterolemic rabbit corpus cavernosum","volume":"13","author":"Murat","year":"2016","journal-title":"J. Sex. Med."},{"key":"10.1016\/j.vph.2016.08.003_bb0220","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.fct.2013.07.026","article-title":"Resveratrol prevents high-fructose corn syrup-induced vascular insulin resistance and dysfunction in rats","volume":"60","author":"Babacanoglu","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.vph.2016.08.003_bb0225","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.biochi.2011.11.001","article-title":"Antioxidant effects of resveratrol and other stilbene derivatives on oxidative stress and *NO bioavailability: potential benefits to cardiovascular diseases","volume":"94","author":"Frombaum","year":"2012","journal-title":"Biochimie"},{"key":"10.1016\/j.vph.2016.08.003_bb0230","doi-asserted-by":"crossref","first-page":"814","DOI":"10.3181\/00379727-232-2320814","article-title":"Chronic resveratrol enhances endothelium-dependent relaxation but does not alter eNOS levels in aorta of spontaneously hypertensive rats","volume":"232","author":"Rush","year":"2007","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.vph.2016.08.003_bb0235","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00011-015-0810-4","article-title":"Resveratrol alleviates vascular inflammatory injury by inhibiting inflammasome activation in rats with hypercholesterolemia and vitamin D2 treatment","volume":"64","author":"Deng","year":"2015","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.vph.2016.08.003_bb0240","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.niox.2014.11.006","article-title":"Hydrogen sulfide protects against apoptosis under oxidative stress through SIRT1 pathway in H9c2 cardiomyocytes","volume":"46","author":"Wu","year":"2015","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.vph.2016.08.003_bb0245","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00592-013-0501-y","article-title":"Hydrogen sulfide induces heme oxygenase-1 in human kidney cells","volume":"51","author":"D'Araio","year":"2014","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.vph.2016.08.003_bb0250","doi-asserted-by":"crossref","first-page":"H18","DOI":"10.1152\/ajpheart.00260.2010","article-title":"Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2","volume":"299","author":"Ungvari","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."}],"container-title":["Vascular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189116300519?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1537189116300519?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T21:48:38Z","timestamp":1718747318000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1537189116300519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":53,"alternative-id":["S1537189116300519"],"URL":"https:\/\/doi.org\/10.1016\/j.vph.2016.08.003","relation":{},"ISSN":["1537-1891"],"issn-type":[{"value":"1537-1891","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hydrogen sulfide: A novel mechanism for the vascular protection by resveratrol under oxidative stress in mouse aorta","name":"articletitle","label":"Article Title"},{"value":"Vascular Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.vph.2016.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}